{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T19:05:49Z","timestamp":1772651149339,"version":"3.50.1"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["URP"],"abstract":"<jats:p>Objective: This study aimed to evaluate retrospectively the outcomes of Abobotulinumtoxin-A (Dysport\u00ae) intravesical injection in refractory interstitial cystitis\/ bladder pain syndrome patients to first- and second-line treatment.\n\nMaterials and Methods: From March 2016 to 2021, 44 adult patients with bladder pain syndrome who were refractory to first- and second-line treatment were enrolled in our study. The Bladder Pain\/Interstitial Cystitis Symptom Score questionnaire was filled out for every patient before and 1-3 months after intervention in addition to urodynamic evaluation. Patient satisfaction was evaluated using a scoring system that was defined as high or &gt;80% improvement (highly satisfied), intermediate 40%-79% (intermediate satisfaction), and poor 0%-39% improvement.\n\nResults: The mean age of our study population was 57 years, including 41 females and 3 males. The mean follow-up time was 9 months. According to the results of urodynamics, 68% of cases had low capacity, and detrusor overactivity, while 18% had only low capacity. In terms of the endpoint outcome, half of the patients (52%) had intermediate satisfaction, whereas 41% reported a good response. Only 3 cases had no response or felt (7%) any improvement after the intervention (poor response). The paired t-test analysis revealed that the mean Bladder Pain\/Interstitial Cystitis Symptom Score was reduced after injection (P = .001).\n\nConclusion: Our results showed the efficacy and safety of intravesical injections with Abobotulinumtoxin-A (Dysport\u00ae) in patients with interstitial cystitis\/bladder pain syndrome. Further randomized controlled trials are recommended to investigate its superiority over placebo considering the need for anesthesia, the occurrence of local complications, risks of urinary retention, and a large post-void residual (PVR) volume.\n\nCite this article as: Rahnama\u2019i M, Salehi-Pourmehr H, Saeedi S, Tayebi S, Hajebrahimi S. Intravesical injection of abobotulinumtoxin-A in patients with bladder pain syndrome\/interstitial cystitis. Urol Res Pract. 2023;49(3):205-210<\/jats:p>","DOI":"10.5152\/tud.2023.22243","type":"journal-article","created":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T03:13:41Z","timestamp":1681960421000},"page":"205-210","source":"Crossref","is-referenced-by-count":3,"title":["Intravesical Injection of Abobotulinumtoxin-A in Patients with Bladder Pain Syndrome\/Interstitial Cystitis"],"prefix":"10.5152","volume":"49","author":[{"given":"Mohammad-Sajjad","family":"Rahnamai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanieh","family":"Salehi-Pourmehr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sana","family":"Saeedi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sona","family":"Tayebi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakineh","family":"Hajebrahimi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3111","published-online":{"date-parts":[[2023,5,17]]},"container-title":["Urology Research and Practice"],"original-title":[],"link":[{"URL":"https:\/\/urologyresearchandpractice.org\/index.php\/pub\/article\/download\/3557\/3553","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T17:01:41Z","timestamp":1772643701000},"score":1,"resource":{"primary":{"URL":"https:\/\/urologyresearchandpractice.org\/index.php\/pub\/article\/view\/3557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,17]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,1,1]]}},"URL":"https:\/\/doi.org\/10.5152\/tud.2023.22243","relation":{},"ISSN":["2980-1478"],"issn-type":[{"value":"2980-1478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,17]]}}}