{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:53:50Z","timestamp":1789610030253,"version":"build-2803163510"},"reference-count":29,"publisher":"Korean Continence Society","issue":"3","license":[{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"name":"Sao Paulo Research Foundation","award":["2016\/14146-5"],"award-info":[{"award-number":["2016\/14146-5"]}]},{"DOI":"10.13039\/100004856","name":"New York State Department of Health","doi-asserted-by":"publisher","award":["R01DK129462"],"award-info":[{"award-number":["R01DK129462"]}],"id":[{"id":"10.13039\/100004856","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["einj.org"],"crossmark-restriction":true},"short-container-title":["Int Neurourol J"],"published-print":{"date-parts":[[2024,9,30]]},"abstract":"<jats:p>Purpose: Recent research has highlighted the mechanotransducer PIEZO2 as a crucial factor in lower urinary tract function, demonstrating associations with bladder compliance (BC), bladder wall thickening, and elevated bladder pressure. We explored the hypothesis that &lt;i&gt;PIEZO2&lt;\/i&gt; expression may be associated with lower urinary tract dysfunction in men with bladder outlet obstruction (BOO) due to benign prostatic hyperplasia (BPH).Methods: The study included a consecutive series of patients undergoing open prostatectomy for BPH at our hospital between September 2014 and January 2016. All participants underwent comprehensive preoperative evaluations, including urodynamic assessments. During prostatectomy, a full-thickness fragment of the bladder wall was obtained for subsequent &lt;i&gt;PIEZO2&lt;\/i&gt; gene expression analysis. Cadaveric organ donors served as the control group.Results: &lt;i&gt;PIEZO2&lt;\/i&gt; expression was downregulated in the detrusor muscle of men with BPH compared to the control group. Among patients with BPH, those experiencing urinary retention and requiring an indwelling catheter exhibited significantly lower &lt;i&gt;PIEZO2&lt;\/i&gt; messenger RNA (mRNA) expression than patients capable of spontaneous voiding. &lt;i&gt;PIEZO2&lt;\/i&gt; mRNA expression was similar in men with and without detrusor overactivity. Additionally, a positive correlation was found between &lt;i&gt;PIEZO2&lt;\/i&gt; mRNA expression levels and BC.Conclusions: Our findings indicate that &lt;i&gt;PIEZO2&lt;\/i&gt; is downregulated in the detrusor muscle of men with BPH, particularly in those experiencing urinary retention and those with reduced BC. These results suggest a potential role for PIEZO2 in BOOinduced bladder dysfunction. Further research is required to clarify the role of PIEZO mechanotransducers in the bladder and to explore their therapeutic implications.<\/jats:p>","DOI":"10.5213\/inj.2448298.149","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T04:39:58Z","timestamp":1727325598000},"page":"225-231","update-policy":"https:\/\/doi.org\/10.5213\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Downregulation of PIEZO2 in the Detrusor of Men With Bladder Outlet Obstruction and Its Association With Urinary Retention and Decreased Bladder Compliance"],"prefix":"10.5213","volume":"28","author":[{"given":"Carlos Henrique Suzuki","family":"Bellucci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago 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