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The changes of expression of inflammatory factors by polydeoxyribonucleotide (PDRN) administration in the PM10-exposed trachea inflammation model were evaluated.Methods: PM&lt;sub&gt;10&lt;\/sub&gt; was administered to mouse trachea to induce acute inflammatory damage, and changes in inflammatory factors were observed after administration of PDRN and 3,7-dimethyl-1-propargylxanthine (DMPX) for 3 days daily. Expression of inflammatory cytokines, adenosine A&lt;sub&gt;2A&lt;\/sub&gt; receptor (A&lt;sub&gt;2A&lt;\/sub&gt;R), protein kinase A (PKA), 3\u0384,5\u0384-cyclic adenosine monophosphate responsive element binding protein (CREB) were detected by enzyme\u2010linked immunosorbent assay, immunofluorescence, and western blot assay.Results: PM-exposed trachea showed increased tumor necrosis factor (TNF)-\u03b1 and interleukin (IL)-1\u03b2 expression, and expression of TNF-\u03b1 and IL-1\u03b2 was inhibited by PDRN treatment in PM-exposed mice. PM-exposed trachea showed increased nuclear factor (NF)-\u03baB phosphorylation, and phosphorylation of nuclear factor-kappa B was inhibited by PDRN treatment in PM-exposed mice. PM-exposed trachea showed increased expression of A&lt;sub&gt;2A&lt;\/sub&gt;R, but PDRN treatment more enhanced A&lt;sub&gt;2A&lt;\/sub&gt;R expression in PM-exposed mice. PKA phosphorylation was not changed and CREP phosphorylation was decreased, however PDRN treatment increased phosphorylation of PKA and CREB in PM-exposed mice. DMPX treatment blocked all the effects of PDRN on PM-exposed mice, demonstrating that the action of PDRN occurs via A&lt;sub&gt;2A&lt;\/sub&gt;R.Conclusions: PDRN treatment attenuated inflammation in the trachea of the PM&lt;sub&gt;10&lt;\/sub&gt;-exposed mice. This improving effect of PDRN can be ascribed to the activation of A&lt;sub&gt;2A&lt;\/sub&gt;R through the cAMP-PKA pathway.<\/jats:p>","DOI":"10.5213\/inj.2142168.084","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T06:50:56Z","timestamp":1622098256000},"page":"S19-26","update-policy":"https:\/\/doi.org\/10.5213\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Polydeoxyribonucleotide Attenuates Airway Inflammation Through A2AR Signaling Pathway in PM10-Exposed 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