{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:43:09Z","timestamp":1792118589784,"version":"4.4.0"},"reference-count":20,"publisher":"Korean Association for the Study of Intestinal Diseases","issue":"3","license":[{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["irjournal.org"],"crossmark-restriction":true},"short-container-title":["Intest Res"],"published-print":{"date-parts":[[2024,7,31]]},"abstract":"<jats:p>Background\/Aims: To describe the role of ustekinumab in inducing remission and endoscopic healing in anti-tumor necrosis factor \u03b1 nonresponsive pediatric ulcerative colitis patients at a tertiary care inflammatory bowel disease center. Methods: A retrospective chart review was performed on patients with ulcerative colitis receiving ustekinumab. Primary outcome was steroidfree clinical remission at follow-up. Secondary outcomes were biochemical remission and endoscopic healing. Results: Ten children were analyzed; 7 (70%) had ulcerative colitis, and 3 (30%) had inflammatory bowel disease unspecified with colitis. Median follow-up period was 56 weeks. Nine patients (90%) achieved steroid-free clinical remission and biochemical remission. Seven patients had follow-up colonoscopies, out of which 6 (86%) achieved endoscopic remission, while 1 (14%) underwent colectomy. Out of the 3 patients without a follow-up colonoscopy, fecal calprotectin levels downtrended to &lt; 150 mg\/kg in 2 patients and &lt; 400 mg\/kg in 1 patient from baseline level of &gt; 2,000 mg\/kg. Conclusions: Ustekinumab appears efficacious in achieving not only clinical and biochemical remission but also has promising role in inducing endoscopic healing end point in patients who fail other biologics.<\/jats:p>","DOI":"10.5217\/ir.2023.00091","type":"journal-article","created":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T04:27:47Z","timestamp":1707107267000},"page":"351-356","update-policy":"https:\/\/doi.org\/10.5217\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Ustekinumab for anti-tumor necrosis factor refractory pediatric ulcerative colitis: a promising approach towards endoscopic healing"],"prefix":"10.5217","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5338-4787","authenticated-orcid":true,"given":"Rahiya","family":"Rehman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9465-0425","authenticated-orcid":true,"given":"Muhammad 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