{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:53:14Z","timestamp":1790913194123,"version":"4.1.0"},"reference-count":25,"publisher":"Korean Society of Animal Science and Technology","issue":"5","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"name":"Rural Development Administration","award":["PJ01407901"],"award-info":[{"award-number":["PJ01407901"]}],"id":[{"id":"https:\/\/ror.org\/03xs9yg50","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.ejast.org"],"crossmark-restriction":true},"short-container-title":["J Anim Sci Technol"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:p>Maximum residue limits (MRL) for pesticides in feed have been set to protect\n                    public health and produce safe livestock products. In vivo\n                    experiments to establish MRL are essential, as livestock are commonly used to\n                    obtain reliable In vivo quantitative information. Here, we\n                    aimed to evaluate whether small laboratory animals can replace or reduce\n                    monogastric livestock in experiments to quantify pesticide residues In\n                        vivo after oral consumption through feed. First, 24 pigs and rats\n                    were randomly assigned to four groups and fed 0, 3, 9, or 30 mg\/kg of\n                    sulfoxaflor. After four weeks, serum, muscle, fat, liver, kidney, and small\n                    intestine samples were collected, and sulfoxaflor residues were analyzed using\n                    liquid chromatography \u2013 tandem mass spectrometry. Sulfoxaflor residues in\n                    pig tissues were significantly correlated with those in rat tissues. Model\n                    equations were formulated based on the residual sulfoxaflor amount in pig and\n                    rat tissues. The calculated and measured sulfoxaflor residues in pigs and rats\n                    showed more than 90% similarity. Sulfoxaflor did not affect body weight gain,\n                    feed intake, or the feed conversion ratio. Therefore, we concluded that\n                    pesticide residue quantification in vivo to establish MRL could\n                    be performed using small laboratory animals instead of livestock animals. This\n                    would contribute to obtaining In vivo pesticide residue\n                    information and reducing large-scale livestock animal experiments.<\/jats:p>","DOI":"10.5187\/jast.2022.e67","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T02:02:16Z","timestamp":1665972136000},"page":"911-921","update-policy":"https:\/\/doi.org\/10.5187\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evaluating sulfoxaflor residues in pig tissues using animal\n                    modeling"],"prefix":"10.5187","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3620-9952","authenticated-orcid":false,"given":"Hyun-Woo","family":"Cho","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03xs9yg50","id-type":"ROR","asserted-by":"publisher"}],"name":"National Institute of Animal Science, Rural Development Administration, Wanju 55365, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6152-8536","authenticated-orcid":false,"given":"Kangmin","family":"Seo","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03xs9yg50","id-type":"ROR","asserted-by":"publisher"}],"name":"National Institute of Animal Science, Rural Development Administration, Wanju 55365, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8670-7036","authenticated-orcid":false,"given":"Jin Young","family":"Jeong","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03xs9yg50","id-type":"ROR","asserted-by":"publisher"}],"name":"National Institute of Animal Science, Rural Development Administration, Wanju 55365, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4618-586X","authenticated-orcid":false,"given":"Ju Lan","family":"Chun","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03xs9yg50","id-type":"ROR","asserted-by":"publisher"}],"name":"National Institute of Animal Science, Rural Development Administration, Wanju 55365, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9834-2126","authenticated-orcid":false,"given":"Ki Hyun","family":"Kim","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03xs9yg50","id-type":"ROR","asserted-by":"publisher"}],"name":"National Institute of Animal Science, Rural Development Administration, Wanju 55365, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3132","published-online":{"date-parts":[[2022,9,30]]},"reference":[{"key":"key2.0261002112519e+13_B1","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1093\/advances\/nmy061","article-title":"Assessing the safety of pesticides in food: how current\n                        regulations protect human health","volume":"10","author":"Reeves","year":"2019","journal-title":"Adv Nutr."},{"key":"key2.0261002112519e+13_B2","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.3390\/ijerph8051402","article-title":"Pesticide exposure, safety issues, and risk assessment\n                        indicators","volume":"8","author":"Damalas","year":"2011","journal-title":"Int J Environ Res Public Health."},{"key":"key2.0261002112519e+13_B3","first-page":"430","article-title":"Risk assessment and management of occupational exposure to\n                        pesticides in agriculture","volume":"97","author":"Maroni","year":"2006","journal-title":"Med Lav."},{"key":"key2.0261002112519e+13_B4","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.envsci.2006.08.002","article-title":"Agriculture, pesticides, food security and food\n                        safety","volume":"9","author":"Carvalho","year":"2006","journal-title":"Environ Sci Policy"},{"key":"key2.0261002112519e+13_B5","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.trac.2016.04.017","article-title":"Trends in analysis of pesticide residues to fulfil the European\n                        Regulation (EC) No. 1107\/2009","volume":"80","author":"Villaverde","year":"2016","journal-title":"Trends Analyt Chem."},{"key":"key2.0261002112519e+13_B6","article-title":"The 2019 European Union report on pesticide residues in\n                        food","volume":"19","author":"EFSA [European Food Safety Authority]","year":"2021","journal-title":"EFSA J."},{"key":"key2.0261002112519e+13_B7","volume-title":"Notice to applicants and note for guidance: establishment of maximum\n                        residue limits (MRLs) for residues of veterinary medicinal products in\n                        foodstuffs of animal origin","author":"European Commission","year":"2003"},{"key":"key2.0261002112519e+13_B8","volume-title":"OECD guidance document on defining minor uses of pesticides.\n                        ENV\/JM\/MONO(2009)39 [Internet]","author":"OECD [Organization for Economic Co-operation and\n                            Development]","year":"2009"},{"key":"key2.0261002112519e+13_B9","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1080\/19440049.2021.1934574","article-title":"US Food and Drug Administration regulatory pesticide residue\n                        monitoring of human foods: 2009-2017","volume":"38","author":"Liang","year":"2021","journal-title":"Food Addit Contam Part A Chem Anal Control Expo Risk Assess."},{"key":"key2.0261002112519e+13_B10","volume-title":"Pesticide residues in food and drinking water: human exposure and\n                        risks","author":"Hamilton","year":"2004"},{"key":"key2.0261002112519e+13_B11","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/nature13959","article-title":"Global diets link environmental sustainability and human\n                        health","volume":"515","author":"Tilman","year":"2014","journal-title":"Nature"},{"key":"key2.0261002112519e+13_B12","first-page":"51","article-title":"Use of pesticides in agriculture and livestock animals and its\n                        impact on environment of India","volume":"8","author":"Kumar","year":"2013","journal-title":"Asian J Environ Sci."},{"key":"key2.0261002112519e+13_B13","doi-asserted-by":"crossref","DOI":"10.1201\/9780203165584","volume-title":"Pesticide residues in coastal tropical ecosystems: distribution, fate\n                        and effects","author":"Taylor","year":"2002"},{"key":"key2.0261002112519e+13_B14","first-page":"589","article-title":"Estimating the residue transfer of pesticides in animal\n                        feedstuffs to livestock tissues, milk and eggs: a review","volume":"48","author":"MacLachlan","year":"2008","journal-title":"Aust J Exp Agric."},{"key":"key2.0261002112519e+13_B15","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1039\/D1EM00454A","article-title":"Screening of pesticide distributions in foods of animal origin: a\n                        matrix-based approach for biotransfer factor modeling of grazing\n                        mammals","volume":"24","author":"Li","year":"2022","journal-title":"Environ Sci Process Impacts."},{"key":"key2.0261002112519e+13_B16","volume-title":"Test no. 505: residues in livestock, OECD guidelines for the testing of\n                        chemicals, section 5 [Internet]","author":"OECD [Organization for Economic Cooperation and\n                            Development]","year":"2007"},{"key":"key2.0261002112519e+13_B17","first-page":"117","article-title":"Commonly used animal models","volume-title":"Principles of animal research graduate undergraduate students","author":"Hickman","year":"2017"},{"key":"key2.0261002112519e+13_B18","first-page":"207","article-title":"The Mighty Mouse: the impact of rodents on advances in biomedical\n                        research","volume":"110","author":"Bryda","year":"2013","journal-title":"Mo Med."},{"key":"key2.0261002112519e+13_B19","article-title":"Modification of the existing maximum residue levels for\n                        sulfoxaflor in various crops","volume":"17","author":"EFSA [European Food Safety Authority]","year":"2019","journal-title":"EFSA J."},{"key":"key2.0261002112519e+13_B20","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1021\/acs.jafc.6b00285","article-title":"Determination of sulfoxaflor in animal origin foods using\n                        dispersive solid-phase extraction and multiplug filtration cleanup method\n                        based on multiwalled carbon nanotubes by ultraperformance liquid\n                        chromatography\/tandem mass spectrometry","volume":"64","author":"Tian","year":"2016","journal-title":"J Agric Food Chem."},{"key":"key2.0261002112519e+13_B21","doi-asserted-by":"crossref","first-page":"838S","DOI":"10.1093\/jn\/127.5.838S","article-title":"Components of the AIN-93 diets as improvements in the AIN-76A\n                        diet","volume":"127","author":"Reeves","year":"1997","journal-title":"J Nutr."},{"key":"key2.0261002112519e+13_B22","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s00204-008-0279-9","article-title":"Alternative methods to safety studies in experimental animals:\n                        role in the risk assessment of chemicals under the new European Chemicals\n                        Legislation (REACH)","volume":"82","author":"Lilienblum","year":"2008","journal-title":"Arch Toxicol."},{"key":"key2.0261002112519e+13_B23","unstructured":"Balls\n                            M\n                        \n                    \n                    editor\n                    Alternatives to animal experiments: progress made and challenges\n                        ahead\n                    In\n                    The Proceedings of the ECVAM Status Seminar 2002\n                    2002\n                    Ispra, Italy"},{"key":"key2.0261002112519e+13_B24","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/BF01797915","article-title":"Detoxification pathways in the liver","volume":"14","author":"Grant","year":"1991","journal-title":"J Inherit Metab Dis."},{"key":"key2.0261002112519e+13_B25","volume-title":"The principles of humane experimental technique","author":"Russell","year":"1959"}],"container-title":["Journal of Animal Science and Technology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.ejast.org\/download\/download_pdf?doi=10.5187\/jast.2022.e67","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.ejast.org\/download\/download_pdf?doi=10.5187\/jast.2022.e67","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:54:36Z","timestamp":1790909676000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.ejast.org\/archive\/view_article?doi=10.5187\/jast.2022.e67"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":25,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,9,30]]},"published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.5187\/jast.2022.e67"],"URL":"https:\/\/doi.org\/10.5187\/jast.2022.e67","relation":{},"ISSN":["2672-0191","2055-0391"],"issn-type":[{"value":"2672-0191","type":"print"},{"value":"2055-0391","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"2022-08-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}