{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:15:30Z","timestamp":1792790130847,"version":"4.5.0"},"reference-count":47,"publisher":"Korean Society of Animal Science and Technology","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"name":"Ministry of SMEs and Startups","award":["S3366906"],"award-info":[{"award-number":["S3366906"]}],"id":[{"id":"https:\/\/ror.org\/022c4zk48","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.ejast.org"],"crossmark-restriction":true},"short-container-title":["J Anim Sci Technol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:p>To prevent degenerative joint diseases in dogs, the development of fermented whey\n                    peptides that enhance calcium absorption is essential. This study examined the\n                    physiological traits of lactic acid bacteria (LAB) derived from canine feces.\n                    The functional characteristics of whey peptides produced through fermentation\n                    with these bacterial strains were also investigated. To assess this, three\n                        strains\u2014Lactobacillus acidophilus D5, D6, and\n                        Lactiplantibacillus plantarum D7\u2014were chosen, and\n                    their respective whey protein hydrolysis levels were evaluated after\n                    fermentation. Among these strains, L. plantarum D7 exhibited\n                    the highest hydrolysis rate. Antioxidant and anti-inflammatory activities, along\n                    with calcium solubility, were evaluated. Fraction 2 displayed significant\n                    antioxidant activity and effectively inhibited pro-inflammatory cytokines.\n                    Additionally, 17 amino acids, including leucine, were identified. These findings\n                    suggest that L. plantarum D7 has the potential to be used as a\n                    functional food ingredient to promote canine health.<\/jats:p>","DOI":"10.5187\/jast.2500035","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T09:00:31Z","timestamp":1755507631000},"page":"1189-1212","update-policy":"https:\/\/doi.org\/10.5187\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Functional properties of specific peptides derived from whey protein\n                    fermented with lactic acid bacteria isolated from dog feces"],"prefix":"10.5187","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9845-8903","authenticated-orcid":false,"given":"Haneul","family":"Kim","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/058pdbn81","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Animal Resource and Science, Dankook University, Cheonan, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0382-533X","authenticated-orcid":false,"given":"Jiwon","family":"Lee","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/058pdbn81","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Animal Resource and Science, Dankook University, Cheonan, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6877-5983","authenticated-orcid":false,"given":"Sangjae","family":"Lee","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/058pdbn81","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Animal Resource and Science, Dankook University, Cheonan, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6992-1815","authenticated-orcid":false,"given":"Jeongnam","family":"Kim","sequence":"additional","affiliation":[{"name":"Youdam Co., Ltd., Chungnam, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6546-3976","authenticated-orcid":false,"given":"Hongseog","family":"Kim","sequence":"additional","affiliation":[{"name":"Youdam Co., Ltd., Chungnam, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1905-9948","authenticated-orcid":false,"given":"Cheolhyun","family":"Kim","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/058pdbn81","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Animal Resource and Science, Dankook University, Cheonan, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3132","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"key2.0261002113951e+13_B1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.5187\/jast.2022.e8","article-title":"Perspectives and advances in probiotics and the gut microbiome in\n                     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Sci."},{"key":"key2.0261002113951e+13_B8","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3746\/pnf.2020.25.1.71","article-title":"Effects of the whey protein hydrolysates of various protein\n                        enzymes on the proliferation and differentiation of 3T3-E1\n                        osteoblasts","volume":"25","author":"Jo","year":"2020","journal-title":"Prev Nutr Food Sci."},{"key":"key2.0261002113951e+13_B9","first-page":"103","article-title":"Production of bioactive peptides in milk using two native strains\n                        of Levilactobacillus brevis","volume":"10","author":"Yousefi","year":"2023","journal-title":"Appl Food Biotechnol."},{"key":"key2.0261002113951e+13_B10","doi-asserted-by":"crossref","first-page":"SII82","DOI":"10.17221\/666-CJFS","article-title":"Problems with detection of proteolytic microorganisms and their\n                        undesirable activities in 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                 agar","volume":"33","author":"Pailin","year":"2001","journal-title":"Lett Appl Microbiol."},{"key":"key2.0261002113951e+13_B29","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/10408699991279187","article-title":"Probiotic spectra of lactic acid bacteria (LAB)","volume":"39","author":"Naidu","year":"1999","journal-title":"Crit Rev Food Sci Nutr."},{"key":"key2.0261002113951e+13_B30","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1021\/ct900530f","article-title":"QM\/MM studies on the \u03b2-galactosidase catalytic mechanism:\n                        hydrolysis and transglycosylation reactions","volume":"6","author":"Bras","year":"2010","journal-title":"J Chem Theory Comput."},{"key":"key2.0261002113951e+13_B31","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.foodchem.2008.10.081","article-title":"Chemical properties and antioxidant activity of\n                        exopolysaccharides from mycelial culture of Cordyceps sinensis fungus\n                        Cs-HK1","volume":"114","author":"Leung","year":"2009","journal-title":"Food Chem."},{"key":"key2.0261002113951e+13_B32","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1023\/A:1005577330695","article-title":"Antioxidative effect of intestinal bacteria Bifidobacterium\n                        longum ATCC 15708 and Lactobacillus acidophilus ATCC 4356","volume":"45","author":"Lin","year":"2000","journal-title":"Dig Dis Sci."},{"key":"key2.0261002113951e+13_B33","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1046\/j.0022-202X.2004.22203.x","article-title":"Imiquimod-induced interleukin-1\u03b1 stimulation improves\n                        barrier homeostasis in aged murine epidermis","volume":"122","author":"Barland","year":"2004","journal-title":"J Invest Dermatol."},{"key":"key2.0261002113951e+13_B34","doi-asserted-by":"crossref","first-page":"1404580","DOI":"10.3389\/fvets.2024.1404580","article-title":"Multi-functional properties of lactic acid bacteria strains\n                        derived from canine feces","volume":"11","author":"Liu","year":"2024","journal-title":"Front Vet Sci."},{"key":"key2.0261002113951e+13_B35","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1093\/jas\/skad281.551","article-title":"PSVIII-22 a probiotic blend improves fecal quality and enhances\n                        gut immunity in dogs with chronic diarrhea","volume":"101","author":"Lin","year":"2023","journal-title":"J Anim Sci."},{"key":"key2.0261002113951e+13_B36","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1007\/s12602-017-9256-z","article-title":"Probiotic potential of a Lactobacillus bacterium of canine\n                        faecal-origin and its impact on select gut health indices and immune\n                        response of dogs","volume":"9","author":"Kumar","year":"2017","journal-title":"Probiotics Antimicrob Proteins."},{"key":"key2.0261002113951e+13_B37","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1080\/10408398.2022.2111546","article-title":"A comprehensive review on preparation, structure-activities\n                        relationship, and calcium bioavailability of casein\n                        phosphopeptides","volume":"64","author":"Liu","year":"2022","journal-title":"Crit Rev Food Sci Nutr."},{"key":"key2.0261002113951e+13_B38","first-page":"437","article-title":"Effects of probiotic fermentation of selected milk and whey\n                        protein preparations on bioactive and technological\n                        properties","volume":"31","author":"Skrzypczak","year":"2019","journal-title":"Ital J Food Sci."},{"key":"key2.0261002113951e+13_B39","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s40104-021-00669-w","article-title":"Dietary branched-chain amino acids modulate the dynamics of\n                        calcium absorption and reabsorption in protein-restricted\n                        pigs","volume":"13","author":"Habibi","year":"2022","journal-title":"J Anim Sci Biotechnol."},{"key":"key2.0261002113951e+13_B40","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1021\/acs.jafc.6b05711","article-title":"Bioactive peptides isolated from casein phosphopeptides enhance\n                        calcium and magnesium uptake in Caco-2 cell monolayers","volume":"65","author":"Cao","year":"2017","journal-title":"J Agric Food Chem."},{"key":"key2.0261002113951e+13_B41","doi-asserted-by":"crossref","first-page":"743791","DOI":"10.3389\/fnut.2021.743791","article-title":"Promoting the calcium-uptake bioactivity of casein\n                        phosphopeptides in vitro and in vivo","volume":"8","author":"Liu","year":"2021","journal-title":"Front Nutr."},{"key":"key2.0261002113951e+13_B42","doi-asserted-by":"crossref","first-page":"11281","DOI":"10.3390\/ijms231911281","article-title":"Role of essential amino acids in age-induced bone\n                        loss","volume":"23","author":"Lv","year":"2022","journal-title":"Int J Mol Sci."},{"key":"key2.0261002113951e+13_B43","doi-asserted-by":"crossref","first-page":"7089","DOI":"10.3390\/app10207089","article-title":"Functional and technological potential of whey protein isolate in\n                        production of milk beverages fermented by new strains of Lactobacillus\n                        helveticus","volume":"10","author":"Skrzypczak","year":"2020","journal-title":"Appl Sci."},{"key":"key2.0261002113951e+13_B44","doi-asserted-by":"crossref","first-page":"23306","DOI":"10.1021\/acs.jafc.4c07531","article-title":"Novel antioxidant peptides from fermented whey protein by\n                        Lactobacillus rhamnosus B2-1: separation and identification by in vitro and\n                        in silico approaches","volume":"72","author":"Guo","year":"2024","journal-title":"J Agric Food Chem."},{"key":"key2.0261002113951e+13_B45","first-page":"4091","article-title":"Production and characterization of antioxidative hydrolysates and\n                        peptides from corn gluten meal using papain, ficin, and\n                        bromelain","volume":"25","author":"Hu","year":"2020","journal-title":"Front Vet Sci."},{"key":"key2.0261002113951e+13_B46","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.4315\/0362-028X-69.12.2992","article-title":"Identification of antibacterial peptides from bovine\n                        \u03ba-casein","volume":"69","author":"L\u00f3pez-Exp\u00f3sito","year":"2006","journal-title":"J Food Prot."},{"key":"key2.0261002113951e+13_B47","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.3390\/ani12162037","article-title":"Effects of casein phosphopeptide-selenium complex on the immune\n                        functions in beagle dogs","volume":"12","author":"Wang","year":"2022","journal-title":"Animals."}],"container-title":["Journal of Animal Science and Technology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.ejast.org\/download\/download_pdf?doi=10.5187\/jast.2500035","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.ejast.org\/download\/download_pdf?doi=10.5187\/jast.2500035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:59:26Z","timestamp":1790909966000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.ejast.org\/archive\/view_article?doi=10.5187\/jast.2500035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":47,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,7,31]]},"published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.5187\/jast.2500035"],"URL":"https:\/\/doi.org\/10.5187\/jast.2500035","relation":{},"ISSN":["2672-0191","2055-0391"],"issn-type":[{"value":"2672-0191","type":"print"},{"value":"2055-0391","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2025-02-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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