{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T11:46:50Z","timestamp":1784029610003,"version":"3.55.0"},"reference-count":46,"publisher":"Korean Association for the Study of Intestinal Diseases","issue":"2","license":[{"start":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T00:00:00Z","timestamp":1659916800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["irjournal.org"],"crossmark-restriction":true},"short-container-title":["Intest Res"],"published-print":{"date-parts":[[2023,4,30]]},"abstract":"<jats:p>Background\/Aims: Inflammatory bowel disease (IBD) is increasingly being recognized in elderly patients. Data on clinical spectrum of elderly-onset IBD patients is lacking from India.Methods: A cross-sectional retrospective analysis of a prospectively maintained database of patients diagnosed with IBD was conducted at 2 centers in India. The clinical spectrum of elderly-onset IBD including demographic profile (age and sex), clinical presentation, disease characteristics (disease behavior and severity, extent of disease), and treatment were recorded and compared with adult-onset IBD.Results: During the study period, 3,922 (3,172 ulcerative colitis [UC] and 750 Crohn\u2019s disease [CD]) patients with IBD were recorded in the database. A total of 186 patients (4.74%; 116 males [62.36%]) had elderly-onset IBD (69.35% UC and 30.64% CD). Diarrhea, blood in stools, nocturnal frequency and pain abdomen were the commonest presentations for UC, whereas pain abdomen, weight loss and diarrhea were the most frequent symptoms in CD. For both elderly onset UC and CD, majority of the patients had moderately severe disease. Left-sided colitis was the commonest disease location in UC. Isolated ileal disease and inflammatory behavior were the most common disease location and behavior, respectively in CD. 5-Aminosalicylates were the commonest prescribed drug for both elderly onset UC and CD. Thiopurines and biologics were used infrequently. Prevalence of colorectal cancer was higher in elderly onset IBD.Conclusions: Elderly onset IBD is not uncommon in India. Both the elderly onset UC and CD were milder, with no significant differences in disease characteristics (disease extent, location and behavior) when compared to adult-onset IBD. Colorectal cancer was more common in elderly onset IBD.<\/jats:p>","DOI":"10.5217\/ir.2021.00177","type":"journal-article","created":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T06:50:58Z","timestamp":1659682258000},"page":"216-225","update-policy":"https:\/\/doi.org\/10.5217\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Clinical spectrum of elderly-onset inflammatory bowel disease in India"],"prefix":"10.5217","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6097-8172","authenticated-orcid":true,"given":"Yogesh Kumar","family":"Gupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7163-0454","authenticated-orcid":true,"given":"Arshdeep","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8115-5439","authenticated-orcid":true,"given":"Vikram","family":"Narang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0192-3969","authenticated-orcid":true,"given":"Vandana","family":"Midha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6726-6151","authenticated-orcid":true,"given":"Ramit","family":"Mahajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8867-9526","authenticated-orcid":true,"given":"Varun","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7056-503X","authenticated-orcid":true,"given":"Dharmatma","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3601-4565","authenticated-orcid":true,"given":"Namita","family":"Bansal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2035-1126","authenticated-orcid":true,"given":"Madeline Vithya Barnaba","family":"Durairaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5111-7861","authenticated-orcid":true,"given":"Amit Kumar","family":"Dutta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6961-6389","authenticated-orcid":true,"given":"Ajit","family":"Sood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3168","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/s2468-1253(19)30358-9"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-303864"},{"key":"ref3","first-page":"263","volume-title":"European Crohn\u2019s and Colitis Organisation topical review on IBD in the elderly","author":"Sturm","year":"2017"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-019-0720-7"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20605"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.240"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13826"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjaa181"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjv194"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14263"},{"key":"ref11","first-page":"400","volume-title":"Ulcerative colitis: an epidemiological study based on a regional inception cohort, with special reference to disease course and prognosis","author":"Langholz","year":"1999"},{"key":"ref12","first-page":"287","volume-title":"Crohn\u2019s disease: occurrence, course and prognosis: an epidemiologic cohort-study","author":"Munkholm","year":"1997"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.082909"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/s0016-5085(76)80163-1"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1056\/nejm198712243172603"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2018.16.2.194"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/s0016-5085(98)70421-4"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136\/gut.46.3.336"},{"key":"ref19","first-page":"1839","volume-title":"First prospective, population-based inflammatory bowel disease incidence study in mainland of China: the emergence of \u201cwestern\u201d disease","author":"Zhao","year":"2013"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230x-13-166"},{"key":"ref21","first-page":"157","volume-title":"Epidemiology of inflammatory bowel diseases in the elderly in the province of Li\u00e8ge","author":"Piront","year":"2002"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20029"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2010.08.004"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-00360-x"},{"key":"ref25","first-page":"1059","volume-title":"The incidence and prevalence of inflammatory bowel disease among U.S. veterans: a national cohort study","author":"Hou","year":"2013"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.04.007"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s12664-012-0258-1"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1136\/gut.39.5.690"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0469-6"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2009.10.004"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1002\/9781119077633","volume-title":"Management of inflammatory bowel disease in the elderly patient: challenges and opportunities","author":"Ananthakrishnan","year":"2017"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1985.tb05462.x"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjv059"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v111.pm8780560"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1986.00360160189025"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1097\/meg.0000000000001546"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2012.09.005"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-012-2083-x"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-008597"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.2011.194"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2482-13-s2-s9"},{"key":"ref42","first-page":"218","volume-title":"Risk of surgery and mortality in elderly-onset inflammatory bowel disease: a population-based cohort study","author":"Nguyen","year":"2017"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjw054"},{"key":"ref44","first-page":"2200","volume-title":"Characteristics and behavior of elderly-onset inflammatory bowel disease: a multi-center US study","author":"Hou","year":"2016"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.304"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2016.09.006"}],"container-title":["Intestinal Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/irjournal.org\/upload\/pdf\/ir-2021-00177.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/irjournal.org\/journal\/view.php?doi=10.5217\/ir.2021.00177","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/irjournal.org\/upload\/pdf\/ir-2021-00177.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T06:49:32Z","timestamp":1683182972000},"score":1,"resource":{"primary":{"URL":"http:\/\/irjournal.org\/journal\/view.php?doi=10.5217\/ir.2021.00177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,30]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,4]]}},"URL":"https:\/\/doi.org\/10.5217\/ir.2021.00177","relation":{},"ISSN":["1598-9100","2288-1956"],"issn-type":[{"value":"1598-9100","type":"print"},{"value":"2288-1956","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,30]]},"assertion":[{"value":"2021-12-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-08","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-30","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}