{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T19:18:39Z","timestamp":1772651919825,"version":"3.50.1"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["URP"],"abstract":"<jats:p>Objective: To highlight changing trends of the clinical spectrum, and compare the management options and predictors of Fournier\u2019s gangrene (FG) outcomes in a tertiary care referral center.\n\nMaterial and methods: This study included patients with FG between August 2005 and July 2017. Patients were classified as \u201cresponders\u201d and \u201cnonresponders.\u201d We compared the baseline characteristics, clinical spectrum, biochemical data, management modalities, outcomes, and FG severity index (FGSI) and age-adjusted Charlson Comorbidity Index (ACCI) between responders and nonresponders.\n\nResults: We studied 72 patients and further divided them to responders (60 patients) and non-responders (12 patients). All were males; the mean age was 56.27+19.27 years (range, 47\u201385 years). The most common complaints were perineal discomfort (n=62; 86.1%) and fever (n=48; 66.7%). FG originated from the penoscrotal region in 64 patients (88.8%) and perineal region in 8 patients. Diabetes mellitus was the most common comorbidity (36%). The mean duration of the presentation was 10.19 days (range, 7\u201330 days). Sixteen patients underwent split skin grafting. The mortality rate was 8.3%. Nonresponders had distinct findings relative to responders: advanced age (71.5\u00b17.17 vs. 53.23\u00b119.85 years; p=0.00); high blood sugar (245.83\u00b1116.26 vs. 139.06\u00b135.64 mg\/dL; p&lt;0.01); leukocytosis (27166.67\u00b110295.75 vs. 10558.4\u00b13130.64 cumm; p&lt;0.01); elevated serum creatinine (3.78\u00b11.43 vs. 1.38\u00b11.00; p&lt;0.01); hyponatremia (127.33\u00b111.84 vs. 137.33\u00b13.42 meq\/l; p&lt;0.01), elevated international normalized ratios (1.66\u00b10.28 vs. 1.32\u00b10.07; p&lt;0.01); and high FGSI (9.83\u00b11.11 vs. 6.46\u00b11.68;p&lt;0.01) and ACCI scores (6.33\u00b10.49 vs. 5\u00b10.82; p&lt;0.01). On univariate and multivariate regression analysis, raised blood sugar and deranged international normalized ratios at presentation were significantly associated with decreased response to treatment (p&lt;0.05).\n\nConclusion: An advanced age, diabetes mellitus, renal impairment, leukocytosis, altered sensorium, shock at presentation, deranged international normalized ratios, and high FGSI and ACCI scores can be used as predictors for poor response. FG risk scores adequately characterize the severity and prognosis of FG, but clinician\u2019s judgement is vital. The management comprises of a multidisciplinary approach, including parenteral antibiotics, urgent surgical debridement, and comorbidities optimization.\n\nCite this article as: Garg G, Singh V, Sinha RJ, Sharma A, Pandey S, Aggarwal A. Outcomes of patients with Fournier\u2019s Gangrene: 12-year experience from a tertiary care referral center. Turk J Urol 2019; 45(Supp. 1): S111-S116.<\/jats:p>","DOI":"10.5152\/tud.2019.39586","type":"journal-article","created":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T09:21:22Z","timestamp":1576056082000},"page":"S111-S116","source":"Crossref","is-referenced-by-count":12,"title":["Outcomes of patients with Fournier\u2019s Gangrene: 12-year experience from a tertiary care referral center"],"prefix":"10.5152","volume":"45","author":[{"given":"Gaurav","family":"Garg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishwajeet","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahul Janak","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashish","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siddharth","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay","family":"Aggarwal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3111","published-online":{"date-parts":[[2019,12,2]]},"container-title":["Urology Research and Practice"],"original-title":[],"link":[{"URL":"https:\/\/urologyresearchandpractice.org\/index.php\/pub\/article\/download\/3251\/3247","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T17:38:37Z","timestamp":1772645917000},"score":1,"resource":{"primary":{"URL":"https:\/\/urologyresearchandpractice.org\/index.php\/pub\/article\/view\/3251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,2]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,1,1]]}},"URL":"https:\/\/doi.org\/10.5152\/tud.2019.39586","relation":{},"ISSN":["2980-1478"],"issn-type":[{"value":"2980-1478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,2]]}}}