{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T04:34:56Z","timestamp":1730349296940,"version":"3.28.0"},"reference-count":24,"publisher":"Universa BV","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AGEB"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:p>Background: Bile acid malabsorption (BAM) is a common entity in patients experiencing chronic watery diarrhea. However, literature suggests that BAM is underdiagnosed and undertreated. In many countries 75SeHCAT is the gold standard for diagnosing BAM (1-5). The aim of this retrospective study was to investigate the frequency of BAM using 75SeHCAT scintigraphy and the response to treatment with bile acid sequestrants.\n\nMethods: We retrospectively evaluated the clinical data of 420 patients who had a 75SeHCAT scan from January 2016 to January 2023. Electronic medical records were investigated for risk factors of BAM. BAM was defined as a 75SeHCAT retention of less than 15%. Response to bile acid sequestrants was evaluated based on outpatient clinical reports.\n\nResults: Median age at the time of 75SeHCAT test was 47 years (range 14-87). Out of 420 patients, 192 (46%) had a positive result for BAM. Cholecystectomy and ileal resection were significant predictors for BAM (p&lt;0.001). BAM type 1 is statistically more likely to be more severe compared to type 2 (p&lt;0.0001) and compared to type 3 (p=0.0021). In patients who fulfilled Rome IV criteria for IBS-D or functional diarrhea, 75 out of 121 (38%) tested positive for BAM. Overall, treatment with bile acid binders was effective in 76%.\n\nConclusions: This retrospective study of patients who underwent SeHCAT scanning confirms that about 1\/3 patients presenting with therapy-resistant chronic diarrhea in secondary care suffer from BAM. Including the test in clinical management protocols of chronic diarrhea allows early and quantitative diagnosis and treatment of BAM.<\/jats:p>","DOI":"10.51821\/87.3.13036","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T21:57:47Z","timestamp":1730325467000},"page":"381-387","source":"Crossref","is-referenced-by-count":0,"title":["Bile acid malabsorption investigated by selenium-75-homocholic acid taurine (75SeHCAT) scans, a retrospective single-centre experience"],"prefix":"10.51821","volume":"87","author":[{"given":"F","family":"Vulsteke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"De Gersem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Arts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Vanuytsel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27062","published-online":{"date-parts":[[2024,10]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"DAMSGAARD B., DALBY HR., KROGH K., JORGENSEN SMD., ARVESCHOUGH AK., AGNHOLT J., et al. 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Nature Reviews Gastroenterology and Hepatology, 2014, 11(7): 426-434.","DOI":"10.1038\/nrgastro.2014.32"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"WEDLAKE L., A\u2019HERN R., RUSSELL D., THOMAS K., WALTERS JRF., ANDREYEV HJN. Systematic review: The prevalence of idiopathic bile acid malabsorption as diagnosed by SeHCAT scanning in patients with diarrhoea- predominant irritable bowel syndrome. Aliment Pharmacol Ther., 2009, 30(7): 707-717.","DOI":"10.1111\/j.1365-2036.2009.04081.x"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"CAMILLERI M., NURKO S. Bile Acid Diarrhea in Adults and Adolescents. Neurogastroenterology and Motility, 2022, 34(4): e14287.","DOI":"10.1111\/nmo.14287"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"CAMILLERI M. Bile acid diarrhea: prevalence, pathogenesis, and therapy. Gut and Liver, 2015, 9(3): 332-339.","DOI":"10.5009\/gnl14397"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"VANUYTSEL T., TACK J., FARRE R. The Role of Intestinal Permeability in Gastrointestinal Disorders and Current Methods of Evaluation. Frontiers in Nutrition, 2021, 8: 717925.","DOI":"10.3389\/fnut.2021.717925"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"BORGHEDE MK., SCHL\u00dcTTER JM., AGNHOLT JS., CHRISTENSEN LA., GORMSEN LC., DAHLERUP JF. Bile acid malabsorption investigated by selenium-75-homocholic acid taurine (75SeHCAT) scans: Causes and treatment responses to cholestyramine in 298 patients with chronic watery diarrhoea. Eur J Intern Med., 2011, 22(6): e137-e140.","DOI":"10.1016\/j.ejim.2011.08.013"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"KUNAYO OREKOYA O., MCLAUGHLIN J., LEITAO E., JOHNS W., LAL S., PAINE P. 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American Journal of Gastroenterology, 2020, 115(7): 1094-1102.","DOI":"10.14309\/ajg.0000000000000637"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"SKOURAS T., DODD S., PRASAD Y., RASSAM J., MORLEY N., SUBRAMANIAN S. Brief report: length of ileal resection correlates with severity of bile acid malabsorption in Crohn\u2019s disease. International Journal of Colorectal Disease, 2019, 34(1):185-188.","DOI":"10.1007\/s00384-018-3144-1"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"UNG KA, OLOFSSON G., FAE A., KILANDER A., OHLSSON C., JONSSON O. In vitro determination of active bile acid absorption in small biopsy specimens obtained endoscopically or surgically from the human intestine. European Journal of Clinical Investigation, 2002, 32(2): 115-121.","DOI":"10.1046\/j.0014-2972.2001.00957.x"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"FARAHMANDFAR MR., CHABOK M., ALADE M., BOUHELAL A., PATEL B. 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The efficacy of a low-fat diet to manage the symptoms of bile acid malabsorption \u2013 outcomes in patients previously treated for cancer. Clinical Medicine, 2017, 17(5): 412-418.","DOI":"10.7861\/clinmedicine.17-5-412"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"WALTERS JRF., JOHNSTON IM., NOLAN JD., VASSIE C., PRUZANSKI ME., SHAPIRO DA. The response of patients with bile acid diarrhoea to the farnesoid x receptor agonist obeticholic acid. Aliment Pharmacol Ther., 2015, 41(1): 54-64.","DOI":"10.1111\/apt.12999"}],"container-title":["Acta Gastro Enterologica Belgica"],"original-title":[],"language":"en","deposited":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T21:57:52Z","timestamp":1730325472000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ageb.be\/ageb-journal\/ageb-volume\/ageb-article\/2183\/Bile%20acid%20malabsorption%20investigated%20by%20selenium-75-homocholic%20acid%20taurine(75SeHCAT)%20scans,%20a%20retrospective%20single-centre%20experience\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":24,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,10]]},"published-print":{"date-parts":[[2024,10]]}},"URL":"https:\/\/doi.org\/10.51821\/87.3.13036","relation":{},"ISSN":["1784-3227"],"issn-type":[{"value":"1784-3227","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]}}}