{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:15:28Z","timestamp":1792790128482,"version":"4.5.0"},"reference-count":33,"publisher":"Korean Society of Animal Science and Technology","issue":"6","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"name":"Ministry for Food, Agriculture, Forestry, and\n                                Fisheries","award":["321037-05-2-HD040"],"award-info":[{"award-number":["321037-05-2-HD040"]}]},{"name":"Rural Development Administration","award":["PJ015865"],"award-info":[{"award-number":["PJ015865"]}],"id":[{"id":"https:\/\/ror.org\/03xs9yg50","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.ejast.org"],"crossmark-restriction":true},"short-container-title":["J Anim Sci Technol"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:p>Using antibiotics as growth promoter has been banned in poultry feed industry,\n                    thus various researchers try to seek an alternative to replace the\n                    growth-promoting antibiotics. In this study, we aimed to evaluate the growth\n                    performance via intestinal nutrient utilization and cecal microbial composition\n                    of broiler after dietary supplementation with most commonly using antibiotics,\n                    zinc bacitracin, and sophorolipid. A total of 180 1-day-old chicks were randomly\n                    assigned, and dietary treatment was as follow: CON, basal diet; ZB, 100 ppm of\n                    zinc bacitracin supplemented diet; and SPL, 250 ppm of sophorolipid supplemented\n                    diet. Their growth performance was evaluated and the samples of blood, small\n                    intestine, and ileal and cecal digesta were collected for biochemical,\n                    histological, and genomic analyses. The body weight and average daily gain of\n                    7-day-old chicks were higher in ZB and those in overall experimental period were\n                    improved by ZB and SPL supplementation (p &lt; 0.05). Their\n                    intestinal characteristics were not affected by dietary treatments in duodenum\n                    and ileum. Nonetheless, villus height was increased by SPL supplementation in\n                    jejunum (p &lt; 0.05). Moreover, dietary SPL\n                    supplementation could down-regulate the expression level of pro-inflammatory\n                    cytokine, IL-1\u03b2 (p &lt; 0.05). mRNA\n                    levels of lipid and protein transporters did not differ among the treatments,\n                    however, relative expression levels of carbohydrate transporters,\n                        GLUT2 and SGLT1 were increased in broiler\n                    chicken\u2019s jejumum fed zinc bacitracin and sophorolipid supplemented diets\n                        (p &lt; 0.05). Dietary zinc bacitracin supplementation\n                    could increase the population of Firmicutes in phylum level,\n                    and the portion of Turiciacter in genus level. On the other\n                    hands, the portion of Faecalibacterium was increased by dietary\n                    SPL supplementation compared to the other treatments. Our findings suggest that\n                    SPL supplementation improves growth performance through enhanced carbohydrate\n                    utilization capacity via improvement of gut morphological status and modulation\n                    of the cecal microbial population of broilers.<\/jats:p>","DOI":"10.5187\/jast.2022.e76","type":"journal-article","created":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T03:05:25Z","timestamp":1666321525000},"page":"1092-1104","update-policy":"https:\/\/doi.org\/10.5187\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Dietary effects of sophorolipids on nutrient bioavailability and\n                    intestinal microenvironments in broiler chickens"],"prefix":"10.5187","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9832-3251","authenticated-orcid":false,"given":"Min-Jin","family":"Kwak","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04h9pn542","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Science, Seoul National University, Seoul 08826, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1438-9515","authenticated-orcid":false,"given":"Min Young","family":"Park","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0190ak572","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York 10012, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5390-8309","authenticated-orcid":false,"given":"Ki-Peum","family":"Sung","sequence":"additional","affiliation":[{"name":"Pathway Intermediates, Seoul 06253, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4082-9297","authenticated-orcid":false,"given":"Hanbae","family":"Lee","sequence":"additional","affiliation":[{"name":"Pathway Intermediates, Seoul 06253, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0414-7611","authenticated-orcid":false,"given":"Kwang-Youn","family":"Whang","sequence":"additional","affiliation":[{"name":"Division of Biotechnology, College of Life Science and Biotechnology, Korea University, Seoul 02841, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6769-0657","authenticated-orcid":false,"given":"Younghoon","family":"Kim","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04h9pn542","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Science, Seoul National University, Seoul 08826, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3132","published-online":{"date-parts":[[2022,11,30]]},"reference":[{"key":"key2.0261002112546e+13_B1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1177\/003335490712200111","article-title":"Growth promoting antibiotics in food animal production: an\n                        economic analysis","volume":"122","author":"Graham","year":"2007","journal-title":"Public Health Rep."},{"key":"key2.0261002112546e+13_B2","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1093\/ps\/84.4.634","article-title":"Antibiotic growth promoters in agriculture: history and mode of\n                        action","volume":"84","author":"Dibner","year":"2005","journal-title":"Poult Sci."},{"key":"key2.0261002112546e+13_B3","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.mib.2003.09.009","article-title":"Antibiotics in animal feed and their role in resistance\n                        development","volume":"6","author":"Wegener","year":"2003","journal-title":"Curr Opin Microbiol."},{"key":"key2.0261002112546e+13_B4","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3389\/fmicb.2014.00033","article-title":"Antibiotic growth promoters enhance animal production by\n                        targeting intestinal bile salt hydrolase and its producers","volume":"5","author":"Lin","year":"2014","journal-title":"Front Microbiol."},{"key":"key2.0261002112546e+13_B5","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.tvjl.2010.03.003","article-title":"An update on alternatives to antimicrobial growth promoters for\n                        broilers","volume":"187","author":"Huyghebaert","year":"2011","journal-title":"Vet J."},{"key":"key2.0261002112546e+13_B6","doi-asserted-by":"crossref","first-page":"114833","DOI":"10.1016\/j.anifeedsci.2021.114833","article-title":"The effects of multispecies probiotic formulations on growth\n                        performance, hepatic metabolism, intestinal integrity and fecal microbiota\n                        in growing-finishing pigs","volume":"274","author":"Kwak","year":"2021","journal-title":"Anim Feed Sci Technol."},{"key":"key2.0261002112546e+13_B7","doi-asserted-by":"crossref","first-page":"520","DOI":"10.5187\/jast.2021.e44","article-title":"Effects of dietary inactivated probiotics on growth performance\n                        and immune responses of weaned pigs","volume":"63","author":"Kang","year":"2021","journal-title":"J Anim Sci Technol."},{"key":"key2.0261002112546e+13_B8","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.5187\/jast.2021.e94","article-title":"Multispecies probiotics alter fecal short-chain fatty acids and\n                        lactate levels in weaned pigs by modulating gut microbiota","volume":"63","author":"Oh","year":"2021","journal-title":"J Anim Sci Technol."},{"key":"key2.0261002112546e+13_B9","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.5187\/jast.2021.e109","article-title":"Effects of Bacillus-based probiotics on growth performance,\n                        nutrient digestibility, and intestinal health of weaned pigs","volume":"63","author":"Mun","year":"2021","journal-title":"J Anim Sci Technol."},{"key":"key2.0261002112546e+13_B10","first-page":"115","article-title":"Gut microbiology and growth-promoting antibiotics in\n                        swine","volume":"20","author":"Anderson","year":"1999","journal-title":"Pig News Inf."},{"key":"key2.0261002112546e+13_B11","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1111\/j.1365-2672.2007.03699.x","article-title":"Effects of zinc bacitracin, bird age and access to range on\n                        bacterial microbiota in the ileum and caeca of broiler\n                        chickens","volume":"104","author":"Gong","year":"2008","journal-title":"J Appl Microbiol."},{"key":"key2.0261002112546e+13_B12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0084290","article-title":"Highly variable microbiota development in the chicken\n                        gastrointestinal tract","volume":"8","author":"Stanley","year":"2013","journal-title":"PLOS ONE"},{"key":"key2.0261002112546e+13_B13","doi-asserted-by":"crossref","first-page":"4301","DOI":"10.1007\/s00253-014-5646-2","article-title":"Microbiota of the chicken gastrointestinal tract: influence on\n                        health, productivity and disease","volume":"98","author":"Stanley","year":"2014","journal-title":"Appl Microbiol Biotechnol."},{"key":"key2.0261002112546e+13_B14","doi-asserted-by":"crossref","first-page":"37376","DOI":"10.1038\/srep37376","article-title":"Differential fecal microbiota are retained in broiler chicken\n                        lines divergently selected for fatness traits","volume":"6","author":"Hou","year":"2016","journal-title":"Sci Rep."},{"key":"key2.0261002112546e+13_B15","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s40104-021-00606-x","article-title":"Dietary sophorolipid accelerates growth by modulation of gut\n                        microbiota population and intestinal environments in broiler\n                        chickens","volume":"12","author":"Kwak","year":"2021","journal-title":"J Anim Sci Biotechnol."},{"key":"key2.0261002112546e+13_B16","doi-asserted-by":"crossref","first-page":"635","DOI":"10.3390\/ani12050635","article-title":"Effects of sophorolipid on growth performance, organ\n                        characteristics, lipid digestion markers, and gut functionality and\n                        integrity in broiler chickens","volume":"12","author":"Kwak","year":"2022","journal-title":"Animals."},{"key":"key2.0261002112546e+13_B17","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12917-021-03105-3","article-title":"Sophorolipid protects against early-weaning syndrome by improving\n                        the gut microenvironment in early-weaned piglets","volume":"18","author":"Kwak","year":"2022","journal-title":"BMC Vet Res."},{"key":"key2.0261002112546e+13_B18","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1039\/D1FO03109K","article-title":"Protective and restorative effects of sophorolipid on intestinal\n                        dystrophy 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chickens","volume":"26","author":"Ao","year":"2013","journal-title":"Asian-Australas J Anim Sci."},{"key":"key2.0261002112546e+13_B27","doi-asserted-by":"crossref","first-page":"962","DOI":"10.3382\/ps.0610962","article-title":"The efficacy of bacitracin methylene disalicylate and zinc\n                        bacitracin in turkey nutrition","volume":"61","author":"Daghighian","year":"1982","journal-title":"Poult Sci."},{"key":"key2.0261002112546e+13_B28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ismej.2014.99","article-title":"Modulation of gut microbiota during probiotic-mediated\n                        attenuation of metabolic syndrome in high fat diet-fed mice","volume":"9","author":"Wang","year":"2015","journal-title":"ISME J."},{"key":"key2.0261002112546e+13_B29","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1099\/ijs.0.64709-0","article-title":"Barnesiella viscericola gen. nov., sp. nov., a novel member of\n                        the family Porphyromonadaceae isolated from chicken caecum","volume":"57","author":"Sakamoto","year":"2007","journal-title":"Int J Syst Evol Microbiol."},{"key":"key2.0261002112546e+13_B30","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/nature05414","article-title":"An obesity-associated gut microbiome with increased capacity for\n                        energy harvest","volume":"444","author":"Turnbaugh","year":"2006","journal-title":"Nature."},{"key":"key2.0261002112546e+13_B31","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1128\/CMR.16.2.175-188.2003","article-title":"Antimicrobial growth promoters used in animal feed: effects of\n                        less well known antibiotics on gram-positive bacteria","volume":"16","author":"Butaye","year":"2003","journal-title":"Clin Microbiol Rev."},{"key":"key2.0261002112546e+13_B32","doi-asserted-by":"crossref","first-page":"4320412","DOI":"10.1155\/2016\/4320412","article-title":"The bacteriomes of ileal mucosa and cecal content of broiler\n                        chickens and turkeys as revealed by metagenomic analysis","volume":"2016","author":"Wei","year":"2016","journal-title":"Int J Microbiol."},{"key":"key2.0261002112546e+13_B33","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.4014\/jmb.1709.09027","article-title":"Deciphering diversity indices for a better understanding of\n                        microbial communities","volume":"27","author":"Kim","year":"2017","journal-title":"J Microbiol Biotechnol."}],"updated-by":[{"DOI":"10.5187\/jast.2022.e76.e","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000}}],"container-title":["Journal of Animal Science and Technology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.ejast.org\/download\/download_pdf?doi=10.5187\/jast.2022.e76","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.ejast.org\/download\/download_pdf?doi=10.5187\/jast.2022.e76","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:57:32Z","timestamp":1790909852000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.ejast.org\/archive\/view_article?doi=10.5187\/jast.2022.e76"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":33,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,11,30]]},"published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.5187\/jast.2022.e76"],"URL":"https:\/\/doi.org\/10.5187\/jast.2022.e76","relation":{},"ISSN":["2672-0191","2055-0391"],"issn-type":[{"value":"2672-0191","type":"print"},{"value":"2055-0391","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"2022-09-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}