{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T13:45:36Z","timestamp":1697982336166},"reference-count":10,"publisher":"Universa BV","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AGEB"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:p>Background: Faecal microbiota transplantation (FMT) has high efficacy against recurrent Clostridioides difficile infection (CDI). Despite the increasing use of this therapy, the delay between diagnosis and treatment is excessive. Furthermore, donor selection is an important and time-consuming process.\n\nMethods: We reviewed patients who underwent FMT for recurrent CDI at the CHU Charleroi Hospital between 2015 and 2022. The general context, type of administration, adverse events, and donor selection were reported. FMT was conducted using gastroduodenoscopy, colonoscopy, and enema with either fresh or frozen material.\n\nResults: Ten patients with multiple comorbidities were treated by FMT. Seven patients were cured after one procedure. One patient was successfully cured after a change to an unrelated donor, and preliminary efficacy was established.\n\nConclusions: FMT is an effective treatment that should be considered during the earlier phases of treatment. Stool donors should be thoroughly screened for infectious diseases and other criteria related to microbiota composition.<\/jats:p>","DOI":"10.51821\/86.3.11795","type":"journal-article","created":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T17:26:07Z","timestamp":1697909167000},"page":"486-489","source":"Crossref","is-referenced-by-count":0,"title":["Treatment of recurrent Clostridioides difficile infections with faecal microbiota transplantation: peri-procedural methods in a consecutive case series"],"prefix":"10.51821","volume":"86","author":[{"given":"K","family":"Korpak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Defourny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Lali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Delvall\u00e9e","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Demeester","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Toussaint","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27062","published-online":{"date-parts":[[2023,10]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"HOTA SS, SALES V, TOMLINSON G, SALPETER MJ et al. Oral Vancomycin Followed by Fecal Transplantation Versus Tapering Oral Vancomycin Treatment for Recurrent Clostridium difficile Infection: An Open-Label, Randomized Controlled Trial. Clin Infect Dis. 2017 Feb 1;64(3):265-271.","DOI":"10.1093\/cid\/ciw731"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"LEE CH, STEINER T, PETROF EO, SMIEJA M et al Frozen vs Fresh Fecal Microbiota Transplantation and Clinical Resolution of Diarrhea in Patients with Recurrent Clostridium difficile Infection: A Randomized Clinical Trial. JAMA. 2016 Jan 12;315(2):142-149.","DOI":"10.1001\/jama.2015.18098"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"MCDONALD LC, GERDING DN, JOHNSON S, BAKKEN JS et al Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children:  2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA). Clin Infect Dis. 2018 Mar 19;66(7):987-994.","DOI":"10.1093\/cid\/ciy149"},{"key":"ref3","unstructured":"https:\/\/www.health.belgium.be\/en\/node\/20895."},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"MULLISH BH, QURAISHI MN, SEGAL JP, MCCUNE VL et al The use of faecal microbiota transplant as treatment for recurrent or refractory Clostridium difficile infection and other potential indications: joint British Society of Gastroenterology (BSG) and Healthcare Infection Society (HIS) guidelines. Gut. 2018 Nov;67(11):1920-1941.","DOI":"10.1136\/gutjnl-2018-316818"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"VAN NOOD E, VRIEZE A, NIEUWDORP M, et al Duodenal infusion of donor feces for recurrent Clostridium difficile. N Engl J Med 2013 Jan;368(5):407-415.","DOI":"10.1056\/nejmoa1205037"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"URBONAS T, IANIRO G, GEDGAUDAS R, SABANAS P et al. Fecal Microbiome Transplantation for Recurrent Clostridioides difficile Infection: Treatment Efficacy, Short and Long-term Follow-up Results from Consecutive Case Series. J Gastrointestin Liver Dis. 2021 Dec 21;30(4):470-476.","DOI":"10.15403\/jgld-3800"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"TARIQ R, HAYAT M, PARDI D, KHANNA S. Predictors of failure after fecal microbiota transplantation for recurrent Clostridioides difficile infection: a systematic review and meta-analysis. Eur J Clin Microbiol Infect Dis. 2021 Jul;40(7):1383-1392.","DOI":"10.1007\/s10096-021-04163-z"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"IANIRO G, PUN\u010cOCH\u00c1\u0158 M, KARCHER N, PORCARI S et al Variability of strain engraftment and predictability of microbiome composition after fecal microbiota transplantation across different diseases. Nat Med. 2022 Sep;28(9):1913-1923.","DOI":"10.1038\/s41591-022-01964-3"},{"key":"ref9","unstructured":"GUTI\u00c9RREZ-DELGADO EM, GARZA-GONZ\u00c1LEZ E, MART\u00cdNEZ-V\u00c1ZQUEZ MA, GONZ\u00c1LEZ-GONZ\u00c1LEZ JA, MALDONADO-GARZA HJ, MENDOZA-OLAZARAN S, HERN\u00c1NDEZ-BALBOA CL, CAMACHO-ORTIZ A. Fecal transplant for Clostridium difficile infection relapses using \u201cpooled\u201d frozen feces from non-related donors. Acta Gastroenterol Belg. 2016 Apr-Jun;79(2):268-70."}],"container-title":["Acta Gastro Enterologica Belgica"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T17:26:14Z","timestamp":1697909174000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ageb.be\/ageb-journal\/ageb-volume\/ageb-article\/2122\/Treatment%20of%20recurrent%20Clostridioides%20difficile%20infections%20with%20faecal%20microbiota%20transplantation:%20peri-procedural%20methods%20in%20a%20consecutive%20case%20series\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":10,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,10]]},"published-print":{"date-parts":[[2023,9]]}},"URL":"https:\/\/doi.org\/10.51821\/86.3.11795","relation":{},"ISSN":["1784-3227"],"issn-type":[{"value":"1784-3227","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]}}}