{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T17:10:04Z","timestamp":1750093804764,"version":"3.41.0"},"reference-count":22,"publisher":"Michigan State University College of Osteopathic Medicine Statewide Campus System","issue":"3","license":[{"start":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T00:00:00Z","timestamp":1551657600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec id=\"introduction-to-the-topic\"> <jats:title>INTRODUCTION TO THE TOPIC<\/jats:title> <jats:p>Inverted papilloma is a rare condition of the middle ear. In this paper, the authors present a case report of a patient at a Midwestern health system with inverted papilloma. To supplement the case report, a literature review was also performed to identify clinical trends predisposing such cases to recurrence, malignant transformation, and response to radiation. In addition, the authors also propose a surveillance algorithm derived from this case and previously published surveillance strategies.<\/jats:p> <\/jats:sec> <jats:sec id=\"case-report\"> <jats:title>CASE REPORT<\/jats:title> <jats:p>The authors present a rare case of inverted papilloma of the middle ear. To the authors\u2019 knowledge, this is the youngest case presentation (mid-teenage years) of this condition to have been reported in the literature. The patient underwent surgical excision, had recurrence, and has been disease free since revision surgery.<\/jats:p> <\/jats:sec> <jats:sec id=\"summary-of-the-evidence\"> <jats:title>SUMMARY OF THE EVIDENCE<\/jats:title> <jats:p>Our literature review identified 25 cases previously published with ours being the 26th. An inadequate number of cases exist to abstract statically relevant clinical trends in presentation and tumor behavior. Additionally, no tumor characteristics have been identified that predispose tumors to future malignant transformation. No assessments can be made regarding the benefits of radiation therapy. Most cases to date have been surveyed with a combination of CT, MRI, and clinical follow-up.<\/jats:p> <\/jats:sec> <jats:sec id=\"conclusions\"> <jats:title>CONCLUSIONS<\/jats:title> <jats:p>Inverted papillomas of the middle ear space are rare. Although this case report adds to the literature, additional cases are needed to draw statistically relevant clinical characteristics and responses to medical and surgical therapy.<\/jats:p> <\/jats:sec>","DOI":"10.51894\/001c.7406","type":"journal-article","created":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T19:47:07Z","timestamp":1613418427000},"source":"Crossref","is-referenced-by-count":0,"title":["Inverted Papilloma of the Middle Ear and Mastoid Cavity: A Case Report, Literature Review, And Surveillance Proposal"],"prefix":"10.51894","volume":"3","author":[{"given":"Christopher M.","family":"Metz","sequence":"first","affiliation":[{"name":"St John Providence Health System, Madison Heights, Michigan; St. John Providence Otolaryngology Division, Novi, MI","department":["Osteopathic Division;"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert T.","family":"Standring","sequence":"additional","affiliation":[{"name":"St. John Providence Otolaryngology Division, Novi, MI; Ear Nose and Throat Consultants, Southfield MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seilesh C.","family":"Babu","sequence":"additional","affiliation":[{"name":"St. John Providence Otolaryngology Division, Novi, MI; Michigan Ear Institute, Farmington Hills, MI; Wayne State University, Detroit, MI; St John Providence Health System, Novi, Michigan; Oakland University William Beaumont School of Medicine, Rochester, Michigan","department":["Department of Otolaryngology\u2013Head and Neck Surgery; Neurotology Division; Department of Surgery"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian E.","family":"Keller","sequence":"additional","affiliation":[{"name":"Henry Ford Hospital, Detroit, MI","department":["Department of Pathology"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"29343","published-online":{"date-parts":[[2019,3,4]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1097\/MAO.0b013e3181d2f07e","article-title":"Inverted papilloma of the middle ear","volume":"32","author":"R. 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