{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T22:00:11Z","timestamp":1740175211802,"version":"3.37.3"},"reference-count":65,"publisher":"Copernicus GmbH","issue":"1","license":[{"start":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T00:00:00Z","timestamp":1559692800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004413","name":"International Foundation for Science","doi-asserted-by":"publisher","award":["I1B\/4718-1"],"award-info":[{"award-number":["I1B\/4718-1"]}],"id":[{"id":"10.13039\/100004413","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch. Anim. Breed."],"abstract":"<jats:p>Abstract. A total of 184 Djallonk\u00e9 lambs from Burkina Faso with phenotypes\nfor packed-cell volume (PCV), log-transformed fecal egg count (lnFEC), and\nFAffa MAlan CHArt (FAMACHA\u00a9) eye scores were typed with the OvineSNP50 BeadChip of Illumina to contribute to the knowledge of the genetic basis of\ngastrointestinal (GIN) parasite resistance in sheep. Association analysis\nidentified a total of 22 single-nucleotide polymorphisms (SNPs) related with PCV (6 SNPs), lnFEC (7), and FAMACHA\nscores (9) distributed among 14 Ovis aries chromosomes (OAR). The identified SNPs\naccounted for 18.76\u2009% of the phenotypic variance for PCV, 21.24\u2009% for\nlnFEC, and 34.38\u2009% for FAMACHA scores. Analyses pointed out the importance\nof OAR2 for PCV, OAR3 for FAMACHA scores, and OAR6 for lnFEC. The 125\u2009kb\nregions surrounding the identified SNPs overlapped with seven previously\nreported quantitative trait loci (QTLs) for the traits analyzed in the current work. The only\nchromosome harboring markers associated with the three traits studied was\nOAR2. In agreement with the literature, two different chromosomal areas on\nOAR2 can play a major role in the traits studied. Gene-annotation enrichment\nanalysis allowed us to identify a total of 34 potential candidate genes for PCV\n(6 genes), lnFEC (4), and FAMACHA scores (24). Annotation analysis allowed us to\nidentify one functional term cluster with a significant enrichment score\n(1.302). The cluster included five genes (TRIB3, CDK4, CSNK2A1, MARK1, and SPATA5) involved in\nimmunity-related and cell-proliferation processes. Furthermore, this\nresearch suggests that the MBL2 gene can underlie a previously reported QTL for\nimmunoglobulin A levels on OAR22 and confirms the importance of genes\ninvolved in growth and size (such as the ADAMTS17 gene on OAR18) for GIN resistance\ntraits. Since association studies for the ascertainment of the genetic basis\nof GIN resistance may be affected by genotype\u2013environment interactions,\nobtaining information from local sheep populations managed in harsh\nenvironments contributes to the identification of novel genomic areas of\nfunctional importance for GIN resistance for that trait.\n                    <\/jats:p>","DOI":"10.5194\/aab-62-313-2019","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T12:33:26Z","timestamp":1559738006000},"page":"313-323","source":"Crossref","is-referenced-by-count":12,"title":["Identification of genomic regions and candidate genes of functional importance for gastrointestinal parasite resistance traits in Djallonk\u00e9 sheep of Burkina Faso"],"prefix":"10.5194","volume":"62","author":[{"given":"Isabel","family":"\u00c1lvarez","sequence":"first","affiliation":[]},{"given":"Iv\u00e1n","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[]},{"given":"Albert","family":"Soudr\u00e9","sequence":"additional","affiliation":[]},{"given":"Amadou","family":"Traor\u00e9","sequence":"additional","affiliation":[]},{"given":"Luc\u00eda","family":"P\u00e9rez-Pardal","sequence":"additional","affiliation":[]},{"given":"Moumouni","family":"Sanou","sequence":"additional","affiliation":[]},{"given":"Stephane A. R.","family":"Tapsoba","sequence":"additional","affiliation":[]},{"given":"Nuria A.","family":"Men\u00e9ndez-Arias","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6872-1045","authenticated-orcid":false,"given":"F\u00e9lix","family":"Goyache","sequence":"additional","affiliation":[]}],"member":"3145","published-online":{"date-parts":[[2019,6,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Alexander, D. H. and Lange, K.: Enhancements to the ADMIXTURE algorithm for\nindividual ancestry estimation, BMC Bioinform., 12, 1471\u20132105, https:\/\/doi.org\/10.1186\/1471-2105-12-246, 2011.","DOI":"10.1186\/1471-2105-12-246"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Altorjay, I., Vitalis, Z., Tornai, I., Palatka, K., Kacska, S., Farkas, G.,\nUdvardy, M., Harsfalvi, J., Dinya, T., Orosz, P., Lombay, B., Par, G., Par,\nA., Csak, T., Osztovits, J., Szalay, F., Csepregi, A., Lakatos, P. 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