{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T23:47:27Z","timestamp":1762300047728,"version":"3.37.0"},"reference-count":13,"publisher":"Galenos Yayinevi","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Facts Views Vis ObGyn"],"published-print":{"date-parts":[[2022,3,31]]},"abstract":"<jats:p>It is known that Clomiphene citrate (CC) reduces endometrial thickness, but it is unknown if additional gonadotrophin stimulation increases endometrial thickness and if this has an effect on implantation rate in in vitro fertilization (IVF).\n\nThe retrospective study included 263 minimal stimulation IVF-cycles stimulated with 25 mg CC per day (CC- IVF), and 161 IVF-cycles stimulated with CC plus 75IU hMG (human Menopausal Gonadotrophin) per day (CC\/ hMG-IVF). Endometrial and oestradiol (E2) measurements were analysed between day -4 and 0 (0 = day of oocyte retrieval) and the association of endometrial thickness and treatment on implantation rates were studied after multiple adjustments.\n\nIt was shown that on day 0, endometrium was significantly thicker in CC\/hMG-IVF versus CC-IVF cycles (9.81 \u00b12.68 versus 9.06 \u00b12.54 mm, p = 0.005). However, increased endometrial thickness did not have an effect on implantation and live birth rates.\n\nIn conclusion, gonadotrophins should not be added to low dose CC treated IVF cycles just to increase endometrial thickness as increased endometrial thickness does not increase implantation rate.<\/jats:p>","DOI":"10.52054\/fvvo.14.1.013","type":"journal-article","created":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T13:58:34Z","timestamp":1649080714000},"page":"77-81","source":"Crossref","is-referenced-by-count":7,"title":["Clomiphene citrate stimulated cycles \u2013 additional gonadotrophin stimulation increases endometrium thickness without increasing implantation rate"],"prefix":"10.52054","volume":"14","author":[{"given":"I","family":"Magaton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Helmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Roumet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Stute","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Von Wolff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2811","published-online":{"date-parts":[[2022,4]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Abe T, Yabuuchi A, Ezoe Ket al. Success rates in minimal stimulation cycle IVF with clomiphene citrate only. J Assist Reprod Genet. 2020;37:297\u2013304.","DOI":"10.1007\/s10815-019-01662-z"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Dehbashi S, Parsanezhad ME, Alborzi S et al. Effect of clomiphene citrate on endometrium thickness and echogenic patterns. Int J Gynecol Obstet. 2003;80:49-53.","DOI":"10.1016\/s0020-7292(02)00341-7"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Gerli S, Gholami H, Manna A et al. Use of ethinyl estradiol to reverse the antiestrogenic effects of clomiphene citrate in patients undergoing intrauterine insemination: A comparative, randomized study. Fertil Steril. 2000;73:85\u20139.","DOI":"10.1016\/s0015-0282(99)00447-1"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Gonen Y, Casper RF. Sonographic determination of a possible adverse effect of domiphene citrate on endometrial growth. Hum Reprod.1990;5:670-4.","DOI":"10.1093\/oxfordjournals.humrep.a137165"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Gonen Y, Casper RF, Jacobson W et al. Endometrial thickness and growth during ovarian stimulation: A possible predictor of implantation in in vitro fertilization. Fertil Steril. 1989;52:446\u201350.","DOI":"10.1016\/s0015-0282(16)60916-0"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Imoedemhe DAG, Shaw RW, Kirkland A et al. Ultrasound measurement of endometrial thickness on different ovarian stimulation regimens during in-vitro fertilization. Hum Reprod. 1987;2:545\u20137.","DOI":"10.1093\/oxfordjournals.humrep.a136586"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Kasius A, Smit JG, Torrance HL et al. Endometrial thickness and pregnancy rates after IVF: A systematic review and meta-analysis. Hum Reprod Update. 2014;20:530\u201341.","DOI":"10.1093\/humupd\/dmu011"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Kohl Schwartz AS, Calzaferri I, Roumet M et al. Follicular flushing leads to higher oocyte yield in monofollicular IVF: a randomized controlled trial. Hum Reprod. 2020;35:2253\u201361.","DOI":"10.1093\/humrep\/deaa165"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Ronnberg L, Isotalo H, Kauppila A et al. Clomiphene-Induced Changes in Endometrial Receptor Kinetics on the Day of Ovum Collection after Ovarian Stimulation: A Study on Cytosol and Nuclear Estrogen and Progestin Receptors and 17B-Hydroxysteroid Dehydrogenase. Report. 1985;408-15.","DOI":"10.1111\/j.1749-6632.1985.tb37547.x"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Satirapod C, Wingprawat S, Jultanmas R et al. Effect of estradiol valerate on endometrium thickness during clomiphene citrate-stimulated ovulation. J Obstet Gynaecol Res. 2013;40:96-101.","DOI":"10.1111\/jog.12130"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Teramoto S, Kato O. Minimal ovarian stimulation with clomiphene citrate: A large-scale retrospective study. Reprod Biomed Online. 2007;15:134\u201348.","DOI":"10.1016\/s1472-6483(10)60701-8"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Von Wolff M. The role of Natural Cycle IVF in assisted reproduction. Best Pract Res Clin Endocrinol Metab. 2019;33:35-45.","DOI":"10.1016\/j.beem.2018.10.005"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"Von Wolff M, Nitzschke M, Stute P et al. Low-dosage clomiphene reduces premature ovulation rates and increases transfer rates in natural-cycle IVF. Reprod Biomed Online. 2014;29:209\u201315.","DOI":"10.1016\/j.rbmo.2014.04.013"}],"container-title":["Facts, Views and Vision in ObGyn"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T05:55:28Z","timestamp":1739512528000},"score":1,"resource":{"primary":{"URL":"https:\/\/fvvo.eu\/articles\/doi\/FVVO.14.1.013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,31]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,4]]},"published-print":{"date-parts":[[2022,3]]}},"URL":"https:\/\/doi.org\/10.52054\/fvvo.14.1.013","relation":{},"ISSN":["2684-4230","2032-0418"],"issn-type":[{"type":"electronic","value":"2684-4230"},{"type":"print","value":"2032-0418"}],"subject":[],"published":{"date-parts":[[2022,3,31]]}}}