{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T11:22:05Z","timestamp":1783336925436,"version":"3.54.6"},"reference-count":0,"publisher":"Universa BV","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Gastroenterol. Belg."],"abstract":"<jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>Since the onset of the COVID-19 pandemic, both SARS-CoV-2 infection and vaccination have been implicated as potential triggers for de novo autoimmune hepatitis (AIH). This review summarizes published cases, outlining clinical and biological features, treatment approaches, and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A PubMed search identified reports of new-onset AIH following SARS-CoV-2 infection or COVID-19 vaccination up to February 1, 2025. Inclusion criteria encompassed case reports, series, and reviews. Data were extracted on demographics, vaccine type, onset timing, laboratory findings, histology, treatments, and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 74 post-vaccination AIH cases and 22 post-infection cases were included. Post-vaccination AIH predominantly affected older women (median age 62) and occurred mainly after mRNA vaccines, with a median onset of 14 days. Most patients showed marked transaminase elevation, high IgG, and positive ANA (74.3%). Liver biopsies (performed in 92% of cases) showed features compatible with AIH. A total of 80% of the 50 cases of our study with available serology and liver histology were classified as probable \/ definite AIH, according to the simplified AIH score. Corticosteroid therapy was effective in most cases (survival 95.9%). Post-infection AIH cases showed similar features but affected younger individuals (median age 47), with uniformly favorable responses to immunosuppression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>New-onset AIH can occur following both SARS-CoV-2 infection or vaccination. Although these events remain rare, recognition of this association is essential for timely diagnosis and management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.51821\/89.2.15138","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T11:01:22Z","timestamp":1783335682000},"page":"341-354","source":"Crossref","is-referenced-by-count":0,"title":["Auto-immune hepatitis following COVID-19 Vaccination and SARS-COV2 infection : A narrative Review"],"prefix":"10.51821","volume":"89","author":[{"given":"M","family":"Bendoumou","sequence":"first","affiliation":[{"name":"Universit\u00e9 Libre de Bruxelles, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Langlet","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Centre Hospitalier Interr\u00e9gional Edith Cavell, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Gustot","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, Cliniques Universitaires de Bruxelles H\u00f4pital Erasme, Universit\u00e9 Libre de Bruxelles, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27062","published-online":{"date-parts":[[2026,6]]},"container-title":["Acta Gastro-Enterologica Belgica"],"original-title":[],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T11:01:25Z","timestamp":1783335685000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ageb.be\/ageb-journal\/ageb-volume\/ageb-article\/2297\/Auto-immune%20hepatitis%20following%20COVID-19%20Vaccination%20and%20SARS-COV2%20infection%20:%20A%20narrative%20Review"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,6]]}},"URL":"https:\/\/doi.org\/10.51821\/89.2.15138","relation":{},"ISSN":["0001-5644","1784-3227"],"issn-type":[{"value":"0001-5644","type":"print"},{"value":"1784-3227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]}}}