{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T05:18:51Z","timestamp":1648617531328},"reference-count":0,"publisher":"University Library System, University of Pittsburgh","license":[{"start":{"date-parts":[[2014,3,27]],"date-time":"2014-03-27T00:00:00Z","timestamp":1395878400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/us\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["cajgh"],"abstract":"<jats:p>Introduction: APP\/PS1 double-transgenic mouse models of Alzheimer\u2019s disease (AD), which overexpress mutated forms of the gene for the human amyloid precursor protein (APP) and presenilin 1 (PS1), have provided robust neuropathological hallmarks of an AD-like pattern at early ages. This study aimed to characterize immunocytochemical patterns of the AD mouse brain, which is treated with the EB101 vaccine, as a model for human AD.Material and methods: In this novel vaccine, a new approach has been taken to circumvent past failures with A\u03b2 vaccines by judiciously selecting an adjuvant consisting of a physiological matrix embedded in liposomes, composed of naturally occurring phospholipids (phosphatidylcholine, phosphatidylglycerol, and cholesterol).Results: Our findings showed that the administration of amyloid-\u03b21\u221242 (A\u03b2) and sphingosine-1-phosphate emulsified in liposome complex (EB101) to APP\/PS1 mice before the onset of A\u03b2 brain deposition (at 7 weeks of age) and\/or at an older age (35 weeks of age) can be effective in both halting the progression and clearing the AD-like neuropathological hallmarks. In addition, passive immunization with EB101 did not activate inflammatory responses from the immune system and astrocytes. Consistent with a decreased inflammatory background, the basal immunological interaction between the T cells and the affected areas (hippocampus) in the brain of treated mice was notably reduced.Conclusion: These results provide strong evidence that immunization with the EB101 vaccine prevents and attenuates AD neuropathology in this type of double-transgenic mice.<\/jats:p>","DOI":"10.5195\/cajgh.2013.119","type":"journal-article","created":{"date-parts":[[2014,3,27]],"date-time":"2014-03-27T14:34:08Z","timestamp":1395930848000},"source":"Crossref","is-referenced-by-count":1,"title":["Immunocytochemical Characterization of Alzheimer\u2019s Disease Hallmarks in APP\/PS1 Transgenic Mice Treated with a New Anti-Amyloid-&amp;#946; Vaccine"],"prefix":"10.5195","volume":"2","author":[{"given":"Ivan","family":"Carrera","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Etcheverria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Fernandez-Novoa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valter","family":"Lombardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Vigo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hector H.","family":"Palacios","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valery V.","family":"Benberin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramon","family":"Cacabelos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gjumrakch","family":"Aliev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3176","published-online":{"date-parts":[[2014,3,27]]},"container-title":["Central Asian Journal of Global Health"],"original-title":[],"link":[{"URL":"http:\/\/cajgh.pitt.edu\/ojs\/cajgh\/article\/download\/119\/147","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/cajgh.pitt.edu\/ojs\/cajgh\/article\/download\/119\/147","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T15:26:00Z","timestamp":1620919560000},"score":1,"resource":{"primary":{"URL":"http:\/\/cajgh.pitt.edu\/ojs\/cajgh\/article\/view\/119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,27]]},"references-count":0,"URL":"https:\/\/doi.org\/10.5195\/cajgh.2013.119","relation":{},"ISSN":["2166-7403"],"issn-type":[{"value":"2166-7403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,27]]}}}