{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T02:44:48Z","timestamp":1788835488564,"version":"build-2803163510"},"reference-count":25,"publisher":"Korean Continence Society","issue":"Suppl 2","license":[{"start":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T00:00:00Z","timestamp":1606089600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["einj.org"],"crossmark-restriction":true},"short-container-title":["Int Neurourol J"],"published-print":{"date-parts":[[2020,11,30]]},"abstract":"<jats:p>Purpose: Polydeoxyribonucleotide (PDRN) is a substance known to suppress inflammation and accelerate wound healing. In this experiment, the effect of PDRN treatment on carbon tetrachloride (CCl&lt;sub&gt;4&lt;\/sub&gt;)-evoked acute liver injury (ALI) was investigated using mice.Methods: We analyzed the levels of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and conducted hematoxylin and eosin staining in accompany with terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling staining. Western blot analysis was also conducted to assess the expressions of tumor necrosis factor (TNF)-\u03b1, interleukin (IL)-1\u03b2, IL-6, adenosine A&lt;sub&gt;2A&lt;\/sub&gt; receptor, Bcl-2-associated X protein (Bax), and B-cell lymphoma 2 (Bcl-2). The mice were received intraperitoneal injection of 10-mL\/kg CCl&lt;sub&gt;4&lt;\/sub&gt;, 4 times, once every 2 days. The mice in the PDRN treatment groups received intraperitoneal injection of 200-\u03bcL distilled water comprising each concentration of PDRN for 7 days starting 1 day after first CCl&lt;sub&gt;4&lt;\/sub&gt; injection.Results: ALT and AST concentrations in the serum were reduced and TNF-\u03b1, IL-1\u03b2, and IL-6 expressions were decreased by PDRN injection in CCl&lt;sub&gt;4&lt;\/sub&gt;-evoked ALI mice. PDRN injection suppressed Bax versus Bcl-2 ratio and reduced the percentage of TUNE-positive cells in CCl&lt;sub&gt;4&lt;\/sub&gt;-evoked ALI mice. PDRN injection overexpressed adenosine A&lt;sub&gt;2A&lt;\/sub&gt; receptor in CCl&lt;sub&gt;4&lt;\/sub&gt;-evoked ALI mice.Conclusions: The therapeutic efficacy of PDRN also can be expected for CCl&lt;sub&gt;4&lt;\/sub&gt;-evoked acute urogenital injury in addition to ALI. The current research suggests that PDRN may be used for the therapeutic agent of CCl&lt;sub&gt;4&lt;\/sub&gt;-evoked ALI.<\/jats:p>","DOI":"10.5213\/inj.2040430.215","type":"journal-article","created":{"date-parts":[[2020,11,29]],"date-time":"2020-11-29T23:56:31Z","timestamp":1606694191000},"page":"88-95","update-policy":"https:\/\/doi.org\/10.5213\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Protective Effect of Polydeoxyribonucleotide Against CCl4-Induced Acute Liver Injury in Mice"],"prefix":"10.5213","volume":"24","author":[{"given":"Seunghwan","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu Yeoun","family":"Won","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8755-9701","authenticated-orcid":true,"given":"Sunhyung","family":"Joo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3166","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60274-7"},{"key":"ref2","first-page":"359","volume-title":"Influence of the pro-inflammatory cytokines on P-glycoprotein expression and functionality","author":"Fernandez","year":"2004"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2016.11.006"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00061.2009"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.12965\/jer.1836264.132"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v036a04"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.12965\/jer.1836248.124"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.12965\/jer.1836508.254"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i4.568"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.8.3991"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.2174\/187152509789541909"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.07.1047"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1080\/19768354.2014.983968"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/art.30538"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.02.016"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.04.009"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.5213\/inj.1938216.108"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.5213\/inj.1836224.112"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-017-1604-8"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1100\/tsw.2011.22"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2016.11.028"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.03.007"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1186\/1743-7075-10-20"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2003.10.004"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.12965\/jer.36394.197"}],"container-title":["International Neurourology Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/einj.org\/upload\/pdf\/inj-2040430-215.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/einj.org\/journal\/view.php?doi=10.5213\/inj.2040430.215","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/einj.org\/upload\/pdf\/inj-2040430-215.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,29]],"date-time":"2020-11-29T23:56:52Z","timestamp":1606694212000},"score":1,"resource":{"primary":{"URL":"http:\/\/einj.org\/journal\/view.php?doi=10.5213\/inj.2040430.215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,30]]},"references-count":25,"journal-issue":{"issue":"Suppl 2","published-print":{"date-parts":[[2020,11]]}},"URL":"https:\/\/doi.org\/10.5213\/inj.2040430.215","relation":{},"ISSN":["2093-6931"],"issn-type":[{"value":"2093-6931","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,30]]},"assertion":[{"value":"2020-09-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-23","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-30","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}