{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T11:20:28Z","timestamp":1783336828308,"version":"3.54.6"},"reference-count":0,"publisher":"Universa BV","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Gastroenterol. Belg."],"abstract":"<jats:sec>\n                    <jats:title>Background and study aims<\/jats:title>\n                    <jats:p>Leptin, Galectin-1 and Galectin-3 are essential players in tumorigenesis, angiogenesis, and metastasis, but their lymphangiogenic role is unclear. Here, the associations of leptin, Galectin-1 and Galectin-3 with markers of lymphangiogenesis were evaluated in colorectal cancer (CRC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>A total of 120 patients with CRC were included in the study. The expressions of leptin, Galectin-1, Galectin-3, and vascular endothelial growth factor- C (VEGF-C) were analyzed in CRC tissue and compared with lymphatic vessel density (LVD). Also, the concentrations of Galectin-1 and Galectin-3 were determined in the sera of CRC patients (n=38).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>LVD positively correlated with the intensity of leptin or Galectin-1 expression (as defined by intensity score, IS) in tissues. Although there was no significant association between tissue expression of Galectin-3 and LVD, serum Galectin-3 concentrations were markedly decreased in patients with high LVD. The positive correlation was observed between intensity of VEGF-C and leptin expressions. No significant relationship was found between VEGF-C and Galectin-1 expression, while the intensity of VEGF-C expression positively correlated with Galectin-3 expression in tumor tissue. Further, high leptin expression, determined by a total score (sum of percentage score (PS) and IS) &gt; 4, was related to regional lymph node metastasis and TNM stages, indicating a more aggressive CRC phenotype.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results suggest that leptin and Galectin-1 are involved in the formation of new lymphatic vessels in tumor, either dependently or independently of VEGF-C. It seems that high leptin expression reflects regional metastases and progression of CRC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.51821\/89.2.14594","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T11:01:22Z","timestamp":1783335682000},"page":"285-294","source":"Crossref","is-referenced-by-count":0,"title":["Significance of leptin, Galectin-1 and Galectin-3 in tumor lymphangiogenesis"],"prefix":"10.51821","volume":"89","author":[{"given":"S M","family":"Petrovic","sequence":"first","affiliation":[{"name":"Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Serbia"},{"name":"Department of Infectious diseases, Faculty of Medical Sciences, University of Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Simovic Markovic","sequence":"additional","affiliation":[{"name":"Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Jovanovic","sequence":"additional","affiliation":[{"name":"Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Jevtovic","sequence":"additional","affiliation":[{"name":"Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Serbia"},{"name":"Department of Otorhinolaryngology, Faculty of Medical Sciences, University of Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Pantic","sequence":"additional","affiliation":[{"name":"Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G D","family":"Radosavljevic","sequence":"additional","affiliation":[{"name":"Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27062","published-online":{"date-parts":[[2026,6]]},"container-title":["Acta Gastro-Enterologica Belgica"],"original-title":[],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T11:01:23Z","timestamp":1783335683000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ageb.be\/ageb-journal\/ageb-volume\/ageb-article\/2291\/Significance%20of%20leptin,%20Galectin-1%20and%20Galectin-3%20in%20tumor%20lymphangiogenesis"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,6]]}},"URL":"https:\/\/doi.org\/10.51821\/89.2.14594","relation":{},"ISSN":["0001-5644","1784-3227"],"issn-type":[{"value":"0001-5644","type":"print"},{"value":"1784-3227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]}}}