{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T06:04:49Z","timestamp":1774591489674,"version":"3.50.1"},"reference-count":15,"publisher":"Korean Continence Society","issue":"1","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"KAKENHI","doi-asserted-by":"crossref","award":["2412506"],"award-info":[{"award-number":["2412506"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100009666","name":"Salt Science Research Foundation","doi-asserted-by":"publisher","award":["2434"],"award-info":[{"award-number":["2434"]}],"id":[{"id":"10.13039\/100009666","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009666","name":"Salt Science Research Foundation","doi-asserted-by":"publisher","award":["202530"],"award-info":[{"award-number":["202530"]}],"id":[{"id":"10.13039\/100009666","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["einj.org"],"crossmark-restriction":true},"short-container-title":["Int Neurourol J"],"published-print":{"date-parts":[[2026,3,31]]},"abstract":"<jats:p>Purpose: This study was aimed at assessing the effects of cerebral sympathetic nervous system activity and renal denervation (RD) on the intrarenal renin-angiotensin system (RAS) and salt-induced nocturnal polyuria (NP).Methods: To establish a mouse model, NP was induced by N\u03c9-nitro-L-arginine methyl ester and a high-salt diet. Mice were subjected to dietary, pharmacological, and RD interventions, with blood pressure, urine output, renal norepinephrine, kidney protein expression, and c-Fos positive cells in the hypothalamic paraventricular nucleus (PVN) assessed using standardized physiological, biochemical, and histological methods.Results: Renal angiotensinogen (AGT) and PVN c-Fos were significantly increased in NP model mice, indicating sympathetic activation. RD lowered renal AGT and the diurnal polyuria index versus sham (1.070\u00b10.091 vs. 1.595\u00b10.136 arbitrary units, P&lt;0.01; 0.182\u00b10.018 vs. 0.338\u00b10.021, P&lt;0.01).Conclusions: Cerebral sympathetic activation may promote intrarenal RAS activity and salt-induced NP; therefore, RD may be a potential therapeutic strategy to improve NP.<\/jats:p>","DOI":"10.5213\/inj.2550326.163","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T04:32:18Z","timestamp":1774585938000},"page":"35-43","update-policy":"https:\/\/doi.org\/10.5213\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cerebral Sympathetic Nervous System Activation Promotes Intrarenal Renin-Angiotensin System Activity and Salt-Induced Nocturnal 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