{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T14:34:58Z","timestamp":1717684498445},"reference-count":39,"publisher":"Universa BV","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AGEB"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:p>Background and study aims: Ischemic colitis (IC) is thought to occur more frequently in the elderly, but the incidence in young and middle-aged adults is increasing. This study determined the clinical characteristics of and risk factors for young and middle- aged IC patients.\n\nPatients and methods: The medical records of 190 IC patients from 2010-2020 were reviewed. The clinical features of the young and middle-aged IC group (group A, &lt; 60 years [n=70]) were compared to the elderly IC (group B, \u226560 years [n=120]) and age- and gender-matched colon polyp groups (group C, &lt;60 years [n=272]). Independent risk factors for IC in group A were assessed using multivariate logistic regression analysis.\n\nResults: There were no significant differences in groups A and B with respect to season of onset, symptoms, signs, treatment, or recurrences. The main symptoms of group A were abdominal pain (98.6%) and hematochezia (98.6%). Lesions commonly involved the left half of the colon (87.1%) and the clinical conditions were generally not severe. The percentage of patients with constipation (11.4% vs. 4.0%, P=0.034) and using a calcium channel antagonist (21.4% vs. 11.4%, P=0.028) was significantly higher in group A than group C. Regression analysis demonstrated that constipation (OR 2.831, P=0.037) and taking a calcium channel antagonist (OR 2.486, P=0.012) were closely associated with the occurrence of IC in group A.\n\nConclusions: Constipation and taking a calcium channel antagonist were independent risk factors for the onset of IC in young and middle-aged adults. Among young and middle-aged adults with abdominal pain and bloody stools who also have constipation or are taking a calcium channel antagonist to treat hypertension, the diagnosis of IC should be considered.<\/jats:p>","DOI":"10.51821\/85.2.9527","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T15:05:45Z","timestamp":1668006345000},"page":"283-290","source":"Crossref","is-referenced-by-count":3,"title":["Clinical features and risk factors for ischemic colitis in young and middle-aged patients"],"prefix":"10.51821","volume":"85","author":[{"given":"W","family":"Cai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27062","published-online":{"date-parts":[[2022,6]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"BRANDT L.J., FEUERSTADT P., LONGSTRETH G.F., BOLEY S.J. 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