{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:25:58Z","timestamp":1791476758836,"version":"4.3.4"},"reference-count":61,"publisher":"Korean Association for the Study of Intestinal Diseases","issue":"1","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["irjournal.org"],"crossmark-restriction":true},"short-container-title":["Intest Res"],"published-print":{"date-parts":[[2024,1,31]]},"abstract":"<jats:p>Background\/Aims: Insomnia is common in people with chronic medical conditions, such as inflammatory bowel disease (IBD), and is readily treatable through cognitive behavioral therapy for insomnia. This study aimed to describe the associations with insomnia in people with IBD and its relationship to IBD-related disability.Methods: An online questionnaire was administered through 3 tertiary IBD centers, social media, and Crohn\u2019s Colitis Australia. The questionnaire included the Insomnia Severity Index (ISI), a validated assessment of insomnia. Measures of anxiety, depression, physical activity, and disability were also included. IBD activity was assessed using validated patient reported scores. A multivariate model was constructed for clinically significant insomnia and ISI scores. Subpopulations of Crohn\u2019s disease and ulcerative colitis were considered.Results: In a cohort of 670 respondents the median age was 41 years (range, 32\u201370 years), with the majority female (78.4%), the majority had Crohn\u2019s disease (57.3%). Increasingly severe disability was associated with worse insomnia score. Clinically significant insomnia was associated with clinically active IBD, abdominal pain, anxiety, and depression, in a multivariate model. In an ulcerative colitis population, Simple Clinical Colitis Activity Index components of general well-being and urgency were associated with worse ISI score in a model including depression and anxiety. In those with Crohn\u2019s disease, the multivariate model included Harvey Bradshaw Index score in addition to depression and anxiety.Conclusions: Insomnia is common in people with IBD and is associated with increased disability. Abdominal pain and mental health conditions should prompt consideration for screening for insomnia and referral for cognitive behavioral therapy for insomnia.<\/jats:p>","DOI":"10.5217\/ir.2023.00028","type":"journal-article","created":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:59:49Z","timestamp":1698713989000},"page":"104-114","update-policy":"https:\/\/doi.org\/10.5217\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Insomnia is common in inflammatory bowel disease (IBD) and is associated with mental health conditions as well as IBD activity"],"prefix":"10.5217","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1457-6636","authenticated-orcid":true,"given":"Alex","family":"Barnes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7960-2650","authenticated-orcid":true,"given":"Jane M","family":"Andrews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5021-1648","authenticated-orcid":true,"given":"Sutapa","family":"Mukherjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4229-3289","authenticated-orcid":true,"given":"Robert V","family":"Bryant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5873-4459","authenticated-orcid":true,"given":"Peter","family":"Bampton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9667-3864","authenticated-orcid":true,"given":"Robert J.","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0661-8894","authenticated-orcid":true,"given":"R\u00e9me","family":"Mountifield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3168","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.07.022"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/33.5.585"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093\/sleepadvances\/zpac025"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2021.101518"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2020.08.032"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-58807-9"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9072304"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/bjhp.12457"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izx100"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21580"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.01.021"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.10.019"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1186\/s40064-016-3408-6"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.04.021"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-021-07176-y"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/30.2.213"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114742"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.158.10.1099"},{"key":"ref19","first-page":"S221","volume-title":"The impact and prevalence of chronic insomnia and other sleep disturbances associated with chronic illness","author":"Ancoli-Israel","year":"2006"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2007.00571.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2004.07.001"},{"key":"ref22","first-page":"313","volume-title":"Insomnia and heart disease: a review of epidemiologic studies","author":"Schwartz","year":"1999"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.2002.00941.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2004.02.007"},{"key":"ref25","first-page":"171","volume-title":"Professional correlates of insomnia","author":"L\u00e9ger","year":"2006"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgast-2021-000805"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.4103\/sjg.sjg_603_17"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1097\/jcp.0b013e31820ebd2c"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i29.3293"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-013-2890-8"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-57460-6"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.4274\/haseki.galenos.2019.5635"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9092921"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izz258"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/34.5.601"},{"key":"ref36","first-page":"447","volume-title":"Evaluation of insomnia: validity of 3 questionnaires","author":"Blais","year":"1997"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1016\/s1389-9457(00)00065-4"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(80)92767-1"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1097\/mcg.0b013e31828b2196"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1136\/gut.43.1.29"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2012.11.007"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.403"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1249\/01.mss.0000078924.61453.fb"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.10.1092"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.2001.016009606.x"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14496"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-310151"},{"key":"ref48","first-page":"163","volume-title":"Frequency of sleep disorders in patients with rheumatoid arthritis","author":"Mustafa","year":"2019"},{"key":"ref49","volume-title":"","author":"Reynolds","year":"2019"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.13095"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1053\/smrv.2002.0186"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.04.046"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2008.01181.x"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.3316"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2020.101282"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1177\/0269881111421973"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2019.08.002"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.7326\/m14-2841"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsy104"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.4088\/jcp.15m10244"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2020.9049"}],"container-title":["Intestinal Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/irjournal.org\/upload\/pdf\/ir-2023-00028.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/irjournal.org\/journal\/view.php?doi=10.5217\/ir.2023.00028","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/irjournal.org\/upload\/pdf\/ir-2023-00028.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T23:18:47Z","timestamp":1707175127000},"score":1,"resource":{"primary":{"URL":"http:\/\/irjournal.org\/journal\/view.php?doi=10.5217\/ir.2023.00028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,31]]},"references-count":61,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"URL":"https:\/\/doi.org\/10.5217\/ir.2023.00028","relation":{},"ISSN":["1598-9100","2288-1956"],"issn-type":[{"value":"1598-9100","type":"print"},{"value":"2288-1956","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,31]]},"assertion":[{"value":"2023-03-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-01","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-31","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}