{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T03:55:29Z","timestamp":1793246129409,"version":"4.5.0"},"reference-count":72,"publisher":"Korean Society of Animal Science and Technology","issue":"4","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"name":"Rural Development Administration, Korea","award":["PJ011831"],"award-info":[{"award-number":["PJ011831"]}],"id":[{"id":"https:\/\/ror.org\/03xs9yg50","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Rural Development Administration, Korea","award":["PJ013151"],"award-info":[{"award-number":["PJ013151"]}],"id":[{"id":"https:\/\/ror.org\/03xs9yg50","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.ejast.org"],"crossmark-restriction":true},"short-container-title":["J Anim Sci Technol"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:p>Wheat gluten is an increasingly common ingredient in poultry diets but its impact\n                    on the small intestine in chicken is not fully understood. This study aimed to\n                    identify effects of high-gluten diets on chicken small intestines and the\n                    variation of their associated transcriptional responses by age. A total of 120\n                    broilers (Ross Strain) were used to perform two animal experiments consisting of\n                    two gluten inclusion levels (0% or 25%) by bird\u2019s age (1\n                    week or 4 weeks). Transcriptomics and histochemical techniques were employed to\n                    study the effect of gluten on their duodenal mucosa using randomly selected 12\n                    broilers (3 chicks per group). A reduction in feed intake and body weight gain\n                    was found in the broilers fed a high-gluten containing diet at both ages.\n                    Histochemical photomicrographs showed a reduced villus height to crypt depth\n                    ratio in the duodenum of gluten-fed broilers at 1 week. We found mainly a\n                    significant effect on the gene expression of duodenal mucosa in gluten-fed\n                    broilers at 1 week (289 differentially expressed genes [DEGs]). Pathway analyses\n                    revealed that the significant DEGs were mainly involved in ribosome, oxidative\n                    phosphorylation, and peroxisome proliferator-activated receptor (PPAR) signaling\n                    pathways. These pathways are involved in ribosome protein biogenesis, oxidative\n                    phosphorylation and fatty acid metabolism, respectively. Our results suggest a\n                    pattern of differential gene expression in these pathways that can be linked to\n                    chronic inflammation, suppression of cell proliferation, cell cycle arrest and\n                    apoptosis. And via such a mode of action, high-gluten inclusion levels in\n                    poultry diets could lead to the observed retardation of villi development in the\n                    duodenal mucosa of young broiler chicken.<\/jats:p>","DOI":"10.5187\/jast.2022.e42","type":"journal-article","created":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T00:59:56Z","timestamp":1659574796000},"page":"752-769","update-policy":"https:\/\/doi.org\/10.5187\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Transcriptome-wide analysis reveals gluten-induced suppression of\n                    small intestine development in young chickens"],"prefix":"10.5187","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1659-4427","authenticated-orcid":false,"given":"Darae","family":"Kang","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05q92br09","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Animal Biotechnology, Jeonbuk National University, Jeonju 54896, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0819-0553","authenticated-orcid":false,"given":"Donghyun","family":"Shin","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05q92br09","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Agricultural Convergence Technology, Jeonbuk National University, Jeonju 54896, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1973-3568","authenticated-orcid":false,"given":"Hosung","family":"Choe","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05q92br09","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Animal Biotechnology, Jeonbuk National University, Jeonju 54896, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2845-5093","authenticated-orcid":false,"given":"Doyon","family":"Hwang","sequence":"additional","affiliation":[{"name":"Institute for Animal Products Quality Evaluation, Sejong 339011, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9036-8391","authenticated-orcid":false,"given":"Andrew Wange","family":"Bugenyi","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05q92br09","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Agricultural Convergence Technology, Jeonbuk National University, Jeonju 54896, Korea"},{"name":"National Agricultural Research Organization, Entebbe 295, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8979-5633","authenticated-orcid":false,"given":"Chong-Sam","family":"Na","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05q92br09","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Animal Biotechnology, Jeonbuk National University, Jeonju 54896, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5387-4885","authenticated-orcid":false,"given":"Hak-Kyo","family":"Lee","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05q92br09","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Animal Biotechnology, Jeonbuk National University, Jeonju 54896, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9721-8043","authenticated-orcid":false,"given":"Jaeyoung","family":"Heo","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05q92br09","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Animal Biotechnology, Jeonbuk National University, Jeonju 54896, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4996-3700","authenticated-orcid":false,"given":"Kwanseob","family":"Shim","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05q92br09","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Animal Biotechnology, Jeonbuk National University, Jeonju 54896, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3132","published-online":{"date-parts":[[2022,7,31]]},"reference":[{"key":"key2.0261002112443e+13_B1","unstructured":"FAO [Food and Agriculture 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yield","volume":"122","author":"Monaghan","year":"2001","journal-title":"Euphytica"},{"key":"key2.0261002112443e+13_B4","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jcs.2007.07.010","article-title":"Effects of variety and fertiliser nitrogen on alcohol yield,\n                        grain yield, starch and protein content, and protein composition of winter\n                        wheat","volume":"48","author":"Kindred","year":"2008","journal-title":"J Cereal Sci."},{"key":"key2.0261002112443e+13_B5","first-page":"1185","article-title":"Biotechnology of breadmaking: unraveling and manipulating the\n                        multi-protein gluten complex","volume":"13","author":"Shewry","year":"1995","journal-title":"Bio\/Technology"},{"key":"key2.0261002112443e+13_B6","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0733-5210(03)00030-4","article-title":"Molecular and biochemical impacts of environmental factors on\n                        wheat grain development and protein synthesis","volume":"38","author":"Dupont","year":"2003","journal-title":"J Cereal Sci."},{"key":"key2.0261002112443e+13_B7","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.fm.2006.07.004","article-title":"Chemistry of gluten proteins","volume":"24","author":"Wieser","year":"2007","journal-title":"Food Microbiol."},{"key":"key2.0261002112443e+13_B8","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/jgh.13703","article-title":"What is gluten?","volume":"32","author":"Biesiekierski","year":"2017","journal-title":"J Gastroenterol Hepatol."},{"key":"key2.0261002112443e+13_B9","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/S0140-6736(75)91689-X","article-title":"Cell-mediated immunity to gliadin within the small-intestinal\n                        mucosa in coeliac disease","volume":"305","author":"Ferguson","year":"1975","journal-title":"Lancent"},{"key":"key2.0261002112443e+13_B10","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.clnu.2014.08.012","article-title":"Non coeliac gluten sensitivity: A new disease with gluten\n                        intolerance","volume":"34","author":"Czaja-Bulsa","year":"2015","journal-title":"Clin Nutr."},{"key":"key2.0261002112443e+13_B11","doi-asserted-by":"crossref","first-page":"G996","DOI":"10.1152\/ajpgi.00136.2002","article-title":"Intestinal digestive resistance of immunodominant gliadin\n                        peptides","volume":"283","author":"Hausch","year":"2002","journal-title":"Am J Physiol Gastrointest Liver Physiol."},{"key":"key2.0261002112443e+13_B12","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.4049\/jimmunol.176.4.2512","article-title":"Gliadin stimulation of murine macrophage inflammatory gene\n                        expression and intestinal permeability are MyD88-dependent: role of the\n                        innate immune response in Celiac disease","volume":"176","author":"Thomas","year":"2006","journal-title":"J Immunol."},{"key":"key2.0261002112443e+13_B13","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1053\/gast.2002.35381","article-title":"Celiac lesion T cells recognize epitopes that cluster in regions\n                        of gliadins rich in proline residues","volume":"123","author":"Arentz\u2013Hansen","year":"2002","journal-title":"Gastroenterology"},{"key":"key2.0261002112443e+13_B14","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1002\/(SICI)1521-4141(199908)29:08<2506::AID-IMMU2506>3.0.CO;2-9","article-title":"HLA binding and T cell recognition of a tissue\n                        transglutaminase\u2010modified gliadin epitope","volume":"29","author":"Quarsten","year":"1999","journal-title":"Eur J Immunol."},{"key":"key2.0261002112443e+13_B15","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/nri885","article-title":"Coeliac disease: dissecting a complex inflammatory\n                        disorder","volume":"2","author":"Sollid","year":"2002","journal-title":"Nat Rev Immunol."},{"key":"key2.0261002112443e+13_B16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0001614","article-title":"A non-human primate model for gluten sensitivity","volume":"3","author":"Bethune","year":"2008","journal-title":"PLOS ONE"},{"key":"key2.0261002112443e+13_B17","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1136\/gut.33.2.198","article-title":"Dietary modulation of gluten sensitivity in a naturally occurring\n                        enteropathy of Irish setter 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Sci."},{"key":"key2.0261002112443e+13_B24","doi-asserted-by":"crossref","first-page":"e849","DOI":"10.1111\/jpn.12845","article-title":"Effect of gut stress induced by oxidized wheat gluten on the\n                        growth performance, gut morphology and oxidative states of\n                        broilers","volume":"102","author":"Liao","year":"2018","journal-title":"J Anim Physiol Anim Nutr."},{"key":"key2.0261002112443e+13_B25","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.anifeedsci.2007.06.036","article-title":"Effects of whole wheat feeding on the development of the\n                        digestive tract of broiler chickens","volume":"142","author":"Gabriel","year":"2008","journal-title":"Anim Feed Sci Technol."},{"key":"key2.0261002112443e+13_B26","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1017\/S1357729800014417","article-title":"Maintenance of villous height and crypt depth in piglets by\n                        providing continuous nutrition after weaning","volume":"62","author":"Pluske","year":"1996","journal-title":"Anim Sci."},{"key":"key2.0261002112443e+13_B27","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1089\/nat.2012.0367","article-title":"RNA sequencing: platform selection, experimental design, and data\n                        interpretation","volume":"22","author":"Chu","year":"2012","journal-title":"Nucleic Acid Ther."},{"key":"key2.0261002112443e+13_B28","first-page":"83","article-title":"Effect of dietary gluten content on small intestinal inflammatory\n                        response of broilers","author":"Kang","year":"2019","journal-title":"Eur Poult Sci."},{"key":"key2.0261002112443e+13_B29","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory\n                        requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat Methods"},{"key":"key2.0261002112443e+13_B30","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning\n                        sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"key2.0261002112443e+13_B31","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkt214","article-title":"The Subread aligner: fast, accurate and scalable read mapping by\n                        seed-and-vote","volume":"41","author":"Liao","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"key2.0261002112443e+13_B32","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq\n                        data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome 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environmental\n                        performances of a broiler production system in Greece","volume":"12","author":"Giannenas","year":"2017","journal-title":"PLOS ONE"},{"key":"key2.0261002112443e+13_B40","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1080\/00071660410001730888","article-title":"Influence of method of whole wheat inclusion and xylanase\n                        supplementation on the performance, apparent metabolisable energy, digestive\n                        tract measurements and gut morphology of broilers","volume":"45","author":"Wu","year":"2004","journal-title":"Br Poult Sci."},{"key":"key2.0261002112443e+13_B41","doi-asserted-by":"crossref","first-page":"299S","DOI":"10.1093\/ajcn\/55.1.299s","article-title":"Physiology and pathophysiology of intestinal\n                        absorption","volume":"55","author":"Caspary","year":"1992","journal-title":"Am J Clin Nutr."},{"key":"key2.0261002112443e+13_B42","first-page":"163","article-title":"Effect of different growth promoters on broiler performance and\n                        gut morphology","volume":"41","author":"Markovi\u0107","year":"2009","journal-title":"Arch Med Vet."},{"key":"key2.0261002112443e+13_B43","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1093\/jmcb\/mjv014","article-title":"Ribosomal proteins: functions beyond the ribosome","volume":"7","author":"Zhou","year":"2015","journal-title":"J Mol Cell Biol."},{"key":"key2.0261002112443e+13_B44","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.ccr.2009.09.024","article-title":"Signaling to p53: ribosomal proteins find their\n                        way","volume":"16","author":"Zhang","year":"2009","journal-title":"Cancer Cell"},{"key":"key2.0261002112443e+13_B45","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3389\/fgene.2014.00339","article-title":"Utilization of rye as energy source affects bacterial\n                        translocation, intestinal viscosity, microbiota composition, and bone\n                        mineralization in broiler chickens","volume":"5","author":"Tellez","year":"2014","journal-title":"Front Genet."},{"key":"key2.0261002112443e+13_B46","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1182\/blood-2010-07-295238","article-title":"Haploinsufficiency for ribosomal protein genes causes selective\n                        activation of p53 in human erythroid progenitor cells","volume":"117","author":"Dutt","year":"2011","journal-title":"Blood"},{"key":"key2.0261002112443e+13_B47","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0068667","article-title":"Ribosomal proteins RPL37, RPS15 and RPS20 regulate the\n                        Mdm2-p53-MdmX network","volume":"8","author":"Daftuar","year":"2013","journal-title":"PLOS ONE"},{"key":"key2.0261002112443e+13_B48","doi-asserted-by":"crossref","first-page":"5029","DOI":"10.1038\/sj.onc.1210327","article-title":"Ribosomal protein S7 as a novel modulator of p53\u2013MDM2\n                        interaction: binding to MDM2, stabilization of p53 protein, and activation\n                        of p53 function","volume":"26","author":"Chen","year":"2007","journal-title":"Oncogene"},{"key":"key2.0261002112443e+13_B49","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1124\/pr.58.4.5","article-title":"International Union of Pharmacology. LXI. Peroxisome\n                        proliferator-activated receptors","volume":"58","author":"Michalik","year":"2006","journal-title":"Pharmacol Rev."},{"key":"key2.0261002112443e+13_B50","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0050810","article-title":"The ileal lipid binding protein is required for efficient\n                        absorption and transport of bile acids in the distal portion of the murine\n                        small intestine","volume":"7","author":"Praslickova","year":"2012","journal-title":"PLOS ONE"},{"key":"key2.0261002112443e+13_B51","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1042\/bj3560481","article-title":"Bile acid hydrophobicity is correlated with induction of\n                        apoptosis and\/or growth arrest in HCT116 cells","volume":"356","author":"Powell","year":"2001","journal-title":"Biochem J."},{"key":"key2.0261002112443e+13_B52","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/S1388-1981(99)00200-0","article-title":"Intestinal fatty acid binding protein may favor differential\n                        apical fatty acid binding in the intestine","volume":"1483","author":"Alpers","year":"2000","journal-title":"Biochim Biophys Acta"},{"key":"key2.0261002112443e+13_B53","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0009-3084(96)02619-9","article-title":"Intestinal fatty acid-binding protein expression stimulates\n                        fibroblast fatty acid esterification","volume":"84","author":"Prows","year":"1996","journal-title":"Chem Phys Lipids"},{"key":"key2.0261002112443e+13_B54","doi-asserted-by":"crossref","first-page":"25339","DOI":"10.1074\/jbc.M501159200","article-title":"Stearoyl-CoA desaturase is involved in the control of\n                        proliferation, anchorage-independent growth, and survival in human\n             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