{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T09:05:47Z","timestamp":1762074347893,"version":"build-2065373602"},"reference-count":14,"publisher":"Universa BV","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AGEB"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:p>Esophageal melanocytosis (EM) is a rare entity, which is characterized by a non-atypical melanocytic proliferation and melanin deposits in the esophageal mucosa. The confusion between the terms of melanosis and melanocytosis in the literature, the rarity of this lesion (less than 50 cases reported in the literature), its uncertain pathobiological course and the lack of experience of pathologists and gastroenterologists prompt us to draw the attention to this particular entity by reporting two cases and reviewing the literature. Magnifying endoscopy to observe intensive melanin accumulation followed by a biopsy are key for the diagnosis.<\/jats:p>","DOI":"10.51821\/85.2.10126","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T22:47:42Z","timestamp":1668034062000},"page":"390-392","source":"Crossref","is-referenced-by-count":2,"title":["Esophageal Melanocytosis: report of two cases and review of a rare and misunderstood entity"],"prefix":"10.51821","volume":"85","author":[{"given":"A","family":"Dubail","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Dano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"de Suray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Hassaini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Jouret-Mourin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27062","published-online":{"date-parts":[[2022,6]]},"reference":[{"key":"ref0","doi-asserted-by":"crossref","unstructured":"DE LA PAVA S., NIGOGOSYAN G., PICKREN JW., CABRERA A. Melanosis of the esophagus. Cancer., 1963; 16: 48-50.","DOI":"10.1002\/1097-0142(196301)16:1<48::AID-CNCR2820160107>3.0.CO;2-M"},{"key":"ref1","unstructured":"MONTGOMERY E., VOLTAGGIO L. In : Wolters Kluwer. Biopsy Interpretation of the Gastrointestinal Tract Mucosa. Volume 1. 3d ed. Philadelphia, 2018. Chap 1: 8-9."},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"CHANG F., DEERE H. Esophageal Melanocytosis : morphologic features and review of the literature. Arch Pathol Lab Med., 2006; 130: 552-557.","DOI":"10.5858\/2006-130-552-emmfar"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"OHASHI K., KATO Y., KANNO J., KASUGA T. Melanocytes and melanosis of the oesophagus in Japanese subjects \u2013 analysis of factors effecting their increase. Virchows Arch A Pathol Anat Histopath., 1990; 417: 137-43.","DOI":"10.1007\/bf02190531"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"DESTEK S., GUL V., AHIOGLU S., ERBIL Y. A rare disease of the digestive tract: Esophageal melanosis. Gastroenterol Res. 2016; 9(2-3): 56-60.","DOI":"10.14740\/gr670w"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"OHNUMA H., ISHIKAWA K., HIRAKAWA M., KIKUCHI S., SATO Y., MIYANISHI K. et al. Cases of primary malignant melanoma and melanocytosis of the esophagus observed by magnifying endoscopy: Application to differential diagnosis : case series. Medicine., 2017; 96: 17.","DOI":"10.1097\/md.0000000000006701"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"SHARMA S., VENKATESWARAN S., CHACKO A., MATHAN M. Melanosis of the esophagus : an endoscopic, histochemical, and ultrastructural study. Gastroenterology., 1991; 100(1): 13-16.","DOI":"10.1016\/0016-5085(91)90576-7"},{"key":"ref7","unstructured":"KANAVAROS P., GALIAN A., PERIAC P., DYAN S., LICHT H., LAVERGNE A., Primary malignant melanoma of the esophagus arising in melanosis : histological, immunohistochemical and ultrastructural study of a case. Ann pathol. 1989; 9(1): 57-61."},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"MAROY B., BAYLAC F., Primary malignant esophageal melanoma arising from localized bening melanocytosis. Clin Res Hepatol Gastroenterol. 2013Apr; 37(2): e65-7.","DOI":"10.1016\/j.clinre.2012.08.003"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"OSHIRO T., HIDEAKI S., FUMIAKI M., NOBUFUMI U., FUKUNORI K., NAKAYAMA T., et al., Primary malignant melanoma of the Esophagus arising from a melanotic lesion: report of case. Surg Today. (2007)37: 671-675.","DOI":"10.1007\/s00595-006-3444-x"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"YAMAZAKI K., OHMORI T., KUMAGAI Y., MAKUUCHI H., EYDEN B., Ultrastructure of oesophagal melanocytosis. Virchows Arch A Pathol Anat Histopathol. 1991; 418: 515-522.","DOI":"10.1007\/bf01606502"},{"key":"ref11","unstructured":"TAKUBO K. Pathology of the Esophagus. In : Springer Verlag. An Atlas and Textbook. 2nd ed. Japan, 2010. Chap 2: 25."},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"LAM KY., LAW S., CHAN GSW. Esophageal blue nevus: an isolated endoscopic finding. Head Neck., 2001; 23: 506-509.","DOI":"10.1002\/hed.1068"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"YOKOYAMA A., OMORI T., YOKOYAMA T., TANAKA Y., MIZUKAMI T., MATSUSHITA S., et al., Esophageal melanosis, an endoscopic finding associated with squamous cell neoplasms of the upper aerodigestive tract, and inactive aldehyde dehydrogenase-2 in alcoholic Japanese men. 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