{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:16:32Z","timestamp":1792790192487,"version":"4.5.0"},"reference-count":195,"publisher":"Korean Society of Animal Science and Technology","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"name":"National Research Foundation of Korea","award":["RS-2022-NR069268"],"award-info":[{"award-number":["RS-2022-NR069268"]}],"id":[{"id":"https:\/\/ror.org\/013aysd81","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.ejast.org"],"crossmark-restriction":true},"short-container-title":["J Anim Sci Technol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:p>Livestock production systems are increasingly constrained by infectious diseases\n                    and environmental stress. These factors compromise productivity, animal welfare,\n                    and sustainability under heterogeneous field conditions. Immune-related traits\n                    governing disease susceptibility, recovery, and performance loss are polygenic\n                    and influenced by diverse conditions. They arise from coordinated responses\n                    across multiple tissues and molecular layers. As a result, single-omics\n                    approaches often fail to generalize across breeds, environments, and management\n                    systems, limiting their translational value in improving livestock health.\n                    Livestock immunogenomics has emerged as a framework for addressing this\n                    complexity by linking genetic variation with regulatory, cellular, and metabolic\n                    programs that shape immune competence and resilience across diverse biological\n                    and production conditions. In recent years, substantial progress in functional\n                    genome annotation, genotype\u2013tissue regulatory atlases, and single-cell\n                    reference datasets has strengthened the foundation for systems-level analyses in\n                    major livestock species. However, effective translation requires integrative\n                    strategies aligned with field-relevant phenotypes and capable of remaining\n                    interpretable under varying production and biological conditions. In this\n                    review, we synthesized computational and experimental strategies for omics\n                    integration in livestock immunogenomics and examined their applications across\n                    three major domains: infectious diseases, environmental stress, and\n                    xenotransplantation. We highlight design principles that improve\n                    interpretability and transportability, including longitudinal sampling,\n                    phase-aware designs across stages of the response, compartment-resolved analysis\n                    across tissues, integration of regulatory layers, and explicit reduction of\n                    complex outputs into deployable signatures. Case studies in cattle, swine, and\n                    poultry illustrate how integrative frameworks distinguish protective immune\n                    programs from inflammation-associated damage, link molecular modules to\n                    resilience-related phenotypes, and support their application in precision health\n                    management and breeding strategies. Beyond production systems, we discuss\n                    xenotransplantation as an extreme but informative translational setting. In this\n                    context, livestock immunogenomics reveals how immune outcomes emerge from\n                    coordinated regulatory and metabolic programs rather than from individual\n                    antigenic mismatches. Collectively, this review emphasizes that the future\n                    impact of livestock immunogenomics lies not in increasing data dimensionality,\n                    but treating omics integration as a translational pipeline that connects\n                    systems-level immune biology to practical interventions for animal health,\n                    welfare, and sustainable production.<\/jats:p>","DOI":"10.5187\/jast.2600054","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T05:59:05Z","timestamp":1783058345000},"page":"1015-1050","update-policy":"https:\/\/doi.org\/10.5187\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Livestock immunogenomics based on omics integration: from infection\n                    and stress to xenotransplantation"],"prefix":"10.5187","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8489-0044","authenticated-orcid":false,"given":"Byeonghwi","family":"Lim","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01r024a98","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Animal Science and Technology, Chung-Ang University, Anseong, Korea"},{"id":[{"id":"https:\/\/ror.org\/04rswrd78","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Animal Science, Iowa State University, Ames, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6272-4464","authenticated-orcid":false,"given":"Chiwoong","family":"Lim","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01r024a98","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Animal Science and Technology, Chung-Ang University, Anseong, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7404-4258","authenticated-orcid":false,"given":"Min-Jae","family":"Jang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01r024a98","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Animal Science and Technology, Chung-Ang University, Anseong, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7520-7733","authenticated-orcid":false,"given":"Young-Jun","family":"Seo","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01r024a98","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Animal Science and Technology, Chung-Ang University, Anseong, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6934-398X","authenticated-orcid":false,"given":"Jun-Mo","family":"Kim","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01r024a98","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Animal Science and Technology, Chung-Ang University, Anseong, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3132","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"key2.0261002113923e+13_B1","doi-asserted-by":"crossref","first-page":"100286","DOI":"10.1016\/j.animal.2021.100286","article-title":"Review: livestock disease resilience: from individual to herd\n                        level","volume":"15","author":"Doeschl-Wilson","year":"2021","journal-title":"Animal."},{"key":"key2.0261002113923e+13_B2","doi-asserted-by":"crossref","first-page":"E316","DOI":"10.1016\/S2542-5196(17)30141-9","article-title":"Restricting the use of antibiotics in food-producing animals and\n                        its associations with antibiotic resistance in food-producing animals and\n                        human beings: a systematic review and meta-analysis","volume":"1","author":"Tang","year":"2017","journal-title":"Lancet Planet Health"},{"key":"key2.0261002113923e+13_B3","doi-asserted-by":"crossref","first-page":"6751","DOI":"10.3168\/jds.2019-17929","article-title":"Invited review: physiological and behavioral effects of heat\n                        stress in dairy cows","volume":"103","author":"Becker","year":"2020","journal-title":"J Dairy Sci."},{"key":"key2.0261002113923e+13_B4","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1017\/S1751731111002448","article-title":"Adaptation to hot climate and strategies to alleviate heat stress\n                        in livestock production","volume":"6","author":"Renaudeau","year":"2012","journal-title":"Animal."},{"key":"key2.0261002113923e+13_B5","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.5187\/jast.2500224","article-title":"Application of dietary organic acids in laying hens production: a\n                        comprehensive review","volume":"67","author":"Lee","year":"2025","journal-title":"J Anim Sci Technol."},{"key":"key2.0261002113923e+13_B6","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.livsci.2014.04.034","article-title":"Genomics and disease resistance studies in\n                        livestock","volume":"166","author":"Bishop","year":"2014","journal-title":"Livest Sci."},{"key":"key2.0261002113923e+13_B7","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s12711-020-00580-4","article-title":"Why breed disease-resilient livestock, and how?","volume":"52","author":"Knap","year":"2020","journal-title":"Genet Sel Evol."},{"key":"key2.0261002113923e+13_B8","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1146\/annurev-animal-020518-114913","article-title":"Functional annotation of animal genomes (FAANG): current\n                        achievements and roadmap","volume":"7","author":"Giuffra","year":"2019","journal-title":"Annu Rev Anim Biosci."},{"key":"key2.0261002113923e+13_B9","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1186\/s13059-020-02197-8","article-title":"From FAANG to fork: application of highly annotated genomes to\n                        improve farmed animal production","volume":"21","author":"Clark","year":"2020","journal-title":"Genome Biol."},{"key":"key2.0261002113923e+13_B10","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41576-018-0082-2","article-title":"Harnessing genomic information for livestock\n                        improvement","volume":"20","author":"Georges","year":"2019","journal-title":"Nat Rev Genet."},{"key":"key2.0261002113923e+13_B11","article-title":"Construction of a multitissue cell atlas reveals\n                        cell-type-specific regulation of molecular and complex phenotypes in\n                        pigs","volume":"13","author":"Chen","year":"2025","journal-title":"Adv Sci."},{"key":"key2.0261002113923e+13_B12","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1038\/s41588-022-01153-5","article-title":"A multi-tissue atlas of regulatory variants in\n                        cattle","volume":"54","author":"Liu","year":"2022","journal-title":"Nat Genet."},{"key":"key2.0261002113923e+13_B13","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/s41588-023-01585-7","article-title":"A compendium of genetic regulatory effects across pig\n                        tissues","volume":"56","author":"Teng","year":"2024","journal-title":"Nat Genet."},{"key":"key2.0261002113923e+13_B14","doi-asserted-by":"crossref","first-page":"110944","DOI":"10.1016\/j.ygeno.2024.110944","article-title":"Definition of regulatory elements and transcription factors\n                        controlling porcine immune cell gene expression at single cell resolution\n                        using single nucleus ATAC-seq","volume":"116","author":"Yang","year":"2024","journal-title":"Genomics."},{"key":"key2.0261002113923e+13_B15","doi-asserted-by":"crossref","first-page":"899657","DOI":"10.3389\/fimmu.2022.899657","article-title":"Progress in xenotransplantation: immunologic barriers, advances\n                        in gene editing, and successful tolerance induction strategies in\n                        pig-to-primate transplantation","volume":"13","author":"Eisenson","year":"2022","journal-title":"Front Immunol."},{"key":"key2.0261002113923e+13_B16","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/af\/vfz014","article-title":"Genetically modified pigs as donors of cells, tissues, and organs\n                        for xenotransplantation","volume":"9","author":"Wolf","year":"2019","journal-title":"Anim Front."},{"key":"key2.0261002113923e+13_B17","doi-asserted-by":"crossref","first-page":"167","DOI":"10.57603\/EJT-266","article-title":"Immunobiological barriers to pig organ\n                        xenotransplantation","author":"Cooper","year":"2023","journal-title":"Eur J Transplant"},{"key":"key2.0261002113923e+13_B18","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1152\/physrev.00041.2023","article-title":"Physiological basis for xenotransplantation from genetically\n                        modified pigs to humans","volume":"104","author":"Peterson","year":"2024","journal-title":"Physiol Rev."},{"key":"key2.0261002113923e+13_B19","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1093\/icb\/icr011","article-title":"Pathogen pressure puts immune defense into\n                        perspective","volume":"51","author":"Horrocks","year":"2011","journal-title":"Integr Comp Biol."},{"key":"key2.0261002113923e+13_B20","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3389\/fimmu.2012.00025","article-title":"Macroevolutionary immunology: a role for immunity in the\n                        diversification of animal life","volume":"3","author":"Loker","year":"2012","journal-title":"Front Immunol."},{"key":"key2.0261002113923e+13_B21","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s00441-020-03206-9","article-title":"The pig as a model for immunology research","volume":"380","author":"Pabst","year":"2020","journal-title":"Cell Tissue Res."},{"key":"key2.0261002113923e+13_B22","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1186\/1471-2164-14-332","article-title":"Structural and functional annotation of the porcine\n                        immunome","volume":"14","author":"Dawson","year":"2013","journal-title":"BMC Genom."},{"key":"key2.0261002113923e+13_B23","doi-asserted-by":"crossref","first-page":"208","DOI":"10.4049\/jimmunol.1303398","article-title":"Bovine \u03b3\u03b4 T cells are a major regulatory T cell\n                        subset","volume":"193","author":"Guzman","year":"2014","journal-title":"J Immunol."},{"key":"key2.0261002113923e+13_B24","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0165-2427(91)90004-V","article-title":"Overview of the avian immune system","volume":"30","author":"Sharma","year":"1991","journal-title":"Vet Immunol Immunopathol."},{"key":"key2.0261002113923e+13_B25","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3389\/fgene.2012.00263","article-title":"The molecular pathways underlying host resistance and tolerance\n                        to pathogens","volume":"3","author":"Glass","year":"2012","journal-title":"Front Genet."},{"key":"key2.0261002113923e+13_B26","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1038\/s41588-022-01155-3","article-title":"The CattleGTEx atlas reveals regulatory mechanisms underlying\n                        complex traits","volume":"54","author":"Fang","year":"2022","journal-title":"Nat Genet."},{"key":"key2.0261002113923e+13_B27","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1038\/s41588-025-02329-5","article-title":"A multi-tissue single-cell expression atlas in\n                        cattle","volume":"57","author":"Han","year":"2025","journal-title":"Nat Genet."},{"key":"key2.0261002113923e+13_B28","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s12864-024-10044-4","article-title":"Single-cell RNA-seq mapping of chicken peripheral blood\n                        leukocytes","volume":"25","author":"Maxwell","year":"2024","journal-title":"BMC Genom."},{"key":"key2.0261002113923e+13_B29","doi-asserted-by":"crossref","first-page":"6163","DOI":"10.3390\/ijms26136163","article-title":"Applications of spatial transcriptomics in veterinary medicine: a\n                        scoping review of research, diagnostics, and treatment\n                        strategies","volume":"26","author":"Weiderman","year":"2025","journal-title":"Int J Mol Sci."},{"key":"key2.0261002113923e+13_B30","doi-asserted-by":"crossref","first-page":"2306703","DOI":"10.1002\/advs.202306703","article-title":"Integrating single\u2010cell and spatial transcriptomics\n                        reveals heterogeneity of early pig skin development and a subpopulation with\n                        hair placode formation","volume":"11","author":"Wang","year":"2024","journal-title":"Adv Sci."},{"key":"key2.0261002113923e+13_B31","doi-asserted-by":"crossref","first-page":"2297860","DOI":"10.1080\/19490976.2023.2297860","article-title":"Multi-omic approaches for host-microbiome data\n                        integration","volume":"16","author":"Chetty","year":"2024","journal-title":"Gut Microbes."},{"key":"key2.0261002113923e+13_B32","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1093\/bioinformatics\/bty1054","article-title":"DIABLO: an integrative approach for identifying key molecular\n                        drivers from multi-omics assays","volume":"35","author":"Singh","year":"2019","journal-title":"Bioinformatics."},{"key":"key2.0261002113923e+13_B33","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1093\/bioinformatics\/btn482","article-title":"Combining partial correlation and an information theory approach\n                        to the reversed engineering of gene co-expression networks","volume":"24","author":"Reverter","year":"2008","journal-title":"Bioinformatics."},{"key":"key2.0261002113923e+13_B34","doi-asserted-by":"crossref","DOI":"10.15252\/msb.20178124","article-title":"Multi\u2010omics factor analysis\u2014a framework for\n                        unsupervised integration of multi\u2010omics data sets","volume":"14","author":"Argelaguet","year":"2018","journal-title":"Mol Syst Biol."},{"key":"key2.0261002113923e+13_B35","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s13059-020-02015-1","article-title":"MOFA+: a statistical framework for comprehensive integration of\n                        multi-modal single-cell data","volume":"21","author":"Argelaguet","year":"2020","journal-title":"Genome Biol."},{"key":"key2.0261002113923e+13_B36","doi-asserted-by":"crossref","first-page":"2906","DOI":"10.1093\/bioinformatics\/btp543","article-title":"Integrative clustering of multiple genomic data types using a\n                        joint latent variable model with application to breast and lung cancer\n                        subtype analysis","volume":"25","author":"Shen","year":"2009","journal-title":"Bioinformatics."},{"key":"key2.0261002113923e+13_B37","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nmeth.2810","article-title":"Similarity network fusion for aggregating data types on a genomic\n                        scale","volume":"11","author":"Wang","year":"2014","journal-title":"Nat Methods."},{"key":"key2.0261002113923e+13_B38","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network\n                        analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinform."},{"key":"key2.0261002113923e+13_B39","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/nmeth.4463","article-title":"SCENIC: single-cell regulatory network inference and\n                        clustering","volume":"14","author":"Aibar","year":"2017","journal-title":"Nat Methods."},{"key":"key2.0261002113923e+13_B40","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","article-title":"Inference and analysis of cell-cell communication using\n                        CellChat","volume":"12","author":"Jin","year":"2021","journal-title":"Nat Commun."},{"key":"key2.0261002113923e+13_B41","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1038\/s41596-020-0292-x","article-title":"CellPhoneDB: inferring cell\u2013cell communication from\n                        combined expression of multi-subunit ligand\u2013receptor\n                        complexes","volume":"15","author":"Efremova","year":"2020","journal-title":"Nat Protoc."},{"key":"key2.0261002113923e+13_B42","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/s41592-019-0667-5","article-title":"NicheNet: modeling intercellular communication by linking ligands\n                        to target genes","volume":"17","author":"Browaeys","year":"2020","journal-title":"Nat Methods."},{"key":"key2.0261002113923e+13_B43","doi-asserted-by":"crossref","first-page":"5649","DOI":"10.1073\/pnas.1503141112","article-title":"Global trends in antimicrobial use in food\n                        animals","volume":"112","author":"van Boeckel","year":"2015","journal-title":"Proc Natl Acad Sci USA."},{"key":"key2.0261002113923e+13_B44","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3389\/fvets.2019.00317","article-title":"OIE annual report on antimicrobial agents intended for use in\n                        animals: methods used","volume":"6","author":"G\u00f3chez","year":"2019","journal-title":"Front Vet Sci."},{"key":"key2.0261002113923e+13_B45","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13059-017-1215-1","article-title":"Multi-omics approaches to disease","volume":"18","author":"Hasin","year":"2017","journal-title":"Genome Biol."},{"key":"key2.0261002113923e+13_B46","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1111\/age.12466","article-title":"GO-FAANG meeting: a gathering on functional annotation of animal\n                        genomes","volume":"47","author":"Tuggle","year":"2016","journal-title":"Anim Genet."},{"key":"key2.0261002113923e+13_B47","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.immuni.2015.11.012","article-title":"Systems analysis of immunity to influenza vaccination across\n                        multiple years and in diverse populations reveals shared molecular\n                        signatures","volume":"43","author":"Nakaya","year":"2015","journal-title":"Immunity."},{"key":"key2.0261002113923e+13_B48","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.immuni.2010.10.006","article-title":"Systems vaccinology","volume":"33","author":"Pulendran","year":"2010","journal-title":"Immunity."},{"key":"key2.0261002113923e+13_B49","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1084\/jem.20151570","article-title":"Immunometabolism governs dendritic cell and macrophage\n                        function","volume":"213","author":"O\u2019Neill","year":"2016","journal-title":"J Exp Med."},{"key":"key2.0261002113923e+13_B50","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.cell.2017.04.004","article-title":"Metabolic instruction of immunity","volume":"169","author":"Buck","year":"2017","journal-title":"Cell."},{"key":"key2.0261002113923e+13_B51","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/nri3665","article-title":"Innate immunity to influenza virus infection","volume":"14","author":"Iwasaki","year":"2014","journal-title":"Nat Rev Immunol."},{"key":"key2.0261002113923e+13_B52","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1093\/genetics\/157.4.1819","article-title":"Prediction of total genetic value using genome-wide dense marker\n                        maps","volume":"157","author":"Meuwissen","year":"2001","journal-title":"Genetics."},{"key":"key2.0261002113923e+13_B53","doi-asserted-by":"crossref","first-page":"aaf1098","DOI":"10.1126\/science.aaf1098","article-title":"Trained immunity: a program of innate immune memory in health and\n                        disease","volume":"352","author":"Netea","year":"2016","journal-title":"Science"},{"key":"key2.0261002113923e+13_B54","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1017\/S1466252307001375","article-title":"Mannheimia haemolytica and bovine respiratory\n                        disease","volume":"8","author":"Rice","year":"2007","journal-title":"Anim Health Res Rev."},{"key":"key2.0261002113923e+13_B55","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.cvfa.2010.04.004","article-title":"Bacterial pathogens of the bovine respiratory disease\n                        complex","volume":"26","author":"Griffin","year":"2010","journal-title":"Vet Clin N Am Food Anim Pract."},{"key":"key2.0261002113923e+13_B56","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/bjs.9736","article-title":"Transparent reporting of a multivariable prediction model for\n                        individual prognosis or diagnosis (TRIPOD): the TRIPOD\n                        statement","volume":"102","author":"Collins","year":"2015","journal-title":"J Br Surg."},{"key":"key2.0261002113923e+13_B57","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/s41598-019-56809-w","article-title":"Diagnosis of bovine respiratory disease in feedlot cattle using\n                        blood 1H NMR metabolomics","volume":"10","author":"Blakebrough-Hall","year":"2020","journal-title":"Sci Rep."},{"key":"key2.0261002113923e+13_B58","doi-asserted-by":"crossref","first-page":"1046192","DOI":"10.3389\/fgene.2022.1046192","article-title":"Applying multi-omics data to study the genetic background of\n                        bovine respiratory disease infection in feedlot crossbred\n                        cattle","volume":"13","author":"Li","year":"2022","journal-title":"Front Genet."},{"key":"key2.0261002113923e+13_B59","doi-asserted-by":"crossref","DOI":"10.1007\/978-981-97-7395-4","volume-title":"Bioinformatics in veterinary science: vetinformatics","author":"Kim","year":"2025"},{"key":"key2.0261002113923e+13_B60","doi-asserted-by":"crossref","first-page":"10381","DOI":"10.3168\/jds.2017-13023","article-title":"A 100-year review: mastitis detection, management, and\n                        prevention","volume":"100","author":"Ruegg","year":"2017","journal-title":"J Dairy Sci."},{"key":"key2.0261002113923e+13_B61","volume-title":"Diseases of swine","author":"Zimmerman","year":"2012"},{"key":"key2.0261002113923e+13_B62","doi-asserted-by":"crossref","first-page":"ftw106","DOI":"10.1093\/femspd\/ftw106","article-title":"Thermoregulation as a disease tolerance defense\n                        strategy","volume":"74","author":"Schieber","year":"2016","journal-title":"Pathog Dis."},{"key":"key2.0261002113923e+13_B63","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1146\/annurev-animal-022114-111025","article-title":"Porcine reproductive and respiratory syndrome virus (PRRSV):\n                        pathogenesis and interaction with the immune system","volume":"4","author":"Lunney","year":"2016","journal-title":"Annu Rev Anim Biosci."},{"key":"key2.0261002113923e+13_B64","doi-asserted-by":"crossref","first-page":"4069","DOI":"10.1016\/j.vaccine.2015.06.092","article-title":"Live porcine reproductive and respiratory syndrome virus\n                        vaccines: current status and future direction","volume":"33","author":"Renukaradhya","year":"2015","journal-title":"Vaccine."},{"key":"key2.0261002113923e+13_B65","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/tbed.12016","article-title":"Porcine reproductive and respiratory syndrome virus vaccines:\n                        current status and strategies to a universal vaccine","volume":"61","author":"Hu","year":"2014","journal-title":"Transbound Emerg Dis."},{"key":"key2.0261002113923e+13_B66","doi-asserted-by":"crossref","first-page":"104759","DOI":"10.1016\/j.dci.2023.104759","article-title":"Integrative time-serial networks for genome-wide lncRNA-mRNA\n                        interactions reveal interferon-inducible antiviral and T-cell receptor\n                        regulations against PRRSV infection","volume":"147","author":"Lim","year":"2023","journal-title":"Dev Comp Immunol."},{"key":"key2.0261002113923e+13_B67","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13567-025-01451-w","article-title":"Cell deconvolution-based integrated time-series network of whole\n                        blood transcriptome reveals systemic antiviral activities and cell-specific\n                        immunological changes against PRRSV infection","volume":"56","author":"Lim","year":"2025","journal-title":"Vet Res."},{"key":"key2.0261002113923e+13_B68","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1038\/s41467-024-54676-2","article-title":"Single-cell transcriptomics of bronchoalveolar lavage during\n                        PRRSV infection with different virulence","volume":"16","author":"Lim","year":"2025","journal-title":"Nat Commun."},{"key":"key2.0261002113923e+13_B69","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1177\/104063870701900601","article-title":"Porcine circovirus type 2\u2013associated disease: update on\n                        current terminology, clinical manifestations, pathogenesis, diagnosis, and\n                        intervention strategies","volume":"19","author":"Opriessnig","year":"2007","journal-title":"J Vet Diagn Investig."},{"key":"key2.0261002113923e+13_B70","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive integration of single-cell data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell."},{"key":"key2.0261002113923e+13_B71","doi-asserted-by":"crossref","first-page":"272359","DOI":"10.1155\/2015\/272359","article-title":"The complex role of STAT3 in viral infections","volume":"2015","author":"Kuchipudi","year":"2015","journal-title":"J Immunol Res."},{"key":"key2.0261002113923e+13_B72","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.tvjl.2015.02.017","article-title":"Porcine epidemic diarrhea virus infection: etiology,\n                        epidemiology, pathogenesis and immunoprophylaxis","volume":"204","author":"Jung","year":"2015","journal-title":"Vet J."},{"key":"key2.0261002113923e+13_B73","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nmeth.3337","article-title":"Robust enumeration of cell subsets from tissue expression\n                        profiles","volume":"12","author":"Newman","year":"2015","journal-title":"Nat Methods."},{"key":"key2.0261002113923e+13_B74","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/s41586-018-0238-4","article-title":"A naturally occurring antiviral ribonucleotide encoded by the\n                        human genome","volume":"558","author":"Gizzi","year":"2018","journal-title":"Nature."},{"key":"key2.0261002113923e+13_B75","first-page":"231","article-title":"Porcine respiratory disease complex","author":"Brockmeier","year":"2002","journal-title":"Polymicrob Dis."},{"key":"key2.0261002113923e+13_B76","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/1471-2164-13-68","article-title":"Transcription analysis on response of porcine alveolar\n                        macrophages to Haemophilus parasuis","volume":"13","author":"Wang","year":"2012","journal-title":"BMC Genom."},{"key":"key2.0261002113923e+13_B77","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0139106","article-title":"Changes in the porcine intestinal microbiome in response to\n                        infection with Salmonella enterica and Lawsonia\n                        intracellularis","volume":"10","author":"Borewicz","year":"2015","journal-title":"PLOS ONE."},{"key":"key2.0261002113923e+13_B78","doi-asserted-by":"crossref","first-page":"4433","DOI":"10.1016\/j.vaccine.2018.04.066","article-title":"The influence of the intestinal microbiome on vaccine\n                        responses","volume":"36","author":"Zimmermann","year":"2018","journal-title":"Vaccine."},{"key":"key2.0261002113923e+13_B79","doi-asserted-by":"crossref","first-page":"1048861","DOI":"10.3389\/fvets.2022.1048861","article-title":"Porcine respiratory disease complex: dynamics of polymicrobial\n                        infections and management strategies after the introduction of the African\n                        swine fever","volume":"9","author":"Assavacheep","year":"2022","journal-title":"Front Vet Sci."},{"key":"key2.0261002113923e+13_B80","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1177\/10406387211003551","article-title":"Review of methods for the detection of Lawsonia intracellularis\n                        infection in pigs","volume":"33","author":"Campillo","year":"2021","journal-title":"J Vet Diagn Investig."},{"key":"key2.0261002113923e+13_B81","first-page":"683","article-title":"Risk prediction models: II","volume":"98","author":"Moons","year":"2012","journal-title":"external validation, model updating, and impact assessment.\n                        Heart."},{"key":"key2.0261002113923e+13_B82","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1093\/aje\/kwv254","article-title":"Using big data to emulate a target trial when a randomized trial\n                        is not available","volume":"183","author":"Hern\u00e1n","year":"2016","journal-title":"Am J Epidemiol."},{"key":"key2.0261002113923e+13_B83","volume-title":"Newcastle disease","author":"Behboudi","year":"2023"},{"key":"key2.0261002113923e+13_B84","volume-title":"Dataset shift in machine learning","author":"Qui\u00f1onero-Candela","year":"2009"},{"key":"key2.0261002113923e+13_B85","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1038\/nmeth.2688","article-title":"Transposition of native chromatin for fast and sensitive\n                        epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome\n                        position","volume":"10","author":"Buenrostro","year":"2013","journal-title":"Nat Methods."},{"key":"key2.0261002113923e+13_B86","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cell.2014.03.011","article-title":"Role of the microbiota in immunity and\n                        inflammation","volume":"157","author":"Belkaid","year":"2014","journal-title":"Cell."},{"key":"key2.0261002113923e+13_B87","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nri.2016.42","article-title":"Gut microbiota, metabolites and host immunity","volume":"16","author":"Rooks","year":"2016","journal-title":"Nat Rev Immunol."},{"key":"key2.0261002113923e+13_B88","doi-asserted-by":"crossref","first-page":"108962","DOI":"10.1016\/j.isci.2024.108962","article-title":"Newcastle disease virus infection remodels plasma phospholipid\n                        metabolism in chickens","volume":"27","author":"Dai","year":"2024","journal-title":"iScience."},{"key":"key2.0261002113923e+13_B89","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0145-305X(99)00073-7","article-title":"Specific and nonspecific immune responses to Marek\u2019s\n                        disease virus","volume":"24","author":"Schat","year":"2000","journal-title":"Dev Comp Immunol."},{"key":"key2.0261002113923e+13_B90","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/ni.1688","article-title":"Systems biology approach predicts immunogenicity of the yellow\n                        fever vaccine in humans","volume":"10","author":"Querec","year":"2009","journal-title":"Nat Immunol."},{"key":"key2.0261002113923e+13_B91","doi-asserted-by":"crossref","first-page":"100731","DOI":"10.1016\/j.crmeth.2024.100731","article-title":"A multi-omics systems vaccinology resource to develop and test\n                        computational models of immunity","volume":"4","author":"Shinde","year":"2024","journal-title":"Cell Rep Methods."},{"key":"key2.0261002113923e+13_B92","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/9781119949091.ch8","article-title":"Effects of environment on animal health: mechanisms and\n                        regulatory inputs","volume-title":"Environmental physiology of livestock","author":"Elsasser","year":"2012"},{"key":"key2.0261002113923e+13_B93","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.3390\/ani14121745","article-title":"Hypothalamic neuromodulation and control of the dermal surface\n                        temperature of livestock during hyperthermia","volume":"14","author":"Sarubbi","year":"2024","journal-title":"Animals."},{"key":"key2.0261002113923e+13_B94","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3390\/agriculture9090195","article-title":"Muscle energy metabolism, growth, and meat quality in beef\n                        cattle","volume":"9","author":"Wicks","year":"2019","journal-title":"Agriculture."},{"key":"key2.0261002113923e+13_B95","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.aninu.2017.06.003","article-title":"Weaning stress and gastrointestinal barrier development:\n                        Implications for lifelong gut health in pigs","volume":"3","author":"Moeser","year":"2017","journal-title":"Anim Nutr."},{"key":"key2.0261002113923e+13_B96","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.3390\/genes15121551","article-title":"From omics to multi-omics: a review of advantages and\n                        tradeoffs","volume":"15","author":"Hayes","year":"2024","journal-title":"Genes."},{"key":"key2.0261002113923e+13_B97","doi-asserted-by":"crossref","first-page":"12824","DOI":"10.3168\/jds.2025-26997","article-title":"Integrative blood transcriptomic and metabolomic profiling\n                        reveals biomarkers of natural heat tolerance in Holstein\n                        cows","volume":"108","author":"Li","year":"2025","journal-title":"J Dairy Sci."},{"key":"key2.0261002113923e+13_B98","doi-asserted-by":"crossref","first-page":"267","DOI":"10.2174\/1573412919666230406100948","article-title":"Survey on multi-omics, and multi-omics data analysis, integration\n                        and application","volume":"19","author":"Shahrajabian","year":"2023","journal-title":"Curr Pharm Anal."},{"key":"key2.0261002113923e+13_B99","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1007\/s00484-018-1629-9","article-title":"Environmental parameters to assessing of heat stress in dairy\n                        cattle\u2014a review","volume":"62","author":"Herbut","year":"2018","journal-title":"Int J Biometeorol."},{"key":"key2.0261002113923e+13_B100","doi-asserted-by":"crossref","first-page":"804562","DOI":"10.3389\/fmicb.2022.804562","article-title":"Heat stress: effects on rumen microbes and host physiology, and\n                        strategies to alleviate the negative impacts on lactating dairy\n                        cows","volume":"13","author":"Kim","year":"2022","journal-title":"Front Microbiol."},{"key":"key2.0261002113923e+13_B101","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.3168\/jds.S0022-0302(03)73803-X","article-title":"Effects of heat-stress on production in dairy\n                        cattle","volume":"86","author":"West","year":"2003","journal-title":"J Dairy Sci."},{"key":"key2.0261002113923e+13_B102","doi-asserted-by":"crossref","first-page":"4621","DOI":"10.3390\/s23104621","article-title":"Feed conversion ratio (FCR) and performance group estimation\n                        based on predicted feed intake for the optimisation of beef\n                        production","volume":"23","author":"Davison","year":"2023","journal-title":"Sensors."},{"key":"key2.0261002113923e+13_B103","doi-asserted-by":"crossref","DOI":"10.1590\/rbz4720160414","article-title":"Understanding heat stress in beef cattle","volume":"47","author":"Brown-Brandl","year":"2018","journal-title":"Rev Bras Zootec."},{"key":"key2.0261002113923e+13_B104","doi-asserted-by":"crossref","first-page":"322","DOI":"10.3390\/ani9060322","article-title":"The impact of heat load on cattle","volume":"9","author":"Lees","year":"2019","journal-title":"Animals."},{"key":"key2.0261002113923e+13_B105","doi-asserted-by":"crossref","first-page":"928","DOI":"10.2527\/jas.2006-373","article-title":"Growth, carcass quality, and protein and energy metabolism in\n                        beef cattle with different growth potentials and residual feed\n                        intakes","volume":"85","author":"Castro Bulle","year":"2007","journal-title":"J Anim Sci."},{"key":"key2.0261002113923e+13_B106","doi-asserted-by":"crossref","first-page":"627","DOI":"10.3390\/ani14040627","article-title":"Strategies for bovine respiratory disease (BRD) diagnosis and\n                        prognosis: a comprehensive overview","volume":"14","author":"Kamel","year":"2024","journal-title":"Animals."},{"key":"key2.0261002113923e+13_B107","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1002\/mrd.22859","article-title":"Physiological mechanisms through which heat stress compromises\n                        reproduction in pigs","volume":"84","author":"Ross","year":"2017","journal-title":"Mol Reprod Dev."},{"key":"key2.0261002113923e+13_B108","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.applanim.2003.11.002","article-title":"Behavioural, endocrine and immune consequences of mixing in\n                        weaned piglets","volume":"85","author":"Merlot","year":"2004","journal-title":"Appl Anim Behav Sci."},{"key":"key2.0261002113923e+13_B109","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s11259-018-9741-1","article-title":"Impacts on performance of growing-finishing pigs under heat\n                        stress conditions: a meta-analysis","volume":"43","author":"da Fonseca de Oliveira","year":"2019","journal-title":"Vet Res Commun."},{"key":"key2.0261002113923e+13_B110","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.theriogenology.2017.04.004","article-title":"Seasonal infertility in gilts and sows: aetiology, clinical\n                        implications and treatments","volume":"96","author":"de Rensis","year":"2017","journal-title":"Theriogenology."},{"key":"key2.0261002113923e+13_B111","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/0300-9629(89)90112-6","article-title":"Panting and acid-base regulation in heat stressed\n                        birds","volume":"94","author":"Marder","year":"1989","journal-title":"Comp Biochem Physiol A Physiol."},{"key":"key2.0261002113923e+13_B112","doi-asserted-by":"crossref","first-page":"2970","DOI":"10.3382\/ps.2014-04291","article-title":"Growth, efficiency, and yield of commercial broilers from 1957,\n                        1978, and 2005","volume":"93","author":"Zuidhof","year":"2014","journal-title":"Poult Sci."},{"key":"key2.0261002113923e+13_B113","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1080\/00071668.2016.1161727","article-title":"Increasing persistency in lay and stabilising egg quality in\n                        longer laying cycles","volume":"57","author":"Bain","year":"2016","journal-title":"What are the challenges? Br Poult Sci."},{"key":"key2.0261002113923e+13_B114","doi-asserted-by":"crossref","first-page":"12003","DOI":"10.3168\/jds.2020-18675","article-title":"Feed intake\u2013dependent and \u2013independent effects of\n                        heat stress on lactation and mammary gland development","volume":"103","author":"Xiao","year":"2020","journal-title":"J Dairy Sci."},{"key":"key2.0261002113923e+13_B115","doi-asserted-by":"crossref","first-page":"390","DOI":"10.3390\/biom13020390","article-title":"Preliminary transcriptome analysis of long noncoding RNA in\n                        hypothalamic-pituitary-mammary gland axis of dairy cows under heat\n                        stress","volume":"13","author":"Zeng","year":"2023","journal-title":"Biomolecules."},{"key":"key2.0261002113923e+13_B116","doi-asserted-by":"crossref","first-page":"965","DOI":"10.3390\/genes13060965","article-title":"Identification and regulatory network analysis of genes related\n                        to reproductive performance in the hypothalamus and pituitary of Angus\n                        cattle","volume":"13","author":"Huang","year":"2022","journal-title":"Genes."},{"key":"key2.0261002113923e+13_B117","volume-title":"Systems physiology and nutrition in dairy cattle: applications of omics\n                        and bioinformatics to better understand the hepatic metabolomics and\n                        transcriptomics adaptations in transition dairy cows","author":"Shahzad","year":"2017"},{"key":"key2.0261002113923e+13_B118","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jprot.2015.04.014","article-title":"Identification of diagnostic biomarkers and metabolic pathway\n                        shifts of heat-stressed lactating dairy cows","volume":"125","author":"Tian","year":"2015","journal-title":"J Proteom."},{"key":"key2.0261002113923e+13_B119","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1186\/1471-2164-14-872","article-title":"Sequencing the transcriptome of milk production: milk trumps\n                        mammary tissue","volume":"14","author":"Lemay","year":"2013","journal-title":"BMC Genom."},{"key":"key2.0261002113923e+13_B120","doi-asserted-by":"crossref","first-page":"24208","DOI":"10.1038\/srep24208","article-title":"Integrated metabolomics study of the milk of heat-stressed\n                        lactating dairy cows","volume":"6","author":"Tian","year":"2016","journal-title":"Sci Rep."},{"key":"key2.0261002113923e+13_B121","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1007\/s00484-016-1283-z","article-title":"Metabolic responses and \u201comics\u201d technologies for\n                        elucidating the effects of heat stress in dairy cows","volume":"61","author":"Min","year":"2017","journal-title":"Int J Biometeorol."},{"key":"key2.0261002113923e+13_B122","doi-asserted-by":"crossref","first-page":"543","DOI":"10.2527\/jas1986.622543x","article-title":"Potential nutritional strategies for intensively managed cattle\n                        during thermal stress","volume":"62","author":"Beede","year":"1986","journal-title":"J Anim Sci."},{"key":"key2.0261002113923e+13_B123","doi-asserted-by":"crossref","first-page":"917","DOI":"10.5187\/jast.2500366","article-title":"Integrative multi-omics analysis reveals systemic and intestinal\n                        responses to heat stress in finishing pigs","volume":"68","author":"Seok","year":"2026","journal-title":"J Anim Sci Technol."},{"key":"key2.0261002113923e+13_B124","doi-asserted-by":"crossref","first-page":"1482925","DOI":"10.3389\/fmicb.2024.1482925","article-title":"Multi-omics analysis reveals interactions between host and\n                        microbes in Bama miniature pigs during weaning","volume":"15","author":"Ma","year":"2024","journal-title":"Front Microbiol."},{"key":"key2.0261002113923e+13_B125","doi-asserted-by":"crossref","first-page":"961474","DOI":"10.3389\/fgene.2022.961474","article-title":"Gut transcriptome reveals differential gene expression and\n                        enriched pathways linked to immune activation in response to weaning in\n                        pigs","volume":"13","author":"le Bon","year":"2022","journal-title":"Front Genet."},{"key":"key2.0261002113923e+13_B126","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.3389\/fmicb.2020.02055","article-title":"The microbiome\u2013metabolome response in the colon of piglets\n                        under the status of weaning stress","volume":"11","author":"Jiang","year":"2020","journal-title":"Front Microbiol."},{"key":"key2.0261002113923e+13_B127","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s40104-018-0269-6","article-title":"The dynamics of the piglet gut microbiome during the weaning\n                        transition in association with health and nutrition","volume":"9","author":"Guevarra","year":"2018","journal-title":"J Anim Sci Biotechnol."},{"key":"key2.0261002113923e+13_B128","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.livsci.2007.01.041","article-title":"Association between butyrate and short-chain fatty acid\n                        concentrations in gut contents and faeces in weaning piglets","volume":"108","author":"L\u00e6rke","year":"2007","journal-title":"Livest Sci."},{"key":"key2.0261002113923e+13_B129","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.2527\/jas.2014-8347","article-title":"Carcass composition of market weight pigs subjected to heat\n                        stress in utero and during finishing","volume":"93","author":"Cruzen","year":"2015","journal-title":"J Anim Sci."},{"key":"key2.0261002113923e+13_B130","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s12864-024-09999-1","article-title":"Multi-tissue metabolic and transcriptomic responses to a\n                        short-term heat stress in swine","volume":"25","author":"Huau","year":"2024","journal-title":"BMC Genom."},{"key":"key2.0261002113923e+13_B131","doi-asserted-by":"crossref","first-page":"1493284","DOI":"10.3389\/fvets.2024.1493284","article-title":"Integrated transcriptomic and metabolomic analyses reveal\n                        heterosis for meat quality of Neijiang pigs","volume":"11","author":"Dan","year":"2024","journal-title":"Front Vet Sci."},{"key":"key2.0261002113923e+13_B132","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.2527\/jas.2010-3329","article-title":"A meta-analysis of the effects of high ambient temperature on\n                        growth performance of growing-finishing pigs","volume":"89","author":"Renaudeau","year":"2011","journal-title":"J Anim Sci."},{"key":"key2.0261002113923e+13_B133","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.3390\/ani12212967","article-title":"Heat stress during summer attenuates expression of the\n                        hypothalamic kisspeptin, an upstream regulator of the\n                        hypothalamic\u2013pituitary\u2013gonadal axis, in domestic\n                        sows","volume":"12","author":"Kim","year":"2022","journal-title":"Animals."},{"key":"key2.0261002113923e+13_B134","doi-asserted-by":"crossref","DOI":"10.1530\/REP-24-0217","article-title":"IMPACT OF REAL-LIFE ENVIRONMENTAL EXPOSURES ON REPRODUCTION:\n                        systemic and ovarian impacts of heat stress in the porcine\n                        model","volume":"168","author":"Keating","year":"2024","journal-title":"Reproduction."},{"key":"key2.0261002113923e+13_B135","doi-asserted-by":"crossref","first-page":"skae053","DOI":"10.1093\/jas\/skae053","article-title":"Heat stress alters the ovarian proteome in prepubertal\n                        gilts","volume":"102","author":"Roach","year":"2024","journal-title":"J Anim Sci."},{"key":"key2.0261002113923e+13_B136","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1439-0531.2010.01695.x","article-title":"Follicular progesterone levels decrease during the period of\n                        seasonal infertility in sows","volume":"46","author":"Bertoldo","year":"2011","journal-title":"Reprod Domest Anim."},{"key":"key2.0261002113923e+13_B137","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1093\/jas\/sky144","article-title":"Impact of heat stress during the follicular phase on porcine\n                        ovarian steroidogenic and phosphatidylinositol-3 signaling","volume":"96","author":"Dickson","year":"2018","journal-title":"J Anim Sci."},{"key":"key2.0261002113923e+13_B138","doi-asserted-by":"crossref","first-page":"623","DOI":"10.3390\/antiox14060623","article-title":"Multi-omics analysis of chronic heat stress-induced biological\n                        effects, liver injury, and heat tolerance mechanisms via oxidative and\n                        anti-inflammatory pathways in early-pregnancy sows","volume":"14","author":"Chai","year":"2025","journal-title":"Antioxidants."},{"key":"key2.0261002113923e+13_B139","doi-asserted-by":"crossref","first-page":"284","DOI":"10.2141\/jpsa.0190004","article-title":"Heat stress directly affects intestinal integrity in broiler\n                        chickens","volume":"57","author":"Nanto-Hara","year":"2020","journal-title":"J Poult Sci."},{"key":"key2.0261002113923e+13_B140","doi-asserted-by":"crossref","first-page":"skaf310","DOI":"10.1093\/jas\/skaf310","article-title":"Chronic cyclic mild heat stress downregulates genes encoding\n                        muscle structural components, contributing to reduced breast muscle mass in\n                        broiler chickens with minimal impact on meat quality","volume":"103","author":"Achour","year":"2025","journal-title":"J Anim Sci."},{"key":"key2.0261002113923e+13_B141","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0181900","article-title":"Chicken hepatic response to chronic heat stress using integrated\n                        transcriptome and metabolome analysis","volume":"12","author":"Jastrebski","year":"2017","journal-title":"PLOS ONE."},{"issue":"5","key":"key2.0261002113923e+13_B142","doi-asserted-by":"crossref","first-page":"835","DOI":"10.5851\/kosfa.2018.e2","article-title":"The incidence of muscle abnormalities in broiler breast meat\n                        \u2013 a review","volume":"38","author":"Huang","year":"2018","journal-title":"Korean J Food Sci Anim Resour."},{"key":"key2.0261002113923e+13_B143","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.3390\/ani14071076","article-title":"Effects of heat stress on the laying performance, egg quality,\n                        and physiological response of laying hens","volume":"14","author":"Kim","year":"2024","journal-title":"Animals."},{"key":"key2.0261002113923e+13_B144","doi-asserted-by":"crossref","first-page":"1691532","DOI":"10.3389\/fvets.2025.1691532","article-title":"Heat stress in poultry: the role of nutritional supplements in\n                        alleviating heat stress and enhancing gut health in poultry","volume":"12","author":"Olayiwola","year":"2025","journal-title":"Front Vet Sci."},{"key":"key2.0261002113923e+13_B145","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s40104-025-01225-6","article-title":"Heat stress and the chicken gastrointestinal microbiota: a\n                        systematic review","volume":"16","author":"Ncho","year":"2025","journal-title":"J Anim Sci Biotechnol."},{"key":"key2.0261002113923e+13_B146","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s12711-017-0346-x","article-title":"Transcriptional profile of breast muscle in heat stressed layers\n                        is similar to that of broiler chickens at control\n                        temperature","volume":"49","author":"Zahoor","year":"2017","journal-title":"Genet Sel Evol."},{"key":"key2.0261002113923e+13_B147","doi-asserted-by":"crossref","first-page":"1558201","DOI":"10.3389\/fphys.2025.1558201","article-title":"Effect of heat stress on ileal epithelial barrier integrity in\n                        broilers divergently selected for high- and low-water\n                        efficiency","volume":"16","author":"Greene","year":"2025","journal-title":"Front Physiol."},{"key":"key2.0261002113923e+13_B148","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1186\/s12917-022-03388-0","article-title":"Chronic heat stress promotes liver inflammation in broilers via\n                        enhancing NF-\u03baB and NLRP3 signaling pathway","volume":"18","author":"Liu","year":"2022","journal-title":"BMC Vet Res."},{"key":"key2.0261002113923e+13_B149","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1002\/vms3.462","article-title":"Hepatic lipid metabolomics in response to heat stress in local\n                        broiler chickens breed (Huaixiang chickens)","volume":"7","author":"Guo","year":"2021","journal-title":"Vet Med Sci."},{"key":"key2.0261002113923e+13_B150","doi-asserted-by":"crossref","first-page":"176","DOI":"10.3390\/ani14020176","article-title":"Transcriptomic profiles of pectoralis major muscles affected by\n                        spaghetti meat and woody breast in broiler chickens","volume":"14","author":"Che","year":"2024","journal-title":"Animals."},{"key":"key2.0261002113923e+13_B151","doi-asserted-by":"crossref","first-page":"1501362","DOI":"10.3389\/fphys.2024.1501362","article-title":"Skeletal muscle metabolic characteristics and fresh meat quality\n                        defects associated with wooden breast","volume":"15","author":"Rimmer","year":"2024","journal-title":"Front Physiol."},{"key":"key2.0261002113923e+13_B152","doi-asserted-by":"crossref","first-page":"103877","DOI":"10.1016\/j.psj.2024.103877","article-title":"Relationship between wooden breast severity in broiler chicken,\n                        antioxidant enzyme activity and markers of energy metabolism","volume":"103","author":"Li","year":"2024","journal-title":"Poult Sci."},{"key":"key2.0261002113923e+13_B153","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.3390\/ani12111467","article-title":"Effect of heat stress on egg production, steroid hormone\n                        synthesis, and related gene expression in chicken preovulatory follicular\n                        granulosa cells","volume":"12","author":"Yan","year":"2022","journal-title":"Animals."},{"key":"key2.0261002113923e+13_B154","doi-asserted-by":"crossref","first-page":"464","DOI":"10.3390\/vetsci11100464","article-title":"Advances in the effects of heat stress on ovarian granulosa\n                        cells: unveiling novel ferroptosis pathways","volume":"11","author":"Zhu","year":"2024","journal-title":"Vet Sci."},{"key":"key2.0261002113923e+13_B155","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3390\/antiox10010035","article-title":"Radical response: effects of heat stress-induced oxidative stress\n                        on lipid metabolism in the avian liver","volume":"10","author":"Emami","year":"2021","journal-title":"Antioxidants."},{"key":"key2.0261002113923e+13_B156","doi-asserted-by":"crossref","first-page":"467S","DOI":"10.1093\/jn\/129.2.467S","article-title":"Estrogen induction of VLDLy assembly in egg-laying\n                        hens","volume":"129","author":"Walzem","year":"1999","journal-title":"J Nutr."},{"key":"key2.0261002113923e+13_B157","doi-asserted-by":"crossref","first-page":"104993","DOI":"10.1016\/j.psj.2025.104993","article-title":"Ovarian expression of functional MTTP and apoB for VLDL assembly\n                        and secretion in chickens","volume":"104","author":"Chen","year":"2025","journal-title":"Poult Sci."},{"key":"key2.0261002113923e+13_B158","doi-asserted-by":"crossref","first-page":"16853","DOI":"10.1038\/s41598-018-35203-y","article-title":"RNA sequencing-based analysis of the laying hen uterus revealed\n                        the novel genes and biological pathways involved in the eggshell\n                        biomineralization","volume":"8","author":"Sah","year":"2018","journal-title":"Sci Rep."},{"key":"key2.0261002113923e+13_B159","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/1471-2164-15-220","article-title":"Hen uterine gene expression profiling during eggshell formation\n                        reveals putative proteins involved in the supply of minerals or in the shell\n                        mineralization process","volume":"15","author":"Brionne","year":"2014","journal-title":"BMC Genom."},{"key":"key2.0261002113923e+13_B160","doi-asserted-by":"crossref","first-page":"150208","DOI":"10.1016\/j.ijbiomac.2026.150208","article-title":"Genetic and metabolic regulation of eggshell quality in aging\n                        hens: integrated multi-omics insights into CYP7A1, CALM1, and cholic\/stearic\n                        acid metabolism","author":"Zhang","year":"2026","journal-title":"Int J Biol Macromol."},{"key":"key2.0261002113923e+13_B161","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/bmb\/ldx043","article-title":"Xenotransplantation\u2014the current status and\n                        prospects","volume":"125","author":"Cooper","year":"2018","journal-title":"Br Med Bull."},{"key":"key2.0261002113923e+13_B162","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ijsu.2015.06.066","article-title":"The need for xenotransplantation as a source of organs and cells\n                        for clinical transplantation","volume":"23","author":"Ekser","year":"2015","journal-title":"Int J Surg."},{"key":"key2.0261002113923e+13_B163","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1126\/science.aan4187","article-title":"Inactivation of porcine endogenous retrovirus in pigs using\n                        CRISPR-Cas9","volume":"357","author":"Niu","year":"2017","journal-title":"Science."},{"key":"key2.0261002113923e+13_B164","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/ki.2013.381","article-title":"Kidney xenotransplantation","volume":"85","author":"Cowan","year":"2014","journal-title":"Kidney Int."},{"key":"key2.0261002113923e+13_B165","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/iji.12526","article-title":"Immunogenetics of xenotransplantation","volume":"48","author":"Carvalho-Oliveira","year":"2021","journal-title":"Int J Immunogenet."},{"key":"key2.0261002113923e+13_B166","doi-asserted-by":"crossref","first-page":"17755","DOI":"10.1016\/S0021-9258(19)77900-9","article-title":"Man, apes, and old world monkeys differ from other mammals in the\n                        expression of alpha-galactosyl epitopes on nucleated cells","volume":"263","author":"Galili","year":"1988","journal-title":"J Biol Chem."},{"key":"key2.0261002113923e+13_B167","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ijsu.2015.06.068","article-title":"Immunobiological barriers to xenotransplantation","volume":"23","author":"Cooper","year":"2015","journal-title":"Int J Surg."},{"key":"key2.0261002113923e+13_B168","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1097\/TP.0000000000001676","article-title":"An investigation of extracellular histones in pig-to-baboon organ\n                        xenotransplantation","volume":"101","author":"Li","year":"2017","journal-title":"Transplantation."},{"key":"key2.0261002113923e+13_B169","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s12033-017-0024-9","article-title":"Genetically modified pigs as organ donors for\n                        xenotransplantation","volume":"59","author":"Hryhorowicz","year":"2017","journal-title":"Mol Biotechnol."},{"key":"key2.0261002113923e+13_B170","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0140-6736(03)14118-9","article-title":"Clinical xenotransplantion\u2014how close are\n                        we?","volume":"362","author":"Cooper","year":"2003","journal-title":"Lancet."},{"key":"key2.0261002113923e+13_B171","doi-asserted-by":"crossref","first-page":"5062","DOI":"10.1073\/pnas.0609661104","article-title":"Role for CD47-SIRP\u03b1 signaling in xenograft rejection by\n                        macrophages","volume":"104","author":"Ide","year":"2007","journal-title":"Proc Natl Acad Sci USA."},{"key":"key2.0261002113923e+13_B172","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/imr.12527","article-title":"The CD47-SIRP\u03b1 signaling axis as an innate immune\n                        checkpoint in cancer","volume":"276","author":"Matlung","year":"2017","journal-title":"Immunol Rev."},{"key":"key2.0261002113923e+13_B173","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1399-3089.1998.tb00034.x","article-title":"T cell-mediated xenograft rejection: specific tolerance is\n                        probably required for long term xenograft survival","volume":"5","author":"Dorling","year":"1998","journal-title":"Xenotransplantation."},{"key":"key2.0261002113923e+13_B174","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.trim.2008.10.008","article-title":"Coagulation dysregulation as a barrier to xenotransplantation in\n                        the primate","volume":"21","author":"Lin","year":"2009","journal-title":"Transpl Immunol."},{"key":"key2.0261002113923e+13_B175","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s11248-016-9934-8","article-title":"The production of multi-transgenic pigs: update and perspectives\n                        for xenotransplantation","volume":"25","author":"Niemann","year":"2016","journal-title":"Transgenic Res."},{"key":"key2.0261002113923e+13_B176","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/path.4635","article-title":"The role of genetically engineered pigs in xenotransplantation\n                        research","volume":"238","author":"Cooper","year":"2016","journal-title":"J Pathol."},{"key":"key2.0261002113923e+13_B177","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/S0140-6736(11)61091-X","article-title":"Clinical xenotransplantation: the next medical\n                        revolution?","volume":"379","author":"Ekser","year":"2012","journal-title":"Lancet."},{"key":"key2.0261002113923e+13_B178","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/imr.12152","article-title":"Xenotransplantation: immunological hurdles and progress toward\n                        tolerance","volume":"258","author":"Griesemer","year":"2014","journal-title":"Immunol Rev."},{"key":"key2.0261002113923e+13_B179","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.healun.2020.05.004","article-title":"Pig-to-non-human primate heart transplantation: the final step\n                        toward clinical xenotransplantation?","volume":"39","author":"Reichart","year":"2020","journal-title":"J Heart Lung Transpl."},{"key":"key2.0261002113923e+13_B180","first-page":"S28","article-title":"Hyperacute xenograft rejection as an immunologic barrier to\n                        xenotransplantation","volume":"58","author":"Daniels","year":"1997","journal-title":"Kidney Int Suppl."},{"key":"key2.0261002113923e+13_B181","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1080\/19768354.2023.2265150","article-title":"Comparative transcriptome analysis between long- and short-term\n                        survival after pig-to-monkey cardiac xenotransplantation reveals\n                        differential heart failure development","volume":"27","author":"Lim","year":"2023","journal-title":"Anim Cells Syst."},{"key":"key2.0261002113923e+13_B182","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41586-018-0765-z","article-title":"Consistent success in life-supporting porcine cardiac\n                        xenotransplantation","volume":"564","author":"L\u00e4ngin","year":"2018","journal-title":"Nature."},{"key":"key2.0261002113923e+13_B183","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1056\/NEJMoa2120238","article-title":"Results of two cases of pig-to-human kidney\n                        xenotransplantation","volume":"386","author":"Montgomery","year":"2022","journal-title":"N Engl J Med."},{"key":"key2.0261002113923e+13_B184","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/S0140-6736(23)01349-1","article-title":"Immune response after pig-to-human kidney xenotransplantation: a\n                        multimodal phenotyping study","volume":"402","author":"Loupy","year":"2023","journal-title":"Lancet."},{"key":"key2.0261002113923e+13_B185","doi-asserted-by":"crossref","first-page":"3140","DOI":"10.1038\/s41467-024-47454-7","article-title":"Spatiotemporal immune atlas of a clinical-grade gene-edited\n                        pig-to-human kidney xenotransplant","volume":"15","author":"Cheung","year":"2024","journal-title":"Nat Commun."},{"key":"key2.0261002113923e+13_B186","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.jacbts.2022.05.003","article-title":"Cardiac xenotransplantation: challenges, evolution, and\n                        advances","volume":"7","author":"Boulet","year":"2022","journal-title":"JACC Basic Transl Sci."},{"key":"key2.0261002113923e+13_B187","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/xen.12133","article-title":"Systemic inflammation in xenograft recipients precedes activation\n                        of coagulation","volume":"22","author":"Ezzelarab","year":"2015","journal-title":"Xenotransplantation."},{"key":"key2.0261002113923e+13_B188","doi-asserted-by":"crossref","first-page":"751","DOI":"10.3390\/ijms22020751","article-title":"Comprehensive analysis of cardiac xeno-graft unveils rejection\n                        mechanisms","volume":"22","author":"Park","year":"2021","journal-title":"Int J Mol Sci."},{"key":"key2.0261002113923e+13_B189","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/xen.12219","article-title":"The pathobiology of pig-to-primate xenotransplantation: a\n                        historical review","volume":"23","author":"Cooper","year":"2016","journal-title":"Xenotransplantation."},{"key":"key2.0261002113923e+13_B190","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S1074-7613(01)00124-8","article-title":"The immunological barrier to xenotransplantation","volume":"14","author":"Cascalho","year":"2001","journal-title":"Immunity."},{"key":"key2.0261002113923e+13_B191","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1126\/science.1078942","article-title":"Production of \u03b11,3-galactosyltransferase-deficient\n                        pigs","volume":"299","author":"Phelps","year":"2003","journal-title":"Science."},{"key":"key2.0261002113923e+13_B192","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1093\/ilar\/ily015","article-title":"Xenotransplantation: progress along paths uncertain from models\n                        to application","volume":"59","author":"Platt","year":"2018","journal-title":"ILAR J."},{"key":"key2.0261002113923e+13_B193","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1097\/00007890-199112000-00001","article-title":"The barrier to xenotransplantation","volume":"52","author":"Platt","year":"1991","journal-title":"Transplantation."},{"key":"key2.0261002113923e+13_B194","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1080\/07853890410018826","article-title":"Xenotransplantation and risks of zoonotic\n                        infections","volume":"36","author":"Boneva","year":"2004","journal-title":"Ann Med."},{"key":"key2.0261002113923e+13_B195","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/978-3-030-49127-7_7","article-title":"Gene-edited pigs for xenotransplantation","volume-title":"Clinical xenotransplantation: pathways and progress in the\n                        transplantation of organs and tissues between species","author":"Eyestone","year":"2020"}],"container-title":["Journal of Animal Science and Technology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.ejast.org\/download\/download_pdf?doi=10.5187\/jast.2600054","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.ejast.org\/download\/download_pdf?doi=10.5187\/jast.2600054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:57:15Z","timestamp":1790909835000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.ejast.org\/archive\/view_article?doi=10.5187\/jast.2600054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":195,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,7,31]]},"published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.5187\/jast.2600054"],"URL":"https:\/\/doi.org\/10.5187\/jast.2600054","relation":{},"ISSN":["2672-0191","2055-0391"],"issn-type":[{"value":"2672-0191","type":"print"},{"value":"2055-0391","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-02-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}