{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:48:15Z","timestamp":1793137695787,"version":"4.5.0"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["URP"],"abstract":"<jats:p>Abstract\n\tObjective: Currently, the performance of a systematic prostate biopsy under transrectal ultrasound (TRUS) guidance is the standard procedure in the diagnosis of prostate cancer. Although TRUS-guided prostate biopsy is considered to be a safe method, it is an invasive procedure that is not free from complications. We prospectively evaluated the morbidity and complication rates for a TRUS-guided 12-core prostate biopsy.\n\n\t \n\n\tMaterial and methods: The study included 2049 patients undergoing transrectal ultrasound-guided 12-core prostate biopsy. The indications for the prostate biopsy were abnormal digital rectal examination findings and\/or an elevated serum total prostate specific antigen (PSA) level (greater than 4 ng\/mL). The participants received prophylactic oral ciprofloxacin (500 mg) the night before and the morning of the biopsy, followed by 500 mg orally twice daily for 2 days; patients also received oral alpha blockers for 30 days starting the day before the procedure. A Fleets enema was self-administered the night before the procedure. The complications were assessed both 10 days and 1 month after the biopsy.\n\n\t \n\n\tResults: The mean age, serum total PSA level and prostate volume were 65.4\u00b19.6 years, 18.6\u00b122.4 ng\/mL and 51.3\u00b122.4 cc, respectively. From these 2,042 biopsies, 596 cases (29.1%) were diagnosed as prostate cancer. Minor complications, such as hematuria (66.3%), hematospermia (38.8%), rectal bleeding (28.4%), mild to moderate vasovagal episodes (7.7%), and genitourinary tract infection (6.1%) were noted frequently. Major complications were rare and included urosepsis (0.5%), rectal bleeding that required intervention (0.3%), acute urinary retention (0.3%), hematuria that required transfusion (0.05%), Fournier\u2019s gangrene (0.05%), and myocardial infarction (0.05%).\n\n\t \n\n\tConclusion: TRUS-guided prostate biopsy is safe for diagnosing prostate cancer with few major but frequent minor complications. However, patients should be informed and followed-up with regarding possible complications.<\/jats:p>","DOI":"10.5152\/tud.2013.002","type":"journal-article","created":{"date-parts":[[2013,3,11]],"date-time":"2013-03-11T06:17:34Z","timestamp":1362982654000},"page":"6-11","source":"Crossref","is-referenced-by-count":35,"title":["Complications of transrectal ultrasound-guided 12-core prostate  biopsy: a single center experience with 2049 patients"],"prefix":"10.5152","volume":"39","author":[{"given":"Ozan","family":"Efesoy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Bozlu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selahittin","family":"\u00c7ayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdem","family":"Akbay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3111","published-online":{"date-parts":[[2019,7,25]]},"container-title":["Urology Research and Practice"],"original-title":[],"link":[{"URL":"https:\/\/urologyresearchandpractice.org\/index.php\/pub\/article\/download\/2691\/2687","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T18:56:02Z","timestamp":1772650562000},"score":1,"resource":{"primary":{"URL":"https:\/\/urologyresearchandpractice.org\/index.php\/pub\/article\/view\/2691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,25]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,1,1]]}},"URL":"https:\/\/doi.org\/10.5152\/tud.2013.002","relation":{},"ISSN":["2980-1478"],"issn-type":[{"value":"2980-1478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,25]]}}}