{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:53:35Z","timestamp":1790913215202,"version":"4.1.0"},"reference-count":45,"publisher":"Korean Society of Animal Science and Technology","issue":"6","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"name":"National Research Foundation of Korea","award":["NRF-RS-2023-00275307"],"award-info":[{"award-number":["NRF-RS-2023-00275307"]}],"id":[{"id":"https:\/\/ror.org\/013aysd81","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Ministry of Education","award":["2019R1A6C1010033"],"award-info":[{"award-number":["2019R1A6C1010033"]}]},{"name":"Dankook University","id":[{"id":"https:\/\/ror.org\/058pdbn81","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.ejast.org"],"crossmark-restriction":true},"short-container-title":["J Anim Sci Technol"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:p>Minerals is required small amounts among various nutrients, but it has a\n                    significant impact on sow longevity and reproduction performance. This study was\n                    carried out to see the beneficial effects of marine-derived Ca-Mg complex on the\n                    reproductive performance of sows during four-parity periods. Seventy-two gilts\n                    ([Yorkshire \u00d7 Landrace] \u00d7 Duroc), with an average body weight of\n                    181 kg, were randomly allocated to three groups; CON (basal diet), 0.3LC (CON -\n                    MgO - 0.3% limestone + 0.4% Ca-Mg complex), and 0.7LC (CON - MgO - 0.7%\n                    limestone + 0.4% Ca-Mg complex). During parity 3 and 4, the expression level of\n                    SCD gene was lower in the umbilical cord of piglets born to 0.3LC and 0.7LC sows\n                    compared with the CON sows. During parity 2, 3 and 4, SLC2A2\n                    and FABP4 gene expressions were higher in the umbilical cord of\n                    piglets born to 0.7LC sows and the placenta of sows from 0.3LC groups,\n                    respectively. Ca-Mg complex increased (p &lt; 0.05) Ca and\n                    Mg concentrations in sows and their piglets\u2019 serum as well as in\n                    colostrum regardless of parities. The serum vitamin D concentration was higher\n                        (p &lt; 0.05) in their first parity, whereas serum\n                    prolactin and estrogen concentrations were higher (p &lt;\n                    0.05) during the fourth and third parity, respectively. The growth hormone\n                    concentrations were higher (p &lt; 0.05) in the piglets\n                    born to sows during the first and second parity. The fat and immunoglobulin A\n                    (IgA) concentrations in colostrum were higher (p &lt; 0.05)\n                    during the third and fourth parity, respectively. A reduction\n                        (p &lt; 0.05) in salivary cortisol, epinephrine, and\n                    norepinephrine concentrations was observed in 0.3LC and 0.7LC sow groups\n                    compared with CON after farrowing regardless of parity, however before\n                    farrowing, a reduction in norepinephrine was observed. Before farrowing, the\n                    epinephrine and norepinephrine concentrations were higher (p\n                    &lt; 0.05) during the first and second parity. After farrowing, the\n                    concentration of these hormones was higher during the second parity. Taken\n                    together, sows\u2019 parity and dietary Ca-Mg complex supplementation\n                    influenced serum metabolites, colostrum nutrients, stress hormones as well as\n                    the gene expressions related to lipid and glucose metabolism.<\/jats:p>","DOI":"10.5187\/jast.2023.e116","type":"journal-article","created":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T01:01:07Z","timestamp":1698886867000},"page":"1308-1322","update-policy":"https:\/\/doi.org\/10.5187\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Marine-derived Ca-Mg complex influences lipid and glucose metabolism,\n                    serum metabolites, colostrum profile, and stress hormone in sows over\n                    four-parity periods"],"prefix":"10.5187","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2593-2758","authenticated-orcid":false,"given":"Sungbo","family":"Cho","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/058pdbn81","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Animal Resource and Science, Dankook University, Cheonan 31116, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3801-4964","authenticated-orcid":false,"given":"Santi Devi","family":"Upadhaya","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/058pdbn81","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Animal Resource and Science, Dankook University, Cheonan 31116, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1758-7579","authenticated-orcid":false,"given":"Woo Jeong","family":"Seok","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/058pdbn81","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Animal Resource and Science, Dankook University, Cheonan 31116, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9669-4494","authenticated-orcid":false,"given":"Seyoung","family":"Mun","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/058pdbn81","id-type":"ROR","asserted-by":"publisher"}],"name":"Center for Bio-Medical Engineering Core Facility, Dankook University, Cheonan 31116, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9415-0557","authenticated-orcid":false,"given":"Haeun","family":"Lee","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/058pdbn81","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Bioconvergence Engineering, Dankook University, Jukjeon 16890, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1092-7961","authenticated-orcid":false,"given":"Rudolf H.","family":"van der Veen","sequence":"additional","affiliation":[{"name":"Celtic Sea Minerals, Strand Farm, Carrigaline, County Cork P43 NN62, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6791-2408","authenticated-orcid":false,"given":"Kyudong","family":"Han","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/058pdbn81","id-type":"ROR","asserted-by":"publisher"}],"name":"Center for Bio-Medical Engineering Core Facility, Dankook University, Cheonan 31116, Korea"},{"id":[{"id":"https:\/\/ror.org\/058pdbn81","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Microbiology, College of Science and Technology, Dankook University, Cheonan 31116, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6652-2504","authenticated-orcid":false,"given":"In Ho","family":"Kim","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/058pdbn81","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Animal Resource and Science, Dankook University, Cheonan 31116, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3132","published-online":{"date-parts":[[2023,11,30]]},"reference":[{"key":"key2.0261002112941e+13_B1","first-page":"223","article-title":"Nutrient requirements of prolific sows","volume":"19","author":"Ball","year":"2008","journal-title":"Adv Pork Prod."},{"key":"key2.0261002112941e+13_B2","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1093\/jn\/135.9.2137","article-title":"Vegetable proteins enhance the growth of milk-fed piglets,\n                        despite lower apparent ileal digestibility","volume":"135","author":"Ebert","year":"2005","journal-title":"J Nutr."},{"key":"key2.0261002112941e+13_B3","first-page":"85","article-title":"The influence of nutrient intake on biological measures of\n                        breeding herd productivity","volume":"4","author":"Koketsu","year":"1996","journal-title":"J Swine Health Prod."},{"key":"key2.0261002112941e+13_B4","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.2527\/jas1983.5751200x","article-title":"Restricted energy intake and elevated calcium and phosphorus\n                        intake for gilts during growth. 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Characterization of metacarpal,\n                        metatarsal, femur, humerus and turbinate bones of sows during three\n                        parities","volume":"57","author":"Arthur","year":"1983","journal-title":"J Anim Sci."},{"key":"key2.0261002112941e+13_B5","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/2049-1891-5-39","article-title":"Effects of magnesium on the performance of sows and their\n                        piglets","volume":"5","author":"Zang","year":"2014","journal-title":"J Anim Sci Biotechnol."},{"key":"key2.0261002112941e+13_B6","first-page":"183","article-title":"Nutritional manipulation of bone mineralization in developing\n                        gilts","volume-title":"Leman Swine Conference","author":"Crenshaw","year":"2003"},{"key":"key2.0261002112941e+13_B7","doi-asserted-by":"crossref","first-page":"151","DOI":"10.2527\/1995.731151x","article-title":"Effect of initial breeding weight on macro- and micromineral\n                        composition over a three-parity period using a high-producing sow\n                        genotype","volume":"73","author":"Mahan","year":"1995","journal-title":"J Anim Sci."},{"key":"key2.0261002112941e+13_B8","first-page":"21","article-title":"Meeting the mineral needs of highly prolific sows","volume":"24","author":"Mahan","year":"2008","journal-title":"Pig Prog."},{"key":"key2.0261002112941e+13_B9","doi-asserted-by":"crossref","first-page":"3497","DOI":"10.3390\/nu7053497","article-title":"Impacts of maternal nutrition on vascularity of nutrient\n                        transferring tissues during gestation and lactation","volume":"7","author":"Vonnahme","year":"2015","journal-title":"Nutrients."},{"key":"key2.0261002112941e+13_B10","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1093\/emph\/eoz037","article-title":"The Maternal Nutritional Buffering Model: an evolutionary\n                        framework for pregnancy nutritional intervention","volume":"2020","author":"Thayer","year":"2020","journal-title":"Evol Med Public Health."},{"key":"key2.0261002112941e+13_B11","doi-asserted-by":"crossref","first-page":"437","DOI":"10.3945\/jn.109.116327","article-title":"Maternal micronutrient deficiency, fetal development, and the\n                        risk of chronic disease","volume":"140","author":"Christian","year":"2010","journal-title":"J Nutr."},{"key":"key2.0261002112941e+13_B12","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1096\/fasebj.14.9.1132","article-title":"Regulation of adiposity by dietary calcium","volume":"14","author":"Zemel","year":"2000","journal-title":"FASEB J."},{"key":"key2.0261002112941e+13_B13","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s11745-003-1044-6","article-title":"Role of dietary calcium and dairy products in modulating\n                        adiposity","volume":"38","author":"Zemel","year":"2003","journal-title":"Lipids."},{"key":"key2.0261002112941e+13_B14","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/ajcn\/77.2.281","article-title":"Calcium intake and adiposity","volume":"77","author":"Parikh","year":"2003","journal-title":"Am J Clin Nutr."},{"key":"key2.0261002112941e+13_B15","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1093\/jn\/138.6.1047","article-title":"Dietary calcium and dairy products modulate oxidative and\n                        inflammatory stress in mice and humans","volume":"138","author":"Zemel","year":"2008","journal-title":"J Nutr."},{"key":"key2.0261002112941e+13_B16","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.bbrc.2018.09.143","article-title":"Maternal supplementation with calcium varying with feeding time\n                        daily during late pregnancy affects lipid metabolism and transport of\n                        placenta in pigs","volume":"505","author":"Gao","year":"2018","journal-title":"Biochem Biophys Res Commun."},{"key":"key2.0261002112941e+13_B17","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1089\/jmf.2017.0023","article-title":"Effect of calcium derived from Lithothamnion sp. on markers of\n                        calcium metabolism in premenopausal women","volume":"21","author":"Zenk","year":"2018","journal-title":"J Med Food."},{"key":"key2.0261002112941e+13_B18","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s00223-017-0299-7","article-title":"A natural, calcium-rich marine multi-mineral complex preserves\n                        bone structure, composition and strength in an ovariectomised rat model of\n                        osteoporosis","volume":"101","author":"Brennan","year":"2017","journal-title":"Calcif Tissue Int."},{"key":"key2.0261002112941e+13_B19","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1017\/S1751731112002431","article-title":"The influence of a magnesium-rich marine extract on behaviour,\n                        salivary cortisol levels and skin lesions in growing pigs","volume":"7","author":"O\u2019Driscoll","year":"2013","journal-title":"Animal."},{"key":"key2.0261002112941e+13_B20","volume-title":"Nutrient requirements of swine","author":"NRC [National Research Council]","year":"2012","edition":"11th ed"},{"key":"key2.0261002112941e+13_B21","volume-title":"Official methods of analysis AOAC International","author":"AOAC [Association of Official Analytical Chemists]\n                            International","year":"2000","edition":"17th ed"},{"key":"key2.0261002112941e+13_B22","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1017\/S0022029900007871","article-title":"A comparison of the Gerber and R\u00f6se Gottlieb methods for\n                        the determination of fat in milk","volume":"22","author":"Crocker","year":"1955","journal-title":"J Dairy Res."},{"key":"key2.0261002112941e+13_B23","doi-asserted-by":"crossref","first-page":"S52","DOI":"10.1016\/j.placenta.2005.01.003","article-title":"Fetoplacental transport and utilization of amino acids in IUGR-a\n                        review","volume":"26","author":"Regnault","year":"2005","journal-title":"Placenta."},{"key":"key2.0261002112941e+13_B24","doi-asserted-by":"crossref","first-page":"179827","DOI":"10.1155\/2012\/179827","article-title":"Regulation of nutrient transport across the\n                        placenta","volume":"2012","author":"Lager","year":"2012","journal-title":"J Pregnancy."},{"key":"key2.0261002112941e+13_B25","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.2527\/1994.7251315x","article-title":"Effect of dietary calcium concentrations during gestation and\n                        lactation in the sow on milk composition and litter growth","volume":"72","author":"Miller","year":"1994","journal-title":"J Anim Sci."},{"key":"key2.0261002112941e+13_B26","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1749-6632.2011.06303.x","article-title":"The role of stearoyl-CoA desaturase in obesity, insulin\n                        resistance, and inflammation","volume":"1243","author":"Sampath","year":"2011","journal-title":"Ann N Y Acad Sci."},{"key":"key2.0261002112941e+13_B27","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1016\/j.clnu.2019.08.030","article-title":"Associations of maternal and fetal SCD-1 markers with infant\n                        anthropometry and maternal diet: findings from the ROLO\n                        study","volume":"39","author":"Marchioro","year":"2020","journal-title":"Clin Nutr."},{"key":"key2.0261002112941e+13_B28","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1159\/000456886","article-title":"Fatty acid-binding protein 4 in endometrial epithelium is\n                        involved in embryonic implantation","volume":"41","author":"Wang","year":"2017","journal-title":"Cell Physiol Biochem."},{"key":"key2.0261002112941e+13_B29","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00125-014-3451-1","article-title":"GLUT2, glucose sensing and glucose homeostasis","volume":"58","author":"Thorens","year":"2015","journal-title":"Diabetologia."},{"key":"key2.0261002112941e+13_B30","doi-asserted-by":"crossref","first-page":"439","DOI":"10.2527\/jas1969.293439x","article-title":"Effects of dietary levels of manganese and magnesium on\n                        performance of growing-finishing swine raised in confinement and on\n                        pasture","volume":"29","author":"Svajgr","year":"1969","journal-title":"J Anim Sci."},{"key":"key2.0261002112941e+13_B31","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1079\/BJN19800009","article-title":"Metabolic effects of a low-magnesium diet in pigs","volume":"44","author":"Nuoranne","year":"1980","journal-title":"Br J Nutr."},{"key":"key2.0261002112941e+13_B32","first-page":"193","article-title":"Physiology of colostrum production","volume":"9","author":"Delouis","year":"1978","journal-title":"Ann Rech Vet."},{"key":"key2.0261002112941e+13_B33","doi-asserted-by":"crossref","first-page":"183","DOI":"10.5772\/62841","article-title":"The protein component of sow colostrum and milk","volume-title":"Milk proteins - from structure to biological properties and health\n                        aspect","author":"Theil","year":"2016"},{"key":"key2.0261002112941e+13_B34","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1017\/S0021859605005642","article-title":"Nutritional and immunological importance of colostrum for the\n                        new-born pig","volume":"143","author":"Le Dividich","year":"2005","journal-title":"J Agric Sci."},{"key":"key2.0261002112941e+13_B35","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0165-2427(02)00004-1","article-title":"The influence of nonspecific immunostimulation of pregnant sows\n                        on the immunological value of colostrum","volume":"87","author":"Krakowski","year":"2002","journal-title":"Vet Immunol Immunopathol."},{"key":"key2.0261002112941e+13_B36","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1017\/S175173111100070X","article-title":"Colostrum production by sows: variability of colostrum yield and\n                        immunoglobulin G concentrations","volume":"5","author":"Quesnel","year":"2011","journal-title":"Animal."},{"key":"key2.0261002112941e+13_B37","unstructured":"van Heugten\n                            E\n                        \n                    \n                    Magnesium in pig nutrition [Internet]\n                    Professional Pig Community\n                    2009\n                    [cited 2023 Jun 12]\n                    https:\/\/www.pig333.com\/articles\/magnesium-in-pig-nutrition_580\/"},{"key":"key2.0261002112941e+13_B38","doi-asserted-by":"crossref","first-page":"531","DOI":"10.4141\/cjas95-080","article-title":"Endocrine and peripartum behavioral responses of sows fed\n                        high-fiber diets during gestation","volume":"75","author":"Farmer","year":"1995","journal-title":"Can J Anim Sci."},{"key":"key2.0261002112941e+13_B39","doi-asserted-by":"crossref","first-page":"109","DOI":"10.4141\/cjas2012-106","article-title":"Short communication: relations between peripartum concentrations\n                        of prolactin and progesterone in sows and piglet growth in early\n                        lactation","volume":"93","author":"Quesnel","year":"2013","journal-title":"Can J Anim Sci."},{"key":"key2.0261002112941e+13_B40","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.2527\/jas.2011-4874","article-title":"Effect of dam parity on litter performance, transfer of passive\n                        immunity, and progeny microbial ecology","volume":"91","author":"Carney-Hinkle","year":"2013","journal-title":"J Anim Sci."},{"key":"key2.0261002112941e+13_B41","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.2527\/jas.2014-8282","article-title":"Sow and litter factors influencing colostrum yield and\n                        nutritional composition","volume":"93","author":"Declerck","year":"2015","journal-title":"J Anim Sci."},{"key":"key2.0261002112941e+13_B42","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.3390\/ani10101853","article-title":"Effect of parity on reproductive performance and composition of\n                        sow colostrum during first 24 h postpartum","volume":"10","author":"Segura","year":"2020","journal-title":"Animals."},{"key":"key2.0261002112941e+13_B43","doi-asserted-by":"crossref","first-page":"12911","DOI":"10.1021\/acs.jafc.8b03097","article-title":"Evaluation of breed and parity order effects on the lipid\n                        composition of porcine colostrum","volume":"66","author":"Luise","year":"2018","journal-title":"J Agric Food Chem."},{"key":"key2.0261002112941e+13_B44","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.physbeh.2018.12.014","article-title":"Effects of parity and litter size on cortisol measures in\n                        commercially housed sows and their offspring","volume":"201","author":"Roelofs","year":"2019","journal-title":"Physiol Behav."},{"key":"key2.0261002112941e+13_B45","doi-asserted-by":"crossref","first-page":"562","DOI":"10.5187\/jast.2022.e121","article-title":"Marine derived Ca-Mg complex supplementation basal diet during\n                        four subsequent parities improved longevity and performance of sows and\n                        their litters","volume":"65","author":"Upadhaya","year":"2023","journal-title":"J Anim Sci Technol."}],"container-title":["Journal of Animal Science and Technology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.ejast.org\/download\/download_pdf?doi=10.5187\/jast.2023.e116","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.ejast.org\/download\/download_pdf?doi=10.5187\/jast.2023.e116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:59:55Z","timestamp":1790909995000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.ejast.org\/archive\/view_article?doi=10.5187\/jast.2023.e116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":45,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,11,30]]},"published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.5187\/jast.2023.e116"],"URL":"https:\/\/doi.org\/10.5187\/jast.2023.e116","relation":{},"ISSN":["2672-0191","2055-0391"],"issn-type":[{"value":"2672-0191","type":"print"},{"value":"2055-0391","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"2023-08-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}