{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T04:06:58Z","timestamp":1751342818661,"version":"3.41.0"},"reference-count":5,"publisher":"Universa BV","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>To the editor, Hepatitis E Virus (HEV) is the most common cause of acute viral hepatitis globally. Recent European serosurveys show age-dependent increases, corresponding to ongoing zoonotic exposure. Despite this, HEV remains largely underdiagnosed (1,2). Although usually self-limiting, complications are prolonged cholestasis and rarely acute hepatic failure . A distinctive feature of HEV is its extra-hepatic involvement with predominant neurologic manifestations, such as Guillain-Barr\u00e9 Syndrome (GBS) and neuralgic amyotrophy (1). We here report a case of a 66-year old man with an unexpected diagnosis of HEV-associated GBS, illustrating the importance of including HEV in the differential diagnosis of neurological symptoms of unknown origin. His medical history is characterized by Parkinson\u2019s disease and an end-to-end colostomy for rectal carcinoma. He presented to the emergency ward due to general malaise along with progressive hypoesthesia and slight weakness in both lower legs and feet. Despite a slight desaturation (91% on room air), the vital parameters were normal. Blood results showed liver abnormalities, which prompted additional laboratory testing leading to the diagnosis of acute hepatitis E (Table 1, Fig. 1).<\/jats:p>","DOI":"10.51821\/88.1.13825","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T11:01:28Z","timestamp":1751281288000},"page":"211","source":"Crossref","is-referenced-by-count":0,"title":["Acute hepatitis E-related Guillain-Barr\u00e9 syndrome"],"prefix":"10.51821","volume":"88","author":[{"given":"D","family":"Naudts","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Van Overberghe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"De Maeyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Peeters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Vanwolleghem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27062","published-online":{"date-parts":[[2025,6,27]]},"reference":[{"key":"ref0","doi-asserted-by":"crossref","unstructured":"Dalton HR, Kamar N, Baylis SA, Moradpour D, Wedemeyer H, Negro F. EASL Clinical Practice Guidelines on hepatitis E virus infection. J Hepatol. 2018 Jun 1;68(6):1256\u201371.","DOI":"10.1016\/j.jhep.2018.03.005"},{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Ho E, Schenk J, Hutse V, Suin V, Litzroth A, Blaizot S, et al. Stable HEV IgG seroprevalence in Belgium between 2006 and 2014. J Viral Hepat. 2020 Nov;27(11):1253\u201360.","DOI":"10.1111\/jvh.13347"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Choudhary MC, Bajpai V, Anand L, Gupta E. Guillain-Barr\u00e9 syndrome in a patient of acute Hepatitis E virus infection associated with genotype 1: Case report and literature review. Intractable Rare Dis Res. 2019 Feb;8(1):43\u20137.","DOI":"10.5582\/irdr.2018.01099"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Liu H, Ma Y. Hepatitis E virus-associated Guillain\u2013Barre syndrome: Revision of the literature. Brain Behav. 2019 Dec 11;10(1):e01496.","DOI":"10.1002\/brb3.1496"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Dalton HR, Eijk JJJ van, Cintas P, Madden RG, Jones C, Webb GW, et al. Hepatitis E virus infection and acute non-traumatic neurological injury: A prospective multicentre study. J Hepatol. 2017 Nov 1;67(5):925\u201332","DOI":"10.1016\/j.jhep.2017.07.010"}],"container-title":["Acta Gastro Enterologica Belgica"],"original-title":[],"deposited":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T11:01:30Z","timestamp":1751281290000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ageb.be\/ageb-journal\/ageb-volume\/ageb-article\/2244\/Acute%20hepatitis%20E-related%20Guillain-Barr%C3%A9%20syndrome\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,27]]},"references-count":5,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,6,27]]}},"URL":"https:\/\/doi.org\/10.51821\/88.1.13825","relation":{},"ISSN":["1784-3227","1784-3227"],"issn-type":[{"value":"1784-3227","type":"print"},{"value":"1784-3227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,27]]}}}