{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:52:06Z","timestamp":1791330726733,"version":"4.3.1"},"reference-count":22,"publisher":"Korean Continence Society","issue":"3","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["einj.org"],"crossmark-restriction":true},"short-container-title":["Int Neurourol J"],"published-print":{"date-parts":[[2026,9,30]]},"abstract":"<jats:p>Purpose: Urinary frequency and bladder hypersensitivity are among the lower urinary tract symptoms exacerbated by psychological stress. This study investigated whether chronic oxytocin (OXT) administration could alleviate stress-induced bladder dysfunction and modulate central stress pathways.Methods: Female Sprague-Dawley rats were allocated to control, stress, or stress\/OXT groups (n=14 per group) and exposed to repeated variable stress (RVS) for 1 week. Assessments included mechanical sensitivity, cystometric parameters, plasma catecholamine and cortisol levels, bladder histology, c-Fos expression in the paraventricular nucleus (PVN), and gene expression in bladder and brain regions.Results: RVS induced mechanical hypersensitivity, reduced intercontraction intervals, increased bladder weight, and raised plasma adrenaline, dopamine, and cortisol levels. The bladder also showed epithelial thickening, submucosal nerve hyperplasia, and increased prostaglandin E receptor 3 and epithelial sodium channel expression. Stress significantly enhanced PVN activation and increased brainstem expression of choline acetyltransferase, corticotropin-releasing factor, and tyrosine hydroxylase. With OXT treatment, intercontraction intervals normalized, catecholamine and cortisol levels declined, PVN c-Fos activation decreased, and OXT receptor expression increased in the brainstem, hypothalamus, and thalamus, and glutamate decarboxylase 1 expression increased in the hypothalamus and thalamus. Interleukin-6 expression decreased with OXT treatment but did not change in response to stress.Conclusions: Chronic OXT administration was associated with improved stress-induced urinary frequency and modulation of central stress pathways; evidence of direct peripheral anti-inflammatory effects was limited.<\/jats:p>","DOI":"10.5213\/inj.2550358.179","type":"journal-article","created":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T23:43:02Z","timestamp":1784504582000},"page":"224-232","update-policy":"https:\/\/doi.org\/10.5213\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Oxytocin on Rats With Stress-Induced Increased Urinary Frequency"],"prefix":"10.5213","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2244-7941","authenticated-orcid":true,"given":"Saori","family":"Nishijima","sequence":"first","affiliation":[{"name":"Southern Knights\u2019 Laboratory, Okinawa, 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