{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T20:11:29Z","timestamp":1773778289883,"version":"3.50.1"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["URP"],"abstract":"<jats:p>Objective: Prostate cancer is the second- leading cause of cancer death among men.\nWe aimed to evaluate high-intensity focused ultrasound (HIFU), open radical prostatectomy\n(ORP), robot-assisted radical prostatectomy (RARP), and external beam radiation\ntherapy (RT) in the treatment of localized low- and intermediate-risk prostate cancer.\n\nMethods: We searched bibliographic databases for case\u2013control, cohort, and randomized\ncontrolled studies. We used MeSH subject headings and free text terms for prostate\ncancer, HIFU, ORP, RARP, RT, failure-free survival (FFS), biochemical disease-free\nsurvival (BDFS), urinary incontinence (UI), and erectile dysfunction (ED).\n\nResults: Fourteen studies were included in the review, for a total of 34 927 participants.\nAmong the 8 studies of HIFU as the primary treatment of localized low- and intermediate-\nrisk prostate cancer, 4 studies reported 5-year FFS rates ranging from 67.8% to\n97.8%, 3 studies reported 5-year BDFS ranging from 58% to 85.4%, 5 studies reported\n1-year UI rates ranging from 0% to 6%, and 4 studies reported 1-year ED rates ranging\nfrom 11.4% to 38.7%. Furthermore, our search revealed a 5-year FFS benefit favoring\nORP compared to RT, a 1-year UI rate favoring ORP compared to RARP, and a 1-year ED\nrate favoring ORP compared to RARP.\n\nConclusion: Our systematic review and meta-analysis revealed lack of studies with\nactive comparators comparing HIFU to standard of care (ORP, RARP, or RT) in primary\ntreatment of localized low- and intermediate-risk prostate cancer. Open radical prostatectomy\nhas favorable efficacy outcomes compared to RT, while RARP has beneficial\nfunctional outcomes compared to ORP, respectively.\n\nCite this article as: Toeama B, Papadimitropoulos E, Perlis N, Grootendorst P, Hamandi B. A systematic review and\nmeta-analysis of the cancer-related and functional outcomes of high intensity focused ultrasound, open radical\nprostatectomy, robot assisted radical prostatectomy, and external beam radiation therapy in primary treatment of localized\nlow or intermediate risk prostate cancer. Urol Res Pract. 2024;50(1):1-12.<\/jats:p>","DOI":"10.5152\/tud.2024.23123","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T08:54:56Z","timestamp":1708937696000},"page":"1-12","source":"Crossref","is-referenced-by-count":0,"title":["A Systematic Review on HIFU for Prostate Cancer"],"prefix":"10.5152","volume":"50","author":[{"given":"Bassem","family":"Toeama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Papadimitropoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan","family":"Perlis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Grootendorst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bassem","family":"Hamandi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3111","published-online":{"date-parts":[[2024,2,19]]},"container-title":["Urology Research and Practice"],"original-title":[],"link":[{"URL":"https:\/\/urologyresearchandpractice.org\/index.php\/pub\/article\/download\/3590\/3586","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T17:06:07Z","timestamp":1773767167000},"score":1,"resource":{"primary":{"URL":"https:\/\/urologyresearchandpractice.org\/index.php\/pub\/article\/view\/3590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,19]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1,1]]}},"URL":"https:\/\/doi.org\/10.5152\/tud.2024.23123","relation":{},"ISSN":["2980-1478"],"issn-type":[{"value":"2980-1478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,19]]}}}