{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T14:48:21Z","timestamp":1780757301274,"version":"3.54.1"},"reference-count":12,"publisher":"Universa BV","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AGEB"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:p>Acute pancreatitis can be complicated with necrosis of the pancreatic or peripancreatic tissue. This necrosis can become liquified and form a well-defined wall (walled-off necrosis or WON) and can become infected and form abscesses. Necrotizing soft tissue infections are rare infections of the deep tissue and subcutaneous fat and are mostly caused by trauma or perforated visceral organs. They can, however, rarely be caused by infected retroperitoneal collections. To date only 3 case reports have been published of a necrotizing soft tissue infection complicating a necrotizing pancreatitis. Both acute, complicated pancreatitis and necrotizing soft tissue infections carry a high mortality and morbidity rate with surgery being the mainstay therapy for the latter, often leaving the patient disfigured. We report the case of a 62-year-old man presenting to the emergency department with a painful and erythematous rash of the upper leg as complication of an acute necrotizing pancreatitis.<\/jats:p>","DOI":"10.51821\/85.3.8934","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T22:13:14Z","timestamp":1668118394000},"page":"518-521","source":"Crossref","is-referenced-by-count":1,"title":["Necrotizing soft tissue infection of the upper leg as first presentation of necrotizing pancreatitis: a case report"],"prefix":"10.51821","volume":"85","author":[{"given":"A","family":"Vervaecke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"van Ierssel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Vissers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Macken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Op de Beeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Tondu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Thiessen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Francque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Steinhauser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27062","published-online":{"date-parts":[[2022,9]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"SARANI B., STRONG M., PASCUAL J., SCHWAB C.W. Necrotizing fasciitis: current concepts and review of the literature. J Am Coll Surg. 2009; 208(2): 279-88.","DOI":"10.1016\/j.jamcollsurg.2008.10.032"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"FRANCQUE S.M. et al. Perforating oesophageal carcinoma presenting as necrotizing fasciitis of the neck. Eur J Gastroenterol Hepatol. 2001 Oct; 13(10): 1261-4.","DOI":"10.1097\/00042737-200110000-00024"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"STEVENS D.L., BRYANT A.E. Necrotizing Soft-Tissue Infections. N Engl J Med. 2017 Dec 7; 377(23): 2253-2265.","DOI":"10.1056\/nejmra1600673"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"BANKS P.A., FREEMAN M.L.; Practice Parameters Committee of the American College of Gastroenterology. Practice guidelines in acute pancreatitis. Am J Gastroenterol. 2006 Oct; 101(10): 2379-400.","DOI":"10.1111\/j.1572-0241.2006.00856.x"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"BARON T.H., MORGAN D.E. 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