{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:54:14Z","timestamp":1790909654593,"version":"4.1.0"},"reference-count":90,"publisher":"Korean Society of Animal Science and Technology","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["www.ejast.org"],"crossmark-restriction":true},"short-container-title":["J Anim Sci Technol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>In order to evaluate the effects of ARG sources (arginine [ARG] and\n                    Guanidinoacetic acid [GAA]) and phenylalanine (PHE) supplementation on\n                    performance, susceptibility to ascites, intestinal morphology, and nutrient\n                    digestibility in the cold-stressed broilers fed a canola meal (CM)-based diet, a\n                    2\u00d72 factorial experiment with four treatments was conducted. The dietary\n                    treatments included CM-based diet + 2.57 g\/kg ARG, CM-based diet + 2.57 g\/kg ARG\n                    + 1.5 g\/kg PHE, CM-based diet + 1.8 g\/kg GAA and CM-based diet + 1.8 g\/kg GAA +\n                    1.5 g\/kg PHE. The corn-CM diet without supplementation was used as a negative\n                    control (NC) group in the fifth treatment that excluded the factorial\n                    arrangement. The results showed that adding ARG to diets without PHE supplement\n                    increased (p &lt; 0.05) feed intake. Also, birds fed diets\n                    containing ARG had higher (p &lt; 0.05) body weight gain\n                    (BWG) compared to those fed GAA added diets. Supplementation of PHE improved\n                        (p &lt; 0.05) the FCR compared to groups fed diets\n                    without added PHE. Further, ARG addition increased (p &lt;\n                    0.05) plasma nitric oxide (NO) concentration, carcass, breast and leg yields,\n                    duodenal, jejunal, and ileal villus height (VH) to crypt depth (CD, and dry\n                    matter digestibility, while decreasing (p &lt; 0.05)\n                    ascites mortality and right ventricle (RV) to total ventricle (TV) ratio\n                    compared to GAA added groups. Supplementation of PHE also declined\n                    susceptibility to ascites by reducing (p &lt; 0.01) RV to\n                    TV ratio while increasing (p &lt; 0.05) plasma NO level.\n                    The digestibility of ether extract also increased (p &lt;\n                    0.05) in broilers fed GAA supplemented diets versus those fed ARG added diets.\n                    The findings suggested that ARG may improve BWG and lower ascites incidence in\n                    broilers fed a diet based on CM under cold stress because of its\n                    antihypertensive effects. Moreover, the findings of this study demonstrated the\n                    importance of including PHE formulation in ARG-deficient diets to attenuate the\n                    adverse effects of cold stress on broilers. It was also concluded that GAA could\n                    be efficaciously used in cold-stressed broilers fed an ARG-deficient diet.<\/jats:p>","DOI":"10.5187\/jast.2022.e68","type":"journal-article","created":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T03:05:25Z","timestamp":1666321525000},"page":"69-95","update-policy":"https:\/\/doi.org\/10.5187\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effects of arginine and guanidinoacetic acid with or without\n                    phenylalanine on ascites susceptibility in cold-stressed broilers fed canola\n                    meal-based diet"],"prefix":"10.5187","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4199-3104","authenticated-orcid":false,"given":"Negin","family":"Delfani","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/032fk0x53","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Animal Science, Faculty of Agricultural Sciences, Urmia University, Urmia 5756151818, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1854-210X","authenticated-orcid":false,"given":"Mohsen","family":"Daneshyar","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/032fk0x53","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Animal Science, Faculty of Agricultural Sciences, Urmia University, Urmia 5756151818, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9572-0486","authenticated-orcid":false,"given":"Parviz","family":"Farhoomand","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/032fk0x53","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Animal Science, Faculty of Agricultural Sciences, Urmia University, Urmia 5756151818, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7012-2407","authenticated-orcid":false,"given":"Younes Ali","family":"Alijoo","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/032fk0x53","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Animal Science, Faculty of Agricultural Sciences, Urmia University, Urmia 5756151818, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1965-9027","authenticated-orcid":false,"given":"Sina","family":"Payvastegan","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/032fk0x53","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Animal Science, Faculty of Agricultural Sciences, Urmia University, Urmia 5756151818, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1085-6043","authenticated-orcid":false,"given":"Gholamreza","family":"Najafi","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/032fk0x53","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia 5756151818, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3132","published-online":{"date-parts":[[2023,1,31]]},"reference":[{"key":"key2.0261002112628e+13_B1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3382\/ps.2012-02745","article-title":"Pulmonary arterial hypertension (ascites syndrome) in broilers: a\n                        review","volume":"92","author":"Wideman","year":"2013","journal-title":"Poult Sci."},{"key":"key2.0261002112628e+13_B2","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1080\/00071660500098152","article-title":"Effects of early feed restriction and cold temperature on lipid\n                        peroxidation, pulmonary vascular remodelling and ascites morbidity in\n                        broilers under normal and cold temperature","volume":"46","author":"Pan","year":"2005","journal-title":"Br Poult Sci."},{"key":"key2.0261002112628e+13_B3","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1080\/1828051X.2017.1290510","article-title":"Effects of curcumin and nanocurcumin on growth performance, blood\n                        gas indices and ascites mortalities of broiler chickens reared under normal\n                        and cold stress conditions","volume":"16","author":"Rahmani","year":"2017","journal-title":"Ital J Anim Sci."},{"key":"key2.0261002112628e+13_B4","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3382\/ps.2008-00170","article-title":"Changes of biochemical parameters and enzyme activities in\n                        broiler chickens with cold-induced ascites","volume":"88","author":"Daneshyar","year":"2009","journal-title":"Poult Sci."},{"key":"key2.0261002112628e+13_B5","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.anifeedsci.2009.12.009","article-title":"Pulmonary hypertension and ascites as affected by dietary protein\n                        source in broiler chickens reared in cool temperature at high\n                        altitudes","volume":"155","author":"Izadinia","year":"2010","journal-title":"Anim Feed Sci Technol."},{"key":"key2.0261002112628e+13_B6","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.3382\/ps.2011-01618","article-title":"Effects of supplementation of canola meal-based diets with\n                        arginine on performance, plasma nitric oxide, and carcass characteristics of\n                        broiler chickens grown at high altitude","volume":"90","author":"Khajali","year":"2011","journal-title":"Poult Sci."},{"key":"key2.0261002112628e+13_B7","doi-asserted-by":"crossref","first-page":"282","DOI":"10.2141\/jpsa.0160147","article-title":"Evaluation of different levels of canola meal on performance,\n                        organ weights, hepatic deiodinase gene expression and thyroid morphology in\n                        broiler chickens","volume":"54","author":"Payvastegan","year":"2017","journal-title":"J Poult Sci."},{"key":"key2.0261002112628e+13_B8","volume-title":"Nutrient requirements of poultry.","author":"National Research Council","year":"1994","edition":"9th rev. ed"},{"key":"key2.0261002112628e+13_B9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/jpn.12315","article-title":"Nutritional approaches to ameliorate pulmonary hypertension in\n                        broiler chickens","volume":"100","author":"Khajali","year":"2016","journal-title":"J Anim Physiol Anim Nutr."},{"key":"key2.0261002112628e+13_B10","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1017\/S0043933910000711","article-title":"Dietary arginine: metabolic, environmental, immunological and\n                        physiological interrelationships","volume":"66","author":"Khajali","year":"2010","journal-title":"Worlds Poult Sci J."},{"key":"key2.0261002112628e+13_B11","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1093\/ps\/81.6.815","article-title":"The effects of toasting canola meal on body weight, feed\n                        conversion efficiency, and mortality in broiler chickens","volume":"81","author":"Newkirk","year":"2002","journal-title":"Poult Sci."},{"key":"key2.0261002112628e+13_B12","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1080\/00071668.2016.1257779","article-title":"Interactive effects of temperature and dietary supplementation of\n                        arginine or guanidinoacetic acid on nutritional and physiological responses\n                        in male broiler chickens","volume":"58","author":"Kodambashi Emami","year":"2017","journal-title":"Br Poult Sci."},{"key":"key2.0261002112628e+13_B13","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.tvjl.2005.08.004","article-title":"L-arginine prevents reduced expression of endothelial nitric\n                        oxide synthase (NOS) in pulmonary arterioles of broilers exposed to cool\n                        temperatures","volume":"173","author":"Tan","year":"2007","journal-title":"Vet J."},{"key":"key2.0261002112628e+13_B14","doi-asserted-by":"crossref","first-page":"890","DOI":"10.3382\/ps\/pex378","article-title":"Efficacy of guanidinoacetic acid on growth and muscle energy\n                        metabolism in broiler chicks receiving arginine-deficient\n                        diets","volume":"97","author":"DeGroot","year":"2018","journal-title":"Poult Sci."},{"key":"key2.0261002112628e+13_B15","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1183\/09031936.00188809","article-title":"Tetrahydrobiopterin and the regulation of hypoxic pulmonary\n                        vasoconstriction","volume":"36","author":"Francis","year":"2010","journal-title":"Eur Respir J."},{"key":"key2.0261002112628e+13_B16","doi-asserted-by":"crossref","first-page":"3040","DOI":"10.1089\/ars.2013.5566","article-title":"Tetrahydrobiopterin in cardiovascular health and\n                        disease","volume":"20","author":"Bendall","year":"2014","journal-title":"Antioxid Redox Signal."},{"key":"key2.0261002112628e+13_B17","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1385\/CBB:41:3:415","article-title":"Regulation of tetrahydrobiopterin synthesis and bioavailability\n                        in endothelial cells","volume":"41","author":"Shi","year":"2004","journal-title":"Cell Biochem Biophys."},{"key":"key2.0261002112628e+13_B18","doi-asserted-by":"crossref","first-page":"316","DOI":"10.4330\/wjc.v2.i10.316","article-title":"Contribution of oxidative stress to pulmonary arterial\n                        hypertension","volume":"2","author":"DeMarco","year":"2010","journal-title":"World J Cardiol."},{"key":"key2.0261002112628e+13_B19","first-page":"2724","article-title":"The role of oxidative stress in development of congestive heart\n                        failure (CHF) in broiler with pulmonary hypertension syndrome\n                        (PHS)","volume":"10","author":"Fathi","year":"2011","journal-title":"J Anim Vet Adv."},{"key":"key2.0261002112628e+13_B20","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.3382\/ps\/pev148","article-title":"The effects of increasing levels of dietary garlic bulb on growth\n                        performance, systolic blood pressure, hematology, and ascites syndrome in\n                        broiler chickens","volume":"94","author":"Varmaghany","year":"2015","journal-title":"Poult Sci."},{"key":"key2.0261002112628e+13_B21","volume-title":"Official methods of analysis of AOAC International.","author":"AOAC [Association of Official Analytical Chemists]\n                            International","year":"2000","edition":"17th ed"},{"key":"key2.0261002112628e+13_B22","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0377-8401(95)00916-7","article-title":"Determination of titanium dioxide added as an inert marker in\n                        chicken digestibility studies","volume":"59","author":"Short","year":"1996","journal-title":"Anim Feed Sci Technol."},{"key":"key2.0261002112628e+13_B23","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.3382\/ps.2013-03812","article-title":"Arginine affects appetite via nitric oxide in\n                        ducks","volume":"93","author":"Wang","year":"2014","journal-title":"Poult Sci."},{"key":"key2.0261002112628e+13_B24","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.3382\/ps\/pey504","article-title":"L-Arginine supplementation enhances growth performance, lean\n                        muscle, and bone density but not fat in broiler chickens","volume":"98","author":"Castro","year":"2019","journal-title":"Poult Sci."},{"key":"key2.0261002112628e+13_B25","doi-asserted-by":"crossref","first-page":"27484","DOI":"10.1016\/S0955-2863(01)00139-5","article-title":"Dietary supplements of mixtures of indispensable amino acids\n                        lacking threonine, phenylalanine or histidine increase the activity of\n                        hepatic threonine dehydrogenase, phenylalanine hydroxylase or histidase,\n                        respectively, and prevent growth depressions in chicks caused by dietary\n                        excesses of threonine, phenylalanine, or histidine","volume":"12","author":"Keene","year":"2001","journal-title":"J Nutr Biochem."},{"key":"key2.0261002112628e+13_B26","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.cbpa.2010.01.011","article-title":"Norepinephrine does not alter NPY and POMC mRNA expression in\n                        neonatal chicks","volume":"156","author":"Katayama","year":"2010","journal-title":"Comp Biochem Physiol A Mol Integr Physiol."},{"key":"key2.0261002112628e+13_B27","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3382\/ps.2007-00268","article-title":"Phenylalanine requirement, imbalance, and dietary excess in\n                        one-week-old chicks: growth and phenylalanine hydroxylase\n                        activity","volume":"87","author":"Lartey","year":"2008","journal-title":"Poult Sci."},{"key":"key2.0261002112628e+13_B28","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1093\/ps\/82.1.100","article-title":"Interactions of various supplies of isoleucine, valine, leucine\n                        and tryptophan on the performance of laying hens","volume":"82","author":"Peganova","year":"2003","journal-title":"Poult Sci."},{"key":"key2.0261002112628e+13_B29","doi-asserted-by":"crossref","first-page":"829","DOI":"10.3382\/ps\/pew305","article-title":"Estimation of optimal ratios of digestible phenylalanine +\n                        tyrosine, histidine, and leucine to digestible lysine for performance and\n                        breast yield in broilers","volume":"96","author":"Franco","year":"2017","journal-title":"Poult Sci."},{"key":"key2.0261002112628e+13_B30","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1038\/ijo.2017.164","article-title":"L-Phenylalanine modulates gut hormone release and glucose\n                        tolerance, and suppresses food intake through the calcium-sensing receptor\n                        in rodents","volume":"41","author":"Alamshah","year":"2017","journal-title":"Int J Obes."},{"key":"key2.0261002112628e+13_B31","doi-asserted-by":"crossref","first-page":"4814","DOI":"10.1073\/pnas.97.9.4814","article-title":"L-amino acid sensing by the extracellular Ca2+-sensing\n                        receptor","volume":"97","author":"Conigrave","year":"2000","journal-title":"Proc Natl Acad Sci."},{"key":"key2.0261002112628e+13_B32","doi-asserted-by":"crossref","first-page":"101060","DOI":"10.1016\/j.psj.2021.101060","article-title":"Molecular distribution and localization of extracellular\n                        calcium-sensing receptor (CaSR) and vitamin D receptor (VDR) at three\n                        different laying stages in laying hens (Gallus gallus\n                        domesticus)","volume":"100","author":"Hui","year":"2021","journal-title":"Poult Sci."},{"key":"key2.0261002112628e+13_B33","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1111\/jpn.12695","article-title":"Marginal deficiencies of dietary arginine and methionine could\n                        suppress growth performance and immunological responses in broiler\n                        chickens","volume":"102","author":"Jahanian","year":"2018","journal-title":"J Anim Physiol Anim Nutr."},{"key":"key2.0261002112628e+13_B34","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.livsci.2018.01.001","article-title":"Dietary arginine supplementation enhances the growth performance\n                        and immune status of broiler chickens","volume":"209","author":"Xu","year":"2018","journal-title":"Livest Sci."},{"key":"key2.0261002112628e+13_B35","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3382\/ps.2012-02425","article-title":"Dietary guanidino acetic acid is an efficacious replacement for\n                        arginine for young chicks","volume":"92","author":"Dilger","year":"2013","journal-title":"Poult Sci."},{"key":"key2.0261002112628e+13_B36","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3382\/japr.2012-00575","article-title":"Effects of guanidinoacetic acid supplementation to broiler diets\n                        with varying energy contents","volume":"22","author":"Mousavi","year":"2013","journal-title":"J Appl Poult Res."},{"key":"key2.0261002112628e+13_B37","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1080\/00071668.2018.1476678","article-title":"Guanidinoacetic acid supplementation in broiler chickens fed on\n                        corn-soybean diets affects performance in the finisher period and energy\n                        metabolites in breast muscle independent of diet nutrient\n                        density","volume":"59","author":"Majdeddin","year":"2018","journal-title":"Br Poult Sci."},{"key":"key2.0261002112628e+13_B38","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.3382\/ps\/pey097","article-title":"Effect of guanidinoacetic acid supplementation on live\n                        performance, meat quality, pectoral myopathies and blood parameters of male\n                        broilers fed corn-based diets with or without poultry\n                        by-products","volume":"97","author":"C\u00f3rdova-Noboa","year":"2018","journal-title":"Poult Sci."},{"key":"key2.0261002112628e+13_B39","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1080\/00071668.2019.1631447","article-title":"Effects of methionine and guanidinoacetic acid supplementation on\n                        performance and energy metabolites in breast muscle of male broiler chickens\n                        fed corn-soybean diets","volume":"60","author":"Majdeddin","year":"2019","journal-title":"Br Poult Sci."},{"key":"key2.0261002112628e+13_B40","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1080\/00071668.2018.1562156","article-title":"Performance and physiological responses of broiler chickens to\n                        supplemental guanidinoacetic acid in arginine-deficient\n                        diets","volume":"60","author":"Ale Saheb Fosoul","year":"2019","journal-title":"Br Poult Sci."},{"key":"key2.0261002112628e+13_B41","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1080\/00071668.2015.1054258","article-title":"L-Arginine supplementation of reduced-protein diets improves\n                        pulmonary hypertensive response in broiler chickens reared at high\n                        altitude","volume":"56","author":"Sharifi","year":"2015","journal-title":"Br Poult Sci."},{"key":"key2.0261002112628e+13_B42","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.jacbts.2018.01.015","article-title":"L-Phenylalanine restores vascular function in spontaneously\n                        hypertensive rats through activation of the GCH1-GFRP\n                        complex","volume":"3","author":"Heikal","year":"2018","journal-title":"JACC Basic Transl Sci."},{"key":"key2.0261002112628e+13_B43","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1161\/ATVBAHA.111.226456","article-title":"Tetrahydrobiopterin deficiency and nitric oxide synthase\n                        uncoupling contribute to atherosclerosis induced by disturbed\n                        flow","volume":"31","author":"Li","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"key2.0261002112628e+13_B44","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1146\/annurev.nutr.22.110901.145329","article-title":"Regulation of nitric oxide synthesis by dietary\n                        factors","volume":"22","author":"Wu","year":"2002","journal-title":"Annu Rev Nutr."},{"key":"key2.0261002112628e+13_B45","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3382\/ps.2011-01585","article-title":"Supplementation of guanidinoacetic acid to broiler diets: effects\n                        on performance, carcass characteristics, meat quality, and energy\n                        metabolism","volume":"91","author":"Michiels","year":"2012","journal-title":"Poult Sci."},{"key":"key2.0261002112628e+13_B46","doi-asserted-by":"crossref","first-page":"60","DOI":"10.2141\/jpsa.0170044","article-title":"Growth performance and right ventricular hypertrophy responses of\n                        broiler chickens to guanidinoacetic acid supplementation under hypobaric\n                        hypoxia","volume":"55","author":"Ahmadipour","year":"2018","journal-title":"J Poult Sci."},{"key":"key2.0261002112628e+13_B47","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1080\/1828051X.2019.1698325","article-title":"Performance, antioxidant status, nutrient retention and serum\n                        profile responses of laying Japanese quails to increasing addition levels of\n                        dietary guanidinoacetic acid","volume":"19","author":"Raei","year":"2020","journal-title":"Ital J Anim Sci."},{"key":"key2.0261002112628e+13_B48","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1080\/00071668.2013.864381","article-title":"The effect of feeding excess arginine on lipogenic gene\n                        expression and growth performance in broilers","volume":"55","author":"Ebrahimi","year":"2014","journal-title":"Br Poult Sci."},{"key":"key2.0261002112628e+13_B49","doi-asserted-by":"crossref","first-page":"357","DOI":"10.4025\/actascianimsci.v32i4.10990","article-title":"Arginine metabolism in uricotelic species","volume":"32","author":"Fernandes","year":"2010","journal-title":"Acta Sci Anim Sci."},{"key":"key2.0261002112628e+13_B50","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.3382\/ps\/pew471","article-title":"Effects of dietary L-arginine levels on small intestine protein\n                        turnover and the expression of genes related to protein synthesis and\n                        proteolysis of layers","volume":"96","author":"Miao","year":"2017","journal-title":"Poult Sci."},{"key":"key2.0261002112628e+13_B51","doi-asserted-by":"crossref","first-page":"1178646920927380","DOI":"10.1177\/1178646920927380","article-title":"Plasma serotonin in laying hens (Gallus gallus domesticus) with\n                        and without foot pad dermatitis","volume":"13","author":"Alberghina","year":"2020","journal-title":"Int J Tryptophan Res."},{"key":"key2.0261002112628e+13_B52","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/0010-406X(66)90591-3","article-title":"Effect of feeding 5 per cent L-phenylalanine to young\n                        chicks","volume":"17","author":"Tamimie","year":"1966","journal-title":"Comp Biochem Physiol."},{"key":"key2.0261002112628e+13_B53","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1017\/S1751731113000347","article-title":"Dietary L-arginine supplementation reduces abdominal fat content\n                        by modulating lipid metabolism in broiler chickens","volume":"7","author":"Fouad","year":"2013","journal-title":"Animal."},{"key":"key2.0261002112628e+13_B54","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2174\/1389557516666160609081602","article-title":"Beneficial effects of the amino acid glycine","volume":"17","author":"P\u00e9rez-Torres","year":"2017","journal-title":"Mini Rev Med Chem."},{"key":"key2.0261002112628e+13_B55","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.virol.2008.06.027","article-title":"Host responses in the bursa of Fabricius of chickens infected\n                        with virulent Marek\u2019s disease virus","volume":"379","author":"Abdul-Careem","year":"2008","journal-title":"Virology."},{"key":"key2.0261002112628e+13_B56","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.psj.2020.10.050","article-title":"Marine algal polysaccharides alleviate aflatoxin B1-induced bursa\n                        of Fabricius injury by regulating redox and apoptotic signaling pathway in\n                        broilers","volume":"100","author":"Guo","year":"2021","journal-title":"Poult Sci."},{"key":"key2.0261002112628e+13_B57","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1080\/03079450500096372","article-title":"Anatomical parameters of cardiopulmonary system in three\n                        different lines of chickens: further evidence for involvement in ascites\n                        syndrome","volume":"34","author":"Hassanzadeh","year":"2005","journal-title":"Avian Pathol."},{"key":"key2.0261002112628e+13_B58","doi-asserted-by":"crossref","first-page":"404","DOI":"10.5056\/jnm14143","article-title":"Effects of intraduodenal infusions of L-phenylalanine and\n                        L-glutamine on antropyloroduodenal motility and plasma cholecystokinin in\n                        healthy men","volume":"21","author":"Steinert","year":"2015","journal-title":"J Neurogastroenterol Motil."},{"key":"key2.0261002112628e+13_B59","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1439-0396.2011.01140.x","article-title":"The trophic effect of cholecystokinin on the pancreas declines in\n                        rats on total parenteral nutrition","volume":"96","author":"Wu","year":"2012","journal-title":"J Anim Physiol Anim Nutr."},{"key":"key2.0261002112628e+13_B60","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1007\/s00394-015-1050-7","article-title":"Advanced physiological roles of guanidinoacetic\n                        acid","volume":"54","author":"Ostojic","year":"2015","journal-title":"Eur J Nutr."},{"key":"key2.0261002112628e+13_B61","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1071\/AN12302","article-title":"Growth performance and intestinal morphology in broiler chickens\n                        produced from hyperthyroid breeder hens","volume":"53","author":"Akhlaghi","year":"2013","journal-title":"Anim Prod Sci."},{"key":"key2.0261002112628e+13_B62","doi-asserted-by":"crossref","first-page":"6","DOI":"10.22219\/aras.v1i1.8299","article-title":"Relative weight of small intestine and lymphoid organ of finisher\n                        period broiler chicken at different rearing temperatures","volume":"1","author":"Rotiah","year":"2019","journal-title":"J Anim Res Appl Sci."},{"key":"key2.0261002112628e+13_B63","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s40104-017-0193-1","article-title":"The impact of synbiotic administration through in ovo technology\n                        on the microstructure of a broiler chicken small intestine tissue on the 1st\n                        and 42nd day of rearing","volume":"8","author":"Sobolewska","year":"2017","journal-title":"J Anim Sci Biotechnol."},{"key":"key2.0261002112628e+13_B64","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.livsci.2017.01.018","article-title":"Growth performance, nutrient digestibility, metabolizable energy,\n                        and intestinal morphology of growing turkeys fed diet supplemented with\n                        arginine","volume":"198","author":"Oso","year":"2017","journal-title":"Livest Sci."},{"key":"key2.0261002112628e+13_B65","doi-asserted-by":"crossref","first-page":"110","DOI":"10.5713\/ajas.17.0150","article-title":"Effects of dietary glutamine and arginine supplementation on\n                        performance, intestinal morphology and ascites mortality in broiler chickens\n                        reared under cold environment","volume":"32","author":"Abdulkarimi","year":"2019","journal-title":"Asian-Australas J Anim Sci."},{"key":"key2.0261002112628e+13_B66","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.aninu.2015.11.005","article-title":"Effects of dietary leucine supplementation on the gene expression\n                        of mammalian target of rapamycin signaling pathway and intestinal\n                        development of broilers","volume":"1","author":"Chang","year":"2015","journal-title":"Anim Nutr."},{"key":"key2.0261002112628e+13_B67","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1002\/jsfa.8609","article-title":"In ovo feeding of L-arginine regulates intestinal barrier\n                        functions of posthatch broilers by activating the mTOR signaling\n                        pathway","volume":"98","author":"Gao","year":"2018","journal-title":"J Sci Food Agric."},{"key":"key2.0261002112628e+13_B68","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1017\/S0021859618001156","article-title":"Effects of dietary supplementation of guanidino acetic acid on\n                        growth performance, thigh meat quality and development of small intestine in\n                        Partridge-Shank broilers","volume":"156","author":"Ren","year":"2018","journal-title":"J Agric Sci."},{"key":"key2.0261002112628e+13_B69","doi-asserted-by":"crossref","first-page":"19820","DOI":"10.1073\/pnas.1302840110","article-title":"Control of creatine metabolism by HIF is an endogenous mechanism\n                        of barrier regulation in colitis","volume":"110","author":"Glover","year":"2013","journal-title":"Proc Natl Acad Sci."},{"key":"key2.0261002112628e+13_B70","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1080\/03079457.2010.539590","article-title":"Nutrition and immunity: the effects of the combination of\n                        arginine and tryptophan on growth performance, serum parameters and immune\n                        response in broiler chickens challenged with infectious bursal disease\n                        vaccine","volume":"40","author":"Emadi","year":"2011","journal-title":"Avian Pathol."},{"key":"key2.0261002112628e+13_B71","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1093\/alcalc\/agh074","article-title":"High AST\/ALT ratio may indicate advanced alcoholic liver disease\n                        rather than heavy drinking","volume":"39","author":"Nyblom","year":"2004","journal-title":"Alcohol Alcohol."},{"key":"key2.0261002112628e+13_B72","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.anifeedsci.2013.07.002","article-title":"Effect of olive leaves on ascites incidence, hematological\n                        parameters and growth performance in broilers reared under standard and cold\n                        temperature conditions","volume":"185","author":"Varmaghany","year":"2013","journal-title":"Anim Feed Sci Technol."},{"key":"key2.0261002112628e+13_B73","first-page":"632","article-title":"Total serum lactate dehydrogenase activity in acute Plasmodium\n                        falciparum malaria infection","volume":"46","author":"Garba","year":"2005","journal-title":"Singapore Med J."},{"key":"key2.0261002112628e+13_B74","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1093\/ps\/80.3.358","article-title":"Plasma levels of arginine, ornithine, and urea and growth\n                        performance of broilers fed supplemental L-arginine during cool temperature\n                        exposure","volume":"80","author":"Ruiz-Feria","year":"2001","journal-title":"Poult Sci."},{"key":"key2.0261002112628e+13_B75","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3382\/ps.2009-00401","article-title":"Uric acid, urea, and ammonia concentrations in serum and uric\n                        acid concentration in excreta as indicators of amino acid utilization in\n                        diets for broilers","volume":"89","author":"Donsbough","year":"2010","journal-title":"Poult Sci."},{"key":"key2.0261002112628e+13_B76","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1017\/S0007114517003701","article-title":"Energy utilisation of broiler chickens in response to\n                        guanidinoacetic acid supplementation in diets with various energy\n                        contents","volume":"120","author":"Ale Saheb Fosoul","year":"2018","journal-title":"Br J Nutr."},{"key":"key2.0261002112628e+13_B77","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.3382\/ps.2014-03894","article-title":"Effects of dietary supplementation of meat-type quail breeders\n                        with guanidinoacetic acid on their reproductive parameters and progeny\n                        performance","volume":"93","author":"Murakami","year":"2014","journal-title":"Poult Sci."},{"key":"key2.0261002112628e+13_B78","first-page":"109241","article-title":"Influence of Eimeria spp","volume":"286","author":"Yazdanabadi","year":"2020","journal-title":"infection and dietary inclusion of arginine on intestine histological\n                        parameters, serum amino acid profile and ileal amino acids digestibility in\n                        broiler chicks. Vet Parasitol."},{"key":"key2.0261002112628e+13_B79","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/S0026-895X(24)12201-8","article-title":"Functional and analytical evidence for scavenging of oxygen\n                        radicals by L-arginine","volume":"61","author":"Lass","year":"2002","journal-title":"Mol Pharmacol."},{"key":"key2.0261002112628e+13_B80","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s12011-009-8378-x","article-title":"Effects of dietary zinc and l-arginine supplementation on total\n                        antioxidants capacity, lipid peroxidation, nitric oxide, egg weight, and\n                        blood biochemical values in Japanese quails","volume":"132","author":"Atakisi","year":"2009","journal-title":"Biol Trace Elem Res."},{"key":"key2.0261002112628e+13_B81","doi-asserted-by":"crossref","first-page":"114208","DOI":"10.1016\/j.anifeedsci.2019.114208","article-title":"Ef\ufb01cacy of guanidinoacetic acid at different dietary crude\n                        protein levels on growth performance, stress indicators, antioxidant status,\n                        and intestinal morphology in broiler chickens subjected to cyclic heat\n                        stress","volume":"254","author":"Amiri","year":"2019","journal-title":"Anim Feed Sci Technol."},{"key":"key2.0261002112628e+13_B82","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1002\/mnfr.200800504","article-title":"Creatine supplementation prevents the inhibition of myogenic\n                        differentiation in oxidatively injured C2C12 murine\n                        myoblasts","volume":"53","author":"Sestili","year":"2009","journal-title":"Mol Nutr Food Res."},{"key":"key2.0261002112628e+13_B83","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.3382\/ps.2010-00764","article-title":"L-Arginine and antioxidant vitamins E and C improve the\n                        cardiovascular performance of broiler chickens grown under chronic hypobaric\n                        hypoxia","volume":"89","author":"Bautista-Ortega","year":"2010","journal-title":"Poult Sci."},{"key":"key2.0261002112628e+13_B84","doi-asserted-by":"crossref","first-page":"5844","DOI":"10.1016\/j.psj.2020.08.017","article-title":"The effects of L-arginine supplementation on growth performance\n                        and intestinal health of broiler chickens challenged with Eimeria\n                        spp","volume":"99","author":"Castro","year":"2020","journal-title":"Poult Sci."},{"key":"key2.0261002112628e+13_B85","doi-asserted-by":"crossref","first-page":"e166","DOI":"10.1111\/jpn.12724","article-title":"Effects of in ovo feeding of L-arginine on the development of\n                        digestive organs, intestinal function and post-hatch performance of broiler\n                        embryos and hatchlings","volume":"102","author":"Gao","year":"2018","journal-title":"J Anim Physiol Anim Nutr."},{"key":"key2.0261002112628e+13_B86","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1017\/S0007114517002094","article-title":"Dietary L-Arginine inhibits intestinal Clostridium perfringens\n                        colonisation and attenuates intestinal mucosal injury in broiler\n                        chickens","volume":"118","author":"Zhang","year":"2017","journal-title":"Br J Nutr."},{"key":"key2.0261002112628e+13_B87","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.3382\/ps.2013-03171","article-title":"Supplemental glycine and threonine effects on performance,\n                        intestinal mucosa development, and nutrient utilization of growing broiler\n                        chickens","volume":"92","author":"Ospina-Rojas","year":"2013","journal-title":"Poult Sci."},{"key":"key2.0261002112628e+13_B88","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1152\/ajpgi.00387.2010","article-title":"Amino acids stimulate cholecystokinin release through the\n                        Ca2+-sensing receptor","volume":"300","author":"Wang","year":"2011","journal-title":"Am J Physiol Gastrointest Liver Physiol."},{"key":"key2.0261002112628e+13_B89","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1093\/ps\/78.11.1506","article-title":"Effects of daily oral doses of L-arginine on coccidiosis\n                        infections in chickens","volume":"78","author":"Allen","year":"1999","journal-title":"Poult Sci."},{"key":"key2.0261002112628e+13_B90","doi-asserted-by":"crossref","first-page":"988","DOI":"10.3945\/jn.114.192120","article-title":"Dietary arginine supplementation of mice alters the microbial\n                        population and activates intestinal innate immunity","volume":"144","author":"Ren","year":"2014","journal-title":"J Nutr."}],"container-title":["Journal of Animal Science and Technology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.ejast.org\/download\/download_pdf?doi=10.5187\/jast.2022.e68","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.ejast.org\/download\/download_pdf?doi=10.5187\/jast.2022.e68","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:43:01Z","timestamp":1790908981000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.ejast.org\/archive\/view_article?doi=10.5187\/jast.2022.e68"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":90,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1,31]]},"published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.5187\/jast.2022.e68"],"URL":"https:\/\/doi.org\/10.5187\/jast.2022.e68","relation":{},"ISSN":["2672-0191","2055-0391"],"issn-type":[{"value":"2672-0191","type":"print"},{"value":"2055-0391","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"2022-01-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}