{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T22:57:26Z","timestamp":1784329046952,"version":"3.55.0"},"reference-count":30,"publisher":"Korean Association for the Study of Intestinal Diseases","issue":"1","license":[{"start":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T00:00:00Z","timestamp":1611273600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["irjournal.org"],"crossmark-restriction":true},"short-container-title":["Intest Res"],"published-print":{"date-parts":[[2022,1,30]]},"abstract":"<jats:p>Background\/Aims: Inflammatory bowel disease (IBD) patients frequently have zinc deficiency. IBD patients with zinc deficiency have higher risks of IBD-related hospitalization, complications, and requiring surgery. This study aimed to examine the effectiveness of zinc acetate hydrate (ZAH; Nobelzin) in IBD patients with zinc deficiency.Methods: IBD patients with zinc deficiency who received ZAH from March 2017 to April 2020 were registered in this 2-center, retrospective, observational study. Changes in serum zinc levels and disease activity (Crohn\u2019s Disease Activity Index [CDAI]) before and after ZAH administration were analyzed.Results: Fifty-one patients with Crohn\u2019s disease (CD, n = 40) or ulcerative colitis (UC, n = 11) were registered. Median serum zinc level and median CDAI scores significantly improved (55.5\u201391.0 \u03bcg\/dL, P&lt; 0.001; 171.5\u2013129, P&lt; 0.001, respectively) in CD patients 4 weeks after starting ZAH administration. Similarly, median serum zinc levels and CDAI scores significantly improved (57.0\u201381.0 \u03bcg\/dL, P&lt; 0.001; 177\u2013148, P= 0.012, respectively) 20 weeks after starting ZAH administration. Similar investigations were conducted in groups where no treatment change, other than ZAH administration, was implemented; significant improvements were observed in both serum zinc level and CDAI scores. Median serum zinc levels in UC patients 4 weeks after starting ZAH administration significantly improved from 63.0 to 94.0 \u03bcg\/dL (P= 0.002), but no significant changes in disease activity were observed. One patient experienced side effects of abdominal discomfort and nausea.Conclusions: ZAH administration is effective in improving zinc deficiency and may contribute to improving disease activity in IBD.<\/jats:p>","DOI":"10.5217\/ir.2020.00124","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T07:37:32Z","timestamp":1611214652000},"page":"78-89","update-policy":"https:\/\/doi.org\/10.5217\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Effectiveness of administering zinc acetate hydrate to patients with inflammatory bowel disease and zinc deficiency: a retrospective observational two-center study"],"prefix":"10.5217","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8178-8984","authenticated-orcid":true,"given":"Kensuke","family":"Sakurai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7054-5730","authenticated-orcid":true,"given":"Shigeru","family":"Furukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7400-2514","authenticated-orcid":true,"given":"Takehiko","family":"Katsurada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2209-9334","authenticated-orcid":true,"given":"Shinsuke","family":"Otagiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4680-8123","authenticated-orcid":true,"given":"Kana","family":"Yamanashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0528-0390","authenticated-orcid":true,"given":"Kazunori","family":"Nagashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0353-4839","authenticated-orcid":true,"given":"Reizo","family":"Onishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3316-5843","authenticated-orcid":true,"given":"Keiji","family":"Yagisawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8458-5293","authenticated-orcid":true,"given":"Haruto","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5228-4840","authenticated-orcid":true,"given":"Takahiro","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9182-8502","authenticated-orcid":true,"given":"Atsuo","family":"Maemoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0061-059X","authenticated-orcid":true,"given":"Naoya","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3168","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(79)90389-5"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.59.697.690"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800591018"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800591018"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.22906"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-318484"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2307\/3431820"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/01.mib.0000206541.15963.c3"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1177\/0148607107031004311"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000198059"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/mib.0000000000000989"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(80)90576-4"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136\/gut.21.5.387"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1080\/00365529850172098"},{"key":"ref15","first-page":"22","volume-title":"A proposal of the clinical standard value for diagnose of zinc deficiency by serum zinc value","author":"Tomita","year":"2008"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-018-1439-1"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1056\/nejm198712243172603"},{"key":"ref18","first-page":"439","volume-title":"Development of a Crohn\u2019s disease activity index. 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