{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:54:36Z","timestamp":1790909676119,"version":"4.1.0"},"reference-count":81,"publisher":"Korean Society of Animal Science and Technology","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"name":"USM-Probionic","award":["304\/PTEKIND\/6501096"],"award-info":[{"award-number":["304\/PTEKIND\/6501096"]}]},{"name":"USM-Industry","award":["1001\/PTEKIND\/8070037"],"award-info":[{"award-number":["1001\/PTEKIND\/8070037"]}]}],"content-domain":{"domain":["www.ejast.org"],"crossmark-restriction":true},"short-container-title":["J Anim Sci Technol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Constipation, which refers to difficulties in defecation and infrequent bowel\n                    movement in emptying the gastrointestinal system that ultimately produces\n                    hardened fecal matters, is a health concern in livestock and aging animals. The\n                    present study aimed to evaluate the potential effects of dairy-isolated lactic\n                    acid bacteria (LAB) strains to alleviate constipation as an alternative\n                    therapeutic intervention for constipation treatment in the aging model. Rats\n                    were aged via daily subcutaneous injection of D-galactose (600 mg\/body weight\n                    [kg]), prior to induction of constipation via oral administration of loperamide\n                    hydrochloride (5 mg\/body weight [kg]). LAB strains (L.\n                        fermentum USM 4189 or L. plantarum USM 4187) were\n                    administered daily via oral gavage (1 \u00d7 10 Log CFU\/day) while the control\n                    group received sterile saline. Aged rats as shown with shorter telomere lengths\n                    exhibited increased fecal bulk and soften fecal upon administration of LAB\n                    strains amid constipation as observed using the Bristol Stool Chart, accompanied\n                    by a higher fecal moisture content as compared to the control\n                        (p &lt; 0.05). Fecal water-soluble metabolite profiles\n                    showed a reduced concentration of threonine upon administration of LAB strains\n                    compared to the control (p &lt; 0.05). Histopathological\n                    analysis also showed that the administration of LAB strains contributed to a\n                    higher colonic goblet cell count as compared to the control (p\n                    &lt; 0.05). The present study illustrates the potential of dairy-sourced LAB\n                    strains as probiotics to ameliorate the adverse effect of constipation amid\n                    aging, and as a potential dietary intervention strategy for dairy foods\n                    including yogurt and cheese.<\/jats:p>","DOI":"10.5187\/jast.2023.e93","type":"journal-article","created":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T20:38:02Z","timestamp":1694551082000},"page":"178-203","update-policy":"https:\/\/doi.org\/10.5187\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Constipation anti-aging effects by dairy-based lactic acid\n                    bacteria"],"prefix":"10.5187","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8219-0677","authenticated-orcid":false,"given":"Mohamad 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Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6377-3305","authenticated-orcid":false,"given":"Svetoslav Dimitrov","family":"Todorov","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/036rp1748","id-type":"ROR","asserted-by":"publisher"}],"name":"ProBacLab, Department of Food Science and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo 05508-090, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8795-9075","authenticated-orcid":false,"given":"Yong-Ha","family":"Park","sequence":"additional","affiliation":[{"name":"Probionic Corp., Iksan 54576, 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