{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:57:49Z","timestamp":1785776269939,"version":"3.56.0"},"reference-count":32,"publisher":"Korean Association for the Study of Intestinal Diseases","issue":"3","license":[{"start":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T00:00:00Z","timestamp":1584662400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["irjournal.org"],"crossmark-restriction":true},"short-container-title":["Intest Res"],"published-print":{"date-parts":[[2020,7,30]]},"abstract":"<jats:p>Background\/Aims: Latent tuberculosis screening is mandatory prior to initiating anti-tumor necrosis factor (anti-TNF) medications. Guidelines recommend interferon-gamma release assays (IGRA) as first line screening method for the general population. Studies provided conflicting evidence on IGRA and tuberculin skin test (TST) performance in inflammatory bowel disease (IBD) patients. We assessed test concordance and the effects of immunosuppression on their performance in IBD patients.Methods: We searched MEDLINE, Embase and Cochrane databases (2011\u20132018) for studies testing TST and IGRA in IBD. Primary outcome was TST and IGRA concordance. Secondary outcomes were effects of immunosuppressive therapy on performance. Immunosuppression defined as either steroids, thiopurine, methotrexate or cyclosporine use. We used the pooled random effects model to adjust for heterogeneity analyzed using (I&lt;sup&gt;2&lt;\/sup&gt;\u2013Q statistics). We compared the fixed model to exclude smaller study effects.Results: Sixteen studies (2,488 patients) were included. Pooled TST and IGRA concordance was 85% (95% confidence interval [CI], 81%\u201388%; &lt;i&gt;P&lt;\/i&gt;=0.01). Effects of immunosuppression were reported in 8 studies (814 patients). The odds ratio of testing positive by IGRA decreased to 0.57 if immunosuppressed (95% CI, 0.31\u20131.03; &lt;i&gt;P&lt;\/i&gt;=0.06). The odds ratio of testing positive by TST if immunosuppressed was 1.14 (95% CI, 0.61\u20132.12; &lt;i&gt;P&lt;\/i&gt;=0.69). The fixed model yielded similar results, however the negative effect of immunosuppression on IGRA reached statistical significance (&lt;i&gt;P&lt;\/i&gt;=0.01).Conclusions: While concordance was 85% between TST and IGRA, the performance of IGRA seems to be negatively affected by immunosuppression. Given the importance of detecting latent tuberculosis prior to anti-TNF initiation, further randomized controlled trials comparing the performance of TST and IGRA in IBD patients are needed.<\/jats:p>","DOI":"10.5217\/ir.2019.00116","type":"journal-article","created":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T02:26:55Z","timestamp":1584498415000},"page":"306-314","update-policy":"https:\/\/doi.org\/10.5217\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Concordance between tuberculin skin test and interferon-gamma release assay for latent tuberculosis screening in inflammatory bowel disease"],"prefix":"10.5217","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7713-3018","authenticated-orcid":true,"given":"Saad","family":"Alrajhi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9985-9859","authenticated-orcid":true,"given":"Pascale","family":"Germain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8317-613X","authenticated-orcid":true,"given":"Myriam","family":"Martel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3948-6488","authenticated-orcid":true,"given":"Peter","family":"Lakatos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2610-1910","authenticated-orcid":true,"given":"Talat","family":"Bessissow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6717-9613","authenticated-orcid":true,"given":"Talal","family":"Al-Taweel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6869-0982","authenticated-orcid":true,"given":"Waqqas","family":"Afif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3168","reference":[{"key":"ref1","first-page":"704","volume-title":"Update on the incidence and prevalence of inflammatory bowel disease in the United States","author":"Loftus","year":"2016"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/201430"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.03.001"},{"key":"ref4","first-page":"41","volume-title":"Tumor necrosis factor and chemokine interactions in the formation and maintenance of granulomas in tuberculosis","author":"Algood","year":"2005"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw778"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(04)01206-X"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.22901"},{"key":"ref8","volume-title":"TST and IGRA for tuberculosis screening in inflammatory bowel disease","author":"Alrajhi"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-155-8-201110180-00009"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000147"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.15403\/jgld.2014.1121.244.bcg"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12363_2"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/S1873-9946(13)60146-4"},{"key":"ref15","first-page":"p305","volume-title":"Detection of IFN-gamma responses for diagnosis of tuberculosis infection in chronic inflammatory disease patients","author":"Latorre","year":"2011"},{"key":"ref16","first-page":"146","volume-title":"P0361: Interferon-gamma release assay versus tuberculin skin test in patients with moderate-to-severely active ulcerative colitis: results from the pursuit UC program","author":"Marano","year":"2015"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(11)63219-8"},{"key":"ref18","first-page":"260","volume-title":"Tuberculin skin test and Quantiferon TB Gold in Romanian BCG vaccinated, immunosuppressed patients with moderate-to-severe Crohn\u2019s disease: a comparison with a Hungarian cohort","author":"Preda","year":"2016"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2016.08.107"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-018-5178-1"},{"key":"ref21","first-page":"21","volume-title":"Comparison of Quantiferon-TB Gold versus tuberculin skin test for tuberculosis screening in inflammatory bowel disease patients","author":"Andrisani","year":"2013"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21605"},{"key":"ref23","first-page":"241","volume-title":"Latent tuberculosis screening tests and active tuberculosis infection rates in Turkish inflammatory bowel disease patients under anti-tumor necrosis factor therapy","author":"\u00c7eki\u00e7","year":"2015"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2015.1064470"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21427"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-012-0192-7"},{"key":"ref27","first-page":"61","volume-title":"","author":"Borenstein","year":"2009"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.02050.x"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21329"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(04)00060-6"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-10-7"},{"key":"ref32","first-page":"49","volume-title":"","author":"Hopewell","year":"2005"}],"container-title":["Intestinal Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.irjournal.org\/upload\/pdf\/ir-2019-00116.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.irjournal.org\/journal\/view.php?doi=10.5217\/ir.2019.00116","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.irjournal.org\/upload\/pdf\/ir-2019-00116.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T01:58:04Z","timestamp":1595815084000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.irjournal.org\/journal\/view.php?doi=10.5217\/ir.2019.00116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,30]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,7]]}},"URL":"https:\/\/doi.org\/10.5217\/ir.2019.00116","relation":{},"ISSN":["1598-9100","2288-1956"],"issn-type":[{"value":"1598-9100","type":"print"},{"value":"2288-1956","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,30]]},"assertion":[{"value":"2019-09-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-20","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-30","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}