{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T21:52:49Z","timestamp":1769550769857,"version":"3.49.0"},"reference-count":39,"publisher":"Universa BV","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AGEB"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:p>Introduction : Auto-immune hepatitis (AIH) is a rare condition which primarily affects young women. Several diagnostic scoring systems exist based on clinical, biochemical, immunologic and histologic characteristics of AIH. Additionally, prognostic parameters can be identified. The purpose of this literary review is to compare the clinical value, strengths and limitations of these diagnostic and prognostic scoring systems.\n\nMethods : A literature search was performed in two databases and selected based on diagnostic and prognostic criteria. Only studies concerning AIH in adults were included.\n\nResults : The backbone of scoring systems remains the revised AIH criteria published in 1999 and the simplified from 2008. The revised system shows a higher sensitivity, lower specificity and lower diagnostic accuracy compared to the simplified. Limitations to these scoring systems include limited diagnostic accuracy in acute or fulminant liver failure, insufficient inclusion of atypical auto-antibodies and lacking diagnostic power in presence of overlap syndromes. Concerning these overlap syndromes, the Paris criteria show a higher diagnostic accuracy compared to the scoring systems for AIH. Presently, no clinical prognostic scoring systems are available. However, a first system based on response to treatment accurately predicts long-term survival in AIH.\n\nConclusion : Diagnostic scoring systems are useful in diagnosing AIH and have complementary value. However, they are no sub- stitute for the gold standard of appropriate clinical assessment and are mostly useful in defining cohorts for research purposes. An evolution towards a more dynamic scoring system, using prognostic parameters and the progression of typical features, seems more valuable than the current diagnostic systems.<\/jats:p>","DOI":"10.51821\/84.3.014","type":"journal-article","created":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T21:23:55Z","timestamp":1621545835000},"page":"487-495","source":"Crossref","is-referenced-by-count":8,"title":["Diagnostic and prognostic scoring systems for autoimmune hepatitis : a review"],"prefix":"10.51821","volume":"84","author":[{"given":"O","family":"Ducazu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Degroote","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Geerts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Schouten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Van Vlierberghe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X","family":"Verhelst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27062","published-online":{"date-parts":[[2021,9]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"MACK CL, ADAMS D, ASSIS DN, KERKAR N, MANNS MP, MAYO MJ, et al. Diagnosis and Management of Autoimmune Hepatitis in Adults and Children : 2019 Practice Guidance and Guidelines From the American Association for the Study of Liver Diseases. Hepatology (Baltimore, Md). 2020, 72(2)  : 671-722.","DOI":"10.1002\/hep.31065"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"European Association for the Study of the L. EASL Clinical Practice Guidelines : Autoimmune hepatitis. Journal of hepatology. 2015, 63(4) : 971-1004.","DOI":"10.1016\/j.jhep.2015.06.030"},{"key":"ref2","unstructured":"DALEKOS GN, KOSKINAS J, PAPATHEODORIDIS GV. Hellenic Association for the Study of the Liver Clinical Practice Guidelines : Autoimmune hepatitis. Annals of gastroenterology. 2019, 32(1) : 1-23."},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"GATSELIS NK, ZACHOU K, KOUKOULIS GK, DALEKOS GN. Autoimmune hepatitis, one disease with many faces : etiopathogenetic, clinico-laboratory and histological characteristics. World journal of gastro-enterology. 2015, 21(1) : 60-83.","DOI":"10.3748\/wjg.v21.i1.60"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"CZAJA AJ. Diagnosis and Management of Autoimmune Hepatitis : Current Status and Future Directions. Gut and liver. 2016, 10(2) : 177-203.","DOI":"10.5009\/gnl15352"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"VERGANI D, MIELI-VERGANI G. Autoimmune hepatitis : Diagnostic criteria and serological testing. Clinical liver disease. 2014, 3(2) : 38-41.","DOI":"10.1002\/cld.321"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"ALVAREZ F, BERG PA, BIANCHI FB, BIANCHI L, BURROUGHS AK, CANCADO EL, et al. International Autoimmune Hepatitis Group Report : review of criteria for diagnosis of autoimmune hepatitis. Journal of hepatology. 1999, 31(5) : 929-38.","DOI":"10.1016\/S0168-8278(99)80297-9"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"KRIESE S, HENEGHAN MA. Current concepts in the diagnosis and management of autoimmune hepatitis. Frontline gastroenterology. 2013, 4(1) : 2-11.","DOI":"10.1136\/flgastro-2012-100208"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"ABDOLLAHI MR, SOMI MH, FARAJI E. Role of international criteria in the diagnosis of autoimmune hepatitis. World journal of gastroenterology. 2013, 19(23) : 3629-33.","DOI":"10.3748\/wjg.v19.i23.3629"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"MOREIRA RK, REVETTA F, KOEHLER E, WASHINGTON MK. Diagnostic utility of IgG and IgM immunohistochemistry in autoimmune liver disease. World journal of gastroenterology. 2010, 16(4) : 453-7.","DOI":"10.3748\/wjg.v16.i4.453"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"CABIBI D, TARANTINO G, BARBARIA F, CAMPIONE M, CRAXI A, DI MARCO V. Intrahepatic IgG\/IgM plasma cells ratio helps in classifying autoimmune liver diseases. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. 2010, 42(8) : 585-92.","DOI":"10.1016\/j.dld.2009.12.006"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"HENNES EM, ZENIYA M, CZAJA AJ, PARES A, DALEKOS GN, KRAWITT EL, et al. Simplified criteria for the diagnosis of autoimmune hepatitis. Hepatology (Baltimore, Md). 2008, 48(1) : 169-76.","DOI":"10.1002\/hep.22322"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"SEBODE M, WEILER-NORMANN C, LIWINSKI T, SCHRAMM C. Autoantibodies in Autoimmune Liver Disease-Clinical and Diagnostic Relevance. Frontiers in immunology. 2018, 9 : 609.","DOI":"10.3389\/fimmu.2018.00609"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"TERJUNG B, SPENGLER U, SAUERBRUCH T, WORMAN HJ. \u201cAtypical p-ANCA\u201d in IBD and hepatobiliary disorders react with a 50-kilo-dalton nuclear envelope protein of neutrophils and myeloid cell lines. Gastroenterology. 2000, 119(2) : 310-22.","DOI":"10.1053\/gast.2000.9366"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"HAUSDORF G, ROGGENBUCK D, FEIST E, BUTTNER T, JUNGBLUT PR, CONRAD K, et al. Autoantibodies to asialoglycoprotein receptor (ASGPR) measured by a novel ELISA \u2013 revival of a disease-activity marker in autoimmune hepatitis. Clinica chimica acta, international journal of clinical chemistry. 2009, 408(1-2) : 19-24.","DOI":"10.1016\/j.cca.2009.06.035"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"BALITZER D, SHAFIZADEH N, PETERS MG, FERRELL LD, ALSHAK N, KAKAR S. Autoimmune hepatitis : review of histologic features included in the simplified criteria proposed by the international autoimmune hepatitis group and proposal for new histologic criteria. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2017, 30(5) : 773-83.","DOI":"10.1038\/modpathol.2016.267"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"JABLONSKA J, CIELECKA-KUSZYK J, MIKULA T, KOZLOWSKA J, WIERCINSKA-DRAPALO A. Hepatopathy of unknown etiology-is liver biopsy a good tool in differential diagnosis? Archives of medical science : AMS. 2019, 15(6) : 1462-7.","DOI":"10.5114\/aoms.2019.82637"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"CHAZOUILLERES O, WENDUM D, SERFATY L, MONTEMBAULT S, ROSMORDUC O, POUPON R. Primary biliary cirrhosis-autoimmune hepatitis overlap syndrome : clinical features and response to therapy. Hepatology (Baltimore, Md). 1998, 28(2) : 296-301.","DOI":"10.1002\/hep.510280203"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"ZHANG W, DE D, MOHAMMED KA, MUNIGALA S, CHEN G, LAI JP, et al. New scoring classification for primary biliary cholangitis-autoimmune hepatitis overlap syndrome. Hepatology communications. 2018, 2(3) : 245-53.","DOI":"10.1002\/hep4.1148"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"FEBRES-ALDANA CA, ALGHAMDI S, KRISHNAMURTHY K, POPPITI RJ. Liver Fibrosis Helps to Distinguish Autoimmune Hepatitis from DILI with Autoimmune Features : A Review of Twenty Cases. Journal of clinical and translational hepatology. 2019, 7(1) : 21-6.","DOI":"10.14218\/jcth.2018.00053"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"JOHNSON PJ, MCFARLANE IG. Meeting report : International Autoimmune Hepatitis Group. Hepatology (Baltimore, Md). 1993, 18(4) : 998-1005.","DOI":"10.1002\/hep.1840180435"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"CZAJA A, CARPENTER HA. Validation of scoring system for diagnosis of autoimmune hepatitis. Digestive diseases and sciences. 1996, 41(2) : 305-14.","DOI":"10.1007\/bf02093820"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"Lohse AW. Recognizing autoimmune hepatitis : scores help, but no more. Journal of hepatology. 2011, 54(2) : 193-4.","DOI":"10.1016\/j.jhep.2010.07.013"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"FUJIWARA K, YASUI S, TAWADA A, FUKUDA Y, NAKANO M, YOKOSUKA O. Diagnostic value and utility of the simplified International Autoimmune Hepatitis Group criteria in acute-onset autoimmune hepatitis. Liver international : official journal of the International Association for the Study of the Liver. 2011, 31(7) : 1013-20.","DOI":"10.1111\/j.1478-3231.2011.02524.x"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"LI Y, PENG M, GONG G. Evaluation of the revised versus the simplified scoring system in patients with autoimmune hepatitis. Experimental and therapeutic medicine. 2014, 7(1) : 131-6.","DOI":"10.3892\/etm.2013.1366"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"GATSELIS NK, ZACHOU K, PAPAMICHALIS P, KOUKOULIS GK, GABETA S, DALEKOS GN, et al. Comparison of simplified score with the revised original score for the diagnosis of autoimmune hepatitis : a new or a complementary diagnostic score? Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. 2010, 42(11) : 807-12.","DOI":"10.1016\/j.dld.2010.03.005"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"MUNOZ-ESPINOSA L, ALARCON G, MERCADO-MOREIRA A, CORDERO P, CABALLERO E, AVALOS V, et al. Performance of the international classifications criteria for autoimmune hepatitis diagnosis in Mexican patients. Autoimmunity. 2011, 44(7) : 543-8.","DOI":"10.3109\/08916934.2011.592884"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"KIM BH, KIM YJ, JEONG SH, TAK WY, AHN SH, LEE YJ, et al. Clinical features of autoimmune hepatitis and comparison of two diagnostic criteria in Korea : a nationwide, multicenter study. Journal of gastroenterology and hepatology. 2013, 28(1) : 128-34.","DOI":"10.1111\/j.1440-1746.2012.07292.x"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"QIU D, WANG Q, WANG H, XIE Q, ZANG G, JIANG H, et al. Validation of the simplified criteria for diagnosis of autoimmune hepatitis in Chinese patients. Journal of hepatology. 2011, 54(2) : 340-7.","DOI":"10.1016\/j.jhep.2010.06.032"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"LIBERAL R, VERGANI D. Effect of ethnicity on the clinical presentation and outcome of autoimmune hepatitis. Expert review of gastroenterology & hepatology. 2012, 6(3) : 267-9.","DOI":"10.1586\/egh.12.17"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"KUIPER EM, ZONDERVAN PE, VAN BUUREN HR. Paris criteria are effective in diagnosis of primary biliary cirrhosis and autoimmune hepatitis overlap syndrome. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2010, 8(6) : 530-4.","DOI":"10.1016\/j.cgh.2010.03.004"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"HOEROLDT B, MCFARLANE E, DUBE A, BASUMANI P, KARAJEH M, CAMPBELL MJ, et al. Long-term outcomes of patients with autoimmune hepatitis managed at a nontransplant center. Gastroenterology. 2011, 140(7) : 1980-9.","DOI":"10.1053\/j.gastro.2011.02.065"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"PAPE S, GEVERS TJG, BELIAS M, MUSTAFAJEV IF, VROLIJK JM, VAN HOEK B, et al. Predniso(lo)ne Dosage and Chance of Remission in Patients With Autoimmune Hepatitis. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2019, 17(10) : 2068-75 e2.","DOI":"10.1016\/j.cgh.2018.12.035"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"KIRSTEIN MM, METZLER F, GEIGER E, HEINRICH E, HALLENSLEBEN M, MANNS MP, et al. Prediction of short- and long-term outcome in patients with autoimmune hepatitis. Hepatology (Baltimore, Md). 2015, 62(5) : 1524-35.","DOI":"10.1002\/hep.27983"},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"PAPE S, GEVERS TJG, VROLIJK JM, VAN HOEK B, BOUMA G, VAN NIEUWKERK CMJ, et al. Rapid Response to Treatment of Autoimmune Hepatitis Associated With Remission at 6 and 12 Months. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2020, 18(7) : 1609-17 e4.","DOI":"10.1016\/j.cgh.2019.11.013"},{"key":"ref35","doi-asserted-by":"publisher","unstructured":"VAN GERVEN NM, VERWER BJ, WITTE BI, VAN HOEK B, COENRAAD MJ, VAN ERPECUM KJ, et al. Relapse is almost universal after withdrawal of immunosuppressive medication in patients with autoimmune hepatitis in remission. Journal of hepatology. 2013, 58(1) : 141-7.","DOI":"10.1016\/j.jhep.2012.09.009"},{"key":"ref36","doi-asserted-by":"publisher","unstructured":"EDMUNDS C, EKONG UD. Autoimmune Liver Disease Post-Liver Transplantation : A Summary and Proposed Areas for Future Research. Transplantation. 2016, 100(3) : 515-24.","DOI":"10.1097\/tp.0000000000000922"},{"key":"ref37","doi-asserted-by":"publisher","unstructured":"KERKAR N, YANNI G. \u2018De novo\u2019 and \u2018recurrent\u2019 autoimmune hepatitis after liver transplantation : A comprehensive review. Journal of autoimmunity. 2016, 66 : 17-24.","DOI":"10.1016\/j.jaut.2015.08.017"},{"key":"ref38","unstructured":"A NEW. \u201cTreatment-Response Score\u2019\u2019 for AUTO Immune Hepatitis Is Predictive of LONG-TERM Event-Free Survival and Overall Survival. A Multicenter Belgian Cohort Study. AASLD The Liver Meeting, San Francisco, Hepatology 2018, 68 : S1 ; 1977B."}],"container-title":["Acta Gastro Enterologica Belgica"],"original-title":[],"language":"en","deposited":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T16:30:49Z","timestamp":1632846649000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ageb.be\/ageb-journal\/ageb-volume\/ageb-article\/1937\/Diagnostic%20and%20prognostic%20scoring%20systems%20for%20autoimmune%20hepatitis:%20a%20review\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":39,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,5,24]]},"published-print":{"date-parts":[[2021,9]]}},"URL":"https:\/\/doi.org\/10.51821\/84.3.014","relation":{},"ISSN":["1784-3227"],"issn-type":[{"value":"1784-3227","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]}}}