{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:54:38Z","timestamp":1790909678166,"version":"4.1.0"},"reference-count":83,"publisher":"Korean Society of Animal Science and Technology","issue":"2","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"name":"Ministry of Agriculture, Food and Rural\n                                Affairs","award":["RS-2023-00254212"],"award-info":[{"award-number":["RS-2023-00254212"]}]},{"name":"Ministry of Education","award":["2025-RISE-17-001"],"award-info":[{"award-number":["2025-RISE-17-001"]}]}],"content-domain":{"domain":["www.ejast.org"],"crossmark-restriction":true},"short-container-title":["J Anim Sci Technol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:p>The weaning transition is a critical phase in piglet development, marked by\n                    physiological challenges that influence growth and health. Therefore, this study\n                    aims to investigate host-microbiome interactions during the weaning transition\n                    using a multi-omics integrated approach. Fecal samples were collected from\n                    piglets on the weaning day (W0), 7 days post-weaning (W7), and 14 days\n                    post-weaning (W14). Ileal microbiota, microbial-derived metabolites, and tissue\n                    samples (ileum, thymus, and mesenteric lymph nodes) were collected at W0 and\n                    W14. Fecal microbiota analysis revealed a more stable community at W14 than at\n                    W7, with increased presence of fiber-degrading bacteria, including\n                        Prevotella, Treponema,\n                        Muribaculaceae, and Lachnospiraceae. The\n                    ileal microbiota exhibited an adaptive pattern with increases in\n                        Lactobacillus, Clostridium_sensu\n                    stricto_1, and Enterobacteriaceae, optimized for solid\n                    feed digestion and gut stabilization. Morphological analysis of the ileum showed\n                    changes in villus architecture between W0 and W14, including increased crypt\n                    depth and villus area and decreased villus width, while villus height and goblet\n                    cell counts were numerically higher at W14. Transcriptomic profiling revealed\n                    the ileum as the primary site of molecular adaptation, with 506 differentially\n                    expressed genes (DEGs) involved in immune response pathways, including viral\n                    protein interactions with cytokine and cytokine receptor pathways and T cell\n                    receptor signaling. The thymus (158 DEGs) and mesenteric lymph nodes (30 DEGs)\n                    exhibited modulation of structural pathways linked to systemic immune\n                    development, indicating tissue-specific molecular adaptation. Integrated\n                    analysis of the host transcriptome and microbial-derived metabolites revealed\n                    upregulated glycerophospholipid and glutathione metabolic pathways in piglets 14\n                    days post-weaning, consistent with modulation of membrane structure, barrier\n                    function, and antioxidant defense during gut adaptation. Overall, the\n                    multi-omics findings provide a comprehensive description of molecular changes\n                    associated with weaning adaptation and identify candidate targets for piglet\n                    health management during the weaning transition.<\/jats:p>","DOI":"10.5187\/jast.2500436","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T10:27:00Z","timestamp":1772188020000},"page":"603-628","update-policy":"https:\/\/doi.org\/10.5187\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multi-omics integrated approach reveals host-microbiome interactions\n                    in the adaptive mechanisms of weaning piglets"],"prefix":"10.5187","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0775-7191","authenticated-orcid":false,"given":"Ji-Yeong","family":"Lee","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01r024a98","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Animal Science and Technology, Chung-Ang University, Anseong 17546, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6272-4464","authenticated-orcid":false,"given":"Chiwoong","family":"Lim","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01r024a98","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Animal Science and Technology, Chung-Ang University, Anseong 17546, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7520-7733","authenticated-orcid":false,"given":"Young-Jun","family":"Seo","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01r024a98","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Animal Science and Technology, Chung-Ang University, Anseong 17546, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5742-5374","authenticated-orcid":false,"given":"Hyunjin","family":"Kyoung","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0227as991","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Animal and Dairy Science, Chungnam National University, Daejeon 34134, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7643-337X","authenticated-orcid":false,"given":"Sanghoon","family":"Lee","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05hnb4n85","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Animal Biotechnology, College of Applied Life Science, Jeju National University, Jeju 63243, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6769-0657","authenticated-orcid":false,"given":"Younghoon","family":"Kim","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04h9pn542","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Agricultural Biotechnology, Research Institute of Agriculture and Life Science, Seoul National University, Seoul 08826, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3649-4570","authenticated-orcid":false,"given":"Minhye","family":"Shin","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01easw929","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Microbiology, College of Medicine, Inha University, Incheon 22212, Korea"},{"id":[{"id":"https:\/\/ror.org\/01easw929","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biomedical Science, Program in Biomedical Science and Engineering, Inha University, Incheon 22212, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4515-5212","authenticated-orcid":false,"given":"Minho","family":"Song","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0227as991","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Animal and Dairy Science, Chungnam National University, Daejeon 34134, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8940-624X","authenticated-orcid":false,"given":"YounChul","family":"Ryu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05hnb4n85","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Biotechnology, Sustainable Agriculture Research Institute, Jeju National University, Jeju 63243, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6934-398X","authenticated-orcid":false,"given":"Jun-Mo","family":"Kim","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01r024a98","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Animal Science and Technology, Chung-Ang University, Anseong 17546, 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