{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T19:12:16Z","timestamp":1779909136049,"version":"3.53.1"},"reference-count":11,"publisher":"Universa BV","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AGEB"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:p>Acute colitis is a common feature of infection with Shiga-toxin producing Escherichia coli (STEC) and can mimic acute severe ulcerative colitis. Early recognition is important as there is a risk of developing Shiga toxin-induced haemolytic uremic syndrome (STEC-HUS), defined by the triad of microangiopathic haemolytic anemia, thrombocytopenia and organ damage. In severe cases STEC-HUS can cause severe neurological complications and can be fatal.\n\nCase: We present a patient with a medical history of refractory ulcerative colitis, where making the diagnosis of STEC-HUS was challenging since the initial clinical presentation was difficult to differentiate from a flare of ulcerative colitis.\n\nConclusion: This case illustrates that STEC induced colitis can mimic acute severe ulcerative colitis. This finding is of utmost clinical importance because of the potential life-threatening complications of STEC-HUS. Therefore it should be excluded promptly in patients with acute severe ulcerative colitis by using multiplex-PCR assay on a faecal sample.<\/jats:p>","DOI":"10.51821\/87.1.11652","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T20:00:45Z","timestamp":1712692845000},"page":"37-39","source":"Crossref","is-referenced-by-count":2,"title":["STEC colitis mimicking acute severe colitis with life-threatening consequences: a case report"],"prefix":"10.51821","volume":"87","author":[{"given":"T","family":"Hendrickx","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Peetermans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"D\u2019Hoore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Claes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Van Hootegem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Sabino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27062","published-online":{"date-parts":[[2024,4]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"JOSEPH A., COINTE A., MARIANI KURKDJIAN P., RAFAT C., & HERTIG A. Shiga Toxin-Associated Hemolytic Uremic Syndrome: A Narrative Review. Toxins., 2020, 12(2):67.","DOI":"10.3390\/toxins12020067"},{"key":"ref1","unstructured":"BIANCHI L., GAIANI F., VINCENZI, F., KAYALI S., DI MARIO F., LEANDRO G et al. Hemolytic uremic syndrome: differential diagnosis with the onset of inflammatory bowel diseases. Acta Biomed., 2018, 89(9-S): 153- 157."},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"NADDEI R., BRUNO V., MARTEMUCCI L., PECORARO C., DI NARDO G. Shiga Toxin Producing Escherichia coli-Hemolytic Uremic Syndrome Mimicking Acute Severe Ulcerative Colitis in a Child With Bloody Diarrhea. Inflamm Bowel Dis., 2019, 25(8):e92-e93.","DOI":"10.1093\/ibd\/izz058"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"BYRNE L., JENKINS C., LAUNDERS N., ELSON R., ADAK G. K. The epidemiology, microbiology and clinical impact of Shiga toxin-producing Escherichia coli in England, 2009-2012. Epidemiol. Infect., 2015,143(16): 3475-3487.","DOI":"10.1017\/s0950268815000746"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"TRAVERT B., DOSSIER A., JAMME M., COINTE A., DELMAS Y., MALOT S. et al. Shiga Toxin-Associated Hemolytic Uremic Syndrome in Adults, France, 2009-2017. Emerg Infect Dis., 2021, 27(7):1876-1885.","DOI":"10.3201\/eid2707.204638"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"TARR P.I., FREEDMAN S.B. Why antibiotics should not be used to treat Shiga toxin-producing Escherichia coli infections. Curr Opin Gastroenterol., 2022, 38(1):30-38.","DOI":"10.1097\/mog.0000000000000798"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"NITSCHKE M., SAYK F., H\u00c4RTEL C., ROSELAND R.T., HAUSWALDT S., STEINHOFF J. et al. Association between azithromycin therapy and duration of bacterial shedding among patients with Shiga toxin-producing enteroaggregative Escherichia coli O104:H4. JAMA., 2012, 307(10):1046-52.","DOI":"10.1001\/jama.2012.264"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"MAGNUS T., R\u00d6THER J., SIMOVA O., MEIER-CILLIEN M., REPENTHIN J., M\u00d6LLER F. et al. The neurological syndrome in adults during the 2011 northern German E. coli serotype O104:H4 outbreak. Brain., 2012, 135(Pt 6): 1850-1859.","DOI":"10.1093\/brain\/aws090"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"BRUYAND M., MARIANI-KURKDJIAN P., GOUALI M., DE VALK H., KING L. A., LE HELLO S. et al. Hemolytic uremic syndrome due to Shiga toxin-producing Escherichia coli infection. Med Mal Infect., 2018, 48(3):167-174.","DOI":"10.1016\/j.medmal.2017.09.012"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"WEBB T. N., GRIFFITHS H., MIYASHITA Y., BHATT R., JAFFE R., MORITZ M., et al. Atypical Hemolytic Uremic Syndrome and Chronic Ulcerative Colitis Treated with Eculizumab. Int J Med Pharm Case Reports., 2015, 4(5): 105-112.","DOI":"10.9734\/ijmpcr\/2015\/18771"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"MONTASSER K., OSMAN H. A., ABOZAID H., KHALIL H. S., HATEM AMER W., SABRY A. M. M. (2022). Multiplex PCR: Aid to more-timely and directed therapeutic intervention for patients with infectious gastroenteritis. 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