{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T11:46:47Z","timestamp":1784029607586,"version":"3.55.0"},"reference-count":49,"publisher":"Korean Association for the Study of Intestinal Diseases","issue":"4","license":[{"start":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T00:00:00Z","timestamp":1605830400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["irjournal.org"],"crossmark-restriction":true},"short-container-title":["Intest Res"],"published-print":{"date-parts":[[2021,10,31]]},"abstract":"<jats:p>Background\/Aims: Information on pediatric inflammatory bowel disease (PIBD) and very early onset IBD (VEOIBD) are sparse in India, where IBD is emerging. We aimed to evaluate characteristics of VEOIBD and later onset PIBD (LO-PIBD) in India.Methods: We performed retrospective analysis of a large, prospectively maintained IBD registry. PIBD was divided in to VEOIBD ( &lt; 6 years) and LO-PIBD (6\u201317 years). Demographic data, disease characteristics and treatment were compared between the PIBD groups and with other Asian\/Western studies as well as the adult patients of the registry.Results: Of 3,752 IBD patients, 292 (7.8%) had PIBD (0\u201317 years) (175 Crohn\u2019s disease [CD], 113 ulcerative colitis [UC], 4 IBD-undifferentiated; 22 VEOIBD [7.5%], and 270 LO-PIBD [92.5%]). VEOIBD patients had more severe disease compared to LO-PIBD in both UC (P= 0.003) and CD (P&lt; 0.001). Familial IBD was more common in VEOIBD (13.6%) compared to LO-PIBD (9.2%). Ileal disease (L1) was an independent risk factor for diagnostic delay in pediatric CD. Diagnostic delay ( &gt; 6 months) was significantly lower in VEOIBD (40.9%) than in LO-PIBD (78.8%) (P&lt; 0.001). Compared to other Asian and Western studies, extensive UC (72.5%) and complicated CD (stricturing\/penetrating: 42.7%) were relatively more common. Perianal CD was relatively less frequent (7.4%). PIBD had a significantly higher number of complicated and ileal CD and extensive UC comparison to adult cohort of the registry.Conclusions: VEOIBD has more aggressive phenotype than LO-PIBD. Disease appears distinct from other Asian and Western studies and adult onset disease, with more complicated CD and extensive UC.<\/jats:p>","DOI":"10.5217\/ir.2020.00107","type":"journal-article","created":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T06:34:17Z","timestamp":1605767657000},"page":"398-407","update-policy":"https:\/\/doi.org\/10.5217\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Very early onset inflammatory bowel disease in a South Asian country where inflammatory bowel disease is emerging: a distinct clinical phenotype from later onset disease"],"prefix":"10.5217","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3753-4933","authenticated-orcid":true,"given":"Rupa","family":"Banerjee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7090-9004","authenticated-orcid":true,"given":"Partha","family":"Pal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2713-4781","authenticated-orcid":true,"given":"Zaheer","family":"Nabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2233-0161","authenticated-orcid":true,"given":"Upender","family":"Shava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3909-4206","authenticated-orcid":true,"given":"Girish","family":"Ganesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7540-0496","authenticated-orcid":true,"given":"D. 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