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Methods: This retrospective observational study assessed the relationships among patient-reported outcome (PRO2), LRG, and other blood markers. The influence of LRG on clinical relapse was assessed in patients in remission with CD. Results: Data of 94 patients tested for LRG between January 2021 and May 2023 were collected. LRG level did not correlate with PRO2 score (\u03c1 = 0.06); however, it strongly correlated with C-reactive protein (CRP) level (r=0.79) and serum albumin level (r=\u20130.70). Among 69 patients in clinical remission, relapse occurred in 22 patients (31.9%). In the context of predicting relapse, LRG showed the highest area under the curve, followed by CRP level, platelet count, and albumin level. Multivariate analysis revealed that only LRG (P= 0.02) was an independent factor for predicting clinical remission. The cumulative non-relapse rate was significantly higher in patients with LRG &lt; 13.8 \u03bcg\/mL than in patients in remission with LRG \u2265 13.8 \u03bcg\/mL and normal CRP level (P= 0.002) or normal albumin level (P= 0.001). Cumulative non-relapse rate was also higher in patients with LRG &lt; 13.8 \u03bcg\/mL compared to those with LRG \u2265 13.8 \u03bcg\/mL in patients with L3 or B2+B3 of Montreal calcification. Conclusions: LRG is useful in predicting clinical relapse in patients with CD during biological remission. LRG is a useful biomarker for predicting prognosis, even in patients with intestinal stenosis, or previous\/present fistulas.<\/jats:p>","DOI":"10.5217\/ir.2024.00042","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:12:26Z","timestamp":1724285546000},"page":"170-181","update-policy":"https:\/\/doi.org\/10.5217\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Leucine-rich alpha-2 glycoprotein is useful in predicting clinical relapse in patients with Crohn\u2019s disease during biological 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