{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T05:07:49Z","timestamp":1779944869312,"version":"3.53.1"},"reference-count":26,"publisher":"Korean Continence Society","issue":"Suppl 1","license":[{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI22C0647"],"award-info":[{"award-number":["HI22C0647"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["einj.org"],"crossmark-restriction":true},"short-container-title":["Int Neurourol J"],"published-print":{"date-parts":[[2026,5,31]]},"abstract":"<jats:p>Purpose: Current therapies using midurethral sling mesh to treat stress urinary incontinence (SUI) are often considered insufficient. This study aims to evaluate the therapeutic efficacies of a minimally invasive implantable wireless electrical stimulator as an alternative treatment of SUI.Methods: SUI was induced in 12 female, 12-week-old Sprague-Dawley rats with a deteriorated urethral sphincter complex by mechanical dilatation of the vagina. Six rats underwent sham operations. Four weeks after inducing SUI, 12 rats with SUI were divided into 2 groups. One group received a transplantation of an implantable wireless electrical stimulator, and the other midline incision and suturing. A total of 4 electrical stimulations were applied for 30 minutes twice weekly for 4 weeks in implantation model. Cystometric parameters including leak point pressure, urethral pressure and electromyography, histological examinations, immunostaining for Masson trichrome stain were measured at 4 weeks after intervention.Results: After SUI induction, mean leak point pressure (LPP) was significantly lower in SUI groups than in controls (25.0\u00b16.9 cm H&lt;sub&gt;2&lt;\/sub&gt;O vs. 62.6\u00b14.1 cm H&lt;sub&gt;2&lt;\/sub&gt;O, P=0.012). At 4-week postintervention, the +ES group (SUI rat model with stimulation) demonstrated significantly higher LPP than the \u2212ES group (48.8\u00b18.4 cm H&lt;sub&gt;2&lt;\/sub&gt;O vs. 26.0\u00b16.6 cm H&lt;sub&gt;2&lt;\/sub&gt;O, P=0.002). Urethral pressure showed a nonsignificant upward trend in the +ES group (SUI rat model without stimulation) compared with \u2212ES (20.5\u00b11.4 cm H&lt;sub&gt;2&lt;\/sub&gt;O vs. 18.1\u00b11.1 cm H&lt;sub&gt;2&lt;\/sub&gt;O, P=0.070). Histology showed improved tissue organization with reduced inflammatory infiltration, and Masson staining demonstrated a trend toward higher collagen density in +ES (bladder: 28.3%\u00b15.2% vs. 32.5%\u00b17.6%, P=0.292; urethra: 44.2%\u00b18.6% vs. 51.7%\u00b18.2%, P=0.153).Conclusions: These results indicate that an implantation of a wireless electrical stimulator can help to improve urethral sphincter function in SUI rat model. Moreover, the minimally invasive wireless electrical strategy may represent a promising therapeutic modality for pelvic floor muscle rehabilitation in the treatment of SUI with potential for clinical translation.<\/jats:p>","DOI":"10.5213\/inj.2652012.006","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T04:59:54Z","timestamp":1779944394000},"page":"S36-47","update-policy":"https:\/\/doi.org\/10.5213\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Efficacy of Minimally Invasive Implantable Wireless Electrical Stimulation for the Treatment of Stress Urinary Incontinence in a Rat Model"],"prefix":"10.5213","volume":"30","author":[{"given":"Miho","family":"Song","sequence":"first","affiliation":[{"name":"Department of Urology, Soonchunhyang University College of Medicine, Seoul, 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