{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T19:06:55Z","timestamp":1772651215999,"version":"3.50.1"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["URP"],"abstract":"<jats:p>Objective: The excessive desire to void with discomfort in the supra-pubic region, which is experienced postoperatively by patients who underwent urinary catheterization, is known as catheter-related bladder discomfort. In this study, we evaluated duloxetine, a selective serotonin and norepinephrine reuptake inhibitor, in preventing catheter-related bladder discomfort.\n\nMaterial and methods: Around 64 adults (18-60 years), of either sex, with American Society of American Society of Anesthesiologists (ASA) physical status I and II, scheduled to undergo elective gastrointestinal carcinoma surgeries under general anesthesia were analyzed in the final assessment of 2 comparative groups C and D of 32 patients each. Group D received 1 ranitidine tablet of 150 mg and 1 duloxetine tablet of 60 mg, while group C patients received 2 tablets of ranitidine of 75 mg 2 hours prior to induction. A 16 F Foley catheter was used to catheterize bladder intra-operatively, and 10 mL of distilled water was used to fill the balloon. At 0, 1, 2, and 6 hours, the catheter-related bladder discomfort was evaluated, and categorized into none, mild, moderate, and severe. The study drug's adverse effects, if any, were reported.\n\nResults: At all-time intervals, group D had lower incidence and severity of catheterrelated bladder discomfort than group C (P &lt; .05). Compared to group C, patients in group D had a higher incidence of nausea, dizziness, and vomiting; nevertheless, the difference was statistically insignificant (P &gt; .05).\n\nConclusion: Duloxetine of 60 mg given orally 2 hours before induction decreases the incidence and severity of catheter-related bladder discomfort.\n\nCite this article as: Rath A, Reena, Yadav G. Duloxetine in reducing catheter-related bladder discomfort: A prospective, randomized, double-blind, placebo-controlled study. Urol Res Pract., 2023;49(1):48-52.<\/jats:p>","DOI":"10.5152\/tud.2023.22195","type":"journal-article","created":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T03:22:38Z","timestamp":1681960958000},"page":"48-52","source":"Crossref","is-referenced-by-count":3,"title":["Duloxetine in Reducing Catheter-Related Bladder Discomfort: A Prospective, Randomized, Double-Blind, Placebo-Controlled Study"],"prefix":"10.5152","volume":"49","author":[{"given":"Amrita","family":"Rath","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":".","family":"Reena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghanshyam","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3111","published-online":{"date-parts":[[2023,3,10]]},"container-title":["Urology Research and Practice"],"original-title":[],"link":[{"URL":"https:\/\/urologyresearchandpractice.org\/index.php\/pub\/article\/download\/3535\/3531","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T17:04:06Z","timestamp":1772643846000},"score":1,"resource":{"primary":{"URL":"https:\/\/urologyresearchandpractice.org\/index.php\/pub\/article\/view\/3535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,10]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1,1]]}},"URL":"https:\/\/doi.org\/10.5152\/tud.2023.22195","relation":{},"ISSN":["2980-1478"],"issn-type":[{"value":"2980-1478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,10]]}}}