{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T13:07:43Z","timestamp":1775480863095,"version":"3.50.1"},"reference-count":85,"publisher":"Journal of Sports Science and Medicine","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["jsportscimed"],"abstract":"<jats:p>This study aimed to examine the effects of aerobic and strength training methodologies, either combined with or without cognitive training, on mitigating cognitive decline. A total of 154 subjects were recruited (72.8 \u00b1 6.1 years, 69% females) and were divided into four groups: i) strength plus cognitive training (STCT, n = 56); ii) strength training (ST, n = 23); iii) aerobic training (AT, n = 41); and iv) aerobic plus cognitive training (ATCT, n = 34). Subjects were previously cognitively assessed and showed cognitive decline (less than 26 points on the Montreal Cognitive Assessment, MoCA). For 12 weeks, all groups performed 3 times a week, for 60 minutes, a training program corresponding to their attributed group. The MoCA test and the Senior Fitness test were applied at the beginning and the end of the intervention. A repeated-measures ANCOVA revealed significant time-by-group interactions for physical performance measures, including the 2-minute step-in-place (p = 0.026), arm curl (p &lt; 0.001), chair sit-and-reach (p &lt; 0.001), back-scratch (p &lt; 0.001), 8-foot up-and-go (p &lt; 0.001), and 6-minute walk tests (p &lt; 0.001). However, no significant improvements were observed for cognitive function (MoCA, p = 0.242) or lower body strength (chair stand, p = 0.411). The AT group showed greater improvements in upper body strength compared to STCT and ST (p &lt; 0.001; d = 0.698; p = 0.004; d = 0.598), while STCT significantly improved flexibility compared to ATCT (p &lt; 0.001; d = 1.049). ATCT had the greatest improvements in aerobic endurance compared to STCT and ST (p = 0.004; d = 0.133; p &lt; 0.001; d = 0.350). It was demonstrated that aerobic and strength training significantly improved overall physical performance in elderly individuals. However, no significant effects were observed on cognitive performance. Although these findings suggest that both aerobic and strength exercise, with or without cognitive training, improve overall physical fitness, further research is needed to determine its impact on cognitive performance.<\/jats:p>","DOI":"10.52082\/jssm.2025.172","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T07:23:30Z","timestamp":1740381810000},"page":"172-186","source":"Crossref","is-referenced-by-count":4,"title":["The Effect of Aerobic or Strength Training in Elderly with Cognitive Decline: The Fit4Alz Project"],"prefix":"10.52082","author":[{"given":"Ana Filipa","family":"Silva","sequence":"first","affiliation":[]},{"given":"Filipe Manuel","family":"Clemente","sequence":"additional","affiliation":[]},{"given":"Mafalda Sofia","family":"Roriz","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9 Alberto","family":"Azevedo","sequence":"additional","affiliation":[]},{"given":"Olivera","family":"Jovanovic","sequence":"additional","affiliation":[]},{"given":"Marko","family":"Adamovic","sequence":"additional","affiliation":[]},{"given":"Aleksandar","family":"Bozic","sequence":"additional","affiliation":[]},{"given":"Rui","family":"Silva","sequence":"additional","affiliation":[]}],"member":"29163","published-online":{"date-parts":[[2025,3,1]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Afonso J., Ramirez-Campillo R., Mosc\u00e3o J., Rocha T., Zacca R., Martins A., Milheiro A. A., Ferreira J., Sarmento H., Clemente F. M. (2021) Strength Training versus Stretching for Improving Range of Motion: A Systematic Review and Meta-Analysis. Healthcare 9, 427.  Crossref","DOI":"10.3390\/healthcare9040427"},{"key":"ref1","unstructured":"Journal of Sports Science and Medicine Alzheimer's Disease International and World Health Organization, (2012) Dementia: a public health priority. Geneva: World Health Organization. Available form URL: http:\/\/www.who.int\/mental_health\/publications\/dementia_report_2012\/en\/, accessed 8 March 2017."},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Journal of Sports Science and Medicine Alzheimer\u2019s Association (2015) Alzheimer\u2019s disease facts and figures. Dementia Journal of Alzheimer\u2019s Association 11, 332.  Crossref","DOI":"10.1016\/j.jalz.2015.02.003"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine An J., Su Z., Meng S. (2024) Effect of aerobic training versus resistance training for improving cardiorespiratory fitness and body composition in middle-aged to older adults: A systematic review and meta-analysis of randomized controlled trials. Archives of Gerontology and Geriatrics 126, 105530.  Crossref","DOI":"10.1016\/j.archger.2024.105530"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Anderson N.D. (2019) State of the science on mild cognitive impairment (MCI). CNS Spectrums 24, 78-87.  Crossref","DOI":"10.1017\/s1092852918001347"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Bai X., Soh K.G., Omar Dev R.D., Talib O., Xiao W., Soh K.L., Ong S. L., Zhao C., Galeru O., Casaru C. (2021) Aerobic Exercise Combination Intervention to Improve Physical Performance Among the Elderly: A Systematic Review. Frontiers in Physiology 12, 798068.  Crossref","DOI":"10.3389\/fphys.2021.798068"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Barha C.K., Hsiung G.-Y.R., Best J.R., Davis J.C., Eng J.J., Jacova C., Lee P. E., Munkacsy M., Winnie C., Liu-Ambrose T. (2017) Sex Difference in Aerobic Exercise Efficacy to Improve Cognition in Older Adults with Vascular Cognitive Impairment: Secondary Analysis of a Randomized Controlled Trial. Journal of Alzheimer\u2019s Disease 60, 1397-1410.  Crossref","DOI":"10.3233\/jad-170221"},{"key":"ref7","unstructured":"Journal of Sports Science and Medicine Borg, G. (1998) Perceive Exertion and Pain Scales. Champaign Il, USA: Human Kinetics."},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Bossers W.J.R., van der Woude L.H.V., Boersma F., Hortob\u00e1gyi T., Scherder E.J.A., van Heuvelen M.J.G. (2015) A 9-Week Aerobic and Strength Training Program Improves Cognitive and Motor Function in Patients with Dementia: A Randomized, Controlled Trial. The American Journal of Geriatric Psychiatry 23, 1106-1116.  Crossref","DOI":"10.1016\/j.jagp.2014.12.191"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine C\u00e1mara-Calmaestra R., Mart\u00ednez-Amat A., Aibar-Almaz\u00e1n A., Hita-Contreras F., de Miguel Hernando N., Achalandabaso-Ochoa A. (2022) Effectiveness of Physical Exercise on Alzheimer\u2019s disease. A Systematic Review. The Journal of Prevention of Alzheimer\u2019s Disease 9, 601-616.  Crossref","DOI":"10.14283\/jpad.2022.57"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Campbell E.B., Delgadillo M., Lazzeroni L.C., Louras P.N., Myers J., Yesavage J., Kaci Fairchild J. (2023) Cognitive Improvement Following Physical Exercise and Cognitive Training Intervention for Older Adults With MCI. The journals of gerontology. Series A, Biological sciences and medical sciences 78, 554-560.  Crossref","DOI":"10.1093\/gerona\/glac189"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Cass S.P. (2017) Alzheimer\u2019s Disease and Exercise: A Literature Review. Current Sports Medicine Reports 16, 19-22.  Crossref","DOI":"10.1249\/jsr.0000000000000332"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Castellote-Caballero Y., Carcel\u00e9n Fraile M. del C., Aibar-Almaz\u00e1n A., Afanador-Restrepo D.F., Gonz\u00e1lez-Mart\u00edn A.M. (2024) Effect of combined physical-cognitive training on the functional and cognitive capacity of older people with mild cognitive impairment: a randomized controlled trial. BMC Medicine 22, 281.  Crossref","DOI":"10.1186\/s12916-024-03469-x"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Ceballos-Laita L., Lahuerta-Mart\u00edn S., Carrasco-Uribarren A., Cabanillas-Barea S., Hern\u00e1ndez-L\u00e1zaro H., P\u00e9rez-Guill\u00e9n S., Jim\u00e9nez-del-Barrio S. (2023) Strength Training vs. Aerobic Training for Managing Pain and Physical Function in Patients with Knee Osteoarthritis: A Systematic Review and Meta-Analysis. Healthcare 12, 33.  Crossref","DOI":"10.3390\/healthcare12010033"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Journal of Sports Science and Medicine Cendoroglo M.S. (2014) Exercise programs for people with dementia. Sao Paulo medical journal = Revista paulista de medicina 132, 195-196.  Crossref","DOI":"10.1590\/1516-3180.20141323T2"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Chae H.J., Lee S.H. (2023) Effectiveness of online-based cognitive intervention in community-dwelling older adults with cognitive dysfunction: A systematic review and meta-analysis. International Journal of Geriatric Psychiatry 38.  Crossref","DOI":"10.1002\/gps.5853"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Chieffi S., Messina G., Villano I., Messina A., Esposito M., Monda V., Valenzano A., Moscatelli F., Esposito T., Carotenuto M., Viggiano A., Cibelli G., Monda M. (2017) Exercise Influence on Hippocampal Function: Possible Involvement of Orexin-A. Frontiers in Physiology 8.  Crossref","DOI":"10.3389\/fphys.2017.00085"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Colcombe S., Kramer A.F. (2003) Fitness Effects on the Cognitive Function of Older Adults. Psychological Science 14, 125-130.  Crossref","DOI":"10.1111\/1467-9280.t01-1-01430"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Colcombe S.J., Erickson K.I., Scalf P.E., Kim J.S., Prakash R., McAuley E., Elavsky S., Marquez D. X., Hu L., Kramar A. F. (2006) Aerobic Exercise Training Increases Brain Volume in Aging Humans. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 61, 1166-1170.  Crossref","DOI":"10.1093\/gerona\/61.11.1166"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Cooley S.A., Heaps J.M., Bolzenius J.D., Salminen L.E., Baker L.M., Scott S.E., Paul R. H. (2015) Longitudinal Change in Performance on the Montreal Cognitive Assessment in Older Adults. The Clinical neuropsychologist 29, 824-835.  Crossref","DOI":"10.1080\/13854046.2015.1087596"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Deadwyler S.A., Porrino L., Siegel J.M., Hampson R.E. (2007) Systemic and Nasal Delivery of Orexin-A (Hypocretin-1) Reduces the Effects of Sleep Deprivation on Cognitive Performance in Nonhuman Primates. The Journal of Neuroscience 27, 14239-14247.  Crossref","DOI":"10.1523\/jneurosci.3878-07.2007"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Di Lorito C., Long A., Byrne A., Harwood R.H., Gladman J.R.F., Schneider S., Logan P., Bosco A., Wardt V. (2021) Exercise interventions for older adults: A systematic review of meta-analyses. Journal of Sport and Health Science 10, 29-47.  Crossref","DOI":"10.1016\/j.jshs.2020.06.003"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Duchowny K.A., Ackley S.F., Brenowitz W.D., Wang J., Zimmerman S.C., Caunca M.R., Glymour M. M. (2022) Associations Between Handgrip Strength and Dementia Risk, Cognition, and Neuroimaging Outcomes in the UK Biobank Cohort Study. JAMA Network Open 5, e2218314.  Crossref","DOI":"10.1001\/jamanetworkopen.2022.18314"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Erickson K.I., Kramer A.F. (2009) Aerobic exercise effects on cognitive and neural plasticity in older adults. British Journal of Sports Medicine 43, 22-24.  Crossref","DOI":"10.1136\/bjsm.2008.052498"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Erickson K.I., Voss M.W., Prakash R.S., Basak C., Szabo A., Chaddock L., Kim J. S., Heo S., Alves H., Wojcicki T. R., Mailey E., Vieira V. J., Martin S. A., Pence B. D., Woods J. A., McAuley E., Kramer A. F. (2011) Exercise training increases size of hippocampus and improves memory. Proceedings of the National Academy of Sciences 108, 3017-3022.  Crossref","DOI":"10.1073\/pnas.1015950108"},{"key":"ref25","unstructured":"Journal of Sports Science and Medicine European Union, (2025) Ageing Europe - statistics on population developments. https:\/\/ec.europa.eu\/eurostat\/statistics-explained\/index.php?title=Ageing_Europe_-_statistics_on_population_developments."},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Faul F., Erdfelder E., Lang A., Buchner A. (2007) G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behavior Research Methods 39, 175-191.  Crossref","DOI":"10.3758\/bf03193146"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Fernandes R.M., Correa M.G., dos Santos M.A.R., Almeida A.P.C.P.S.C., Fagundes N.C.F., Maia L.C., Lima R. R. (2018) The Effects of Moderate Physical Exercise on Adult Cognition: A Systematic Review. Frontiers in Physiology 9.  Crossref","DOI":"10.3389\/fphys.2018.00667"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Flicker L., Almeida O.P., Acres J., Le M.T., Tuohy R.J., Jamrozik K., Hankey G., Norman P. (2005) Predictors of impaired cognitive function in men over the age of 80 years: results from the Health in Men Study. Age Ageing 34, 77-80.  Crossref","DOI":"10.1093\/ageing\/afh235"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Foster C., Florhaug J.A., Franklin J., Gottschall L., Hrovatin L.A., Parker S., Doleshal P., Dodge C. (2001) A new approach to monitoring exercise training. Journal of Strength and Conditioning Research 15, 109-115.  Crossref","DOI":"10.1519\/00124278-200102000-00019"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Freitas S., Sim\u00f5es M.R., Mar\u00f4co J., Alves L., Santana I. (2012) Construct Validity of the Montreal Cognitive Assessment (MoCA). Journal of the International Neuropsychological Society 18, 242-250.  Crossref","DOI":"10.1017\/s1355617711001573"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Ghai S., Ghai I., Effenberg A.O. (2017) Effects of dual tasks and dual-task training on postural stability: a systematic review and meta-analysis. Clinical Interventions in Aging 12, 557-577.  Crossref","DOI":"10.2147\/cia.s125201"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Gordon B.A., Rykhlevskaia E.I., Brumback C.R., Lee Y., Elavsky S., Konopack J.F., McAuley E., Kramer A. F., Colombe S., Gratton G., Fabiani M. (2008) Neuroanatomical correlates of aging, cardiopulmonary fitness level, and education. Psychophysiology 45, 825-838.  Crossref","DOI":"10.1111\/j.1469-8986.2008.00676.x"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Hamer M., Chida Y. (2009) Physical activity and risk of neurodegenerative disease: a systematic review of prospective evidence. Psychological Medicine 39, 3-11.  Crossref","DOI":"10.1017\/s0033291708003681"},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Hoogendam Y.Y., Hofman A., van der Geest J.N., van der Lugt A., Ikram M.A. (2014) Patterns of cognitive function in aging: the Rotterdam Study. European Journal of Epidemiology 29, 133-140.  Crossref","DOI":"10.1007\/s10654-014-9885-4"},{"key":"ref35","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Hopkins W.G., Marshall S.W., Batterham A.M., Hanin J. (2009) Progressive Statistics for Studies in Sports Medicine and Exercise Science. Medicine & Science in Sports & Exercise 41, 3-13.  Crossref","DOI":"10.1249\/mss.0b013e31818cb278"},{"key":"ref36","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Ishigaki E.Y., Ramos L.G., Carvalho E.S., Lunardi A.C. (2014) Effectiveness of muscle strengthening and description of protocols for preventing falls in the elderly: a systematic review. Brazilian Journal of Physical Therapy 18, 111-118.  Crossref","DOI":"10.1590\/s1413-35552012005000148"},{"key":"ref37","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Islam N., Hashem R., Gad M., Brown A., Levis B., Renoux C., Thombs B. D., Mclnnes M. D. F. (2023) Accuracy of the Montreal Cognitive Assessment tool for detecting mild cognitive impairment: A systematic review and meta-analysis. Alzheimer\u2019s & Dementia 19, 3235-3243.  Crossref","DOI":"10.1002\/alz.13040"},{"key":"ref38","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Jacobo S.M.P., Kazlauskas A. (2015) Insulin-like Growth Factor 1 (IGF-1) Stabilizes Nascent Blood Vessels. Journal of Biological Chemistry 290, 6349-6360.  Crossref","DOI":"10.1074\/jbc.m114.634154"},{"key":"ref39","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Jasey N., Ward I. (2019) Neuroplasticity in Brain Injury: Maximizing Recovery. Current Physical Medicine and Rehabilitation Reports 7, 333-340.  Crossref","DOI":"10.1007\/s40141-019-00242-7"},{"key":"ref40","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Kraiwong R., Vongsirinavarat M., Rueankam M., Sumalrot T. (2021) Effects of physical-cognitive training on physical and psychological functions among older adults with type 2 diabetes and balance impairment: a randomized controlled trial. Journal of Exercise Rehabilitation 17, 120-130.  Crossref","DOI":"10.12965\/jer.2142106.053"},{"key":"ref41","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Lam F.M., Huang M.-Z., Liao L.-R., Chung R.C., Kwok T.C., Pang M.Y. (2018) Physical exercise improves strength, balance, mobility, and endurance in people with cognitive impairment and dementia: a systematic review. Journal of Physiotherapy 64, 4-15.  Crossref","DOI":"10.1016\/j.jphys.2017.12.001"},{"key":"ref42","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Lampit A., Hallock H., Valenzuela M. (2014) Computerized cognitive training in cognitively healthy older adults: a systematic review and meta-analysis of effect modifiers. Plos Medicine 11, e1001756.  Crossref","DOI":"10.1371\/journal.pmed.1001756"},{"key":"ref43","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Lee S.J., Baek J.-H., Kim Y.-H. (2015) Brain-derived Neurotrophic Factor Is Associated with Cognitive Impairment in Elderly Korean Individuals. Clinical Psychopharmacology and Neuroscience 13, 283-287.  Crossref","DOI":"10.9758\/cpn.2015.13.3.283"},{"key":"ref44","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Lovell D.I., Cuneo R., Gass G.C. (2010) Can Aerobic Training Improve Muscle Strength and Power in Older Men?. Journal of Aging and Physical Activity 18, 14-26.  Crossref","DOI":"10.1123\/japa.18.1.14"},{"key":"ref45","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine McKhann G.M., Knopman D.S., Chertkow H., Hyman B.T., Jack C.R., Kawas C.H., Klunk W. E., Koroshetz W. J., Manly J. J., Mayeux R., Mohs R. C., Morris J. C., Rossor M. N., Scheltens P., Carrillo M. C., Thies B., Weintraub S., Phelps C. H. (2011) The diagnosis of dementia due to Alzheimer\u2019s disease: Recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease. Alzheimer\u2019s & Dementia 7, 263-269.  Crossref","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"ref46","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Mercer\u00f3n-Mart\u00ednez D., Ibaceta-Gonz\u00e1lez C., Salazar C., Almaguer-Melian W., Bergado-Rosado J.A., Palacios A.G. (2021) Alzheimer\u2019s Disease, Neural Plasticity, and Functional Recovery. Journal of Alzheimer\u2019s Disease 82, 37-50.  Crossref","DOI":"10.3233\/jad-201178"},{"key":"ref47","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Merkow R.P., Kaji A.H., Itani K.M.F. (2021) The CONSORT Framework. JAMA Surgery 156, 877.  Crossref","DOI":"10.1001\/jamasurg.2021.0549"},{"key":"ref48","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Messina G., Di Bernardo G., Viggiano A., De Luca V., Monda V., Messina A. (2016) Exercise increases the level of plasma orexin A in humans. Journal of Basic and Clinical Physiology and Pharmacology 27, 611-616.  Crossref","DOI":"10.1515\/jbcpp-2015-0133"},{"key":"ref49","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Mielke M., Vemuri P., Rocca W. (2014) Clinical epidemiology of Alzheimer&rsquo;s disease: assessing sex and gender differences. Clinical Epidemiology 37.  Crossref","DOI":"10.2147\/clep.s37929"},{"key":"ref50","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Morland C., Andersson K.A., Haugen \u00d8.P., Hadzic A., Kleppa L., Gille A., Rnholm J. E., Palibrk V., Diget E. H., Kennedy L. H., Stolen T., Hennestad E., Moldestad O., Cai Y., Puchades M., Offermanns S., Vervaeke Bjoras M., Wisloff U., Storm-Mathisen J., Bergersen L. (2017) Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1. Nature Communications 8, 15557.  Crossref","DOI":"10.1038\/ncomms15557"},{"key":"ref51","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Murray K.O., Mahoney S.A., Venkatasubramanian R., Seals D.R., Clayton Z.S. (2023) Aging, aerobic exercise, and cardiovascular health: Barriers, alternative strategies and future directions. Experimental Gerontology 173, 112105.  Crossref","DOI":"10.1016\/j.exger.2023.112105"},{"key":"ref52","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Nettiksimmons J., Simonsick E.M., Harris T., Satterfield S., Rosano C., Yaffe K. (2014) The Associations between Serum Brain-Derived Neurotrophic Factor, Potential Confounders, and Cognitive Decline: A Longitudinal Study. Plos One 9, e91339.  Crossref","DOI":"10.1371\/journal.pone.0091339"},{"key":"ref53","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Norton S., Matthews F.E., Barnes D.E., Yaffe K., Brayne C. (2014) Potential for primary prevention of Alzheimer\u2019s disease: an analysis of population-based data. The Lancet Neurology 13, 788-794.  Crossref","DOI":"10.1016\/s1474-4422(14)70136-x"},{"key":"ref54","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Ozaki H., Loenneke J., Thiebaud R., Abe T. (2015) Cycle training induces muscle hypertrophy and strength gain: strategies and mechanisms. Acta Physiologica Hungarica 102, 1-22.  Crossref","DOI":"10.1556\/aphysiol.102.2015.1.1"},{"key":"ref55","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Park J.-H. (2021) Effects of Cognitive-Physical Dual-Task Training on Executive Function and Activity in the Prefrontal Cortex of Older Adults with Mild Cognitive Impairment. Brain & NeuroRehabilitation 14, e23.  Crossref","DOI":"10.12786\/bn.2021.14.e23"},{"key":"ref56","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Pedrinolla A., Venturelli M., Fonte C., Tamburin S., Di Baldassarre A., Naro F., Varalta V., Giuriato G., Ghinassi B., Mutti E., Smania N., Schna F. (2020) Exercise training improves vascular function in patients with Alzheimer\u2019s disease. European Journal of Applied Physiology 120, 2233-2245.  Crossref","DOI":"10.1007\/s00421-020-04447-w"},{"key":"ref57","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Pereira Oliva H.N., Mansur Machado F.S., Rodrigues V.D., Le\u00e3o L.L., Monteiro-J\u00fanior R.S. (2020) The effect of dual-task training on cognition of people with different clinical conditions: An overview of systematic reviews. IBRO Reports 9, 24-31.  Crossref","DOI":"10.1016\/j.ibror.2020.06.005"},{"key":"ref58","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Porsteinsson A.P., Isaacson R.S., Knox S., Sabbagh M.N., Rubino I. (2021) Diagnosis of Early Alzheimer\u2019s Disease: Clinical Practice in 2021. The Journal of Prevention of Alzheimer\u2019s Disease , 1-16.  Crossref","DOI":"10.14283\/jpad.2021.23"},{"key":"ref59","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Proverbio A.M. (2023) Sex differences in the social brain and in social cognition. Journal of Neuroscience Research 101, 730-738.  Crossref","DOI":"10.1002\/jnr.24787"},{"key":"ref60","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Qian Y., Ma Q., Sun H., Xu Y., Pan C. (2020) Combined effect of three common lifestyle factors on cognitive impairment among older Chinese adults: a community-based, cross-sectional survey. Psychogeriatrics 20, 844-849.  Crossref","DOI":"10.1111\/psyg.12604"},{"key":"ref61","unstructured":"Journal of Sports Science and Medicine Rikli, R.E. and Jones, C.J. (2013) Senior Fitness Test Manual. Human Kinetics Champaign, Illinois, USA."},{"key":"ref62","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Ruscheweyh R., Willemer C., Kr\u00fcger K., Duning T., Warnecke T., Sommer J., Volker K., Ho H. V., Kneccht S., Floel A. (2011) Physical activity and memory functions: An interventional study. Neurobiology of Aging 32, 1304-1319.  Crossref","DOI":"10.1016\/j.neurobiolaging.2009.08.001"},{"key":"ref63","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Sbardelotto M.L., Costa R.R., Malysz K.A., Pedroso G.S., Pereira B.C., Sorato H.R., Silveira P., Nesi R. T., Grande A. J., Pinho R. A. (2019) Improvement in muscular strength and aerobic capacities in elderly people occurs independently of physical training type or exercise model. Clinics (Sao Paulo, Brazil) 74, e833.  Crossref","DOI":"10.6061\/clinics\/2019\/e833"},{"key":"ref64","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Sewell K.R., Erickson K.I., Rainey-Smith S.R., Peiffer J.J., Sohrabi H.R., Brown B.M. (2021) Relationships between physical activity, sleep and cognitive function: A narrative review. Neuroscience & Biobehavioral Reviews 130, 369-378.  Crossref","DOI":"10.1016\/j.neubiorev.2021.09.003"},{"key":"ref65","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Silva A.F., Silva R.M., Murawska-Cia\u0142owicz E., Zurek G., Danek N., Cialowicz M., Carvalho J., Clemente F. M. (2024) Cognitive Training with Older Adults Using Smartphone and Web-Based Applications: A Scoping Review. The Journal of Prevention of Alzheimer\u2019s Disease.  Crossref","DOI":"10.14283\/jpad.2024.17"},{"key":"ref66","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Silva M.H., Andre Barbosa De Lira C., Steele J., Fisher J.P., Mota J.F., Gomes A.C., Gentil P. (2022) Cycle ergometer training and resistance training similarly increase muscle strength in trained men. Journal of Sports Sciences 40, 583-590.  Crossref","DOI":"10.1080\/02640414.2021.2005282"},{"key":"ref67","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Smith P.J., Blumenthal J.A., Hoffman B.M., Cooper H., Strauman T.A., Welsh-Bohmer K., Browndyke J. N., Sherwood A. (2010) Aerobic Exercise and Neurocognitive Performance: A Meta-Analytic Review of Randomized Controlled Trials. Psychosomatic Medicine 72, 239-252.  Crossref","DOI":"10.1097\/psy.0b013e3181d14633"},{"key":"ref68","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Sobol N.A., Hoffmann K., Frederiksen K.S., Vogel A., Vestergaard K., Br\u00e6ndgaard H., Gottrup H., Lolk A., Wermuth L., Jakobsen S., Laugesen L., Gergelyffy R., Hogh P., Bjerregaard E., Siersma V., Andersen B. B., Johannsen P., Walderman G., Hasselbalch S., Beyer N. (2016) Effect of aerobic exercise on physical performance in patients with Alzheimer\u2019s disease. Alzheimer\u2019s & Dementia 12, 1207-1215.  Crossref","DOI":"10.1016\/j.jalz.2016.05.004"},{"key":"ref69","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Szuhany K.L., Bugatti M., Otto M.W. (2015) A meta-analytic review of the effects of exercise on brain-derived neurotrophic factor. Journal of Psychiatric Research 60, 56-64.  Crossref","DOI":"10.1016\/j.jpsychires.2014.10.003"},{"key":"ref70","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Tan X., Wang K., Sun W., Li X., Wang W., Tian F. (2024) A Review of Recent Advances in Cognitive-Motor Dual-Tasking for Parkinson\u2019s Disease Rehabilitation. Sensors 24, 6353.  Crossref","DOI":"10.3390\/s24196353"},{"key":"ref71","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Toricelli M., Pereira A.R., Souza Abrao G., Malerba H., Maia J., Buck H., Ara\u00fajo V. T. (2021) Mechanisms of neuroplasticity and brain degeneration: strategies for protection during the aging process. Neural Regeneration Research 16, 58.  Crossref","DOI":"10.4103\/1673-5374.286952"},{"key":"ref72","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Tsantali E., Economidis D., Rigopoulou S. (2017) Testing the Benefits of Cognitive Training vs. Cognitive Stimulation in Mild Alzheimer\u2019s Disease: A Randomised Controlled Trial. Brain Impairment 18, 188-196.  Crossref","DOI":"10.1017\/brimp.2017.6"},{"key":"ref73","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Tzioras M., McGeachan R.I., Durrant C.S., Spires-Jones T.L. (2023) Synaptic degeneration in Alzheimer disease. Nature Reviews Neurology 19, 19-38.  Crossref","DOI":"10.1038\/s41582-022-00749-z"},{"key":"ref74","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Varma V.R., Tang X., Carlson M.C. (2016) Hippocampal sub-regional shape and physical activity in older adults. Hippocampus 26, 1051-1060.  Crossref","DOI":"10.1002\/hipo.22586"},{"key":"ref75","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Vasconcelos Rocha S., Souza Dos Santos S., Carneiro Vasconcelos L.R., Alves Dos Santos C. (2016) Strength and ability to implement the activities of daily living in elderly resident in rural areas. Colombia medica (Cali, Colombia) 47, 167-171.  Crossref","DOI":"10.25100\/cm.v47i3.1593"},{"key":"ref76","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Vigorito C., Giallauria F. (2014) Effects of exercise on cardiovascular performance in the elderly. Frontiers in Physiology 5.  Crossref","DOI":"10.3389\/fphys.2014.00051"},{"key":"ref77","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Walsh J.J., Tschakovsky M.E. (2018) Exercise and circulating BDNF: Mechanisms of release and implications for the design of exercise interventions. Applied Physiology, Nutrition, and Metabolism 43, 1095-1104.  Crossref","DOI":"10.1139\/apnm-2018-0192"},{"key":"ref78","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Wollesen B., Fricke M., Jansen C.-P., Gordt K., Schwenk M., Muehlbauer T., Morawietz C., Kruse A., Gramann K. (2020) A three-armed cognitive-motor exercise intervention to increase spatial orientation and life-space mobility in nursing home residents: study protocol of a randomized controlled trial in the PROfit project. BMC Geriatrics 20, 437.  Crossref","DOI":"10.1186\/s12877-020-01840-0"},{"key":"ref79","unstructured":"Journal of Sports Science and Medicine World Health Organization, (2017) Global Action Plan on the Public Health Response to Dementia 2017-2025. World Health Organization."},{"key":"ref80","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Xu X., Chew K.A., Wong Z.X., Phua A.K.S., Chong E.J.Y., Teo C.K.L., Sathe N., Chooi Y. C., Chia W. P. F., Henry C. J., Chew E., Wang M., Maier A. B., Kandiah N., Chen C. L. (2022) The SINgapore GERiatric Intervention Study to Reduce Cognitive Decline and Physical Frailty (SINGER): Study Design and Protocol. The Journal of Prevention of Alzheimer\u2019s Disease 9, 40-48.  Crossref","DOI":"10.14283\/jpad.2022.5"},{"key":"ref81","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Yaffe K., Barnes D., Nevitt M., Lui L.-Y., Covinsky K. (2001) A Prospective Study of Physical Activity and Cognitive Decline in Elderly Women. Archives of Internal Medicine 161, 1703.  Crossref","DOI":"10.1001\/archinte.161.14.1703"},{"key":"ref82","doi-asserted-by":"crossref","unstructured":"Journal of Sports Science and Medicine Yagi S., Galea L.A.M. (2019) Sex differences in hippocampal cognition and neurogenesis. Neuropsychopharmacology 44, 200-213.  Crossref","DOI":"10.1038\/s41386-018-0208-4"},{"key":"ref83","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Yang J., Deng Y., Yan H., Li B., Wang Z., Liao J., Xiaoli C., Li Z., Wei T., Shuang R. (2022) Association Between Grip Strength and Cognitive Function in US Older Adults of NHANES 2011-2014. Journal of Alzheimer\u2019s Disease 89, 427-436.  Crossref","DOI":"10.3233\/jad-215454"},{"key":"ref84","doi-asserted-by":"publisher","unstructured":"Journal of Sports Science and Medicine Yeom C.-W., Park Y.-J., Choi S.-W., Bhang S.-Y. (2016) Association of peripheral BDNF level with cognition, attention and behavior in preschool children. Child and Adolescent Psychiatry and Mental Health 10, 10.  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