{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:55:13Z","timestamp":1790909713469,"version":"4.1.0"},"reference-count":42,"publisher":"Korean Society of Animal Science and Technology","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"name":"National Research Foundation of Korea","award":["2022R1C1C1009606"],"award-info":[{"award-number":["2022R1C1C1009606"]}],"id":[{"id":"https:\/\/ror.org\/013aysd81","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Research Foundation of Korea","award":["2022R1I1A1A01071265"],"award-info":[{"award-number":["2022R1I1A1A01071265"]}],"id":[{"id":"https:\/\/ror.org\/013aysd81","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.ejast.org"],"crossmark-restriction":true},"short-container-title":["J Anim Sci Technol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Porcine epidemic diarrhea virus (PEDV) is a highly pathogenic virus that causes\n                    severe gastrointestinal disease in neonatal piglets, often leading to high\n                    mortality. To better understand PEDV pathogenesis, we developed porcine\n                    intestinal apical-out organoids derived from the duodenum, jejunum, and ileum\n                    that support viral replication and enable long-term experimental manipulation.\n                    In this study, we investigated the region-specific responses of these organoids\n                    to PEDV infection, focusing on regional characteristics, gene expression, and\n                    susceptibility to infection. PEDV replicated efficiently in the apical-out\n                    organoids, with significantly higher viral loads in jejunal and ileal organoids\n                    than duodenal organoids, indicating region-specific susceptibility. Bulk RNA\n                    sequencing and a differential gene expression analysis revealed unique\n                    transcriptomic responses across regions. The jejunal and ileal organoids\n                    exhibited stronger activation of pathways related to cellular processes, immune\n                    regulation, and antiviral defense than the duodenal organoids. Notably, viral\n                    entry receptor genes such as ANPEP, ACE2, and\n                        DPP4 were expressed at higher levels in jejunal and ileal\n                    organoids under uninfected conditions, suggesting an innate predisposition for\n                    viral entry in these regions. Further analysis identified key upregulated genes\n                    involved in immune modulation, inflammation regulation, and tissue integrity,\n                    such as SLIT2, MMD2, and\n                        PKHD1, along with downregulated genes, including\n                        IL-1A, MMP13, and GNA15,\n                    that help control inflammation and minimize tissue damage. In conclusion, PEDV\n                    infection in porcine intestinal organoids elicits region-specific responses,\n                    with increased susceptibility and antiviral activation in jejunal and ileal\n                    organoids driven by the differential expression of viral entry receptors and\n                    immune-regulatory genes.<\/jats:p>","DOI":"10.5187\/jast.2024.e114","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:30:53Z","timestamp":1732062653000},"page":"258-272","update-policy":"https:\/\/doi.org\/10.5187\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Transcriptomic profiling of porcine duodenal, jejunal, and ileal\n                    organoids in response to porcine epidemic diarrhea virus"],"prefix":"10.5187","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7271-6708","authenticated-orcid":false,"given":"Jiyoung","family":"Heo","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04h9pn542","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8995-1944","authenticated-orcid":false,"given":"Jae Han","family":"Park","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04h9pn542","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8210-2823","authenticated-orcid":false,"given":"Hyun Sung","family":"Park","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04h9pn542","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7002-2992","authenticated-orcid":false,"given":"Dong-Hoon","family":"Chae","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04h9pn542","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0731-7422","authenticated-orcid":false,"given":"Aaron","family":"Yu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04h9pn542","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2235-942X","authenticated-orcid":false,"given":"Keonwoo","family":"Cho","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04h9pn542","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6727-4036","authenticated-orcid":false,"given":"Dong Ha","family":"Bhang","sequence":"additional","affiliation":[{"name":"Attislab Inc., Anyang 14059, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8121-3291","authenticated-orcid":false,"given":"Yoo Yong","family":"Kim","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04h9pn542","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7678-0027","authenticated-orcid":false,"given":"Mi-Kyung","family":"Oh","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04h9pn542","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4685-3223","authenticated-orcid":false,"given":"Kyung-Rok","family":"Yu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04h9pn542","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3132","published-online":{"date-parts":[[2026,1,31]]},"reference":[{"key":"key2.0261002113643e+13_B1","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1002\/9781119350927.ch31","article-title":"Coronaviruses","author":"Saif","year":"2019","journal-title":"Diseases of swine"},{"key":"key2.0261002113643e+13_B2","doi-asserted-by":"crossref","first-page":"198045","DOI":"10.1016\/j.virusres.2020.198045","article-title":"Porcine epidemic diarrhea virus (PEDV): an update on etiology,\n                        transmission, pathogenesis, and prevention and control","volume":"286","author":"Jung","year":"2020","journal-title":"Virus Res."},{"key":"key2.0261002113643e+13_B3","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s11262-012-0713-1","article-title":"Porcine epidemic diarrhoea virus: a comprehensive review of\n                        molecular epidemiology, diagnosis, and vaccines","volume":"44","author":"Song","year":"2012","journal-title":"Virus Genes"},{"key":"key2.0261002113643e+13_B4","doi-asserted-by":"crossref","first-page":"865336","DOI":"10.3389\/fmicb.2022.865336","article-title":"Long-term expansion of porcine intestinal organoids serves as an\n                        in vitro model for swine enteric Coronavirus infection","volume":"13","author":"Zhang","year":"2022","journal-title":"Front Microbiol"},{"key":"key2.0261002113643e+13_B5","doi-asserted-by":"crossref","first-page":"392","DOI":"10.2174\/0929866529666220316145149","article-title":"Porcine epidemic diarrhea: causative agent, epidemiology,\n                        clinical characteristics, and treatment strategy targeting main\n                        protease","volume":"29","author":"Shamsi","year":"2022","journal-title":"Protein Pept Lett."},{"key":"key2.0261002113643e+13_B6","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.chom.2020.02.003","article-title":"Using diverse model systems to define intestinal epithelial\n                        defenses to enteric viral infections","volume":"27","author":"Segrist","year":"2020","journal-title":"Cell Host Microbe"},{"key":"key2.0261002113643e+13_B7","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.tvjl.2015.02.017","article-title":"Porcine epidemic diarrhea virus infection: etiology,\n                        epidemiology, pathogenesis and immunoprophylaxis","volume":"204","author":"Jung","year":"2015","journal-title":"Vet J."},{"key":"key2.0261002113643e+13_B8","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.vetmic.2019.04.014","article-title":"Susceptibility of porcine IPI-2I intestinal epithelial cells to\n                        infection with swine enteric coronaviruses","volume":"233","author":"Wang","year":"2019","journal-title":"Vet Microbiol."},{"key":"key2.0261002113643e+13_B9","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.vetmic.2018.05.019","article-title":"Susceptibility of porcine IPEC-J2 intestinal epithelial cells to\n                        infection with porcine deltacoronavirus (PDCoV) and serum cytokine responses\n                        of gnotobiotic pigs to acute infection with IPEC-J2 cell culture-passaged\n                        PDCoV","volume":"221","author":"Jung","year":"2018","journal-title":"Vet Microbiol."},{"key":"key2.0261002113643e+13_B10","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3389\/fvets.2019.00034","article-title":"PEDV and PDCoV pathogenesis: the interplay between host innate\n                        immune responses and porcine enteric Coronaviruses","volume":"6","author":"Koonpaew","year":"2019","journal-title":"Front Vet Sci."},{"key":"key2.0261002113643e+13_B11","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.3390\/v14051110","article-title":"Porcine intestinal organoids: overview of the state of the\n                        art","volume":"14","author":"Ma","year":"2022","journal-title":"Viruses"},{"key":"key2.0261002113643e+13_B12","doi-asserted-by":"crossref","first-page":"15671","DOI":"10.3390\/ijms242115671","article-title":"A strainer-based platform for the collection and immunolabeling\n                        of porcine epidemic diarrhea virus-infected porcine intestinal\n                        organoid","volume":"24","author":"Liu","year":"2023","journal-title":"Int J Mol Sci."},{"key":"key2.0261002113643e+13_B13","doi-asserted-by":"crossref","first-page":"01682","DOI":"10.1128\/JVI.01682-18","article-title":"Porcine intestinal enteroids: a new model for studying enteric\n                        Coronavirus porcine epidemic diarrhea virus infection and the host innate\n                        response","volume":"93","author":"Li","year":"2019","journal-title":"J Virol."},{"key":"key2.0261002113643e+13_B14","doi-asserted-by":"crossref","first-page":"3811","DOI":"10.1038\/s41467-018-06056-w","article-title":"An alternative pathway of enteric PEDV dissemination from nasal\n                        cavity to intestinal mucosa in swine","volume":"9","author":"Li","year":"2018","journal-title":"Nat Commun."},{"key":"key2.0261002113643e+13_B15","doi-asserted-by":"crossref","first-page":"00480","DOI":"10.1128\/JVI.00480-20","article-title":"Aminopeptidase N expression, not interferon responses, determines\n                        the intestinal segmental tropism of porcine Deltacoronavirus","volume":"94","author":"Yin","year":"2020","journal-title":"J Virol."},{"key":"key2.0261002113643e+13_B16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0088515","article-title":"Extensive expression differences along porcine small intestine\n                        evidenced by transcriptome sequencing","volume":"9","author":"Mach","year":"2014","journal-title":"PLoS ONE."},{"key":"key2.0261002113643e+13_B17","doi-asserted-by":"crossref","DOI":"10.4142\/jvs.23017","article-title":"Evaluation of porcine intestinal organoids as an in vitro model\n                        for mammalian orthoreovirus 3 infection","volume":"24","author":"Lee","year":"2023","journal-title":"J Vet Sci."},{"key":"key2.0261002113643e+13_B18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/JVI.01006-20","article-title":"Next-generation porcine intestinal organoids: an apical-out\n                        organoid model for swine enteric virus infection and immune response\n                        investigations","volume":"94","author":"Li","year":"2020","journal-title":"J Virol."},{"key":"key2.0261002113643e+13_B19","doi-asserted-by":"crossref","first-page":"1451154","DOI":"10.3389\/fimmu.2024.1451154","article-title":"Development and characterization of segment-specific enteroids\n                        from the pig small intestine in Matrigel and transwell inserts: insights\n                        into susceptibility to porcine epidemic diarrhea virus","volume":"15","author":"Yen","year":"2024","journal-title":"Front Immunol."},{"key":"key2.0261002113643e+13_B20","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.rvsc.2006.03.007","article-title":"Oral efficacy of vero cell attenuated porcine epidemic diarrhea\n                        virus DR13 strain","volume":"82","author":"Song","year":"2007","journal-title":"Res Vet Sci."},{"key":"key2.0261002113643e+13_B21","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3390\/biomedicines9020209","article-title":"Extracellular vesicles from thapsigargin-treated mesenchymal stem\n                        cells ameliorated experimental colitis via enhanced immunomodulatory\n                        properties","volume":"9","author":"Joo","year":"2021","journal-title":"Biomedicines"},{"key":"key2.0261002113643e+13_B22","doi-asserted-by":"crossref","first-page":"3082","DOI":"10.1038\/s41596-019-0213-z","article-title":"Generation of blood vessel organoids from human pluripotent stem\n                        cells","volume":"14","author":"Wimmer","year":"2019","journal-title":"Nat Protoc."},{"key":"key2.0261002113643e+13_B23","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s13287-024-03731-2","article-title":"Cigarette smoke impairs the hematopoietic supportive property of\n                        mesenchymal stem cells via the production of reactive oxygen species and\n                        NLRP3 activation","volume":"15","author":"Park","year":"2024","journal-title":"Stem Cell Res Ther."},{"key":"key2.0261002113643e+13_B24","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/pro.4218","article-title":"PANTHER: making genome-scale phylogenetics accessible to\n                        all","volume":"31","author":"Thomas","year":"2021","journal-title":"Protein Sci."},{"key":"key2.0261002113643e+13_B25","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1093\/bioinformatics\/btz931","article-title":"ShinyGO: a graphical gene-set enrichment tool for animals and\n                        plants","volume":"36","author":"Ge","year":"2019","journal-title":"Bioinformatics"},{"key":"key2.0261002113643e+13_B26","doi-asserted-by":"crossref","first-page":"D545","DOI":"10.1093\/nar\/gkaa970","article-title":"KEGG: integrating viruses and cellular organisms","volume":"49","author":"Kanehisa","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"key2.0261002113643e+13_B27","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1186\/1471-2164-9-488","article-title":"BioVenn \u2013 a web application for the comparison and\n                        visualization of biological lists using area-proportional Venn\n                        diagrams","volume":"9","author":"Hulsen","year":"2008","journal-title":"BMC Genomics"},{"issue":"8","key":"key2.0261002113643e+13_B28","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1007\/s00705-022-05461-3","article-title":"Study of the effect of intestinal immunity in neonatal piglets\n                        coinfected with porcine Deltacoronavirus and porcine epidemic diarrhea\n                        virus","volume":"167","author":"Liang","year":"2022","journal-title":"Arch Virol."},{"key":"key2.0261002113643e+13_B29","doi-asserted-by":"crossref","first-page":"1273589","DOI":"10.3389\/fmicb.2023.1273589","article-title":"Isolation, identification, and pathogenicity of porcine epidemic\n                        diarrhea virus","volume":"14","author":"Sun","year":"2023","journal-title":"Front Microbiol"},{"key":"key2.0261002113643e+13_B30","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3390\/v12040402","article-title":"Role of porcine aminopeptidase N and sialic acids in porcine\n                        Coronavirus infections in primary porcine enterocytes","volume":"12","author":"Cui","year":"2020","journal-title":"Viruses"},{"key":"key2.0261002113643e+13_B31","doi-asserted-by":"crossref","first-page":"13186","DOI":"10.1038\/s41598-019-49838-y","article-title":"Aminopeptidase N-null neonatal piglets are protected from\n                        transmissible gastroenteritis virus but not porcine epidemic diarrhea\n                        virus","volume":"9","author":"Luo","year":"2019","journal-title":"Sci Rep."},{"key":"key2.0261002113643e+13_B32","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1007\/s12250-019-00127-y","article-title":"Aminopeptidase N knockout pigs are not resistant to porcine\n                        epidemic diarrhea virus infection","volume":"34","author":"Zhang","year":"2019","journal-title":"Virol Sin."},{"key":"key2.0261002113643e+13_B33","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13567-023-01169-7","article-title":"Changes in intestinal morphology, number of mucus-producing cells\n                        and expression of coronavirus receptors APN, DPP4, ACE2 and TMPRSS2 in pigs\n                        with aging","volume":"54","author":"Saleem","year":"2023","journal-title":"Vet Res."},{"key":"key2.0261002113643e+13_B34","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abc3582","article-title":"TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small\n                        intestinal enterocytes","volume":"5","author":"Zang","year":"2020","journal-title":"Sci Immunol."},{"key":"key2.0261002113643e+13_B35","doi-asserted-by":"crossref","first-page":"15987","DOI":"10.1074\/jbc.RA119.009773","article-title":"Iterative, multiplexed CRISPR-mediated gene editing for\n                        functional analysis of complex protease gene clusters","volume":"294","author":"Callies","year":"2019","journal-title":"J Biol Chem."},{"key":"key2.0261002113643e+13_B36","doi-asserted-by":"crossref","first-page":"385","DOI":"10.4049\/jimmunol.1302021","article-title":"Slit2\u2013Robo4 pathway modulates lipopolysaccharide-induced\n                        endothelial inflammation and its expression is dysregulated during\n                        endotoxemia","volume":"192","author":"Zhao","year":"2014","journal-title":"J Immunol."},{"key":"key2.0261002113643e+13_B37","doi-asserted-by":"crossref","first-page":"19443","DOI":"10.1038\/s41598-022-24190-w","article-title":"Co-infection of porcine Deltacoronavirus and porcine epidemic\n                        diarrhea virus induces early TRAF6-mediated NF-\u03baB and IRF7 signaling\n                        pathways through TLRs","volume":"12","author":"Saeng-Chuto","year":"2022","journal-title":"Sci Rep."},{"key":"key2.0261002113643e+13_B38","doi-asserted-by":"crossref","first-page":"1163198","DOI":"10.3389\/fimmu.2023.1163198","article-title":"Interleukin 36 receptor-inducible matrix metalloproteinase 13\n                        mediates intestinal fibrosis","volume":"14","author":"Koop","year":"2023","journal-title":"Front Immunol"},{"key":"key2.0261002113643e+13_B39","doi-asserted-by":"crossref","first-page":"102763","DOI":"10.1016\/j.autrev.2021.102763","article-title":"Interleukin 1\u03b1: a comprehensive review on the role of\n                        IL-1\u03b1 in the pathogenesis and treatment of autoimmune and\n                        inflammatory diseases","volume":"20","author":"Cavalli","year":"2021","journal-title":"Autoimmun Rev."},{"key":"key2.0261002113643e+13_B40","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.3389\/fimmu.2019.01266","article-title":"Divergent roles for the IL-1 family in gastrointestinal\n                        homeostasis and inflammation","volume":"10","author":"McEntee","year":"2019","journal-title":"Front Immunol"},{"key":"key2.0261002113643e+13_B41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0231723","article-title":"Immune responses to porcine epidemic diarrhea virus (PEDV) in\n                        swine and protection against subsequent infection","volume":"15","author":"Krishna","year":"2020","journal-title":"PLOS ONE."},{"key":"key2.0261002113643e+13_B42","doi-asserted-by":"crossref","first-page":"109880","DOI":"10.1016\/j.virol.2023.109880","article-title":"PEDV promotes the differentiation of CD4+T cells towards Th1,\n                        Tfh, and Treg cells via CD103+DCs","volume":"587","author":"Yu","year":"2023","journal-title":"Virology"}],"container-title":["Journal of Animal Science and Technology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.ejast.org\/download\/download_pdf?doi=10.5187\/jast.2024.e114","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.ejast.org\/download\/download_pdf?doi=10.5187\/jast.2024.e114","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:45:28Z","timestamp":1790909128000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.ejast.org\/archive\/view_article?doi=10.5187\/jast.2024.e114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,31]]},"published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.5187\/jast.2024.e114"],"URL":"https:\/\/doi.org\/10.5187\/jast.2024.e114","relation":{},"ISSN":["2672-0191","2055-0391"],"issn-type":[{"value":"2672-0191","type":"print"},{"value":"2055-0391","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2024-11-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}