{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T15:13:38Z","timestamp":1774624418241,"version":"3.50.1"},"reference-count":25,"publisher":"Korean Continence Society","issue":"1","license":[{"start":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T00:00:00Z","timestamp":1680220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","award":["2014-1825"],"award-info":[{"award-number":["2014-1825"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["einj.org"],"crossmark-restriction":true},"short-container-title":["Int Neurourol J"],"published-print":{"date-parts":[[2023,3,31]]},"abstract":"<jats:p>Purpose: To investigate the effect of detrusor overactivity (DO) on the urethral expression of caveolin (CAV)-1, -2, and -3 of urethra in an animal model of cyclophosphamide (CYP)-induced cystitis rat.Methods: Female Sprague-Dawley rats were divided into the control group (n=20) and the cystitis group (n=20). Cystitis was induced by intraperitoneal injection of CYP (200 mg\/kg). An urodynamic study was done 3 days after the CYP injection to measure functional change of the urinary bladder and urethra. Cellular localization and expression of CAV-1, -2, and -3 in the rat urethra were determined by immunohistochemistry (IHC) and Western blot.Results: Urodynamic experiments demonstrated a decreased contraction interval in the cystitis group compared to the control (3.9\u00b11.0 minutes vs. 6.6\u00b11.2 minutes, P&lt;0.05). Conversely, contraction pressure increased significantly in the cystitis group compared to the control (22.4\u00b10.7 mmHg vs. 11.5\u00b10.4 mmHg, P&lt;0.05). The urethral pressure was decreased in the cystitis group compared to the control (4.05 \u00b12.5 mmHg vs. 5.8 \u00b12.8 mmHg, P &lt;0.05). The IHC and Western blot data showed that CAV-1, -2, and -3 expression decreased significantly in the cystitis group compared control group (P&lt;0.05).Conclusions: The decreased urethral CAV-1, -2, and -3 in the DO rats suggests that CAVs might be related with the functional change of urethra in association with DO of urinay bladder.<\/jats:p>","DOI":"10.5213\/inj.2244236.118","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T01:26:10Z","timestamp":1680225970000},"page":"47-54","update-policy":"https:\/\/doi.org\/10.5213\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Decreased Expression of Urethral Caveolin-1, -2, and -3 in the Rat Model of Overactive Bladder: Potential Mediator of Functional Interaction of Urethra and Urinary Bladder"],"prefix":"10.5213","volume":"27","author":[{"given":"Hyun 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