{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:17:34Z","timestamp":1792790254554,"version":"4.5.0"},"reference-count":30,"publisher":"Korean Society of Animal Science and Technology","issue":"5","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"name":"Chungnam National University","award":["RS-2021-RD010125"],"award-info":[{"award-number":["RS-2021-RD010125"]}],"id":[{"id":"https:\/\/ror.org\/0227as991","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Chungnam National University","award":["PJ016205"],"award-info":[{"award-number":["PJ016205"]}],"id":[{"id":"https:\/\/ror.org\/0227as991","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.ejast.org"],"crossmark-restriction":true},"short-container-title":["J Anim Sci Technol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>Anserine is an abundant peptide in chicken meat and influences the meat flavor.\n                    The content of anserine in meat as other flavor precursors is influenced by many\n                    genes as well as environmental factors. This study aimed to identify the single\n                    nucleotide polymorphisms (SNPs) in the HNMT-like gene and\n                    assess their possible associations with the content of anserine in the red-brown\n                    Korean native chicken (KNC-R). We used three hundred and eighty-four chickens\n                    (males, n = 192; females, n = 192) aged 10 weeks old to genotype three\n                    synonymous SNPs (rs317607580C&gt;T, rs316762204A&gt;G, and rs316857074A&gt;G) in\n                        HNMT-like gene by using PACE genotyping technology. We used\n                    a two-way ANOVA of the R program to test the effects of the\n                        HNMT-like genotypes on the content of anserine in KNC-R. We\n                    found a significant association (p &lt; 0.05) between the\n                    genotypes of the synonymous SNP: rs316762204A&gt;G and the content of the\n                    anserine in KNC-R. The synonymous SNP: rs316762204A&gt;G of the\n                        HNMT-like gene might be used as a genetic marker in the\n                    selection and breeding of chickens with desired flavored meat.<\/jats:p>","DOI":"10.5187\/jast.2400225","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:59:43Z","timestamp":1787025583000},"page":"1362-1370","update-policy":"https:\/\/doi.org\/10.5187\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Histamine-N-methyltransferase-like (HNMT-like) gene\n                    polymorphisms on the anserine and carnosine content in chicken breast\n                    meat"],"prefix":"10.5187","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2521-3339","authenticated-orcid":false,"given":"Jean Pierre","family":"Munyaneza","sequence":"first","affiliation":[{"name":"Department of Animal Science and Biotechnology, Chungnam National University, Daejeon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8173-8431","authenticated-orcid":false,"given":"Minjun","family":"Kim","sequence":"additional","affiliation":[{"name":"Poultry Research Center, National Institute of Animal Science, Pyeongchang, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4800-1603","authenticated-orcid":false,"given":"Eunjin","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Animal Science and Biotechnology, Chungnam National University, Daejeon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1789-8956","authenticated-orcid":false,"given":"Aera","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Applied Animal Science, College of Animal Life Science, Kangwon National University, Chuncheon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2109-3798","authenticated-orcid":false,"given":"Cheorun","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Agricultural Biotechnology, Center for Food and Bioconvergence, and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2432-3045","authenticated-orcid":false,"given":"Ki-Chang","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Animal Science and Technology, Sunchon National University, Suncheon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7747-5077","authenticated-orcid":false,"given":"Hyo Jun","family":"Choo","sequence":"additional","affiliation":[{"name":"Poultry Research Center, National Institute of Animal Science, Pyeongchang, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3996-9209","authenticated-orcid":false,"given":"Jun Heon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Animal Science and Biotechnology, Chungnam National University, Daejeon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3132","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"key2.0261013094153e+13_B1","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.meatsci.2015.08.002","article-title":"Meat flavor precursors and factors influencing flavor\n                        precursors\u2014a systematic review","volume":"110","author":"Khan","year":"2015","journal-title":"Meat Sci."},{"key":"key2.0261013094153e+13_B2","doi-asserted-by":"crossref","first-page":"407","DOI":"10.7744\/kjoas.20220029","article-title":"Genome-wide association studies of meat quality traits in\n                        chickens: a review","volume":"49","author":"Munyaneza","year":"2022","journal-title":"Korean J Agric Sci."},{"key":"key2.0261013094153e+13_B3","doi-asserted-by":"crossref","first-page":"732","DOI":"10.5713\/ajas.2012.12619","article-title":"Flavour chemistry of chicken meat: a review","volume":"26","author":"Jayasena","year":"2013","journal-title":"Asian-Australas J Anim Sci."},{"key":"key2.0261013094153e+13_B4","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1186\/s12864-017-4275-4","article-title":"Effect of two non-synonymous ecto-5\u2032-nucleotidase variants\n                        on the genetic architecture of inosine 5\u2032-monophosphate (IMP) and its\n                        degradation products in Japanese Black beef","volume":"18","author":"Uemoto","year":"2017","journal-title":"BMC Genomics"},{"key":"key2.0261013094153e+13_B5","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.3382\/ps.2014-04241","article-title":"Comparison of the amounts of taste-related compounds in raw and\n                        cooked meats from broilers and Korean native chickens","volume":"93","author":"Jayasena","year":"2014","journal-title":"Poult Sci."},{"key":"key2.0261013094153e+13_B6","doi-asserted-by":"crossref","first-page":"237","DOI":"10.5851\/kosfa.2020.e94","article-title":"Taste-active and nutritional components of Thai native chicken\n                        meat: a perspective of consumer satisfaction","volume":"41","author":"Lengkidworraphiphat","year":"2021","journal-title":"Food Sci Anim Resour."},{"key":"key2.0261013094153e+13_B7","doi-asserted-by":"crossref","first-page":"3275","DOI":"10.3382\/ps.2013-03441","article-title":"Carnosine, anserine, creatine, and inosine\n                        5\u2032-monophosphate contents in breast and thigh meats from 5 lines of\n                        Korean native chicken","volume":"92","author":"Jung","year":"2013","journal-title":"Poult Sci."},{"key":"key2.0261013094153e+13_B8","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s00217-015-2449-3","article-title":"Influence of specific taste-active components on meat flavor as\n                        affected by intrinsic and extrinsic factors: an overview","volume":"241","author":"Dashdorj","year":"2015","journal-title":"Eur Food Res Technol."},{"key":"key2.0261013094153e+13_B9","doi-asserted-by":"crossref","first-page":"4849","DOI":"10.1113\/JP272050","article-title":"Carnosine and anserine homeostasis in skeletal muscle and heart\n                        is controlled by \u03b2-alanine transamination","volume":"594","author":"Blancquaert","year":"2016","journal-title":"J Physiol."},{"key":"key2.0261013094153e+13_B10","doi-asserted-by":"crossref","first-page":"103590","DOI":"10.1016\/j.psj.2024.103590","article-title":"Genome-wide association studies of anserine and carnosine\n                        contents in the breast meat of Korean native chickens","volume":"103","author":"Kim","year":"2024","journal-title":"Poult Sci."},{"key":"key2.0261013094153e+13_B11","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3184\/175815510X12742871317581","article-title":"Analysis of the genetic effects of three single nucleotide\n                        polymorphisms on inosine monophosphate content in Chinese Baier\n                        chicken","volume":"3","author":"Shu","year":"2010","journal-title":"Avian Biol Res."},{"key":"key2.0261013094153e+13_B12","article-title":"Specific expression pattern of IMP metabolism related-genes in\n                        chicken muscle between cage and free range conditions","volume":"13","author":"Zhang","year":"2018","journal-title":"PLOS ONE"},{"key":"key2.0261013094153e+13_B13","doi-asserted-by":"crossref","first-page":"2966","DOI":"10.3390\/ani13182966","article-title":"Genome-wide association study on the content of\n                        nucleotide-related compounds in Korean native chicken breast\n                        meat","volume":"13","author":"Kim","year":"2023","journal-title":"Animals"},{"key":"key2.0261013094153e+13_B14","doi-asserted-by":"crossref","first-page":"8159","DOI":"10.3390\/ijms22158159","article-title":"Fatty acid synthesis in glial cells of the CNS","volume":"22","author":"Garcia Corrales","year":"2021","journal-title":"Int J Mol Sci."},{"key":"key2.0261013094153e+13_B15","doi-asserted-by":"crossref","first-page":"57","DOI":"10.5187\/jast.2022.e96","article-title":"Genome-wide association study for the free amino acid and\n                        nucleotide components of breast meat in an F2 crossbred chicken\n                        population","volume":"65","author":"Kim","year":"2023","journal-title":"J Anim Sci Technol."},{"key":"key2.0261013094153e+13_B16","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.5713\/ab.23.0552","article-title":"Association of histamine-N-methyl transferase gene polymorphisms\n                        with carnosine content in red-brown Korean native chickens","volume":"37","author":"Munyaneza","year":"2024","journal-title":"Anim Biosci."},{"key":"key2.0261013094153e+13_B17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0064805","article-title":"Molecular identification of carnosine N-methyltransferase as\n                        chicken histamine N-methyltransferase-like protein\n                        (HNMT-like)","volume":"8","author":"Drozak","year":"2013","journal-title":"PLOS ONE"},{"key":"key2.0261013094153e+13_B18","doi-asserted-by":"crossref","first-page":"128316","DOI":"10.1016\/j.foodchem.2020.128316","article-title":"Potential of 2D qNMR spectroscopy for distinguishing chicken\n                        breeds based on the metabolic differences","volume":"342","author":"Kim","year":"2021","journal-title":"Food Chem."},{"key":"key2.0261013094153e+13_B19","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780195135848.001.0001","volume-title":"Molecular 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Resour."},{"key":"key2.0261013094153e+13_B25","article-title":"Anserine is expressed in human cardiac and skeletal\n                        muscles","volume":"11","author":"de Souza Gon\u00e7alves","year":"2023","journal-title":"Physiol Rep."},{"key":"key2.0261013094153e+13_B26","doi-asserted-by":"crossref","first-page":"771","DOI":"10.2174\/1389203719666180226155657","article-title":"Biosynthesis of carnosine and related dipeptides in\n                        vertebrates","volume":"19","author":"Kwiatkowski","year":"2018","journal-title":"Curr Protein Pept Sci."},{"key":"key2.0261013094153e+13_B27","doi-asserted-by":"crossref","first-page":"35","DOI":"10.21839\/jfna.2018.v1i1.216","article-title":"The effect of rearing system and cooking method on the carnosine\n                        and anserine content of poultry and game meat","volume":"1","author":"Juniper","year":"2018","journal-title":"J Food Nutr Agric."},{"key":"key2.0261013094153e+13_B28","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1080\/09712119.2015.1124328","article-title":"Exploring the genetic variants of insulin-like growth factor II\n                        gene and their associations with two production traits in Langshan\n                        chicken","volume":"45","author":"Yan","year":"2017","journal-title":"J Appl Anim Res."},{"key":"key2.0261013094153e+13_B29","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1136\/jmedgenet-2016-104072","article-title":"Single synonymous mutation in factor IX alters protein properties\n                        and underlies haemophilia B","volume":"54","author":"Simhadri","year":"2017","journal-title":"J Med Genet."},{"key":"key2.0261013094153e+13_B30","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.bej.2009.12.021","article-title":"From SNPs to functional polymorphism: the insight into\n                        biotechnology applications","volume":"49","author":"Liao","year":"2010","journal-title":"Biochem Eng J."}],"container-title":["Journal of Animal Science and Technology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.ejast.org\/download\/download_pdf?doi=10.5187\/jast.2400225","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.ejast.org\/download\/download_pdf?doi=10.5187\/jast.2400225","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:42:28Z","timestamp":1791877348000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.ejast.org\/archive\/view_article?doi=10.5187\/jast.2400225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":30,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,9,30]]},"published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.5187\/jast.2400225"],"URL":"https:\/\/doi.org\/10.5187\/jast.2400225","relation":{},"ISSN":["2672-0191","2055-0391"],"issn-type":[{"value":"2672-0191","type":"print"},{"value":"2055-0391","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2024-07-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}