{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T23:53:20Z","timestamp":1652831600992},"reference-count":18,"publisher":"Universa BV","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AGEB"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:p>Condyloma acuminatum (CA) is a manifestation of Human Papillomavirus (HPV) infection which usually occurs in genital and perianal regions. We report a 46-year-old man with an ulcerative proctitis diagnosed four years earlier, asymptomatic for a long time under azathioprine but without any follow-up for three years. A colonoscopy was performed prior to potential immunosuppressive treatment discontinuation and showed a circumferential \u201claterally spreading tumour\u201d in the rectum. Surprisingly biopsies revealed a CA with a very focally high-grade intra-epithelial lesion. Azathioprine was stopped and a transanal surgical resection was performed. At guided anamnesis, patient confirmed to be a former active \u201cmen who have sex with men\u201d. No recurrence of proctitis occurred despite azathioprine discontinuation. A retrospective review of the histological sections suggests that it was, in fact, an intestinal spirochetosis misdiagnosed as inflammatory bowel disease. Involvement of the rectal mucosa by HPV is a rare condition and this may have been promoted by inappropriate immunosuppressive treatment.<\/jats:p>","DOI":"10.51821\/84.3.018","type":"journal-article","created":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T21:24:08Z","timestamp":1621545848000},"page":"509-512","source":"Crossref","is-referenced-by-count":2,"title":["Unusual intra-rectal \u201claterally spreading tumour\u201d in immunosuppressed patient with ulcerative colitis"],"prefix":"10.51821","volume":"84","author":[{"given":"S","family":"Vieujean","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Latour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Coimbra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Delvenne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Louis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Van Kemseke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27062","published-online":{"date-parts":[[2021,9]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"KANE S., KHATIBI B., REDDY D. 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Med., 2015, 8(4) : 6365-6368."},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"AZZOLINI F., CECINATO P., IORI V., MARCO L., ZECCHINI R., FODERO C., et al. Endoscopic submucosal dissection of an unusual flat rectal neoplasm. Gut., 2015, 64(1) : 180-183.","DOI":"10.1136\/gutjnl-2014-308298"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"ORTENZI M., GHISELLI R., CAPPELLETTI TROMBETTONI M., CARDINALI L., GUERRIERI M. Transanal endoscopic microsurgery as optimal option in treatment of rare rectal lesions: a single centre experience. World J. Gastrointest. Endosc., 2016, 8(17) : 623-627.","DOI":"10.4253\/wjge.v8.i17.623"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"GROOME M., ROBINSON E., MOWAT C., MORIEUX A., ALLSTAFF S. Are patients in the IBD clinic at risk of proctitis secondary to sexually transmitted infections? Frontline Gastroenterol., 2017, 8(4) : 267-271.","DOI":"10.1136\/flgastro-2016-100790"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"BANURA C., MIREMBE F., OREM J., MBONYE A., KASASA S., MBIDDE E. Prevalence, incidence and risk factors for anogenital warts in Sub Saharan Africa : a systematic review and meta analysis. Infect. Agent Cancer, 2013, 8(1) : 27.","DOI":"10.1186\/1750-9378-8-27"},{"key":"ref12","unstructured":"VAN KEMSEKE C. Sexually transmitted diseases and anorectum. Acta Gastroenterol. Belg., 2009, 72(4) : 413-419."},{"key":"ref13","unstructured":"GALLEGOS M., BRADLY D., JAKATE S., KESHAVARZIAN A. Lymphogranuloma venereum proctosigmoiditis is a mimicker of inflammatory bowel disease. World J. Gastroenterol., 2012, 18(25) : 3317-3321."},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"CLUTTERBUCK D., FLOWERS P., BARBER T., WILSON H., NELSON M., HEDGE B. et al. UK national guideline on safer sex advice. Int. J. Std. AIDS, 2012, 23(6) : 381-388.","DOI":"10.1258\/ijsa.2012.200312"},{"key":"ref15","unstructured":"TSINGANOU E., GEBBERS J. Human intestinal spirochetosis--a review. Ger. Med. Sci., 2010, 8 : Doc01."},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"NISHII S., HIGASHIYAMA M., OGATA S., KOMOTO S., ITO S., MIZOGUCHI A., et al. Human intestinal spirochetosis mimicking ulcerative colitis. Clin. J.. Gastroenterol., 2018, 11(2) : 145-149.","DOI":"10.1007\/s12328-017-0807-3"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"SINHA A., MAK T., PETKAR S., ALLAN A. Intestinal spirochetosis: do we always treat it or is it a self-limiting disease? Saudi J. Gastroenterol., 2009, 15(2) : 139-141.","DOI":"10.4103\/1319-3767.49010"}],"container-title":["Acta Gastro Enterologica Belgica"],"original-title":[],"language":"en","deposited":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T16:17:27Z","timestamp":1632845847000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ageb.be\/ageb-journal\/ageb-volume\/ageb-article\/1941\/Unusual%20intra-rectal%20%E2%80%9Claterally%20spreading%20tumour%E2%80%9D%20in%20immunosuppressed%20patientwith%20ulcerative%20colitis\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":18,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,5,24]]},"published-print":{"date-parts":[[2021,9]]}},"URL":"https:\/\/doi.org\/10.51821\/84.3.018","relation":{},"ISSN":["1784-3227"],"issn-type":[{"value":"1784-3227","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]}}}