{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T10:12:49Z","timestamp":1790849569786,"version":"4.1.0"},"reference-count":72,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":961,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Critical Care and Resuscitation"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.51893\/2021.1.oa3","type":"journal-article","created":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T06:47:24Z","timestamp":1627886844000},"page":"32-46","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Fibrinogen Early In Severe Trauma studY (FEISTY): results from an Australian multicentre randomised controlled pilot trial"],"prefix":"10.1016","volume":"23","author":[{"given":"James","family":"Winearls","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Wullschleger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Wake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe","family":"McQuilten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Reade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Hurn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melita","family":"Trout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Walsham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Holley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shane","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne","family":"Dyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"McCullough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerben","family":"Keijzers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Presneill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.51893\/2021.1.OA3_bb0005","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1007\/s00268-007-9087-2","article-title":"Epidemiology of urban trauma deaths: a comprehensive reassessment 10 years later","volume":"31","author":"Cothren","year":"2007","journal-title":"World J Surg"},{"issue":"Suppl 5","key":"10.51893\/2021.1.OA3_bb0010","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1186\/cc3779","article-title":"The epidemiology and modern management of traumatic hemorrhage: US and international perspectives","volume":"9","author":"Kauvar","year":"2005","journal-title":"Crit Care"},{"key":"10.51893\/2021.1.OA3_bb0015","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1056\/NEJMra1109343","article-title":"Injuries","volume":"368","author":"Norton","year":"2013","journal-title":"N Engl J Med"},{"key":"10.51893\/2021.1.OA3_bb0020","article-title":"A decade of damage control resuscitation: new transfusion practice, new survivors, new directions","author":"Cole","year":"2019","journal-title":"Ann Surg"},{"key":"10.51893\/2021.1.OA3_bb0025","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1097\/MCC.0b013e3282f1e78f","article-title":"Acute coagulopathy of trauma: mechanism, identification and effect","volume":"13","author":"Brohi","year":"2007","journal-title":"Curr Opin Crit Care"},{"key":"10.51893\/2021.1.OA3_bb0030","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1097\/TA.0000000000000729","article-title":"Mechanisms of early trauma-induced coagulopathy: the clot thickens or not?","volume":"79","author":"Dobson","year":"2015","journal-title":"J Trauma Acute Care Surg"},{"key":"10.51893\/2021.1.OA3_bb0035","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1213\/ANE.0000000000004478","article-title":"Pathophysiological response to trauma-induced coagulopathy: a comprehensive review","volume":"130","author":"Duque","year":"2020","journal-title":"Anesth Analg"},{"key":"10.51893\/2021.1.OA3_bb0040","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1055\/s-0037-1615947","article-title":"A cell-based model of hemostasis","volume":"85","author":"Hoffman","year":"2001","journal-title":"Thromb Haemost"},{"key":"10.51893\/2021.1.OA3_bb0045","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1111\/trf.12431","article-title":"Fibrinogen as a therapeutic target for bleeding: a review of critical levels and replacement therapy","volume":"54","author":"Levy","year":"2014","journal-title":"Transfusion"},{"key":"10.51893\/2021.1.OA3_bb0050","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1213\/ane.0b013e3181966675","article-title":"The effects of fibrinogen levels on thromboelastometric variables in the presence of thrombocytopenia","volume":"108","author":"Lang","year":"2009","journal-title":"Anesth Analg"},{"key":"10.51893\/2021.1.OA3_bb0055","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1111\/j.1538-7836.2005.01365.x","article-title":"Fibrinogen and fibrin structure and functions","volume":"3","author":"Mosesson","year":"2005","journal-title":"J Thromb Haemost"},{"key":"10.51893\/2021.1.OA3_bb0060","doi-asserted-by":"crossref","first-page":"R52","DOI":"10.1186\/cc13798","article-title":"Prevalence, predictors and outcome of hypofibrinogenaemia in trauma: a multicentre observational study","volume":"18","author":"Hagemo","year":"2014","journal-title":"Crit Care"},{"key":"10.51893\/2021.1.OA3_bb0065","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.injury.2010.11.003","article-title":"Early coagulopathy in trauma patients: an on-scene and hospital admission study","volume":"43","author":"Floccard","year":"2012","journal-title":"Injury"},{"key":"10.51893\/2021.1.OA3_bb0070","doi-asserted-by":"crossref","first-page":"R265","DOI":"10.1186\/cc10539","article-title":"FIBTEM provides early prediction of massive transfusion in trauma","volume":"15","author":"Schochl","year":"2011","journal-title":"Crit Care"},{"key":"10.51893\/2021.1.OA3_bb0075","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.jamcollsurg.2012.10.017","article-title":"Impact of fibrinogen levels on outcomes after acute injury in patients requiring a massive transfusion","volume":"216","author":"Inaba","year":"2013","journal-title":"J Am Coll Surg"},{"key":"10.51893\/2021.1.OA3_bb0080","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1111\/j.1538-7836.2012.04752.x","article-title":"Fibrinogen levels during trauma hemorrhage, response to replacement therapy, and association with patient outcomes","volume":"10","author":"Rourke","year":"2012","journal-title":"J Thromb Haemost"},{"key":"10.51893\/2021.1.OA3_bb0085","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/bjh.14804","article-title":"Fibrinogen concentration and use of fibrinogen supplementation with cryoprecipitate in patients with critical bleeding receiving massive transfusion: a bi-national cohort study","volume":"179","author":"McQuilten","year":"2017","journal-title":"Br J Haematol"},{"key":"10.51893\/2021.1.OA3_bb0090","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.injury.2016.11.021","article-title":"Fibrinogen is an independent predictor of mortality in major trauma patients: a five-year statewide cohort study","volume":"48","author":"McQuilten","year":"2017","journal-title":"Injury"},{"key":"10.51893\/2021.1.OA3_bb0095","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.injury.2012.08.047","article-title":"The exclusive use of coagulation factor concentrates enables reversal of coagulopathy and decreases transfusion rates in patients with major blunt trauma","volume":"44","author":"Innerhofer","year":"2013","journal-title":"Injury"},{"key":"10.51893\/2021.1.OA3_bb0100","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1001\/jamasurg.2013.764","article-title":"Association of cryoprecipitate and tranexamic acid with improved survival following wartime injury: findings from the MATTERs II study","volume":"148","author":"Morrison","year":"2013","journal-title":"JAMA Surg"},{"key":"10.51893\/2021.1.OA3_bb0105","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s13054-019-2347-3","article-title":"The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition","volume":"23","author":"Spahn","year":"2019","journal-title":"Crit Care"},{"key":"10.51893\/2021.1.OA3_bb0110","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1365-2141.2004.04868.x","article-title":"Efficacy of standard dose and 30 ml\/kg fresh frozen plasma in correcting laboratory parameters of haemostasis in critically ill patients","volume":"125","author":"Chowdary","year":"2004","journal-title":"Br J Haematol"},{"key":"10.51893\/2021.1.OA3_bb0115","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s00134-014-3584-1","article-title":"Damage control resuscitation using blood component therapy in standard doses has a limited effect on coagulopathy during trauma hemorrhage","volume":"41","author":"Khan","year":"2015","journal-title":"Intensive Care Med"},{"key":"10.51893\/2021.1.OA3_bb0120","doi-asserted-by":"crossref","first-page":"R239","DOI":"10.1186\/cc10488","article-title":"Clinical effectiveness of fresh frozen plasma compared with fibrinogen concentrate: a systematic review","volume":"15","author":"Kozek-Langenecker","year":"2011","journal-title":"Crit Care"},{"key":"10.51893\/2021.1.OA3_bb0125","doi-asserted-by":"crossref","first-page":"e258","DOI":"10.1016\/S2352-3026(17)30077-7","article-title":"Reversal of trauma-induced coagulopathy using first-line coagulation factor concentrates or fresh frozen plasma (RETIC): a single-centre, parallel-group, open-label, randomised trial","volume":"4","author":"Innerhofer","year":"2017","journal-title":"Lancet Haematol"},{"key":"10.51893\/2021.1.OA3_bb0130","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/bja\/aes227","article-title":"Supplementation of fibrinogen in acquired bleeding disorders: experience, evidence, guidelines, and licences","volume":"109","author":"Ranucci","year":"2012","journal-title":"Br J Anaesth"},{"key":"10.51893\/2021.1.OA3_bb0135","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1093\/bja\/aeu158","article-title":"Cryoprecipitate therapy","volume":"113","author":"Nascimento","year":"2014","journal-title":"Br J Anaesth"},{"key":"10.51893\/2021.1.OA3_bb0140","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1080\/17474086.2018.1458610","article-title":"Do we still need cryoprecipitate? Cryoprecipitate and fibrinogen concentrate as treatments for major hemorrhage \u2014 how do they compare?","volume":"11","author":"Novak","year":"2018","journal-title":"Expert Rev Hematol"},{"key":"10.51893\/2021.1.OA3_bb0145","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1093\/bja\/aev134","article-title":"Early cryoprecipitate for major haemorrhage in trauma: a randomised controlled feasibility trial","volume":"115","author":"Curry","year":"2015","journal-title":"Br J Anaesth"},{"key":"10.51893\/2021.1.OA3_bb0150","first-page":"CD008864","article-title":"Fibrinogen concentrate in bleeding patients","volume":"8","author":"Wikkelso","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"10.51893\/2021.1.OA3_bb0155","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1093\/bja\/aew343","article-title":"Fibrinogen in the initial resuscitation of severe trauma (FiiRST): a randomized feasibility trial","volume":"117","author":"Nascimento","year":"2016","journal-title":"Br J Anaesth"},{"key":"10.51893\/2021.1.OA3_bb0160","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/s13054-018-2086-x","article-title":"Early fibrinogen concentrate therapy for major haemorrhage in trauma (E-FIT 1): results from a UK multi-centre, randomised, double blind, placebo-controlled pilot trial","volume":"22","author":"Curry","year":"2018","journal-title":"Crit Care"},{"key":"10.51893\/2021.1.OA3_bb0165","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/vox.12417","article-title":"Cryoprecipitate AHF vs. fibrinogen concentrates for fibrinogen replacement in acquired bleeding patients \u2014 an economic evaluation","volume":"111","author":"Okerberg","year":"2016","journal-title":"Vox Sang"},{"key":"10.51893\/2021.1.OA3_bb0170","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1186\/s13063-017-1980-x","article-title":"Fibrinogen Early In Severe Trauma studY (FEISTY): study protocol for a randomised controlled trial","volume":"18","author":"Winearls","year":"2017","journal-title":"Trials"},{"issue":"Suppl 1","key":"10.51893\/2021.1.OA3_bb0175","first-page":"S33","article-title":"Multicenter validation of a simplified score to predict massive transfusion in trauma","volume":"69","author":"Cotton","year":"2010","journal-title":"J Trauma"},{"key":"10.51893\/2021.1.OA3_bb0180","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1001\/jama.2015.12","article-title":"Transfusion of plasma, platelets, and red blood cells in a 1: 1: 1 vs a 1: 1: 2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial","volume":"313","author":"Holcomb","year":"2015","journal-title":"JAMA"},{"key":"10.51893\/2021.1.OA3_bb0185","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1097\/SLA.0000000000002825","article-title":"Data-driven development of ROTEM and TEG algorithms for the management of trauma hemorrhage: a prospective observational multicenter study","volume":"270","author":"Baksaas-Aasen","year":"2019","journal-title":"Ann Surg"},{"key":"10.51893\/2021.1.OA3_bb0190","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1213\/ANE.0000000000001516","article-title":"Targeted coagulation management in severe trauma: the controversies and the evidence","volume":"123","author":"Winearls","year":"2016","journal-title":"Anesth Analg"},{"key":"10.51893\/2021.1.OA3_bb0195","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/jth.14378","article-title":"Towards patient-specific management of trauma hemorrhage: the effect of resuscitation therapy on parameters of thromboelastometry","volume":"17","author":"Juffermans","year":"2019","journal-title":"J Thromb Haemost"},{"key":"10.51893\/2021.1.OA3_bb0200","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1016\/j.injury.2020.05.044","article-title":"Targeted cryoprecipitate transfusion in severe traumatic haemorrhage","volume":"51","author":"Ho","year":"2020","journal-title":"Injury"},{"key":"10.51893\/2021.1.OA3_bb0205","first-page":"171","article-title":"Targeted fibrinogen concentrate use in severe traumatic haemorrhage","volume":"21","author":"Seebold","year":"2019","journal-title":"Crit Care Resusc"},{"key":"10.51893\/2021.1.OA3_bb0210","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1093\/bja\/aeq058","article-title":"Recovery of fibrinogen after administration of fibrinogen concentrate to patients with severe bleeding after cardiopulmonary bypass surgery","volume":"104","author":"Solomon","year":"2010","journal-title":"Br J Anaesth"},{"key":"10.51893\/2021.1.OA3_bb0215","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1423-0410.2007.01024.x","article-title":"Efficacy and tolerability of human fibrinogen concentrate administration to patients with acquired fibrinogen deficiency and active or in high-risk severe bleeding","volume":"94","author":"Danes","year":"2008","journal-title":"Vox Sang"},{"key":"10.51893\/2021.1.OA3_bb0220","unstructured":"ICH Expert Working Group. ICH harmonised guideline: addendum on estimands and sensitivity analysis in clinical trials to the guideline on statistical principles for clinical trials E9(R1). https:\/\/database.ich.org\/sites\/default\/files\/E9-R1_Step4_Guideline_2019_1203.pdf (viewed May 2020)."},{"key":"10.51893\/2021.1.OA3_bb0225","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1093\/aje\/kwf215","article-title":"Statistical analysis of correlated data using generalized estimating equations: an orientation","volume":"157","author":"Hanley","year":"2003","journal-title":"Am J Epidemiol"},{"key":"10.51893\/2021.1.OA3_bb0230","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/voxs.12376","article-title":"Do we need cryoprecipitate in the era of fibrinogen concentrate and other specific factor replacement options?","volume":"13","author":"Wong","year":"2018","journal-title":"ISBT Sci Ser"},{"key":"10.51893\/2021.1.OA3_bb0235","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1309\/AJCPH16YXJEFSHEO","article-title":"Frequency and characteristics of coagulopathy in trauma patients treated with a low- or high-plasma-content massive transfusion protocol","volume":"136","author":"Chambers","year":"2011","journal-title":"Am J Clin Pathol"},{"issue":"1 Suppl 1","key":"10.51893\/2021.1.OA3_bb0240","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1097\/TA.0b013e31828fa3ed","article-title":"Cryoprecipitate use in the PROMMTT study","volume":"75","author":"Holcomb","year":"2013","journal-title":"J Trauma Acute Care Surg"},{"key":"10.51893\/2021.1.OA3_bb0245","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/bjs.10052","article-title":"Mortality from trauma haemorrhage and opportunities for improvement in transfusion practice","volume":"103","author":"Stanworth","year":"2016","journal-title":"Br J Surg"},{"key":"10.51893\/2021.1.OA3_bb0250","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.jss.2014.01.055","article-title":"In vitro efficacy of RiaSTAP after rapid reconstitution","volume":"190","author":"Karri","year":"2014","journal-title":"J Surg Res"},{"key":"10.51893\/2021.1.OA3_bb0255","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1186\/s13054-014-0518-9","article-title":"Effect of thromboelastography (TEG(R)) and rotational thromboelastometry (ROTEM(R)) on diagnosis of coagulopathy, transfusion guidance and mortality in trauma: descriptive systematic review","volume":"18","author":"Da Luz","year":"2014","journal-title":"Crit Care"},{"key":"10.51893\/2021.1.OA3_bb0260","first-page":"CD010438","article-title":"Thromboelastography (TEG) and rotational thromboelastometry (ROTEM) for trauma induced coagulopathy in adult trauma patients with bleeding","volume":"2","author":"Hunt","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"10.51893\/2021.1.OA3_bb0265","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1097\/SLA.0000000000001608","article-title":"Goal-directed hemostatic resuscitation of trauma-induced coagulopathy: a pragmatic randomized clinical trial comparing a viscoelastic assay to conventional coagulation assays","volume":"263","author":"Gonzalez","year":"2016","journal-title":"Ann Surg"},{"key":"10.51893\/2021.1.OA3_bb0270","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1186\/s13063-017-2224-9","article-title":"iTACTIC \u2014 implementing treatment algorithms for the correction of trauma-induced coagulopathy: study protocol for a multicentre, randomised controlled trial","volume":"18","author":"Baksaas-Aasen","year":"2017","journal-title":"Trials"},{"key":"10.51893\/2021.1.OA3_bb0275","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1097\/SLA.0b013e3182658180","article-title":"Admission rapid thrombelastography can replace conventional coagulation tests in the emergency department: experience with 1974 consecutive trauma patients","volume":"256","author":"Holcomb","year":"2012","journal-title":"Ann Surg"},{"key":"10.51893\/2021.1.OA3_bb0280","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s13054-015-0823-y","article-title":"Detection of acute traumatic coagulopathy and massive transfusion requirements by means of rotational thromboelastometry: an international prospective validation study","volume":"19","author":"Hagemo","year":"2015","journal-title":"Crit Care"},{"key":"10.51893\/2021.1.OA3_bb0285","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.jss.2014.11.021","article-title":"Fibrinogen in trauma, an evaluation of thrombelastography and rotational thromboelastometry fibrinogen assays","volume":"194","author":"Meyer","year":"2015","journal-title":"J Surg Res"},{"key":"10.51893\/2021.1.OA3_bb0290","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1097\/TA.0000000000000134","article-title":"Thrombelastography and rotational thromboelastometry early amplitudes in 182 trauma patients with clinical suspicion of severe injury","volume":"76","author":"Meyer","year":"2014","journal-title":"J Trauma Acute Care Surg"},{"key":"10.51893\/2021.1.OA3_bb0295","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1093\/bja\/aeu444","article-title":"Pre-emptive treatment with fibrinogen concentrate for postpartum haemorrhage: randomized controlled trial","volume":"114","author":"Wikkelso","year":"2015","journal-title":"Br J Anaesth"},{"key":"10.51893\/2021.1.OA3_bb0300","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/bja\/aew169","article-title":"Randomized evaluation of fibrinogen vs placebo in complex cardiovascular surgery (REPLACE): a double-blind phase III study of haemostatic therapy","volume":"117","author":"Rahe-Meyer","year":"2016","journal-title":"Br J Anaesth"},{"key":"10.51893\/2021.1.OA3_bb0305","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.taap.2014.07.019","article-title":"Analysis of the safety and pharmacodynamics of human fibrinogen concentrate in animals","volume":"280","author":"Beyerle","year":"2014","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.51893\/2021.1.OA3_bb0310","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1160\/TH14-06-0514","article-title":"Safety of fibrinogen concentrate: analysis of more than 27 years of pharmacovigilance data","volume":"113","author":"Solomon","year":"2015","journal-title":"Thromb Haemost"},{"key":"10.51893\/2021.1.OA3_bb0315","doi-asserted-by":"crossref","first-page":"R55","DOI":"10.1186\/cc8948","article-title":"Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM)-guided administration of fibrinogen concentrate and prothrombin complex concentrate","volume":"14","author":"Schochl","year":"2010","journal-title":"Crit Care"},{"key":"10.51893\/2021.1.OA3_bb0320","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.tmrv.2013.01.002","article-title":"Use of prothrombin complex concentrates and fibrinogen concentrates in the perioperative setting: a systematic review","volume":"27","author":"Lin","year":"2013","journal-title":"Transfus Med Rev"},{"key":"10.51893\/2021.1.OA3_bb0325","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13049-016-0221-8","article-title":"Fibrinogen levels in trauma patients during the first seven days after fibrinogen concentrate therapy: a retrospective study","volume":"24","author":"Schlimp","year":"2016","journal-title":"Scand J Trauma Resusc Emerg Med"},{"key":"10.51893\/2021.1.OA3_bb0330","article-title":"CONSORT 2010 statement: extension to randomised pilot and feasibility trials","volume":"355","author":"Eldridge","year":"2016","journal-title":"BMJ"},{"key":"10.51893\/2021.1.OA3_bb0335","doi-asserted-by":"crossref","first-page":"R83","DOI":"10.1186\/cc10078","article-title":"Transfusion in trauma: thromboelastometry-guided coagulation factor concentrate-based therapy versus standard fresh frozen plasma-based therapy","volume":"15","author":"Schochl","year":"2011","journal-title":"Crit Care"},{"key":"10.51893\/2021.1.OA3_bb0340","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1093\/bja\/aen270","article-title":"Fibrinogen concentrate substitution therapy in patients with massive haemorrhage and low plasma fibrinogen concentrations","volume":"101","author":"Fenger-Eriksen","year":"2008","journal-title":"Br J Anaesth"},{"key":"10.51893\/2021.1.OA3_bb0345","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1111\/aas.12734","article-title":"Comparing efficacy and safety of fibrinogen concentrate to cryoprecipitate in bleeding patients: a systematic review","volume":"60","author":"Jensen","year":"2016","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.51893\/2021.1.OA3_bb0350","doi-asserted-by":"crossref","first-page":"R92","DOI":"10.1186\/cc10096","article-title":"The acute management of trauma hemorrhage: a systematic review of randomized controlled trials","volume":"15","author":"Curry","year":"2011","journal-title":"Crit Care"},{"key":"10.51893\/2021.1.OA3_bb0355","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1186\/cc10510","article-title":"The desperate need for good-quality clinical trials to evaluate the optimal source and dose of fibrinogen in managing bleeding","volume":"15","author":"Stanworth","year":"2011","journal-title":"Crit Care"},{"key":"10.51893\/2021.1.OA3_bb0360","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.injury.2016.12.012","article-title":"Fibrinogen in traumatic haemorrhage: a narrative review","volume":"48","author":"Winearls","year":"2017","journal-title":"Injury"}],"container-title":["Critical Care and Resuscitation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1441277223002879?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1441277223002879?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T11:20:50Z","timestamp":1699269650000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1441277223002879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":72,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["S1441277223002879"],"URL":"https:\/\/doi.org\/10.51893\/2021.1.oa3","relation":{},"ISSN":["1441-2772"],"issn-type":[{"value":"1441-2772","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fibrinogen Early In Severe Trauma studY (FEISTY): results from an Australian multicentre randomised controlled pilot trial","name":"articletitle","label":"Article Title"},{"value":"Critical Care and Resuscitation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.51893\/2021.1.OA3","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2021 College of Intensive Care Medicine of Australia and New Zealand.","name":"copyright","label":"Copyright"}]}}