{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T12:09:51Z","timestamp":1789301391199,"version":"build-2803163510"},"reference-count":27,"publisher":"Korean Association for the Study of Intestinal Diseases","issue":"3","license":[{"start":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["irjournal.org"],"crossmark-restriction":true},"short-container-title":["Intest Res"],"published-print":{"date-parts":[[2021,7,30]]},"abstract":"<jats:p>Background\/Aims: Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn\u2019s disease (CD), is increasingly being reported from India and other Asian countries. This study looks into the changing trends of IBD at a tertiary care center in north India over last two decades.Methods: Retrospective analysis of a prospectively maintained database of patients diagnosed with IBD between January 1991 and December 2015 was conducted. The study period was divided into five times cohorts (1991\u20131995, 1996\u20132000, 2001\u20132005, 2006\u20132010, 2011\u20132015).Results: During the study period, 2,467 patients (UC [n = 2,137, 86.6%], CD [n = 330, 13.3%], mean age 38.5 \u00b1 13.3 years; 55.9% males) were registered. The proportion of patients with CD increased (ratio of UC to CD declined from 15.7:1 to 4:1). The mean age at diagnosis decreased for UC (45.7 \u00b1 12.1 years in 1991\u20131995 vs. 37.6 \u00b1 13.0 years in 2011\u20132015; &lt;i&gt;P&lt;\/i&gt;= 0.001) and remained consistent for CD (41.3 \u00b1 13.6 years in 1996\u20132000 vs. 41.3 \u00b1 16.9 years in 2011\u20132015, &lt;i&gt;P&lt;\/i&gt;= 0.86). Patients with proctitis in UC and isolated ileal disease in CD increased over the study period (&lt;i&gt;P&lt;\/i&gt;= 0.001 and &lt;i&gt;P&lt;\/i&gt;= 0.007, respectively). Inflammatory CD increased (&lt;i&gt;P&lt;\/i&gt;= 0.009) whereas stricturing CD decreased (&lt;i&gt;P&lt;\/i&gt;= 0.01) across all cohorts. There was a trend towards less severe presentation of both UC and CD. The use of thiopurines (&lt;i&gt;P&lt;\/i&gt;= 0.02) and biologics increased (&lt;i&gt;P&lt;\/i&gt;= 0.001) with no significant change in trends for requirements of surgery (&lt;i&gt;P&lt;\/i&gt;= 0.9).Conclusions: Increasing prevalence of CD, younger age at diagnosis, diagnosis at an earlier and milder stage, greater use of thiopurines and biologics were observed.<\/jats:p>","DOI":"10.5217\/ir.2020.00010","type":"journal-article","created":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T04:49:04Z","timestamp":1597726144000},"page":"282-290","update-policy":"https:\/\/doi.org\/10.5217\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Trends of inflammatory bowel disease at a tertiary care center in northern India"],"prefix":"10.5217","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6961-6389","authenticated-orcid":true,"given":"Ajit","family":"Sood","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8530-9493","authenticated-orcid":true,"given":"Kirandeep","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7163-0454","authenticated-orcid":true,"given":"Arshdeep","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0192-3969","authenticated-orcid":true,"given":"Vandana","family":"Midha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6726-6151","authenticated-orcid":true,"given":"Ramit","family":"Mahajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3601-4565","authenticated-orcid":true,"given":"Namita","family":"Bansal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8867-9526","authenticated-orcid":true,"given":"Varun","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7056-503X","authenticated-orcid":true,"given":"Dharmatma","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3168","reference":[{"key":"ref1","first-page":"30","volume-title":"Incidence and prevalence of inflammatory bowel disease in Japan: nationwide epidemiological survey during the year 1991","author":"Morita","year":"1995"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-009-0057-3"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.11.1587"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2000.02252.x"},{"key":"ref5","first-page":"14","volume-title":"Clinical features of ulcerative proctocolitis in Hong Kong Chinese: a review of three decades","author":"Lai","year":"1985"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20310"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s12664-012-0258-1"},{"key":"ref8","first-page":"287","volume-title":"Crohn\u2019s disease: occurrence, course and prognosis: an epidemiologic cohort-study","author":"Munkholm","year":"1997"},{"key":"ref9","first-page":"400","volume-title":"Ulcerative colitis: an epidemiological study based on a regional inception cohort, with special reference to disease course and prognosis","author":"Langholz","year":"1999"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.082909"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21493"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(76)80163-1"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198712243172603"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000465522"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.01.063"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3109\/00365529609006410"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3109\/00365529609006411"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70421-4"},{"key":"ref19","volume-title":""},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.09.002"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0469-6"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjv202"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i45.7332"},{"key":"ref24","first-page":"79","volume-title":"Azathioprine versus sulfasalazine in maintenance of remission in severe ulcerative colitis","author":"Sood","year":"2003"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s005350200034"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(17)30004-3"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25516"}],"container-title":["Intestinal Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/irjournal.org\/upload\/pdf\/ir-2020-00010.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/irjournal.org\/journal\/view.php?doi=10.5217\/ir.2020.00010","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/irjournal.org\/upload\/pdf\/ir-2020-00010.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T00:11:00Z","timestamp":1627258260000},"score":1,"resource":{"primary":{"URL":"http:\/\/irjournal.org\/journal\/view.php?doi=10.5217\/ir.2020.00010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,30]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,7]]}},"URL":"https:\/\/doi.org\/10.5217\/ir.2020.00010","relation":{},"ISSN":["1598-9100","2288-1956"],"issn-type":[{"value":"1598-9100","type":"print"},{"value":"2288-1956","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,30]]},"assertion":[{"value":"2020-01-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-18","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-30","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}