{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T12:11:48Z","timestamp":1789301508099,"version":"build-2803163510"},"reference-count":37,"publisher":"Korean Association for the Study of Intestinal Diseases","issue":"3","license":[{"start":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T00:00:00Z","timestamp":1590451200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["irjournal.org"],"crossmark-restriction":true},"short-container-title":["Intest Res"],"published-print":{"date-parts":[[2021,7,30]]},"abstract":"<jats:p>Background\/Aims: Exclusive enteral nutrition (EEN), an established modality for pediatric Crohn\u2019s disease (CD) is seldomly utilized in adults. The present study reports the outcome of EEN in adult CD patients at a tertiary care hospital in India.Methods: This was a retrospective analysis of CD patients who received EEN as a sole modality\/adjunct to other treatment. The primary and secondary outcomes changed in Crohn\u2019s Disease Activity Index (CDAI), and clinical response (decline in CDAI &gt; 70), respectively, at 4 and 8 weeks. Subgroup analysis evaluated response across different phenotypes, EEN formulations and prior treatment. Linear mixed effect model was created to assess the predictors of EEN response.Results: Thirty-one CD patients received EEN over median duration of 4 weeks (range, 2\u20136 weeks). CDAI showed a significant improvement post EEN at 4 (baseline 290 [260\u2013320] vs. 240 [180\u2013280], &lt;i&gt;P&lt;\/i&gt;= 0.001) and 8 weeks (baseline 290 [260\u2013320] vs. 186 [160\u2013240], &lt;i&gt;P&lt;\/i&gt;= 0.001), respectively. The cumulative clinical response rates at 4 and 8 weeks were 37.3% and 80.4% respectively. The clinical response rates at 8 weeks across B1 (n = 4), B2 (n = 18) and B3 (n = 9) phenotypes were 50%, 78.8% and 100% respectively (log-rank test, &lt;i&gt;P&lt;\/i&gt;= 0.093). The response rates at 8 weeks with polymeric (n = 8) and semi-elemental diet (n = 23) were 75% and 82.6%% respectively (log-rank test, &lt;i&gt;P&lt;\/i&gt;= 0.49). Baseline CDAI (odds ratio, 1.008; 95% confidence interval, 1.002\u20131.017; &lt;i&gt;P&lt;\/i&gt;= 0.046) predicted response to EEN.Conclusions: EEN was effective in inducing clinical response across different phenotypes of CD. Baseline disease activity remained the most important predictor of clinical response to EEN.<\/jats:p>","DOI":"10.5217\/ir.2019.09172","type":"journal-article","created":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T04:54:00Z","timestamp":1590382440000},"page":"291-300","update-policy":"https:\/\/doi.org\/10.5217\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Efficacy and tolerability of exclusive enteral nutrition in adult patients with complicated Crohn\u2019s 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