{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:52:13Z","timestamp":1790077933951,"version":"4.0.1"},"reference-count":28,"publisher":"Korean Association for the Study of Intestinal Diseases","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["synapse.koreamed.org"],"crossmark-restriction":true},"short-container-title":["Intest Res"],"published-print":{"date-parts":[[2018]]},"DOI":"10.5217\/ir.2018.16.1.83","type":"journal-article","created":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T00:24:59Z","timestamp":1517531099000},"page":"83","update-policy":"https:\/\/doi.org\/10.5217\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Efficacy and safety of the adalimumab biosimilar Exemptia as induction therapy in moderate-to-severe ulcerative colitis"],"prefix":"10.5217","volume":"16","author":[{"given":"Vandana","family":"Midha","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Dayanand Medical College & Hospital, Ludhiana, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramit","family":"Mahajan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Dayanand Medical College & Hospital, Ludhiana, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varun","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Dayanand Medical College & Hospital, Ludhiana, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikram","family":"Narang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dayanand Medical College & Hospital, Ludhiana, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arshdeep","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Dayanand Medical College & Hospital, Ludhiana, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirandeep","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Dayanand Medical College & Hospital, Ludhiana, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajit","family":"Sood","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Dayanand Medical College & Hospital, Ludhiana, India."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3168","reference":[{"key":"10.5217\/ir.2018.16.1.83_ref1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/ibd.20793","volume":"15","author":"Rubin","year":"2009","journal-title":"Inflamm Bowel Dis"},{"key":"10.5217\/ir.2018.16.1.83_ref2","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1136\/gut.38.6.905","volume":"38","author":"Travis","year":"1996","journal-title":"Gut"},{"key":"10.5217\/ir.2018.16.1.83_ref3","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/med.20103","volume":"28","author":"Danese","year":"2008","journal-title":"Med Res Rev"},{"key":"10.5217\/ir.2018.16.1.83_ref4","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1056\/NEJMoa050516","volume":"353","author":"Rutgeerts","year":"2005","journal-title":"N Engl J Med"},{"key":"10.5217\/ir.2018.16.1.83_ref5","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.3748\/wjg.v13.i16.2328","volume":"13","author":"Peyrin-Biroulet","year":"2007","journal-title":"World J Gastroenterol"},{"key":"10.5217\/ir.2018.16.1.83_ref6","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1136\/gut.2010.221127","volume":"60","author":"Reinisch","year":"2011","journal-title":"Gut"},{"key":"10.5217\/ir.2018.16.1.83_ref7","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1053\/j.gastro.2011.10.032","volume":"142","author":"Sandborn","year":"2012","journal-title":"Gastroenterology"},{"key":"10.5217\/ir.2018.16.1.83_ref8","unstructured":"Humira (adalimumab). Food and Drug Administration. April 23, 2017.  https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/appletter\/2012\/125057orig1s232ltr.pdf"},{"key":"10.5217\/ir.2018.16.1.83_ref9","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1111\/j.1365-2036.2008.03811.x","volume":"28","author":"Oussalah","year":"2008","journal-title":"Aliment Pharmacol Ther"},{"key":"10.5217\/ir.2018.16.1.83_ref10","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1002\/ibd.20924","volume":"15","author":"Afif","year":"2009","journal-title":"Inflamm Bowel Dis"},{"key":"10.5217\/ir.2018.16.1.83_ref11","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1111\/j.1440-1746.2009.05786.x","volume":"24","author":"Trinder","year":"2009","journal-title":"J Gastroenterol Hepatol"},{"key":"10.5217\/ir.2018.16.1.83_ref12","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.crohns.2012.10.004","volume":"7","author":"Garc\u00eda-Bosch","year":"2013","journal-title":"J Crohns Colitis"},{"key":"10.5217\/ir.2018.16.1.83_ref13","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/j.1365-2036.2010.04380.x","volume":"32","author":"Gies","year":"2010","journal-title":"Aliment Pharmacol Ther"},{"key":"10.5217\/ir.2018.16.1.83_ref14","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/j.1365-2036.2010.04531.x","volume":"33","author":"Taxonera","year":"2011","journal-title":"Aliment Pharmacol Ther"},{"issue":"Suppl 1","key":"10.5217\/ir.2018.16.1.83_ref15","doi-asserted-by":"crossref","first-page":"S101","DOI":"10.1016\/S1873-9946(12)60250-5","volume":"6","author":"Armuzzi","year":"2012","journal-title":"J Crohns Colitis"},{"issue":"Suppl 3","key":"10.5217\/ir.2018.16.1.83_ref16","first-page":"A72","volume":"60","author":"Ferrante","year":"2011","journal-title":"Gut"},{"key":"10.5217\/ir.2018.16.1.83_ref17","unstructured":"Guidelines on evaluation of similar biotherapeutic products (SBPs). World Health Organization. Accessed May 4, 2017.  http:\/\/www.who.int\/biologicals\/areas\/biological_therapeutics\/BIOTHERAPEUTICS_FOR_WEB_22APRIL2010.pdf"},{"issue":"Suppl 1","key":"10.5217\/ir.2018.16.1.83_ref18","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1586\/17474124.2015.1091309","volume":"9","author":"Park","year":"2015","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"10.5217\/ir.2018.16.1.83_ref19","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1111\/jgh.12997","volume":"30","author":"Jung","year":"2015","journal-title":"J Gastroenterol Hepatol"},{"key":"10.5217\/ir.2018.16.1.83_ref20","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1007\/s10620-014-3392-z","volume":"60","author":"Kang","year":"2015","journal-title":"Dig Dis Sci"},{"key":"10.5217\/ir.2018.16.1.83_ref21","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1093\/ecco-jcc\/jjv220","volume":"10","author":"Gecse","year":"2016","journal-title":"J Crohns Colitis"},{"key":"10.5217\/ir.2018.16.1.83_ref22","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1517\/14712598.2015.1064893","volume":"15","author":"Farkas","year":"2015","journal-title":"Expert Opin Biol Ther"},{"key":"10.5217\/ir.2018.16.1.83_ref23","doi-asserted-by":"crossref","first-page":"15","DOI":"10.5217\/ir.2016.14.1.15","volume":"14","author":"Park","year":"2016","journal-title":"Intest Res"},{"key":"10.5217\/ir.2018.16.1.83_ref24","unstructured":"Adalimumab biosimilar. psoriatic arthritis, ankylosing spondylitis. Exemptia. Accessed May 4, 2017.  https:\/\/exemptia.com\/zydus-launches-worlds-first-biosimilar-of-adalimumab-2\/"},{"key":"10.5217\/ir.2018.16.1.83_ref25","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1111\/1756-185X.12711","volume":"19","author":"Jani","year":"2016","journal-title":"Int J Rheum Dis"},{"key":"10.5217\/ir.2018.16.1.83_ref26","first-page":"232","volume":"27","author":"Sood","year":"2008","journal-title":"Indian J Gastroenterol"},{"key":"10.5217\/ir.2018.16.1.83_ref27","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s12664-013-0372-8","volume":"33","author":"Sood","year":"2014","journal-title":"Indian J Gastroenterol"},{"key":"10.5217\/ir.2018.16.1.83_ref28","unstructured":"TB statistics for India: national and state statistics. TB Facts.org. April 26, 2017.  http:\/\/www.tbfacts.org\/tb-statistics-india\/"}],"container-title":["Intestinal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/synapse.koreamed.org\/pdf\/10.5217\/ir.2018.16.1.83","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/synapse.koreamed.org\/DOIx.php?id=10.5217\/ir.2018.16.1.83","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.irjournal.org\/upload\/pdf\/ir-16-83.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T15:24:20Z","timestamp":1564154660000},"score":1,"resource":{"primary":{"URL":"http:\/\/irjournal.org\/journal\/view.php?doi=10.5217\/ir.2018.16.1.83"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.5217\/ir.2018.16.1.83","relation":{},"ISSN":["1598-9100","2288-1956"],"issn-type":[{"value":"1598-9100","type":"print"},{"value":"2288-1956","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]},"assertion":[{"value":"2017-07-05","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-09-09","name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-09-09","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-18","name":"published_online","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"\u00a9 Copyright 2018. Korean Association for the Study of Intestinal Diseases.","name":"copyright","label":"Copyright","group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:\/\/creativecommons.org\/licenses\/by-nc\/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","explanation":{"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},"group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}}]}}